Breaking News
February 20, 2019 - Self-reported sleep duration is a useful tool to measure sleep in children, study suggests
February 20, 2019 - T-cells play key role in how the body fights follicular lymphoma
February 20, 2019 - Study shows how 3D organization of genetic material helps perpetuate the species
February 20, 2019 - Researchers engineer stem cell with ‘suicide genes’ to induce cell death in all but beta cells
February 20, 2019 - Health Tip: Get Your Child to School on Time
February 20, 2019 - Shortcut strategy for screening compounds with clinical potentials for drug development
February 20, 2019 - Common acid reflux drugs tied to elevated risk for kidney disease
February 20, 2019 - Microbiome could be culprit when good drugs do harm
February 20, 2019 - Prenatal exposure to forest fires causes stunted growth in children
February 20, 2019 - Gene therapy restores hearing in mice with congenital genetic deafness
February 20, 2019 - First molecular test predicts treatment response for kidney cancer
February 20, 2019 - New method for improved visualization of single-cell RNA- sequencing data
February 20, 2019 - Researchers capture altered brain activity patterns of Parkinson’s in mice
February 20, 2019 - A possible blood test for detecting Alzheimer’s disease before symptoms show
February 20, 2019 - Primary care physicians associated with longevity, new research finds
February 19, 2019 - New study identifies many key lessons to establish sanctioned safe consumption sites
February 19, 2019 - Single CRISPR treatment can safely and stably correct genetic disease
February 19, 2019 - Multinational initiative to study familial primary distal renal tubular acidosis
February 19, 2019 - Breakthrough study highlights the promise of cell therapies for muscular dystrophy
February 19, 2019 - Subsymptom Threshold Exercise Speeds Concussion Recovery
February 19, 2019 - Midline venous catheters – infants: MedlinePlus Medical Encyclopedia
February 19, 2019 - Searching for side effects
February 19, 2019 - Humanity is all right, probably, although human extinction remains quite possible, researcher says
February 19, 2019 - Having Anesthesia Once as a Baby Does Not Cause Learning Disabilities, New Research Shows
February 19, 2019 - Anti-cancer immunotherapy could be used to fight HIV
February 19, 2019 - Customized Micropatterning for Improved Physiological Relevance
February 19, 2019 - Unique gene therapy approach paves new way to tackle rare, inherited diseases
February 19, 2019 - Activating gene that helps excite neurons reverses depression in male mice
February 19, 2019 - Science Puzzling Out Differences in Gut Bacteria Around the World
February 19, 2019 - Cells that destroy the intestine
February 19, 2019 - On recovery, vulnerability and ritual: An exhibit in white
February 19, 2019 - Scientific Duo Gets Back To Basics To Make Childbirth Safer
February 19, 2019 - COPD patients need more support when understanding new chest symptoms
February 19, 2019 - Using light-based method for production of pharmaceutical molecules
February 19, 2019 - Scientists find link between inflammation and cancer
February 19, 2019 - The High Cost Of Sex: Insurers Often Don’t Pay For Drugs To Treat Problems
February 19, 2019 - Hearing impairment associated with accelerated cognitive decline with age
February 19, 2019 - Researchers identify multiple genetic variants associated with body fat distribution
February 19, 2019 - Influenza and common cold are completely different diseases, study shows
February 19, 2019 - Scientists untangle how microbes manufacture key antibiotic compound
February 19, 2019 - Greater primary care physician supply associated with longer life spans
February 19, 2019 - HIV-1 protein suppresses immune response more broadly than thought
February 19, 2019 - Brain imaging indicates potential success of drug therapy in depressive patients
February 19, 2019 - For 2020 Dem Hopefuls, ‘Medicare-For-All’ Is A Defining Issue, However They Define It
February 19, 2019 - Specialized lung cells appear in the developing fetus much earlier than previously thought
February 19, 2019 - KU professor discusses promise of brain-computer interface to aid, restore communication
February 19, 2019 - Highly effective solution for detecting onset of aggregation in nanoparticles
February 19, 2019 - Early marker of cardiac damage triggered by cancer treatment identified
February 19, 2019 - Antidepressant drug could save people from deadly sepsis, research suggests
February 19, 2019 - CRISPR technology creates pluripotent stem cells that are ‘invisible’ to the immune system
February 19, 2019 - New study establishes how stress favors breast cancer growth and spread
February 19, 2019 - Midlife Systemic Inflammation Linked to Later Cognitive Decline
February 19, 2019 - Therapy derived from parasitic worms downregulates proinflammatory pathways
February 19, 2019 - Antimicrobial reusable coffee cups are less likely to become contaminated with bacteria, study shows
February 19, 2019 - Harnessing the evolutionary games played by cancer cells to advance therapies
February 19, 2019 - AHA News: Heart Transplant Survivor Gets Wedding Proposal at Finish Line
February 19, 2019 - HIV hidden in patients’ cells can now be accurately measured
February 19, 2019 - Research finds reasons for sudden cardiac death in patients with stable ischemic disease
February 19, 2019 - New protocol could help physicians to rule out bacterial infections in infants
February 19, 2019 - Women experiencing miscarriage should be offered treatment choices
February 19, 2019 - New protocol can help identify febrile infants at low risk for serious bacterial infections
February 19, 2019 - Innovative way to block HIV runs into a roadblock
February 19, 2019 - Springer Nature with BCRF conduct pilot project to make their research datasets more accessible
February 19, 2019 - Study finds neuromelanin-sensitive MRI as potential biomarker for psychosis
February 19, 2019 - Improvements in cardiovascular care for elderly save billions in health care costs
February 19, 2019 - Chilean food regulations are changing food perceptions and purchasing habits, study suggests
February 19, 2019 - Index endoscopy results are crucial for assessment of Barrett’s patients
February 18, 2019 - Breast cancer screening age should be lowered to 35
February 18, 2019 - Brain synchronization depends on the language of communication
February 18, 2019 - Drug Company Payments Over Time May Influence Rx Practices
February 18, 2019 - Despite socioeconomic gains, black-white ‘health gap’ remains
February 18, 2019 - Researchers report progress in the treatment of aggressive brain tumors
February 18, 2019 - Scientists discover trigger that turns strep infections into devastating disease
February 18, 2019 - Scanning children’s teeth may predict future mental health issues
February 18, 2019 - Health Highlights: Feb. 14, 2019
February 18, 2019 - New knowledge could help predict and prevent depression
February 18, 2019 - More primary care physicians leads to longer life spans | News Center
February 18, 2019 - Study examines link between supply of primary care physicians and life expectancy
February 18, 2019 - New study assesses screen time in young children
February 18, 2019 - Patented IU discovery to treat ARDS has been optioned to Theratome Bio
Person’s sex hormones may play key role in trauma survival, finds study

Person’s sex hormones may play key role in trauma survival, finds study

image_pdfDownload PDFimage_print

A person’s sex hormones may play a role in trauma survival, according to a Kansas State University researcher who has received a $650,000 grant from the U.S. Department of Defense.

Sherry Fleming, professor of biology, is using the three-year grant to study the differences between men and women and how their hormones affect the ways they respond to medication and surgery after a traumatic event. Trauma affects both civilians and military service members and can include a range of events such as a heart attack, a car accident or a blast wound.

“We want to know what is different in men and women, how do we detect the differences and how do we develop better treatments,” Fleming said.

Data from the Department of Defense has shown different survival rates of women and men serving in Afghanistan and Iraq after similar blast wounds or trauma events. Women did not survive nearly as well as men despite similar treatment, Fleming said. Although the number of people in the study was low, one study examined Operation Enduring Freedom, from 2001 to 2003, and found the female case fatality rate of 35.9 percent was double the male rate of 17 percent.

Now Fleming wants to understand why women’s survival rates are so much lower than men’s survival rates, especially since women in the military frequently traverse combat zones.

One reason may be that females are not used as frequently as males during research and trial studies that evaluate if treatments will be effective, Fleming said. As a result, the studies don’t take differences between the sexes into account. One such difference is estrogen and testosterone levels.

“In the past, most of our treatments are based off of studies with participants with high testosterone and that may change the way that the cells and the drugs work,” Fleming said. “We need to understand what is causing the damage so we can find a treatment.”

Even symptoms for trauma are different in men and women, Fleming said. For instance, men often experience chest pain and arm pain before a heart attack, while the American Heart Association says that women are somewhat more likely to experience gastrointestinal symptoms, such as nausea or vomiting, instead.

Those differences in symptoms are key, Fleming said. Women progress two and a half times more often than men to life-threatening acute respiratory distress syndrome, or ARDS, which occurs when fluid leaks into the lungs of a critically ill patient and makes it difficult to breathe.

As part of the project, Fleming will be studying the effectiveness of a drug that her research team patented. The drug, “B2-Glycoprotein I Peptide Inhibitors,” involves therapeutic peptides that can reduce or prevent the damage caused to intestinal tissue when blood and oxygen are restricted, called ischemia. The peptide reduces tissue damage caused by surgery and trauma in animals.

Fleming’s drug also may help treat high blood pressure in pregnant women, which is the leading cause of premature birth and low infant weight. Fleming and her collaborators are studying how the drug can help improve oxygen and blood flow to the placenta, which can lower the blood pressure in the mother and give the baby a better chance to grow.

While Fleming’s latest research focuses on trauma in the military, her work is applicable to a variety of people and can improve many health-related issues, university administrators say.

“Dr. Fleming’s award is an exemplar of how basic science can be aligned with Department of Defense interests, in this case in the biomedical sciences,” said Beth Montelone, Kansas State University senior associate vice president for research. “The Office of Research Development is actively working with faculty to help them find appropriate opportunities within the DOD funding portfolio.”

Source:

https://www.k-state.edu/media/newsreleases/2018-11/fleming111518.html

Tagged with:

About author

Related Articles