Breaking News
October 17, 2018 - Eisai enters into agreement with Eurofarma for development and sales of lorcaserin in 17 countries
October 17, 2018 - Patients once thought incurable can benefit from high-dose radiation therapy
October 17, 2018 - Researchers awarded grant to advance testing of experimental heroin vaccine
October 17, 2018 - Researchers examine SSRI use during pregnancy and major gestational malformations
October 17, 2018 - Study reveals link between childhood abuse and higher arthritis risk in adulthood
October 17, 2018 - FDA Approves Liletta (levonorgestrel-releasing intrauterine system) 52 mg to Prevent Pregnancy for up to Five Years
October 17, 2018 - Weight gain after smoking cessation linked to increased short-term diabetes risk
October 17, 2018 - Researchers find opportunity to control salt-sensitive hypertension without exercising
October 17, 2018 - Metrohm offers robust handheld Raman analyzer for Defense and Security
October 17, 2018 - Modeling Non-Numerical Data in Systems Biology
October 17, 2018 - Research aims to address health disparities in African-American men
October 17, 2018 - Human and cattle decoys trap outdoor-biting mosquitoes in malaria endemic regions
October 17, 2018 - High Circulating Prolactin Level Inversely Linked to T2DM Risk
October 17, 2018 - Study finds gene variant predisposes people to both Type 2 diabetes and low body weight
October 17, 2018 - Metrohm software products make it easy to comply with ALOCA and ALCOA+ guidelines
October 17, 2018 - Network of doctors identify the cause of 31 new conditions
October 17, 2018 - Notable improvement in brain cancer survival among younger patients but not much for elderly
October 17, 2018 - Scientists shed light on roles of transcription factors, TP63 and SOX2, in squamous cell carcinoma
October 17, 2018 - Costs of Medicare Diabetes Prevention Program may be higher than expected reimbursement
October 17, 2018 - Misuse of prescription opioids or benzodiazepines associated with suicidal thoughts
October 17, 2018 - New research seeks to address sex disparities in women’s health
October 17, 2018 - C-Section Rates Have Nearly Doubled Since 2000: Study
October 17, 2018 - Talking to Your Kids About STDs
October 17, 2018 - New classification of periodontal and peri-implant diseases and conditions
October 17, 2018 - Herbert D. Kleber, Pioneer in Addiction Treatment, Dies at 84
October 17, 2018 - Health effects of smoke-filled atmosphere
October 17, 2018 - Down syndrome may hold important clues to onset of Alzheimer’s disease
October 17, 2018 - A special report on US’ aging societies
October 17, 2018 - Birth mode may have acute effects on neurodevelopment, study suggests
October 17, 2018 - Global health innovation system fails to deliver affordable treatments to patients, says report
October 17, 2018 - Simple, inexpensive test quickly detects antibiotic-resistant ‘superbugs’
October 17, 2018 - New drugs could reduce risk of heart disease when added to statins
October 17, 2018 - Visible and valued: Stanford Medicine’s first-ever LGBTQ+ Forum
October 17, 2018 - HVP vaccination not linked with rise in teen risky sex
October 17, 2018 - Potential ‘early warning markers’ for sepsis discovered
October 17, 2018 - Who knew? Life begins (again) at 65
October 17, 2018 - Application of blood pressure guidelines ups treatment
October 17, 2018 - Stanford researchers find that small molecule may help treat enzyme deficiency
October 17, 2018 - Speed Cameras Save Money and Lives in New York City
October 17, 2018 - Men who conform to ‘the man box’ more likely to consider suicide and violence
October 17, 2018 - Researchers aim to create more authentic organoids for drug testing, transplantation
October 16, 2018 - New blood test for pediatric brain tumor patients offers safer approach than surgical biopsies
October 16, 2018 - Age-related estrogen increase may be the culprit behind inguinal hernias in men
October 16, 2018 - Skills-Based Intervention Did Not Cut Systolic BP After Stroke, TIA
October 16, 2018 - Researchers uncover new role of TIP60 protein in controlling tumour formation
October 16, 2018 - Behind the scenes of a lifesaving heart surgery
October 16, 2018 - ‘To See the Suffering’
October 16, 2018 - Drinking concentrated rosemary extract can boost memory by up to 15%, shows research
October 16, 2018 - Medicare Advantage riding high as new insurers flock to sell to seniors
October 16, 2018 - NHS tackles prescription fraud to save millions
October 16, 2018 - New molecular switch may help develop sophisticated photomedications
October 16, 2018 - Improving access to behavioral health screenings for pregnant and postpartum women
October 16, 2018 - Health Highlights: Oct. 12, 2018
October 16, 2018 - Study holds promise for new pediatric brain tumor treatment
October 16, 2018 - Patient advocate uses MRI scans to create art and spark conversations about life with illness
October 16, 2018 - Fish oil based diets may suppress growth and spread of breast cancer cells
October 16, 2018 - Number of VHA facilities offering acupuncture has increased rapidly
October 16, 2018 - Influential Leapfrog Group jumps in to rate 5,600 surgery centers
October 16, 2018 - HIV-infected infants more likely to acquire congenital cytomegalovirus infection
October 16, 2018 - Study pinpoints new marker that can predict Crohn’s disease subtype
October 16, 2018 - Simple procedure could be efficacious intervention for failed back surgery
October 16, 2018 - New research identifies modifiable dementia risk factor in elderly people
October 16, 2018 - Zebrafish study uncovers molecular ‘brake’ that helps control eye lens development
October 16, 2018 - Overlapping copy number variations underlie autism and schizophrenia in Japanese patients
October 16, 2018 - Early menopause and diabetes may reduce life expectancy
October 16, 2018 - Majority of Americans’ ancestry can be traced through existing DNA databases
October 16, 2018 - Patients coerced into mental health care less likely to perceive treatment as effective
October 16, 2018 - Healthy elders can consume walnuts without having negative impact on weight gain, finds study
October 16, 2018 - Interactive robot helps older people exercise and detects underlying health problems
October 16, 2018 - What you need to know about autism spectrum disorder
October 16, 2018 - Antidepressants can be used to treat Alzheimer’s disease
October 16, 2018 - Study uncovers important role of PRMT1 in dilated cardiomyopathy
October 16, 2018 - Nutritional quality of breakfast linked to cardiovascular and metabolic risk factors in children
October 16, 2018 - Study uses novel approach to investigate genetic origins of mental illnesses
October 16, 2018 - Scientists develop dual anthrax-plague vaccine
October 16, 2018 - Poor Outcomes for Hispanic Infants With Congenital Heart Dz
October 16, 2018 - Global study finds youngest in class more likely to be diagnosed with ADHD
October 16, 2018 - Researchers sequence two selfish genes in the fungus Neurospora intermedia
October 16, 2018 - Survey results highlight the need for better communication between patients and HCPs about bacterial vaginosis
October 16, 2018 - Researchers develop fibrin-targeting immunotherapy to protect against neurodegeneration
Infants face high thrombosis risk

Infants face high thrombosis risk

image_pdfDownload PDFimage_print

Russian scientists have carried out tests to compare the process of blood coagulation in adults and newborns and discovered that the latter face an increased risk of thrombosis. The researchers also compared this process in infants carried to term and in preterm babies. The work was carried out as part of a project funded by the Presidential Program of Research Projects of the Russian Science Foundation (RSF), with the results being published in Pediatric Research.

Damage to the blood vessel wall triggers the haemostasis system: an insoluble clot forms at the site of injury, preventing blood loss. The key role in haemostasis is played by blood plasma proteins and platelets, which form the framework of a thrombus, cross-linked with growing filaments of a fibrin clot. These filaments are produced during the clotting process by a cascade of enzymatic reactions, which yield the proteinaceous polymer.

Coagulation system disturbances are one of the leading causes of infant death or disability. Moreover, the risks of bleeding disorders or thrombosis are greatly increased in the presence of complications in newborns, with preterm birth being one of the most significant. No effective methods for diagnosing haemostasis disorders in infants are currently available in clinical practice. On the one hand, the incidence of clinical complications associated with haemostasis system disorders in infants is generally low, making mass screening impractical. On the other hand, such tests could be recommended for high-risk groups, such as in preterm infants or infants with congenital systemic infections. This, however, brings us to another problem: laboratory test instruments are not sensitive enough to detect disorders at the early stages.

“Our work consisted of applying innovative haemostasis tests, which are based on an understanding of the principles and mechanisms by which a thrombus is produced. The tests were carried out to evaluate the condition of the coagulation system in infants carried to term (the control group) and preterm infants (the test group),” explained the author of the article, Anna Balandina (Ph.D. in Biology), RSF Project Leader and Deputy Director for Scientific Affairs at the Center for Theoretical Problems of Physico-Chemical Pharmacology of Russian Academy of Sciences.

The researchers compared the condition of the coagulation system in adults and newborns (carried to term and preterm). The scientists used laboratory tests for haemostasis evaluation, including innovative methods. Deviations in plasma coagulation were analyzed, and the “working” state of platelets was investigated, which involved studying individual cells using light scattering and fluorescence signals (flow cytometry). The scientists noted that all laboratory tests, especially in clinical practice, are expensive, and the RSF grant allowed a wide array of methods to be used.

The work demonstrated that haemostasis in newborns, i.e., the ability to maintain blood in a liquid state while controlling bleeding in the event of damage to vessel walls, is substantially different from that in adults. Newborns face an increased risk of thrombosis, i.e., the formation of thrombi inside blood vessels, which impedes the free flow of blood. Additionally, platelets in newborns exhibit a reduced ability to activate. Moreover, the differences were even more pronounced in the test group of preterm babies. Based on this, the researchers concluded that, during the first days of infancy, haemostasis exists in a unique state of balance that is radically different from the balance in adults: it is more delicate. Any complication, such as preterm birth, upsets this balance and, consequently, results in the increased incidence of thrombosis and bleeding.

“We are now continuing our work and recruiting a group of extremely preterm infants. Additionally, we are trying to understand the underlying causes of such dramatic differences between the haemostasis of adults and infants. We hope that the work will ultimately result in a protocol of infant screening for detecting latent disturbances in the functioning of the haemostasis system,” concluded Anna Balandina.

Source:

http://www.akson.science/

Tagged with:

About author

Related Articles