Breaking News
February 17, 2019 - MUSC researchers discover new mechanism for a class of anti-cancer drugs
February 17, 2019 - HPV misconceptions are causing women to miss smear tests
February 17, 2019 - Sanofi and Regeneron Offer Praluent (alirocumab) at a New Reduced U.S. List Price
February 17, 2019 - Researchers say auditory testing can identify children for autism screening
February 17, 2019 - New method analyzes how single biological cells react to stressful situations
February 17, 2019 - WVU gynecologic oncologist investigates novel treatment for cervical and vaginal cancers
February 17, 2019 - ADHD diagnoses poorly documented
February 17, 2019 - Majority of gender minority youth do not identify with traditional sexual identity labels
February 17, 2019 - AbbVie, Teneobio enter into strategic transaction to develop potential treatment for multiple myeloma
February 17, 2019 - Lower Birth Weight May Up Risk for Psychiatric Disorders
February 17, 2019 - Scientists identify reversible molecular defect underlying rheumatoid arthritis
February 17, 2019 - Moffitt researchers shed light on how CAR T cells function mechanistically
February 16, 2019 - Female Anatomy May Play Big Role in Sperm’s Success
February 16, 2019 - BMI may mediate inverse link between fiber intake, knee OA
February 16, 2019 - Movement impairments in autism can be reversed through behavioral training
February 16, 2019 - Studies address racial disparities in postpartum period and cardiovascular health
February 16, 2019 - Scientists implicate hidden genes in the severity of autism symptoms
February 16, 2019 - Decreased deep sleep linked to early signs of Alzheimer’s disease
February 16, 2019 - Neuroscientists show how the brain responds to texture
February 16, 2019 - Gilead Announces Topline Data From Phase 3 STELLAR-4 Study of Selonsertib in Compensated Cirrhosis (F4) Due to Nonalcoholic Steatohepatitis (NASH)
February 16, 2019 - What Can I Do About Sweating? (for Teens)
February 16, 2019 - Companies navigate dementia conversations with older workers
February 16, 2019 - Newly developed stem cell technologies show promise for treating PD patients
February 16, 2019 - Collaborative material research could advance self-assembling nanomaterials
February 16, 2019 - Researchers take major step in creating technology that mimics the human brain
February 16, 2019 - Erasing memories associated with cocaine use reduces drug seeking behavior
February 16, 2019 - Artificial intelligence can accurately predict prognosis of ovarian cancer patients
February 16, 2019 - Racial disparities in cancer deaths on the decline for America
February 16, 2019 - FDA authorizes new interoperable insulin pump for children, adults with diabetes
February 16, 2019 - Coexisting Medical Conditions, Smoking Explain PTSD-CVD Link
February 16, 2019 - Skin Cancer Screening: MedlinePlus Lab Test Information
February 16, 2019 - ‘Happiness’ exercises can boost mood in those recovering from substance use disorder
February 16, 2019 - Cell manipulation could soon halt or reverse aging
February 16, 2019 - Pumped Breast Milk Falls Short of Breastfed Version
February 16, 2019 - Men’s porn habits could fuel partners’ eating disorders, study suggests
February 16, 2019 - Rapid progression of age-related diseases may result from formation of vicious cycles
February 16, 2019 - Immune checkpoint molecule protects against future development of cancer
February 16, 2019 - New method produces hydrogels that have properties similar to cells’ environment
February 16, 2019 - $4.1 million funding for heart research on Valentine’s Day
February 16, 2019 - General anesthesia in early infancy unlikely to have lasting effects on developing brains
February 16, 2019 - New breakthroughs for muscular dystrophy research
February 16, 2019 - First Opinion: Embryo editing for higher IQ is a fantasy. Embryo profiling for it is almost here
February 16, 2019 - Vapers develop cancer-related gene deregulation as cigarette smokers
February 16, 2019 - Bringing Antimicrobial Susceptibility Testing (AST) to the Community
February 16, 2019 - Decolonization protocol after hospital discharge can prevent dangerous infections
February 16, 2019 - Children with ASD more likely to face maltreatment, study finds
February 16, 2019 - Study finds genetic vulnerability to use of menthol cigarettes
February 16, 2019 - H-RT should be the standard of care for men with low risk prostate cancer, study shows
February 16, 2019 - New technique using patients’ own modified cells could help treat Crohn’s disease
February 16, 2019 - Therapeutic endoscopy has an expanding role in the treatment of IBD
February 16, 2019 - Blood clot discovery could lead to development of better treatments for blood diseases
February 16, 2019 - Intervention can increase exclusive breastfeeding rates
February 16, 2019 - New project explores how gaming technologies can help cancer patients communicate better
February 16, 2019 - Catalyst Biosciences Presents Updated Data from Its Phase 2/3 Trial of Subcutaneous Marzeptacog Alfa (Activated) in Individuals with Hemophilia A or B with Inhibitors at the 12th Annual EAHAD Congress
February 16, 2019 - Rerouting nerves during amputation reduces phantom limb pain before it starts
February 16, 2019 - A Hormone Produced When We Exercise Might Help Fight Alzheimer’s
February 16, 2019 - Millions of British people breathe toxic air travelling to GPs
February 16, 2019 - Conformance of genetic characteristics found to be crucial for longer preservation of kidney graft
February 16, 2019 - Researchers use optogenetic tool to control, visualize receptor signals in neural cells
February 16, 2019 - New reversible antiplatelet therapy could reduce risk of blood clots, prevent cancer metastasis
February 16, 2019 - Testosterone is not the only hormone needed for penis development
February 16, 2019 - FDA Advisory Committee Recommends Approval of Spravato (esketamine) Nasal Spray for Adults with Treatment-Resistant Depression
February 15, 2019 - Heart surgery technology developed at Baptist Health debuts after years of secrecy
February 15, 2019 - Prescription Opioids Double Risk of Triggering Fatal Car Crash
February 15, 2019 - New study helps doctors better understand high blood pressure in pregnant women
February 15, 2019 - Beta wave control in Parkinson’s diseased brain could be a potential therapy
February 15, 2019 - Media representations of love may justify gender-based violence in young people
February 15, 2019 - Yoga May Help With Rheumatoid Arthritis Symptoms, Severity
February 15, 2019 - Obstructive sleep apnea linked to inflammation, organ dysfunction
February 15, 2019 - Master your mind: A challenge from WELL for Life
February 15, 2019 - Why Some Brain Tumors Respond to Immunotherapy
February 15, 2019 - Must-Reads Of The Week From Brianna Labuskes
February 15, 2019 - Researchers uncover novel mechanism and potential new therapeutic target for Alzheimer’s
February 15, 2019 - Genetic variations in a fourth gene associated with higher ALL risk in Hispanic children
February 15, 2019 - Disruptive behavioral problems in kindergarten linked with lower employment earnings in adulthood
February 15, 2019 - New bioengineered device enhances the production of T-cells
February 15, 2019 - HDL proteome behaves like a tiny Velcro ball that is rolling on surfaces
February 15, 2019 - Puerto Rican children more likely to have poor or decreasing use of asthma inhalers
February 15, 2019 - Quality of patient care does not improve after physician-hospital integration
February 15, 2019 - Synopsys release new software for implant design and patient-specific planning
Children with asthma have higher risk of obesity

Children with asthma have higher risk of obesity

image_pdfDownload PDFimage_print

Toddlers with asthma are more likely to become obese children, according to an international study led by USC scientists.

The finding is a turnabout for children’s health as obesity has often been seen as a precursor to asthma in children, not the other way around. The study, conducted by a team of 40 scientists including researchers at the Keck School of Medicine of USC, was recently published in the European Respiratory Journal.

This is the largest study yet about early-onset asthma and obesity. It focused on more than 20,000 youths across Europe. It shows that, beyond wheezing and shortness of breath, asthma can lead to bodies that make young people more susceptible to other health problems later in life.

Lida Chatzi, the senior author and professor of preventive medicine at USC, says asthma and obesity pack a one-two punch against children’s health, which raises concern about a public health crisis due to their prevalence.

“We care about this issue because asthma affects approximately 6.5 million children – about one in 10 – in the United States,” Chatzi said. “It’s a chronic childhood disorder and if it increases the risk of obesity, we can advise parents and physicians on how to treat it and intervene to help young children grow up to enjoy healthy, adult lives.”

For two decades, scientists have documented the parallel epidemics of childhood asthma and obesity, with focus on how obesity is a risk factor for asthma. In adults, obesity is an important risk factor for new asthma, especially among women, but the relationships appear to differ in children. Few studies look at the problem the other way around to understand how asthma contributes to obesity in kids, which prompted scientists to undertake this research.

Drawing upon big data on children’s health collected across Europe, the scientists investigated 21,130 children born between 1990 and 2008 across nine countries, including Denmark, France, Germany, Greece, Italy, the Netherlands, Spain, Sweden and the United Kingdom.

The children were diagnosed by physicians with asthma at 3 to 4 years old and the scientists followed toddlers into childhood up to 8 years of age. Their goal was to focus on health risks of early-onset asthma.

On average, the scientists found that children diagnosed with asthma had a 66 percent higher risk of becoming obese than those without an asthma diagnosis. For children with persistent wheezing symptoms, their risk of developing obesity was 50 percent greater compared to children without such symptoms. Children with active asthma were nearly twice as likely to develop obesity than those without asthma and wheezing, according to the study. The findings are consistent with previous, but smaller, longitudinal studies conducted in the United States that observed asthma increased the risk of obesity.

The causal direction between asthma and obesity is not well understood. Asthma is regarded as a barrier to children’s physical activity that might lead to accumulation of fat in the body, while higher doses of inhaled corticosteroids had been hypothesized to increase risk of obesity in children with asthma. According to the study, children with asthma who used medication had the strongest risk of developing obesity.

Since both asthma and obesity have their origins early in life, it is possible that the asthma-obesity association is also established in this critical time window of child development. Previous studies have shown that in utero exposures, such as prenatal diet or maternal obesity, are associated with increased risk of both disorders.

“Asthma may contribute to the obesity epidemic. We urgently need to know if prevention and adequate treatment of asthma can reduce the trajectory toward obesity,” said Frank Gilliland, professor of preventive medicine at the Keck School of Medicine, who participated in the study.

According to the U.S. Centers for Disease Control and Prevention, about 40 percent of Americans, or 93 million, are obese. The estimated annual medical cost of obesity nationwide was $147 billion in 2008, the CDC estimates. Obesity is linked to diseases such as diabetes, high blood pressure and stroke.

The CDC reports the number of people with asthma in the United States is growing every year. About one in 12 Americans is afflicted with the illness. In smoggy places, like California’s San Joaquin Valley, about 1 in 6 children suffer from asthma, the highest rate in the country.

In Europe, 1 in 8 people die due to lung diseases – or about one person per minute. It includes well-known diseases like asthma and lung cancer and other less-known diseases like chronic obstructive pulmonary disease, which is now the third most common cause of death, according to the European Respiratory Society.

Tagged with:

About author

Related Articles