Breaking News
April 24, 2019 - Making Laboratories More Efficient with the Most Modern LIMS on the Market
April 24, 2019 - Treating cancer patients with personalized, combination therapies improves outcomes
April 24, 2019 - Researchers engineer new molecules to help stop lung cancer
April 24, 2019 - Acupuncture can be a wonderful tool for preventing number of diseases
April 24, 2019 - Daily life disability before hip replacement may predict poor post-operative outcomes
April 24, 2019 - Study finds involuntary staying in housing estates to be a potential health risk
April 24, 2019 - Older kidney disease patients starting dialysis die at higher rates than previously thought
April 24, 2019 - Time-restricted eating shows promise for controlling blood glucose levels
April 24, 2019 - Research provides important insight on the brain-body connection
April 24, 2019 - In 10 Years, Half Of Middle-Income Elders Won’t Be Able To Afford Housing, Medical Care
April 24, 2019 - Researchers study how E. coli clones have become major cause of drug-resistant infections
April 24, 2019 - Bacterial and fungal toxins found in popular electronic cigarettes
April 24, 2019 - Factors affecting absorption of ‘sunshine vitamin’ during spring/summer months
April 24, 2019 - Texting helps improve medication adherence, health outcomes for patients with schizophrenia
April 24, 2019 - Cochrane Review looks at different ways to use nicotine replacement therapies
April 24, 2019 - New review on relationship between COPD and Type 2 diabetes
April 24, 2019 - Brain areas linked to memory and emotion aid odor navigation in humans
April 24, 2019 - Brain stimulation reverses age-related memory loss
April 24, 2019 - Amid Opioid Prescriber Crackdown, Health Officials Reach Out To Pain Patients
April 24, 2019 - $4 million NIH award will help establish UCI Skin Biology Resource-based Center
April 24, 2019 - Cancer drugs reprogram genes in breast tumors to prevent endocrine resistance, finds study
April 24, 2019 - Combination-imaging technique provides new window into macaque brain connections
April 24, 2019 - Researchers identify new allergen responsible for allergy to durum wheat
April 24, 2019 - Researchers define role of rare, influential cells in the bone marrow
April 24, 2019 - DNA rearrangement may predict poor outcomes in multiple myeloma
April 24, 2019 - FDA Approves Skyrizi (risankizumab-rzaa) for Moderate to Severe Plaque Psoriasis
April 24, 2019 - Combination therapy might be beneficial in schizophrenia
April 24, 2019 - Blood test can help match cancer patients to early phase clinical trials
April 24, 2019 - Women tend to underreport snoring and underestimate its loudness
April 24, 2019 - Comprehensive molecular test introduced for diagnosis of malaria caused by P. vivax parasites
April 24, 2019 - New range prediction approach increases accuracy, safety and tolerability of proton therapy
April 24, 2019 - Need for Sedation Up for Regular Cannabis Users
April 24, 2019 - Lack of access to antibiotics is a major global health challenge
April 24, 2019 - New study provides better understanding on safety of deworming programs
April 24, 2019 - EEG used to detect impact of maternal stress on neurodevelopment in 2-month-old infants
April 24, 2019 - FDA Approves First Generic Naloxone Nasal Spray Against Opioid Overdose
April 24, 2019 - A new way of finding compounds that prevent aging
April 24, 2019 - Mechanical training makes synthetic hydrogels perform more like muscle
April 24, 2019 - Study provides new insights into regulatory T cells’ role in protecting against autoimmune disease
April 24, 2019 - Pregnant women with type 1 diabetes are at greater risk of preterm birth
April 24, 2019 - ‘Tummy tuck’ can be safely performed in obese patients with no increase in complications
April 23, 2019 - ‘First’ 3-D print of heart with human tissue, vessels unveiled
April 23, 2019 - Which blood-based method works best to detect TB?
April 23, 2019 - Gene therapy cures infants suffering from ‘bubble boy’ immune disease
April 23, 2019 - Chemical-sampling wristbands detect similar exposures across three continents
April 23, 2019 - Management of Residual Limb Pain
April 23, 2019 - Molecular clock influences immune cell responses
April 23, 2019 - On the importance of culture, partnerships and diversity at the Dean’s Lecture Series
April 23, 2019 - Siddhartha Mukherjee Receives Lewis Thomas Prize for Writing About Science
April 23, 2019 - Dengue mosquito poses greatest danger of spreading Zika virus in Australia
April 23, 2019 - Scientists identify 104 high-risk genes for schizophrenia
April 23, 2019 - Abdominal etching can help patients to get classic ‘six-pack abs’ physique
April 23, 2019 - Alvogen Inc. Issues Voluntary Nationwide Recall of Fentanyl Transdermal System Due to Product Mislabeling
April 23, 2019 - Skype hypnotherapy is effective treatment for IBS
April 23, 2019 - The future hope of “flash” radiation cancer therapy
April 23, 2019 - Bicycling, Recycling, and Beyond: Public Safety to Host Shred Fest and Bike-to-Campus Day 
April 23, 2019 - Skipping breakfast linked with increased risk of death from heart disease
April 23, 2019 - Neuroscientists propose new theory about amyloid precursor protein connection in Alzheimer’s
April 23, 2019 - Mediterranean diet protects against overeating and obesity
April 23, 2019 - NUS scientists uncover novel biomarkers linked with ‘chemobrain’
April 23, 2019 - Novel ECCITE-seq technique expands multimodal single cell analysis
April 23, 2019 - Half of all American workplaces offer health and wellness programs
April 23, 2019 - Hypnosis may offer a genuine alternative to painkillers
April 23, 2019 - Sleep loss greatly interferes with job performance
April 23, 2019 - Study shows how elderberry fruit can help fight against influenza
April 23, 2019 - Parkinson’s sufferers regain mobility with new implant
April 23, 2019 - Perinatal Complications Tied to Childhood Social Anxiety
April 23, 2019 - Research reveals how immune cells help tumors escape body’s defenses
April 23, 2019 - UAB receives $17 million grant to explore immune cells in inaccessible tissues of the human body
April 23, 2019 - Opening blocked arteries may be lifesaver for older heart attack patients
April 23, 2019 - Yposkesi chairman to speak on ‘Manufacturing and the CDMO Perspective’ at Cell and Gene Meeting
April 23, 2019 - Listeria Outbreak Linked to Deli Meats, Cheeses in 4 States
April 23, 2019 - Scientists find another way HIV can hide from vaccines
April 23, 2019 - Improved WIC food packages reduced obesity risk for children, study finds
April 23, 2019 - EU ban on ‘meaty’ names for veggie food products would affect public sector
April 23, 2019 - KNAUER self-tests gender pay gap one month after Equal Pay Day
April 23, 2019 - Johns Hopkins study reports overdiagnosis of schizophrenia
April 23, 2019 - New approach to repair defects in fetal membranes could prevent life-long medical conditions
April 23, 2019 - Reviving the heart’s regenerative capacities using microRNAs
April 23, 2019 - New pediatric blood pressure guidelines can better predict kids at higher risk of heart disease
Cancer trial shows treating the prostate with radiotherapy improves survival

Cancer trial shows treating the prostate with radiotherapy improves survival

image_pdfDownload PDFimage_print
Micrograph showing prostatic acinar adenocarcinoma (the most common form of prostate cancer) Credit: Wikipedia

Treating the prostate with radiotherapy alongside standard treatment led to an 11 per cent increase in survival for some men with advanced prostate cancer, show the results from a study carried out in collaboration with the University of Birmingham and funded by Cancer Research UK.

These findings, from one of the largest ever clinical trials for the disease, are being presented at the 2018 ESMO Annual Meeting in Munich, Germany and published in The Lancet, today.

Previously, it was unclear if there was any benefit treating the prostate directly with radiotherapy, if the cancer had already spread. This research helps answer that question and has implications beyond prostate cancer.

The findings from the STAMPEDE trial could be practice changing and suggest radiotherapy, alongside hormone therapy, should become the standard of care for a group of men with advanced prostate cancer, affecting thousands every year in the UK.

This part of the STAMPEDE study, based at the MRC Clinical Trials Unit at University College London, involved around 2,000 men who had advanced disease. Half were given standard treatment while the other half received standard treatment and radiotherapy to the prostate – the site of the primary tumour.

They found among men whose cancer had spread to their lymph nodes and/or nearby bones and were treated with additional radiotherapy, around 80 per cent survived for at least 3 years. In comparison, 70 per cent of men who did not have the additional radiotherapy treatment, were alive after 3 years. The benefit was unique to this group of men, with no increase in survival among men whose cancer had spread further to other organs or distant bones.

Around 47,000 men are diagnosed with prostate cancer every year in the UK, and over 11,500 men die from the disease.

In this study, 40 per cent of men with newly diagnosed advanced prostate cancer were in the group with disease that had spread to their lymph nodes and/or nearby bones, suggesting the findings could potentially benefit more than 3,000 men every year in England alone, and many thousands more worldwide.

Dr. Chris Parker, lead researcher of the study based at The Royal Marsden, said: “Our results show a powerful effect for certain men with advanced prostate cancer. These findings could and should change standard of care worldwide.

“Until now, it was thought that there was no point in treating the prostate itself if the cancer had already spread because it would be like shutting the stable door after the horse has bolted. However, this study proves the benefit of prostate radiotherapy for these men. Unlike many new drugs for cancer, radiotherapy is a simple, relatively cheap treatment that is readily available in most parts of the world.”

Professor Nicholas James, chief investigator of the Cancer Research UK-funded STAMPEDE trial from the University of Birmingham, said: “Although survival times are improving, no one with advanced prostate cancer is cured of their disease by hormone therapy alone. These important results move the dial significantly further in terms of what we can do for this large group of men. These results should change the standard of care for certain men with advanced prostate cancer – and could be implemented tomorrow.”

Kevin Webber, age 53, although not part of the trial, received radiotherapy to the prostate as part of his treatment for advanced prostate cancer at The Royal Marsden. He said: “I discovered I had prostate cancer in November 2014 and was given a prognosis of as little as two years. My tumour had spread to lymph glands in my abdomen and chest, so I didn’t think radiotherapy was an option for me until Dr. Chris Parker raised the possibility of it.

“Now, nearly four years on from my diagnosis, I’m still incurable—but have been and currently remain fit enough to have just completed my sixth multi day ultra-marathon of 2018. Groundbreaking studies like STAMPEDE give patients hope, and that’s priceless when you have advanced cancer.”

Professor Charles Swanton, Cancer Research UK’s chief clinician, said: “This is a monumental finding that could help thousands of men worldwide. STAMPEDE is making great strides in finding new ways to treat prostate cancer with previous results from the trial already changing clinical practice – data released previously has led to docetaxel chemotherapy now being part of the standard of care for many men with prostate cancer.

“Adding radiotherapy to current treatment shows clear benefit for this subgroup of men with prostate cancer. We now need to investigate whether this could also work for other types of cancer. If we can understand exactly why these men benefit from the additional radiotherapy treatment, we could hopefully use this approach to benefit even more patients.”

Professor Mahesh Parmar, director of the MRC Clinical Trials Unit where STAMPEDE is based, said: “STAMPEDE is changing the face of prostate cancer research because the scale and adaptive nature of the study mean that a number of different treatment options can be investigated rapidly and in parallel and new treatments to be tested can be added. This is enabling scientists to get results much more quickly than they usually would. More data will come out in subsequent years, because of the innovative design of the trial. This shows us the importance of investing in more adaptive trials like STAMPEDE to help us make similar progress in the treatment of other cancers such as breast and lung.”


Explore further:
Adding abiraterone to standard treatment improves prostate cancer survival by 40 percent

More information:
Christopher C Parker et al. Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial, The Lancet (2018). DOI: 10.1016/S0140-6736(18)32486-3

Journal reference:
The Lancet

Provided by:
University of Birmingham

Tagged with:

About author

Related Articles