Breaking News
April 25, 2019 - Cardiometabolic Risk Better ID’d in Children Reclassified to Higher BP
April 25, 2019 - How the obesity epidemic is taking a toll on our bones and joints
April 25, 2019 - E-cigarettes contaminated with dangerous microbial toxins
April 25, 2019 - Researchers document specific characteristics of storefront tobacco advertisements
April 25, 2019 - Oncotype DX-guided treatment could reduce cost for breast cancer care, study suggests
April 25, 2019 - New review highlights how lifestyle affects our genes
April 25, 2019 - Study provides evidence that blood tests can detect Alzheimer’s risk
April 25, 2019 - Physicians turning to antibiotic alternatives for long-term acne treatment
April 25, 2019 - Preschool Is Prime Time to Teach Healthy Lifestyle Habits
April 25, 2019 - Study finds insidious and persistent discrimination among physician mothers
April 25, 2019 - Newly identified skin-gut communication helps illuminate link between food allergy and eczema
April 25, 2019 - Thiazide use linked with reduced risk of low energy fractures in people with Alzheimer’s
April 25, 2019 - Some women are biologically more resilient than others to PTSD
April 25, 2019 - The Current issue of “The view from here” is concerned with Partnerships and Alliances
April 25, 2019 - Imaging method reveals long-lived patterns in cells of the eye
April 25, 2019 - Podcast: KHN’s ‘What The Health?’ The Abortion Wars Rage On
April 25, 2019 - Prolonged exposure therapy is more effective in treating veterans with PTSD, alcohol use disorder
April 24, 2019 - Our artificial cornea breakthrough could lead to self-assembling organs
April 24, 2019 - A Stanford black, female, gay surgery resident speaks out
April 24, 2019 - Donna Lynne on Extreme Sports, Lessons From the '60s, and Taking CUIMC to the Next Level
April 24, 2019 - Pain Clinics’ Doctors Needlessly Tested Hundreds Of Urine Samples, Court Records Show
April 24, 2019 - Researchers uncover potential clue to halt destruction of nerve cells in people with ALS
April 24, 2019 - Study uncovers reasons for poor mental health in bisexual people
April 24, 2019 - Screenings, interventions, and referrals can help adolescents overcome substance abuse
April 24, 2019 - Febrile seizures following vaccination are self-resolving and not dangerous
April 24, 2019 - Flow-UV inline UV-Visible spectrometer monitors dispersion in real time
April 24, 2019 - Rates of Marijuana Use in Cancer Patients on the Rise in U.S.
April 24, 2019 - Versatile drug may protect baby from hazards of intraamniotic infections
April 24, 2019 - Financial transparency may diminish trust in doctors, new study finds
April 24, 2019 - Calling all Riders: Velocity Extends Free Registration 
April 24, 2019 - The Homeless Are Dying In Record Numbers On The Streets Of L.A.
April 24, 2019 - Researchers use brain scans to provide better understanding of unconscious bias
April 24, 2019 - Blocking BRAF ubiquitination may be an effective treatment approach in melanoma
April 24, 2019 - Simple mobility test helps predict hospital readmission in elderly heart attack patients
April 24, 2019 - Novel fluorescence imaging system helps surgeons remove small ovarian tumors
April 24, 2019 - Uncovering the Structure of HIV Integrase to Inform Drug Discovery
April 24, 2019 - Medical Marijuana Use Rising Among Cancer Patients
April 24, 2019 - Artificial intelligence approach optimizes embryo selection for IVF
April 24, 2019 - Doctor or detective? Sleuthing mysteries in medical school
April 24, 2019 - CUIMC Community Gives Blood During Spring 2019 Columbia University Blood Drive
April 24, 2019 - Americans Overwhelmingly Want Federal Protections Against Surprise Medical Bills
April 24, 2019 - Making Laboratories More Efficient with the Most Modern LIMS on the Market
April 24, 2019 - Treating cancer patients with personalized, combination therapies improves outcomes
April 24, 2019 - Researchers engineer new molecules to help stop lung cancer
April 24, 2019 - Acupuncture can be a wonderful tool for preventing number of diseases
April 24, 2019 - Daily life disability before hip replacement may predict poor post-operative outcomes
April 24, 2019 - Study finds involuntary staying in housing estates to be a potential health risk
April 24, 2019 - Older kidney disease patients starting dialysis die at higher rates than previously thought
April 24, 2019 - Time-restricted eating shows promise for controlling blood glucose levels
April 24, 2019 - Ambiguous genitalia in newborns may be more common than previously thought
April 24, 2019 - Research provides important insight on the brain-body connection
April 24, 2019 - In 10 Years, Half Of Middle-Income Elders Won’t Be Able To Afford Housing, Medical Care
April 24, 2019 - Researchers study how E. coli clones have become major cause of drug-resistant infections
April 24, 2019 - Bacterial and fungal toxins found in popular electronic cigarettes
April 24, 2019 - Factors affecting absorption of ‘sunshine vitamin’ during spring/summer months
April 24, 2019 - Texting helps improve medication adherence, health outcomes for patients with schizophrenia
April 24, 2019 - Cochrane Review looks at different ways to use nicotine replacement therapies
April 24, 2019 - New review on relationship between COPD and Type 2 diabetes
April 24, 2019 - Brain areas linked to memory and emotion aid odor navigation in humans
April 24, 2019 - Brain stimulation reverses age-related memory loss
April 24, 2019 - Amid Opioid Prescriber Crackdown, Health Officials Reach Out To Pain Patients
April 24, 2019 - $4 million NIH award will help establish UCI Skin Biology Resource-based Center
April 24, 2019 - Cancer drugs reprogram genes in breast tumors to prevent endocrine resistance, finds study
April 24, 2019 - Combination-imaging technique provides new window into macaque brain connections
April 24, 2019 - Researchers identify new allergen responsible for allergy to durum wheat
April 24, 2019 - Researchers define role of rare, influential cells in the bone marrow
April 24, 2019 - DNA rearrangement may predict poor outcomes in multiple myeloma
April 24, 2019 - FDA Approves Skyrizi (risankizumab-rzaa) for Moderate to Severe Plaque Psoriasis
April 24, 2019 - Combination therapy might be beneficial in schizophrenia
April 24, 2019 - Blood test can help match cancer patients to early phase clinical trials
April 24, 2019 - Women tend to underreport snoring and underestimate its loudness
April 24, 2019 - Comprehensive molecular test introduced for diagnosis of malaria caused by P. vivax parasites
April 24, 2019 - New range prediction approach increases accuracy, safety and tolerability of proton therapy
April 24, 2019 - Need for Sedation Up for Regular Cannabis Users
April 24, 2019 - Lack of access to antibiotics is a major global health challenge
April 24, 2019 - New study provides better understanding on safety of deworming programs
April 24, 2019 - EEG used to detect impact of maternal stress on neurodevelopment in 2-month-old infants
April 24, 2019 - FDA Approves First Generic Naloxone Nasal Spray Against Opioid Overdose
April 24, 2019 - A new way of finding compounds that prevent aging
April 24, 2019 - Mechanical training makes synthetic hydrogels perform more like muscle
Researchers receive $1.2 million grant to test potential treatment for metastatic breast cancer

Researchers receive $1.2 million grant to test potential treatment for metastatic breast cancer

image_pdfDownload PDFimage_print

A team of Medical University of South Carolina (MUSC) Hollings Cancer Center researchers received a three-year, $1.2 million grant from the U.S. Department of Defense (DOD) to test a potential therapeutic antibody that could block breast cancer growth with fewer side effects, opening up potential for future drug development. The team will deploy innovative molecular imaging tools to study a crucial mechanism that appears to drive tumor development.

The study aims to find better ways to treat metastatic breast cancer that could replace current therapies, some of which have life-threatening side effects. Core to the work is Hollings Cancer Center researcher Nancy DeMore, M.D., a leading expert in angiogenesis and therapeutics created for breast cancer.

Angiogenesis, a key phase in malignant growth, involves how blood vessels form, develop and create a network to perfuse different types of solid tumors. Tumors need a blood supply to receive their nutrients and also as an escape route to metastasize to other organs, explains Ann-Marie Broome, Ph.D., director of HCC’s Small Animal Imaging Center, who’s also involved with the study and part of MUSC’s Department of Cell and Molecular Pharmacology & Experimental Therapeutics.

“We have a great team assembled to study this. The power of molecular imaging is clear. We believe that if you can see it, you can dissect its mechanism of action then treat it and attack it. That’s the greatest impact I see for translational imaging studies. That’s why I’m excited.”

Traditional chemotherapeutic drugs kill rapidly dividing cancer cells, but they can also destroy or damage many healthy cells. Developing less toxic interventions requires changing the target from rapidly-dividing cells to one that is specifically expressed in tumors and not in normal tissue.

DeMore’s laboratory is studying the role a novel angiogenesis factor, a protein known as secreted-frizzled-related protein 2 (SFRP2), plays in breast cancer. “The SFRP2 protein is overexpressed in tumor vessels, and later we found that it was overexpressed in a wide variety of tumors, including breast cancer,” said DeMore, who holds the BMW Endowed Chair in Cancer Research at MUSC.

The thought is to inhibit reactions downstream from SFRP2, selectively blocking tumor blood vessels from growing and reducing toxicity to normal tissue.

In preclinical studies, DeMore’s laboratory discovered that a SFRP2 protein has a novel function. The protein activates a mechanism called calcineurin/NFAT, which is critical in blood vessel and tumor growth.

Now the Hollings Cancer Center team seeks to test whether the calcineurin/NFAT mechanism, rather than other potential mechanisms, is driving breast tumor growth, and whether tumor development can be blocked by targeting this pathway. The researchers have developed a novel humanized antibody that has already proved effective in blocking the calcineurin/NFAT pathway and tumor development in cultured human cell models of breast cancer.

“We hope to find out whether our antibody inhibits tumor growth through the calcineurin/NFAT pathway instead of other pathways,” DeMore said.

The researchers plan to study the humanized antibody in an animal model to learn whether it disrupts the calcineurin/NFAT mechanism, preventing in vivo tumor growth while leaving normal tissue unaffected. Broome said the antibody recognizes a protein found on blood vessels.

“By impacting angiogenesis and blood vessel stability within tumors, we can alter the way these tumors are able to survive in the presence of that antibody. We’re creating a fine balance between cutting off the nutrients and normalizing the vasculature so that the tumors are less likely to progress.”

The researchers will use real-time fluorescence imaging systems to highlight and reveal interactions among protein pathways within tumors that have not been seen using other methods. “The fluorescent systems, which are one of the most sensitive imaging tools available, give us faster, clearer images and more specific answers to the questions that we are asking,” Broome said. “It’s not enough just to know that there is a therapeutic response to the antibody. We want to know why and where there is a response.”

The researchers will corroborate fluorescence imaging findings with other modalities, such as computed tomography (CT) images and bioluminescence tools. Tracking SFRP2 pathways with innovative imaging tools could eventually help clinicians track tumor growth and monitor response to chemotherapy. Another aim of the study is to combine the humanized antibody with other drugs commonly used for breast cancer and look for an additive or synergistic effect.

The DOD grant also supports a related study by Shikhar Mehrotra, Ph.D., investigating whether SFRP2 may also play an important role in immune cell function.

A potential treatment is not yet available for human studies, but the team plans to obtain funding for further drug development that could lead to a Phase I clinical trial.

Source:

http://academicdepartments.musc.edu/newscenter/2018/hcc-metastatic-breast-cancer/index.html

Tagged with:

About author

Related Articles