Breaking News
December 19, 2018 - Potential combination therapy against rare disease of the bone marrow could improve treatment
December 19, 2018 - UC San Diego Health offers new DRG stimulation device for phantom limb pain
December 19, 2018 - Study examines relationship between growth restriction and risk of childhood mortality
December 19, 2018 - New study provides insights on increased risk of suicide in young patients visiting ED
December 19, 2018 - AHA: Thyroid Problems Linked to Worsening Heart Failure
December 19, 2018 - World-first coeliac disease vaccine enters Phase 2 trials
December 19, 2018 - RNA sequencing offers novel insights into the microbiome
December 19, 2018 - A promising, effective vaccine for common respiratory disease
December 19, 2018 - Protein may slow progression of emphysema, study finds
December 19, 2018 - Studying atrial fibrillation — and exploring new frontiers in precision health
December 19, 2018 - A New Way To Get College Students Through A Psychiatric Crisis — And Back To School
December 19, 2018 - Optum, UnitedHealthcare take action to help people affected by North Carolina winter storms
December 18, 2018 - Weight change in middle-aged, elderly Chinese Singaporeans related to increased risk of death
December 18, 2018 - Immune cells sacrifice themselves to protect us from invading bacteria
December 18, 2018 - Watching brain cells fire, with a twist of gravitational waves
December 18, 2018 - 2018 in Review
December 18, 2018 - Getting the Most Out of the CLARITY Technique
December 18, 2018 - NVF shoes provide a viable option for track and road racing
December 18, 2018 - CRISPR may restore effectiveness of chemotherapies used to treat lung cancer
December 18, 2018 - New app accurately measures and charts progression of skin wounds
December 18, 2018 - Persistent Discrimination ID’d Among Physician Mothers
December 18, 2018 - Cellphone technology developed to detect HIV
December 18, 2018 - A Stanford doctor hits the field with the 49ers — as their airway management physician
December 18, 2018 - The Rise of Anxiety Baking
December 18, 2018 - Just one night of sleep deprivation increases the urge to eat
December 18, 2018 - Study reveals mechanism behind failed remyelination in MS
December 18, 2018 - New genetic testing method increases the precision of biomarker analysis
December 18, 2018 - Simple technique to effectively treat underdiagnosed cause of debilitating chest pain
December 18, 2018 - Barbershop-based medical intervention can successfully lower blood pressure, new data shows
December 18, 2018 - Food labels have caused changes in consumers’ intake and industry’s use of key additives
December 18, 2018 - Sickest children could benefit from split liver transplants
December 18, 2018 - Scientists create patient-specific model to identify most effective treatment for appendix cancer
December 18, 2018 - ‘Little Foot’ endocast reveals a small brain combining ape-like and human-like features
December 18, 2018 - New therapy for childhood blindness shows ‘very promising’ results
December 18, 2018 - Researchers discover promising new compound against Buruli ulcer
December 18, 2018 - Study finds significant use of traditional, complementary and alternative medicines in Sub-Saharan Africa
December 18, 2018 - California Farm Implicated in Outbreak of E. coli Tied to Romaine Lettuce
December 18, 2018 - Mobile health has power to transform HIV/AIDS nursing
December 18, 2018 - Celiac Vaccine in Clinical Trials at Columbia
December 18, 2018 - Research into mental health first aid prompts practical guidance and resources for workplace
December 18, 2018 - Researcher conducts study to investigate peripheral blood markers of Alzheimer’s disease
December 18, 2018 - Researchers identify link between mucus in the small airways and pulmonary fibrosis
December 18, 2018 - EU Commission’s Health Policy Platform to host EKHA program on transplantation
December 18, 2018 - Survivors of childhood Hodgkin lymphoma have high risk of developing solid tumors
December 18, 2018 - Small changes to cafeteria design can get kids to eat healthier, new assessment tool finds
December 18, 2018 - From Machines to Cyclic Compounds
December 18, 2018 - New study reveals best assessment tools to establish delirium severity
December 18, 2018 - Rice University scientists develop synthetic protein switches to control electron flow
December 18, 2018 - Home-based pulmonary function monitoring for teens with Duchenne muscular dystrophy
December 18, 2018 - Researchers identify potential target for new breast cancer treatments
December 18, 2018 - National Biofilms Innovation Centre award grant to Neem Biotech for novel anti-biofilm drug development
December 18, 2018 - Artificial intelligence and the future of medicine
December 18, 2018 - Montana State doctoral student receives grant for her work to improve neuroscience tool
December 18, 2018 - Early postpartum initiation of opioids associated with persistent use
December 18, 2018 - Russian scientists identify molecular ‘switch’ that could be target for treatment of allergic asthma
December 18, 2018 - Surgeons make more mistakes in the operating room during stressful moments, shows study
December 18, 2018 - Immune cells explode themselves to inform about the danger of invading bacteria
December 18, 2018 - Malnutrition in children with Crohn’s disease linked with increased risk of surgical complications
December 18, 2018 - FDA Approves Motegrity (prucalopride) for Adults with Chronic Idiopathic Constipation (CIC)
December 18, 2018 - The long and short of CDK12
December 18, 2018 - Hologic’s Cynosure division introduces TempSure Surgical RF technology in North America
December 18, 2018 - CMR Surgical partners with Nicholson Center to launch U.S.-based training program for Versius
December 18, 2018 - Findings reinforce guidelines for cautious use of antipsychotics in younger populations
December 18, 2018 - Study finds new strains of hepatitis C virus in sub-Saharan Africa
December 18, 2018 - New battery-free, implantable device aids weight loss
December 18, 2018 - Parental alcohol use disorder associated with offspring marital outcomes
December 18, 2018 - Novel Breast Imaging Technique Might Cut Unnecessary Biopsies
December 18, 2018 - What can a snowflake teach us about how cancer spreads in the body?
December 18, 2018 - Management of nausea and vomiting in pregnancy costs the NHS more than previously thought
December 18, 2018 - Green leafy vegetables may reduce risk of developing liver steatosis
December 18, 2018 - Veganism linked to nutrient deficiencies and malnutrition if not planned correctly
December 18, 2018 - Coming Soon: A Tiny Robot You Swallow to Help You Stay Healthy
December 18, 2018 - Modified malaria drug proven effective at inhibiting Ebola
December 18, 2018 - Study finds epigenetic differences in the brains of individuals with schizophrenia
December 18, 2018 - Fitness instructors’ motivational comments influence women’s body satisfaction
December 18, 2018 - Study focuses on modification of lipid nanoparticles for successful brain cell targeting
December 18, 2018 - New gut bacteria may be effective against obesity, metabolic and mental disorders
December 18, 2018 - New two-in-one powder aerosol to upgrade fight against deadly superbugs in lungs
December 18, 2018 - Biofilms feed with swirling flows
December 17, 2018 - Study identifies specific neurological changes related to traumatic brain injury
Researchers create inexpensive system to test for dangerous levels of lead in water

Researchers create inexpensive system to test for dangerous levels of lead in water

image_pdfDownload PDFimage_print

The discovery of lead in Flint, Michigan’s drinking water drew renewed attention to the health risks posed by the metal. Now researchers at the University of Houston have created an inexpensive system using a smartphone and a lens made with an inkjet printer that can detect lead in tap water at levels commonly accepted as dangerous.

The system builds upon earlier work by Wei-Chuan Shih, associate professor of electrical & computer engineering, and members of his lab, including the discovery of an inexpensive elastomer lens that can convert a basic smartphone into a microscope.

The latest discovery, described in the journal Analytical Chemistry, combines nano-colorimetry with dark-field microscopy, integrated into the smartphone microscope platform to detect levels of lead below the safety threshold set by the Environmental Protection Agency.

“Smartphone nano-colorimetry is rapid, low-cost, and has the potential to enable individual citizens to examine (lead) content in drinking water on-demand in virtually any environmental setting,” the researchers wrote.

Even small amounts of lead can cause serious health problems, with young children especially vulnerable to neurological damage. EPA standards require lead levels in drinking water to be below 15 parts per billion, and Shih said currently available consumer test kits aren’t sensitive enough to accurately detect lead at that level.

By using an inexpensive smartphone equipped with an inkjet-printed lens and using the dark-field imaging mode, researchers were able to produce a system that was both portable and easy to operate, as well as able to detect lead concentrations at 5 parts per billion in tap water. The sensitivity reached 1.37 parts per billion in deionized water.

Shih and his students last year published an open-source dataset in Biomedical Optics Express, explaining how to convert a smartphone equipped with the elastomer lens into a microscope capable of fluorescence microscopy. That paper has been the journal’s most frequently downloaded paper since its publication.

The latest application incorporates color analysis to detect nanoscale lead particles. In addition to Shih, researchers on the project include first author Hoang Nguyen and Yulung Sung, Kelly O’Shaughnessy and Xiaonan Shan, all with the UH Department of Electrical & Computer Engineering. (O’Shaughnessy was a summer intern from the University of Cincinnati under the National Science Foundation’s Research Experiences for Undergraduates program.)

Applying the dataset published in 2017, the researchers built a self-contained smartphone microscope that can operate in both fluorescence and dark-field imaging modes and paired it with an inexpensive Lumina 640 smartphone with an 8-megapixel camera. They spiked tap water with varying amounts of lead, ranging from 1.37 parts per billion to 175 parts per billion. They then added chromate ions, which react with the lead to form lead chromate nanoparticles; the nanoparticles can be detected by combining colorimetric analysis and microscopy.

The analysis measured both the intensity detected from the nanoparticles, correlating that to the lead concentration, and verified that the reaction was spurred by the presence of lead.

The mixture was transferred to a polydimethylsiloxane slab attached to a glass slide; after it dried, deionized water was used to rinse off the chromate compound and the remaining sediment was imaged for analysis.

The microscopy imaging capability proved essential, Shih said, because the quantity of sediment was too small to be imaged with an unassisted smartphone camera, making it impossible to detect relatively low levels of lead.

Building upon the smartphone microscope platform to create a useful consumer product was key, Shih said. “We wanted to be sure we could do something that would be useful from the standpoint of detecting lead at the EPA standard,” he said.

Source:

http://www.uh.edu/news-events/stories/2018/september-2018/09262018shih-smartphone-lead-detection.php

Tagged with:

About author

Related Articles