Breaking News
December 12, 2018 - Study provides new information regarding microRNA function in cellular homeostasis of zebrafish
December 12, 2018 - Study provides new understanding of mysterious ‘hereditary swelling’
December 12, 2018 - Researchers shed new light on how to combat Shiga and ricin toxins
December 12, 2018 - Pregnant Women Commonly Refuse Vaccines
December 12, 2018 - Drug treatment could offer new hope for some patients with brain bleeding
December 12, 2018 - Health care financial burden of animal-related injuries is growing, study says
December 12, 2018 - Macrophage cells could help repair the heart following a heart attack, study finds
December 12, 2018 - Researchers develop new system for efficiently producing human norovirus
December 12, 2018 - New artificial intelligence-based system to differentiate between different types of cancer cells
December 11, 2018 - Healthy Lifestyle Lowers Odds of Breast Cancer’s Return
December 11, 2018 - New research identifies two genes linked to serious congenital heart condition
December 11, 2018 - NIH Director talks science, STEM careers with preteens
December 11, 2018 - Disabling a Cellular Antivirus System Could Improve Gene Therapy
December 11, 2018 - New tool swiftly provides accurate measure of patients’ cognitive difficulties
December 11, 2018 - NICE releases new guidelines for diagnosis and management of COPD
December 11, 2018 - Without Obamacare penalty, think it’ll be nice to drop your plan? Better think twice
December 11, 2018 - Researchers capture high-resolution X-ray and NMR image of key immune regulator
December 11, 2018 - Natural flavonoid is effective at treating leishmanisis infections, study shows
December 11, 2018 - Avoidant grievers unconsciously monitor and block mind-wandering contents, study shows
December 11, 2018 - Study identifies how hantaviruses infect lung cells
December 11, 2018 - Improving PTSD care through genetics
December 11, 2018 - Dermatology providers show interest in recommending cannabinoids to patients
December 11, 2018 - Researchers to study effects of electroconvulsive therapy on Alzheimer’s patients with aggression
December 11, 2018 - Four dried fruits have lower glycemic index than starchy foods, study finds
December 11, 2018 - Optimization of drug dose sizes can reduce pharmaceutical wastage
December 11, 2018 - Ultrarestrictive opioid prescribing strategy linked with reduction in number of pills dispensed
December 11, 2018 - PET scans to optimize tuberculosis meningitis treatments and personalize care, study finds
December 11, 2018 - Researchers aim to identify and target high blood pressure indicators
December 11, 2018 - Researchers identify immune cell subset that may drive chronic inflammation
December 11, 2018 - Ezogabine treatment reduces motor neuron excitability in ALS patients, study shows
December 11, 2018 - One implant, two prices. It depends on who’s paying.
December 11, 2018 - Standardizing feeding practices improves growth trends for micro-preemies
December 11, 2018 - COPD Tied to Obesity in Male, Female Never-Smokers
December 11, 2018 - Flossing: Information for Caregivers
December 11, 2018 - Does breastfeeding hormone protect against type 2 diabetes?
December 11, 2018 - Educating future doctors to prescribe physical activity for their patients
December 11, 2018 - Krystal 2000 microplate design improves fluorescence and luminescence measurement
December 11, 2018 - FDA clears mobile medical app to help increase retention in recovery program for opioid use disorder
December 11, 2018 - Overcoming Challenges in High-Speed Centrifugation Experiments
December 11, 2018 - Study shows link between neighborhoods’ socioeconomic status and dietary choices
December 11, 2018 - Lower BMI before obesity surgery predicts greater post-operative weight loss, study finds
December 11, 2018 - Obesity May Be Driving Rise in Uterine Cancers
December 11, 2018 - Antioxidants may prevent cognitive impairment in diabetes
December 11, 2018 - Study discovers link between meditation and how individuals respond to feedback
December 11, 2018 - Researchers identify potential diagnostic tool for Alzheimer’s disease
December 11, 2018 - Oral cancer prognostic signature identified
December 11, 2018 - How Can I Find Out What Caused My Miscarriage?
December 11, 2018 - Novel personalized medicine tool for assessing inherited colorectal cancer syndrome risk developed
December 11, 2018 - Study uncovers 11 new genes associated with epilepsy
December 11, 2018 - Filling research gaps could help develop more disability-inclusive workplaces
December 11, 2018 - Cartilage tissue engineering brings good news for patients with cartilage defects
December 11, 2018 - Novel 3D printing workflow helps predict leaky heart valves
December 11, 2018 - Imagination can help overcome fear and anxiety-related disorders, shows study
December 11, 2018 - Are caries linked to political regime?
December 11, 2018 - Leader in Diabetes Clinical Trials Wins Naomi Berrie Award
December 11, 2018 - Scientists discover cellular mechanism that triggers pneumonia in humans
December 11, 2018 - Increasing mental health problems related to drug use in over 55’s
December 11, 2018 - High-intensity interval exercise could help combat cognitive dysfunction in obese people
December 11, 2018 - Annual flu shot can save lives of heart failure patients
December 11, 2018 - Researchers compare health outcomes for VA and non-VA hospitals
December 11, 2018 - Recommendations Developed for Psoriatic Arthritis Treatment
December 11, 2018 - Genetic analysis links obesity with diabetes, coronary artery disease
December 11, 2018 - Study shows that having genetic information can affect how the body responds
December 11, 2018 - UNAIDS Report: 9 Million Are Likely HIV Positive And Don't Know It
December 11, 2018 - Lund University researchers succeed in obtaining dendritic cells by direct reprogramming
December 11, 2018 - Breast tumors recruit bone marrow cells to boost their growth, study reveals
December 11, 2018 - Updated breast cancer screening guideline highlights importance of shared decision-making
December 11, 2018 - EHR-related stress associated with physician burnout
December 11, 2018 - AHA: 12-Year-Old Heart Defect Survivor Inspires NFL Player’s Foundation
December 11, 2018 - Breast cancer patients who take heart drug with trastuzumab have less heart damage
December 11, 2018 - Providing aid to those humans – and animals – affected by the California fires
December 11, 2018 - Even without proof, CBD is finding a niche as a cure-all
December 11, 2018 - Drawing leads to better memory than writing
December 11, 2018 - Researchers report novel findings on plant hormone
December 10, 2018 - A Tale of Two Labels
December 10, 2018 - Triple combination cancer immunotherapy improves outcomes in preclinical melanoma model
December 10, 2018 - A 14-year-old explains what it’s like to get a new heart
December 10, 2018 - Team Players Honored with 2018 Baton Awards
December 10, 2018 - Global report highlights how the changing world is affecting children’s physical activity levels
December 10, 2018 - Genes play a role in physical activity and sleep
New device can regulate children’s blood glucose more like natural pancreas

New device can regulate children’s blood glucose more like natural pancreas

image_pdfDownload PDFimage_print

Type 1 diabetes develops in childhood, requiring constant – often painful – management from the start. EU-funded researchers are testing an artificial pancreas that could transform the quality of life of youngsters suffering from the disease.

The wearable device combines a glucose sensor, an insulin pump and a mobile phone with an Android app that automatically matches the insulin supply to a child’s glucose levels.

A pilot study in Austria, Germany, Luxembourg and the UK has shown that the device can regulate children’s blood glucose more like a natural pancreas than can current diabetes treatments. Participating children had very few glucose highs or lows and needed no corrective insulin injections or additional distressing finger-prick blood tests.

The study is the first stage of the EU-funded KIDSAP project to demonstrate to health providers and insurers that the device is safe, effective and possible to use with young children, says the project coordinator, Prof Roman Hovorka, of the University of Cambridge in the United Kingdom.

‘This type of system has not been tried before in such a young population. It could really change the landscape of treatment of young children with type 1 diabetes,’ he adds.

Relief for families

‘Type 1 diabetes is a huge burden on families,’ Hovorka explains. It is an autoimmune condition that stops the pancreas from producing insulin to process glucose from food for energy. Untreated, the disease can lead to serious health problems or even death.

Although existing wearable insulin pumps supply the hormone at a fixed rate, young children’s blood glucose levels vary significantly according to what they eat, their activity levels and their health. Parents have to predict and correct extremes, including at night.

The artificial pancreas could help to relieve the burden. In the KIDSAP pilot study, 24 children with type 1 diabetes aged 18 months to 7 years tested the device at home for two periods of three weeks. ‘We had good feedback from the parents on the impacts on their children’s lives,’ says Hovorka.

The pilot study also helped researchers discover more about how doctors could use the device. It showed that there was no need to use diluted insulin for small children using the artificial pancreas. ‘This surprised us,’ Hovorka says, adding that standard strength insulin is safer and easier to monitor.

Inclusive research

Patients were included in the study through eight universities and teaching hospitals from across the four study countries. Hovorka explains that this enabled researchers to eliminate impacts from differences in national diets and lifestyles and to assess how different healthcare systems will work with the device.

One issue was regulatory approval, especially as the device was being trialled in such young children. ‘It was a logistical challenge. We had to ask each country’s regulatory body and the different universities’ ethics committees for permission to use the device,’ says Hovorka.

Project members are sharing information about the project through the mass media and parents’ groups, as well as publishing KIDSAP results in scientific journals. In the UK, the national health system has publicised this project as one of the most important health research projects in the last 70 years.

The next step in the project is a larger study. This will involve up to 80 children aged 1 to 7 years with type 1 diabetes. Every child will use the artificial pancreas and a state-of-the-art standard insulin pump for four months each to compare their impacts on health, quality of life and cost effectiveness.

Along with the eight study partners, a non-profit research organisation and two SMEs are taking part in KIDSAP. ‘We have established a real consensus to take the research forward. Without the H2020 funding and collaboration network we could not do studies like this,’ Hovorka concludes.

Source:

http://ec.europa.eu/research/infocentre/printversion_en.cfm?id=/research/headlines/news/article_18_11_14_en.html?infocentre&item=Infocentre&artid=49779

Tagged with:

About author

Related Articles