Breaking News
February 19, 2019 - Customized Micropatterning for Improved Physiological Relevance
February 19, 2019 - Unique gene therapy approach paves new way to tackle rare, inherited diseases
February 19, 2019 - Activating gene that helps excite neurons reverses depression in male mice
February 19, 2019 - Science Puzzling Out Differences in Gut Bacteria Around the World
February 19, 2019 - Cells that destroy the intestine
February 19, 2019 - On recovery, vulnerability and ritual: An exhibit in white
February 19, 2019 - Scientific Duo Gets Back To Basics To Make Childbirth Safer
February 19, 2019 - COPD patients need more support when understanding new chest symptoms
February 19, 2019 - Using light-based method for production of pharmaceutical molecules
February 19, 2019 - Scientists find link between inflammation and cancer
February 19, 2019 - The High Cost Of Sex: Insurers Often Don’t Pay For Drugs To Treat Problems
February 19, 2019 - Hearing impairment associated with accelerated cognitive decline with age
February 19, 2019 - Researchers identify multiple genetic variants associated with body fat distribution
February 19, 2019 - Influenza and common cold are completely different diseases, study shows
February 19, 2019 - Scientists untangle how microbes manufacture key antibiotic compound
February 19, 2019 - Greater primary care physician supply associated with longer life spans
February 19, 2019 - HIV-1 protein suppresses immune response more broadly than thought
February 19, 2019 - For 2020 Dem Hopefuls, ‘Medicare-For-All’ Is A Defining Issue, However They Define It
February 19, 2019 - KU professor discusses promise of brain-computer interface to aid, restore communication
February 19, 2019 - Highly effective solution for detecting onset of aggregation in nanoparticles
February 19, 2019 - Early marker of cardiac damage triggered by cancer treatment identified
February 19, 2019 - Antidepressant drug could save people from deadly sepsis, research suggests
February 19, 2019 - CRISPR technology creates pluripotent stem cells that are ‘invisible’ to the immune system
February 19, 2019 - New study establishes how stress favors breast cancer growth and spread
February 19, 2019 - Midlife Systemic Inflammation Linked to Later Cognitive Decline
February 19, 2019 - Therapy derived from parasitic worms downregulates proinflammatory pathways
February 19, 2019 - Antimicrobial reusable coffee cups are less likely to become contaminated with bacteria, study shows
February 19, 2019 - Harnessing the evolutionary games played by cancer cells to advance therapies
February 19, 2019 - AHA News: Heart Transplant Survivor Gets Wedding Proposal at Finish Line
February 19, 2019 - HIV hidden in patients’ cells can now be accurately measured
February 19, 2019 - Research finds reasons for sudden cardiac death in patients with stable ischemic disease
February 19, 2019 - New protocol could help physicians to rule out bacterial infections in infants
February 19, 2019 - Women experiencing miscarriage should be offered treatment choices
February 19, 2019 - New protocol can help identify febrile infants at low risk for serious bacterial infections
February 19, 2019 - Innovative way to block HIV runs into a roadblock
February 19, 2019 - Springer Nature with BCRF conduct pilot project to make their research datasets more accessible
February 19, 2019 - Study finds neuromelanin-sensitive MRI as potential biomarker for psychosis
February 19, 2019 - Improvements in cardiovascular care for elderly save billions in health care costs
February 19, 2019 - Chilean food regulations are changing food perceptions and purchasing habits, study suggests
February 19, 2019 - Index endoscopy results are crucial for assessment of Barrett’s patients
February 18, 2019 - Breast cancer screening age should be lowered to 35
February 18, 2019 - Brain synchronization depends on the language of communication
February 18, 2019 - Drug Company Payments Over Time May Influence Rx Practices
February 18, 2019 - Despite socioeconomic gains, black-white ‘health gap’ remains
February 18, 2019 - Researchers report progress in the treatment of aggressive brain tumors
February 18, 2019 - Scientists discover trigger that turns strep infections into devastating disease
February 18, 2019 - Scanning children’s teeth may predict future mental health issues
February 18, 2019 - Health Highlights: Feb. 14, 2019
February 18, 2019 - New knowledge could help predict and prevent depression
February 18, 2019 - More primary care physicians leads to longer life spans | News Center
February 18, 2019 - Study examines link between supply of primary care physicians and life expectancy
February 18, 2019 - New study assesses screen time in young children
February 18, 2019 - Patented IU discovery to treat ARDS has been optioned to Theratome Bio
February 18, 2019 - Software found to be four times better at monitoring ovarian cancer
February 18, 2019 - Male Y chromosomes not ‘genetic wastelands’
February 18, 2019 - Hormone therapy during gender transition may increase risk for cardiovascular events
February 18, 2019 - NICE renews accreditation for Advanced
February 18, 2019 - FDA Grants Orphan Drug Designation to Amplyx Pharmaceuticals for APX001 for Treatment of Cryptococcosis
February 18, 2019 - Molecule effective in killing tuberculosis bacteria
February 18, 2019 - Columbia researchers unravel why some glioblastomas respond to immunotherapy
February 18, 2019 - Men who are able to do ten push-ups are less likely to have a stroke
February 18, 2019 - Blood-brain barrier disruption could lead to age-related cognitive decline
February 18, 2019 - Combination of PARP inhibitor and immunotherapy results in tumor regression in SCLC mouse models
February 18, 2019 - Heavy smoking could lead to vision loss, study finds
February 18, 2019 - New diagnostic test for malaria uses spit, not blood
February 18, 2019 - New therapeutic molecules show promise in reversing memory loss related to depression, aging
February 18, 2019 - Darla Shine joins anti-vaccination campaigners
February 18, 2019 - New study outlines sex-specific issues in ischemic heart disease
February 18, 2019 - Drug combinations could become first-line treatment for metastatic kidney cancer
February 18, 2019 - Lifetime adversity, increased neural processing during trauma combine to intensify core PTSD symptoms
February 18, 2019 - HRQoL Scores Decrease With Treatment Line in Multiple Myeloma
February 18, 2019 - Convincing evidence that type 2 diabetes is a cause of erectile dysfunction
February 18, 2019 - Study offers implications of advanced age in evaluation, management of ischemic heart disease
February 18, 2019 - Children from homes with flame-retardant sofa have high SVOC concentration in their blood
February 18, 2019 - Art Institute of Chicago announces results of research on five terracotta sculptures
February 18, 2019 - New PET/CT tracer shows high detection rate for diagnosis of acute venous thromboembolism
February 18, 2019 - Smoking may blight immune response against melanoma and reduce survival
February 18, 2019 - How Inactivity and Junk Food Can Harm Your Brain
February 18, 2019 - Diabetes tops common conditions for frequent geriatric emergency patients
February 18, 2019 - Longer-lived sperm produces offspring with healthier lifespans
Researchers identify genes responsible for sun sensitivity and skin cancer vulnerability

Researchers identify genes responsible for sun sensitivity and skin cancer vulnerability

image_pdfDownload PDFimage_print

Research carried out at the Health Sciences department of the Universitat Jaume I (UJI) of Castellón, Spain, has identified the genes responsible for sun sensitivity and skin cancer vulnerability. The Skin Cancer Genetics and Human Pigmentation research group (Melanogén) has analyzed the skin’s response to sun and the ability to get tanned, and they have detected different genetic variants among the population of northern Europe. The results of this work have been published in the Photodermatology, Photoimmunology & Photomedicine journal.

The work coordinated by researchers Conrado Martínez-Cadenas and Bárbara Hernando has studied, with genetic techniques, the genes related to the skin’s response to sun exposure in Spain, with the goal of understanding the genetic determinants that can favor a negative reaction of the skin to ultraviolet radiation. The UJI study has analyzed eight genetic variants related with pigmentation and sun sensitivity in saliva samples from 456 Spanish volunteers, 184 of which showed great vulnerability to sunburns, an indicative sign of cutaneous cellular damage.

Genetic differences with northern Europe

Cutaneous pigmentation and the skin’s response to sun radiation are extremely relevant to determine susceptibility to skin cancer, and “a majority of studies have been conducted in northern Europe”, says Martínez-Cadenas. In fact, the study conducted by the Melanogén group “looks into the features of the population of a Mediterranean origin, who are characterized by a darker skin than people from an area with more intense radiation”, explains Conrado. Due to the increased intensity of the ultraviolet radiation in the Mediterranean area, mainly during the summer months, evolution “has had an effect so that, for example, the proportion of people with the allele F374 in the SLC45A2 gene, responsible for darker skin, is more common in Spain than among northern European populations. It is worth noting that more than 96% of African people, who withstand an excess of sun radiation, have this genetic variant in their genome, which grants them protection against the negative effects of ultraviolet rays and skin cancer,” adds Bárbara Hernando.

Four main genes

Melanogén researchers highlight that the four genes that play a significant role in cutaneous sensitivity to sun among the Spanish population are the following: MC1R, IRF4, HERC2 and SLC45A2. Conrado Martínez-Cadenas says: “We know there is a genetic predisposition to suffering sunburns. The cutaneous response to the sun and the ability to get a tan is mainly related to a type of genetic variants in the MC1R gene – the R variants. These cause the gene to not work properly and for the body to synthesize pheomelanine instead of eumelanine, which results in people having clearer skin, blond or red hair and freckles.” However, this study indicates that “the synergic combination of several variants that determine sun sensitivity lead to added risk or a broader phenotype”, adds the genetics professor. Therefore, “having protective variants in our genome can lessen the negative effect of the R variants of the MC1R gene”, concludes Bárbara Hernando. The UJI teachers insist that prevention and early detection, as well as specific monitoring of the most susceptible population to developing skin cancer, are key for curing the disease.

Individualized treatments

Melanogén’s future research lines include studying the existence of an added risk of developing skin cancer depending on the pigmentary genotype and people’s phenotypic features. This would make it possible to advance in applying the genetic diagnosis as a tool to detect a person’s risk of developing a disease, to guide treatment decisions and assess the risk of developing a progression or recurrence of the disease. Furthermore, it would help specialists create personalized and accurate treatment depending on the risk of each individual patient.

The Melanogén research group of the UJI, headed by Conrado Martínez-Cadenas, conducts three essential lines. The first is the genetic basis of human susceptibility to melanoma and other skin cancers; the second is focused on the molecular mechanisms and the intracellular signaling paths involved in the genesis and progression of skin cancers, both melanomas and non-melanomas (basal and squamous cell carcinomas). Lastly, their studies tackle genetic, hormone and environmental factors involved in the development of benign pigmentary lesions such as ephelides, nevus, liver spots or melasmas.

Source:

http://ruvid.org/ri-world/researchers-identify-the-genes-involved-in-skin-cancer/

Tagged with:

About author

Related Articles