Breaking News
March 22, 2019 - Researchers develop new tool for imaging large groups of neurons in living animals
March 22, 2019 - Certain bacteria and immune factors in vagina may cause or protect against preterm birth
March 22, 2019 - Novel breath test could pave new way to non-invasively measure gut health
March 22, 2019 - Pharmaceutical and personal care products may result in new contaminants in waterways
March 22, 2019 - ACC: Catheter Ablation Does Not Cut Mortality, Stroke in A-Fib
March 22, 2019 - Wiedemann-Rautenstrauch syndrome – Genetics Home Reference
March 22, 2019 - Health insurance is not assurance of healthcare
March 22, 2019 - Supporting “curiosity-driven research” at the Discovery Innovation Awards
March 22, 2019 - Must-Reads Of The Week (Some Flying Below The Radar)
March 22, 2019 - Newly engineered nanoscale protein micelles can be tracked by MRI
March 22, 2019 - Pitt engineers win $550,000 NSF CAREER award to develop new intervention for people with ASD
March 22, 2019 - Early discharge does not increase readmission risk for patients after lung surgery
March 22, 2019 - Creating diverse pool of trained scientists to address Alzheimer’s research needs
March 22, 2019 - Study shows ACA’s positive impact on healthcare affordability and access for women
March 22, 2019 - New combination treatment shows promise for common brain tumor in children
March 22, 2019 - Virginia Tech Helmet Lab releases first youth-specific football helmet ratings
March 22, 2019 - New algae-based treatment could reduce need for limb amputation
March 22, 2019 - Stroke risk reduces in both black and white older Medicare beneficiaries, study reports
March 22, 2019 - City of Hope exhibits current studies and data on cancer therapies at AACR
March 22, 2019 - New study identifies CD40 molecule as key entry point for dangerous bacteria
March 22, 2019 - Health Tip: Six Steps to a Healthier Life
March 22, 2019 - even a little activity helps you live longer
March 22, 2019 - Many individuals recovering from addiction continue to suffer from chronic physical disease
March 22, 2019 - New drugs on PBS for Parkinson’s, MND and Cutaneous T cell lymphoma
March 22, 2019 - Saving energy also saves lives, UW-Madison study says
March 22, 2019 - Former inmates who receive social support have better mental health, study finds
March 22, 2019 - Nanofibrous membrane could enhance periodontal tissue regeneration
March 22, 2019 - Anti-vaxxer Italian leader down with chickenpox
March 22, 2019 - Servier collaborates with Harvard researchers to fight metabolic diseases
March 22, 2019 - National Eating Disorders Association
March 22, 2019 - Pumping up red blood cell production
March 22, 2019 - Excessive phosphate fertilizer may hurt plants by altering microbial composition in soil
March 22, 2019 - Medical marijuana laws could be improving older Americans’ health, study suggests
March 22, 2019 - Study indicates the benefits of stopping aspirin in heart attack patients
March 22, 2019 - Deep brain stimulation offers significant relief for patients with treatment-resistant depression
March 22, 2019 - Mental health problems in young adults on the rise
March 22, 2019 - Innovative membrane offers a viable solution for periodontitis
March 22, 2019 - The FDA Grants Rare Pediatric Disease Designation to Odiparcil for the Treatment of MPS VI
March 22, 2019 - insulin therapy: MedlinePlus Medical Encyclopedia
March 22, 2019 - Guidelines on the use of genetic testing in psychiatry
March 22, 2019 - Aspiring Doctors Seek Advanced Training In Addiction Medicine
March 22, 2019 - A change in focus could enable the development of new treatments for Alzheimer’s disease
March 22, 2019 - A new way to visualize the immune cell “landscape” of bowel cancer tumors
March 22, 2019 - Understanding maintenance of quiescent stem cells in chronic myelogenous leukemia
March 22, 2019 - Ludwig scientists to share advances in cancer research at AACR Annual Meeting 2019
March 22, 2019 - Less invasive valve replacement can be safe and effective alternative for healthier patients
March 22, 2019 - Aphasia research reveals new, complex interactions between thought and language
March 22, 2019 - Artificial neural networks can predict how different areas in the brain respond to words
March 22, 2019 - Age-related changes to gut microbiome have adverse impact on vascular health, study shows
March 22, 2019 - Study provides new insight into blood cell and immune cell production
March 22, 2019 - Isolated seniors chat online to prevent cognitive decline
March 22, 2019 - Repurposing drugs to outsmart cancers
March 22, 2019 - Naltrexone implant more effective in reducing relapses in HIV patients with opioid addiction
March 22, 2019 - The Brain Institute wins $7.04 million grant to investigate ‘neurophilosphy of free will’
March 22, 2019 - Karyopharm Announces FDA Extension of Review Period for Selinexor New Drug Application
March 22, 2019 - Eruptive xanthomatosis
March 22, 2019 - Cause of vascular disease in kidney failure reversed in animal model
March 22, 2019 - Researchers discover possible new therapeutic strategy for pancreatic cancer
March 22, 2019 - Ebola spreads to second largest city in DRC
March 22, 2019 - Perivascular spaces contribute to worse cognitive health in older adults
March 22, 2019 - Adolescent daily users more likely to obtain electronic cigarettes from commercial sources
March 22, 2019 - FDA Approves Genentech’s Tecentriq in Combination With Chemotherapy for the Initial Treatment of Adults With Extensive-Stage Small Cell Lung Cancer
March 22, 2019 - Diabetes myths and facts: MedlinePlus Medical Encyclopedia
March 22, 2019 - TGen and ABL pursue global rollout of advanced TB test
March 22, 2019 - Traffic light labels influence people to choose healthier and more sustainable meals
March 22, 2019 - Alzheimer’s patients using antiepileptic drugs have twice the risk of pneumonia, study shows
March 22, 2019 - Skin diseases may be more prevalent than previously thought
March 22, 2019 - Overall rates of death from breast cancer are falling across the EU
March 22, 2019 - Novel plasmid could hold key to control of mosquito-borne illness
March 22, 2019 - Female Emergency Physicians Paid Less Than Males
March 22, 2019 - Estimated average glucose (eAG): MedlinePlus Medical Encyclopedia
March 22, 2019 - Experimental drug could be new option for type 2 diabetes
March 22, 2019 - Five Things To Know About The Electronic Health Records Mess
March 22, 2019 - TMJ disorders could be treated with tissue-engineered implants after successful animal study
March 22, 2019 - Team-based approach is key to successful care of pregnant women with heart failure
March 22, 2019 - Study identifies gene variant associated with accelerated cellular aging
March 21, 2019 - Salk scientists show how background noise from neurons can interrupt focused attention
March 21, 2019 - New class of drugs could help treat patients diagnosed with ovarian cancer
March 21, 2019 - Tecentriq Approved for Small Cell Lung Cancer
March 21, 2019 - Adipocyte glucocorticoid receptors play a role in developing steroid diabetes
Minimally invasive surgery for cervical cancer may not be a good idea finds a pair of studies

Minimally invasive surgery for cervical cancer may not be a good idea finds a pair of studies

image_pdfDownload PDFimage_print

New research shows that keyhole surgery or minimally invasive laparoscopic robotic surgery could be dangerous in the long run for women with cervical cancer. Unlike open surgeries, minimally invasive surgeries are being increasingly conducted and preferred because of their minimal tissue damage, minimal pain and risk as well as faster recovery. Both studies have been published in the latest issue of the New England Journal of Medicine.

The researchers however found that women who were undergoing minimally invasive hysterectomies including some that use robotic surgery for example with the Da Vinci device, are at a greater risk of their cancers coming back compared to women who have had an open surgery.

Cervical cancer development. Image Credit: Double Brain / Shutterstock

Cervical cancer development. Image Credit: Double Brain / Shutterstock

One of the studies came from the University of Texas MD Anderson Cancer Center that has already stopped minimally invasive hysterectomies for women with cervical cancer. Dr. Joe-Alejandro Rauh-Hain, a gynecologic cancer specialist at MD Anderson and a co-author to one of the studies says that the team was surprised with the results of the study. He said that they had expected survival rates for both kinds of surgeries to be around the same.

Due to the drastically reduced risk of bleeding, pain, infections and surgical complications with keyhole surgeries, they are increasingly being preferred in the US. Rauh-Hain said that after these two studies, the surgeons can no longer recommend minimally invasive surgeries to patients with early stage cervical cancer.

Dr. Alexander Melamed of Massachusetts General Hospital and Harvard Medical School was another co-author of the study. He said that personally he would now refrain from offering “minimally invasive radical hysterectomy” in cervical cancer patients until more research shows that the risks are absent.

This first study looked at 2,461 women who were diagnosed with stage 1 cervical cancer between 2010 and 2013. Around half of these women (1225) underwent minimally invasive surgery for hysterectomy while the other got open surgeries. Of the women who underwent keyhole surgeries, 79 percent had be operated using robotic assistance. Authors wrote, “Over a median follow-up of 45 months, the four-year mortality was 9.1 percent among women who underwent minimally invasive surgery and 5.3 percent among those who underwent open surgery.” Women undergoing minimally invasive surgeries were 65 percent more likely to die within the four years following the operation compared. In comparison to 70 women who died within four years after surgery after an open surgery, 94 women undergoing minimally invasive surgery died during the same period.

In the second study the researchers randomly assigned 631 women to undergo either open surgery or minimally invasive hysterectomy. These procedures were conducted at 33 hospitals across United States, Brazil, Columbia, Italy, Peru, Australia, Mexico and China. At 4.5 years post-surgery, 95 percent women undergoing traditional open surgeries were disease free compared to 86 percent women undergoing minimally invasive surgery.

Dr. Pedro Ramirez, a professor in gynecologic oncology at MD Anderson and one of the researchers on the study explained that for minimally invasive laparoscopic surgery, usually carbon dioxide gas is used to inflate the abdomen to visualize the surgical field. He said that this carbon dioxide gas could play a role in causing the cancer cells to be implanted in different parts of the abdominal cavity while operating.

Dr. Shohreh Shahabi, chief of gynecological oncology at Northwestern University Feinberg School of Medicine was one of the researchers on one of the study teams. He emphasized that these findings are true for cervical cancers alone as of now and there are several other cancers that are being surgically treated using laparoscopic and minimally invasive surgeries.

Dr. Amanda N. Fader, director of the Kelly Gynecologic-Oncology Service at Johns Hopkins University wrote an editorial accompanying the studies saying that these results were a “great blow” to minimally invasive surgical approaches for cervical cancer. She said Johns Hopkins has since this stopped keyhole surgeries for cervical cancers and reverted back to open surgeries.

Source:

https://www.nejm.org/doi/10.1056/NEJMoa1804923 and https://www.nejm.org/doi/10.1056/NEJMoa1806395

Tagged with:

About author

Related Articles