Breaking News
December 14, 2018 - New model could cure the potential to underestimate how quickly diseases spread
December 14, 2018 - Exercise-induced hormone activates cells critical for bone remodeling in mice
December 14, 2018 - Researchers discover new mechanism behind spread of malignant pleural mesothelioma
December 14, 2018 - Health Tip: Celebrate a Healthier Holiday
December 14, 2018 - Scalpel-free surgery enhances quality of life for Parkinson’s patients, study finds
December 14, 2018 - Early physical therapy can reduce risk, amount of long-term opioid use | News Center
December 14, 2018 - Genetic marker, predictor of early relapse in common childhood cancer discovered
December 14, 2018 - Study could lead to a potential new way of treating sepsis
December 14, 2018 - New protein complex helps embryonic stem cells to maintain their indefinite potential
December 14, 2018 - Salk professor receives $1.8 million from NOMIS Foundation for research on mechanisms to promote health
December 14, 2018 - New discovery will improve the safety and predictability of CRISPR
December 14, 2018 - Geneticists discover how sex-linked disorders arise
December 14, 2018 - New method to visualize small-molecule interactions inside cells
December 14, 2018 - Study describes mechanism that makes people more vulnerable to hunger-causing stimuli
December 14, 2018 - Chronic opioid therapy associated with increased healthcare spending and hospital stays
December 14, 2018 - Blood Types
December 14, 2018 - Obesity linked to increased risk of early-onset colorectal cancer
December 14, 2018 - Blood test helps identify distinct molecular signatures in children with cystic fibrosis
December 14, 2018 - Scientists use water to track electrical activity of nerve cells
December 14, 2018 - Recurrence of urinary tract infection may depend on bacterial strain, study shows
December 14, 2018 - GBT Announces U.S. FDA Agrees with its Proposal Relating to Accelerated Approval Pathway for Voxelotor for the Treatment of Sickle Cell Disease and GBT Plans to Submit New Drug Application (NDA)
December 14, 2018 - Partial Thromboplastin Time (PTT) Test: MedlinePlus Lab Test Information
December 14, 2018 - Common tactics for health promotion at work may be detrimental to employees with obesity
December 14, 2018 - Myths about migration and health not supported by available evidence
December 14, 2018 - Recent findings on rare genetic disorder may help develop new treatment options
December 14, 2018 - New drug shows promise in treating sarcomas
December 14, 2018 - Scientists perform lung lavage as new approach for tuberculosis diagnosis in rhinoceros
December 14, 2018 - Recent winners of the Nobel Medicine Prize
December 14, 2018 - KHN’s ‘What the Health?’ Insurance enrollment is lagging — and there are lots of reasons why
December 14, 2018 - Study assesses safety and efficacy of new treatment for pancreatic cancer
December 14, 2018 - Study finds drug targets for Ebola, Dengue, and Zika viruses
December 14, 2018 - Shining new light on neuron firing
December 14, 2018 - Study highlights need for personalized approach to treat ICU acquired delirium
December 14, 2018 - Soot particles from road traffic significantly contribute to air pollution
December 14, 2018 - Massage helps relieve pain, improve mobility in patients with knee osteoarthritis
December 14, 2018 - Researchers explore home healthcare nurses’ knowledge attitudes toward infection control
December 14, 2018 - Average outpatient visit in the U.S. costs nearly $500, shows new study
December 14, 2018 - Reference Infliximab, Biosimilar Equivalent for Crohn’s Disease
December 14, 2018 - New contact lens to treat eye injuries
December 14, 2018 - Acne could have a genetic basis find researchers promising new cure
December 14, 2018 - Higher physical activity associated with improved mood
December 14, 2018 - New UGA study points to optimal hypertension treatment for stroke patients
December 14, 2018 - Study highlights factors that can reduce food cravings
December 14, 2018 - Researchers discover Ebola-fighting protein in human cells
December 14, 2018 - Fentanyl surpasses heroin in cause of U.S. drug overdose deaths
December 14, 2018 - When Heart Attack Strikes, Women Often Hesitate to Call for Help
December 14, 2018 - A warning about costume contacts
December 14, 2018 - Study examines link between peripheral artery disease and heart attack
December 14, 2018 - Researchers develop biotechnological tool to produce antifungal proteins in plants
December 14, 2018 - 3D-printed adaptive aids can benefit patients with arthritis
December 14, 2018 - Chronic bullying during adolescence impacts mental health
December 14, 2018 - Integral Molecular and Merus collaborate to develop bispecific antibody therapeutics
December 13, 2018 - Importance of cell cycle and cellular senescence in the placenta discovered
December 13, 2018 - Gold “nanoprisms” open new window into vessels and single cells
December 13, 2018 - Research findings could lead to new targets for cancer-fighting therapeutics
December 13, 2018 - Butantan Institute signs collaboration agreement with MSD to develop dengue vaccines
December 13, 2018 - Study explores how patients want to discuss symptoms with doctors
December 13, 2018 - RUDN medics first to gather scattered data on hepatitis morbidity in Somalia
December 13, 2018 - Age and gender disparities found in use of bed nets to prevent malaria in sub-Saharan Africa
December 13, 2018 - Caffeine therapy benefits developing brains of premature babies
December 13, 2018 - New review focuses on electrospinning techniques used in musculoskeletal tissue engineering
December 13, 2018 - A new division focused on human immune system
December 13, 2018 - Zogenix Announces Positive Phase 3 Trial Results on the Efficacy and Safety of Fintepla (ZX008) in Dravet Syndrome
December 13, 2018 - BCR ABL Genetic Test: MedlinePlus Lab Test Information
December 13, 2018 - Caffeinated beverages during pregnancy linked to lower birth weight babies
December 13, 2018 - Stanford Medicine Health Trends Report examines opportunity to democratize health care
December 13, 2018 - Obsessive-compulsive disorder may protect individuals from obesity
December 13, 2018 - Scientists investigate how a painful event is processed in the brain
December 13, 2018 - Genetic study reveals new insights into underlying causes of moderate-to-severe asthma
December 13, 2018 - Study uncovers new genetic clues to frontotemporal dementia
December 13, 2018 - Vitamin C supplementation for pregnant smokers may reduce harm to infants’ lungs
December 13, 2018 - New study reveals yin-yang personality of dopamine
December 13, 2018 - Research identifies nerve-signaling pathway behind sustained pain after injury
December 13, 2018 - Children with high levels of callous traits show widespread differences in brain structure
December 13, 2018 - Long-term Benefit of Steroid Injections for Knee Osteoarthritis Challenged
December 13, 2018 - Adding new channels to the brain remote control
December 13, 2018 - In the Spotlight: A different side of neuroscience
December 13, 2018 - Medical Marvels: Using immunotherapy for melanoma that spread to the brain
December 13, 2018 - Puzzles do not keep dementia away finds study
December 13, 2018 - New mouse model shows potential for rapid identification of promising muscular dystrophy therapies
Assessing health impact of new antimicrobials could encourage further drug development

Assessing health impact of new antimicrobials could encourage further drug development

image_pdfDownload PDFimage_print
Credit: CC0 Public Domain

In a new report, researchers at the University of York have investigated the ways in which the value of new antimicrobial drugs could be assessed to help the NHS decide how much should be paid for them.

Commissioned by the Department of Health and Social Care and funded by the National Institute for Health Research (NIHR), the report aims to demonstrate how new drugs could be assessed based on their value to the NHS. Having such a system in place could help to incentivise manufacturers to produce more new antimicrobials.

Antimicrobial resistance (AMR) is a major global health concern, as infectious organisms become increasingly resistant to a range of antimicrobials. Pharmaceutical and biotechnology industries, however, are becoming reluctant to develop new drugs citing limited return on investment.

Pressing issue

Chief Medical Officer for England, Professor Dame Sally Davies, said:”It is no exaggeration to say antimicrobial resistance is among the most pressing issues we face globally.

“Finding ways to incentivise companies to develop new drugs is a vital component of our response to this escalating threat.

“Ensuring the NHS pays a fair price for new antimicrobials whilst conserving their use is essential and this report provides a platform to deliver this.”

International action

The Lord O’Neill Independent Review on AMR had previously recommended that countries should support international action through better national purchasing arrangements of antimicrobial drugs.

This new study informs the various ways that the NHS could pay for new antibiotic drugs, by making recommendations to the National Institute for Health and Care Excellence (NICE) on how to consider the appraisal of new antimicrobials.

Currently a conventional payment method is employed to fund new antimicrobials, which is based on how much of the drug the NHS uses. Some new antimicrobials are held in reserve for use only when existing products are ineffective due to resistance, but this strategy limits revenues to manufacturers reducing the attractiveness of developing new antimicrobials.

‘Delinked’ payment

The government is therefore considering a novel payment approach where the NHS pays for access to the drug; this means that payment is ‘delinked’ from the amount of the drug that is actually used. Establishing appropriate levels of payment, however, is complex.

Mark Sculpher, Professor of Health Economics at the University of York, said: “NICE plays an important role in using evidence to guide the NHS about the effectiveness and value for money of new pharmaceuticals.

“Given the priority associated with having new antimicrobial agents available with increasing drug resistance, any role for NICE in appraising these products needs to involve the most appropriate methods, evidence and process.

“Our latest report looks at how NICE could appraise the benefits of these new drugs so that the NHS can make informed decisions on sustainable funding.”

Evidence

The report recommends that, under a delinked payment system, NICE should use the available evidence to estimate the long-term impact on the health of the population based on the availability of a new antimicrobial.

This can provide more evidence to inform sustainable funding, which also takes into consideration the health benefits that could be produced if those resources were devoted to other NHS activities.

Professor Sculpher said: “Having new drugs available to treat infectious disease is a major priority internationally given the challenge of resistance. But the NHS has to be able to agree funding with the manufacturers of new products based on information about the benefits they are expected to confer on patients over many years.

“Estimating this impact is extremely difficult when the drugs become first available, as relevant evidence is limited. It is essential for the NHS to collect surveillance data on how drugs are used, their outcomes and changes in resistance.”

Public health

The report states that levels of funding by the NHS under ‘delinked’ arrangements cannot be set in stone permanently. Rather, they should be revisited as new evidence becomes available and estimates of population health impact are revised.

Meindert Boysen, Director of the NICE Centre for Health Technology Evaluation, said: “The report provides invaluable insights in to the issues and complexity of capturing the full public health value of new antimicrobials. We will continue to work with partners and stakeholders on how the recommendations could translate to a pragmatic value framework and payment model for new antimicrobials.”


Explore further:
FDA researchers report first evidence of ESBL producing E. Coli in US retail meat

Provided by:
University of York

Tagged with:

About author

Related Articles