Breaking News
January 19, 2019 - Formlabs 3D prints anatomical models
January 19, 2019 - Heart-Healthy Living Also Wards Off Type 2 Diabetes
January 19, 2019 - Teaching Kids to Be Smart About Social Media (for Parents)
January 19, 2019 - Metabolite produced by gut microbiota from pomegranates reduces inflammatory bowel disease
January 19, 2019 - Researchers examine how spray from showers and toilets expose us to disease causing bacteria
January 19, 2019 - Behavioral experiments confirm that additional neurons improve brain function
January 19, 2019 - New study compares performance of real-time infectious disease forecasting models
January 19, 2019 - Obesity can be risk factor for developing renal cell carcinoma, confirms study
January 19, 2019 - New regulation designs on cigarette packs direct smokers’ attention to health warnings
January 19, 2019 - QIAGEN receives first companion diagnostic approval in Japan
January 19, 2019 - Study explores role of Dunning-Kruger effect in anti-vaccine attitudes
January 19, 2019 - Newly identified subset of immune cells may be key to fighting chronic inflammation
January 19, 2019 - New immune response regulators discovered
January 18, 2019 - Poor blood oxygenation during sleep predicts chance of heart-related death
January 18, 2019 - First international consensus on the diagnosis and management of fibromuscular dysplasia
January 18, 2019 - Rapid resistance gene sequencing technology can hasten identification of antibiotic-resistant bacteria
January 18, 2019 - Researchers develop artificial enzymatic pathway for synthesizing isoprenoids in E. coli
January 18, 2019 - Scientists advise caution in immunotherapy research
January 18, 2019 - How children across the world develop language
January 18, 2019 - Columbia Medical Student Receives McDonogh Scholarship
January 18, 2019 - Secretive ‘Rebate Trap’ Keeps Generic Drugs For Diabetes And Other Ills Out Of Reach
January 18, 2019 - Plant based diet could be the best option for the planet says commission
January 18, 2019 - New conservation practice could reduce nitrogen from agricultural drainage, study shows
January 18, 2019 - UIC researchers receive $1.7 million NCI grant to study Southeast Asian fruit
January 18, 2019 - New study determines the fate of DNA derived from genetically modified food
January 18, 2019 - Scientists develop new gene therapy that prevents axon destruction in mice
January 18, 2019 - Study finds critically low HPV vaccination rates among younger adolescents in the U.S.
January 18, 2019 - Brain cells involved in memory play key role in reducing future eating behavior
January 18, 2019 - Risk for Conversion of MS Varies With Different Therapies
January 18, 2019 - Investigational cream may help patients with inflammatory skin disease
January 18, 2019 - Medical school news office receives six writing awards | News Center
January 18, 2019 - County By County, Researchers Link Opioid Deaths To Drugmakers’ Marketing
January 18, 2019 - Research reveals risk for developing more than one mental health disorder
January 18, 2019 - Scientists discover a dramatic pattern of bone growth in female mice
January 18, 2019 - Study finds link between lengthy periods of undisturbed maternal sleep and stillbirths
January 18, 2019 - New nuclear medicine method could improve detection of primary and metastatic melanoma
January 18, 2019 - Combination therapy shows high efficacy in treating people with leishmaniasis and HIV
January 18, 2019 - Health Tip: Don’t Ignore Changes in Skin Color
January 18, 2019 - Dietary Recommendations for Healthy Children
January 18, 2019 - Eliminating the latent reservoir of HIV
January 18, 2019 - Pain From The Government Shutdown Spreads. This Time It’s Food Stamps
January 18, 2019 - Newly discovered regulatory mechanism helps control fat metabolism
January 18, 2019 - New rapid blood tests could speed up TB diagnosis, save the NHS money
January 18, 2019 - Researchers develop intelligent system for ‘tuning’ powered prosthetic knees
January 18, 2019 - Monoclonal antibody pembrolizumab prolongs survival in patients with squamous cell carcinoma
January 18, 2019 - New research detects mosquito known to transmit malaria for the first time in Ethiopia
January 18, 2019 - New guidelines to make swallowing safer for people in Australian nursing homes
January 18, 2019 - Lumex Instruments’ RA-915AM monitor installed at Hg treatment plant in Almadén, Spain
January 18, 2019 - ACCC survey finds multiple threats to growth of cancer programs
January 18, 2019 - Meeting the challenge of engaging men in HIV prevention and treatment
January 18, 2019 - Furloughed Feds’ Health Coverage Intact, But Shutdown Still Complicates Things
January 18, 2019 - Experts discuss various aspects on health risks posed by fumigated containers
January 18, 2019 - Researchers use gene-editing tool CRISPR/Cas9 to limit impact of parasitic diseases
January 18, 2019 - Alpha neurofeedback training could be a means of enhancing learning success
January 18, 2019 - Innovative ‘light’ method demonstrates positive results in fight against malignant tumors
January 18, 2019 - The cytoskeleton of neurons found to play role in Alzheimer’s disease
January 18, 2019 - New resource-based approach to improve HIV care in low- and middle-income countries
January 18, 2019 - Bedfont appoints Dr Jafar Jafari as first member of the Gastrolyzer Medical Advisory Board
January 18, 2019 - New study shows link between secondhand smoke and cardiac arrhythmia
January 18, 2019 - DZIF scientists reveal problems with available diagnostics for Zika and chikungunya virus
January 18, 2019 - Breast cancers more likely to metastasize in young women within 10 years of giving birth
January 18, 2019 - Over 5.6 million Americans exposed to high nitrate levels in drinking water
January 18, 2019 - Blood vessels can now be created perfectly in a petri dish
January 18, 2019 - Study identifies prominent socioeconomic and racial disparities in health behavior in Indiana
January 18, 2019 - Young-Onset Type 2 Diabetes Tied to Increased Hospitalization Risk
January 18, 2019 - For-profit nursing schools associated with lower performance on nurse licensure test
January 18, 2019 - Considering the culture of consent in medicine
January 18, 2019 - Researchers identify comprehensive guidelines for managing severe atopic dermatitis
January 18, 2019 - Analyzing proteins in blister fluid may classify burn severity more accurately
January 18, 2019 - Study finds higher suicide rates among youth who were Medicaid enrollees
January 18, 2019 - Opioid drugs often overprescribed to children for pain relief, say CHOP surgeons
January 18, 2019 - New biodegradable wound dressing material accelerates healing
January 18, 2019 - Life in Space May Take Toll on Spinal Muscles
January 18, 2019 - Bulldogs’ screw tails linked to human genetic disease
January 18, 2019 - Immunotherapy target identified for pediatric cancers
January 18, 2019 - Financial stress may increase heart disease risk in African Americans
January 18, 2019 - Scientists solve another piece of Ebola virus puzzle
January 18, 2019 - New project finds how endocrine disruptors interfere with thyroid functions
January 18, 2019 - Research finds decline in ketone body utilization when coronary circulation is reduced
January 18, 2019 - Let’s map our DNA and save billions each year in health costs
Researchers develop mathematical model for monitoring, controlling spread of melioidosis

Researchers develop mathematical model for monitoring, controlling spread of melioidosis

image_pdfDownload PDFimage_print

An international research team from the University of Leicester, Lomonosov Moscow State University(MSU), and the Moscow Institute of Physics and Technology(MIPT) from Russia has developed a mathematical model for monitoring and controlling the spread of melioidosis in Southeast Asia.

The findings are presented in Scientific Reports, a prestigious journal from the publishers of Nature.

Melioidosis is a serious infectious disease manifesting itself as multiple abscesses of various organs due to severe sepsis. In 40 percent of the cases, the disease leads to death. Patients with diabetes are at a higher risk of being infected. Melioidosis, which is also known as Whitmore’s disease, is caused by the bacterium Burkholderia pseudomallei, which is particularly active in soil and water. This pathogen is widespread in Southeast Asia, Australia, West and East Africa.

“Melioidosis is a severe and dangerous disease, but much of the research into it focuses on the bacterium that causes. Meanwhile, the phages abundantly found in the habitat of the pathogen are not getting enough attention. We wondered whether we could predict the variation in the number of pathogenic bacteria and the impact of phages on it depending on season and environmental conditions,” explains the study co-author Dr Andrew Morozov from the University of Leicester.

To achieve this goal, the researchers developed several mathematical models predicting the seasonal and daily dynamics of the size of B.pseudomallei populations. They focused on the bacterial populations on rice fields in two Thailand provinces— Nakhon Phanom and SaKaeo— and how the pathogen is affected by temperature-dependent phages, viruses selectively killing bacteria. The variation was explored in terms of the change in temperatures and ultraviolet radiation levels.

Simulation results show that the period from March to September poses the greatest threat, because that is when phages killing B.pseudomallei are at their lowest due to high levels of UV radiation. The drop in the number of phages in spring and summer means there are more bacteria unaffected by the virus. At constant UV exposure, temperature takes over as the decisive factor. Specifically, at more than 35degrees Celsius, the phage enters the so-called lytic cycle when it destroys bacterial cells, reducing the pathogen population. The model indicates phage-free bacteria numbers are at their highest around 9a.m. and 8p.m.

Besides UV rays, the number of phage-free bacteria is affected by the use of fertilizers. Recent studies indicate that iron-based chemicals kill off phages, but the effects of other fertilizers are unknown. Since they result in unpredictable dynamics of B.pseudomallei populations, they might pose a risk of more frequent infections in humans.

“Unlike in a lab, in nature, there are factors that limit the size of the populations of both pathogenic and phage-infected bacteria. To make our model more realistic, we measured a host of actual phage parameters. That way the model can predict which combination of seasonal parameters results in a high risk of a melioidosis infection,” adds Professor Andrey Letarov of MSU and MIPT, who also heads the Laboratory of Microbial Viruses at Winogradsky Institute of Microbiology of the Russian Academy of Sciences.

The findings on B.pseudomallei-phage interactions reveal opportunities for disease control. For example, the work on rice fields can be rescheduled depending on season. Also, once the risky periods are identified, preventive measures can be introduced, such as the use of protective gear. Finally, field owners can use agrochemicals that do not harm the phages limiting the population of pathogenic bacteria.

“Mathematical modelling enables us to make predictions under various regimes. In particular, we can estimate the impact of global warming on spread of endemic zones of disease,” says Dr Morozov. “We are resuming this research: This autumn, we will run a series of experiments to study in more detail how agricultural chemicals affect the level of phages in the soil, how phages and bacteria interact in it, and which limiting factors are at play there.”

Source:

https://www2.le.ac.uk/offices/press/press-releases/2018/september-1/researchers-show-bacteriophages-can-affect-melioidosis-disease-acquisition

Tagged with:

About author

Related Articles