Breaking News
May 3, 2019 - Vaping and Smoking May Signal Greater Motivation to Quit
May 3, 2019 - Dementia looks different in brains of Hispanics
May 3, 2019 - Short-Staffed Nursing Homes See Drop In Medicare Ratings
May 3, 2019 - Study of teens with eating disorders explores how substance users differ from non-substance users
May 3, 2019 - Scientists develop new video game that may help in the study of Alzheimer’s
May 3, 2019 - Arc Bio introduces Galileo Pathogen Solution product line at ASM Clinical Virology Symposium
May 3, 2019 - Cornell University study uncovers relationship between starch digestion gene and gut bacteria
May 3, 2019 - How to Safely Use Glucose Meters and Test Strips for Diabetes
May 3, 2019 - Anti-inflammatory drugs ineffective for prevention of Alzheimer’s disease
May 3, 2019 - Study tracks Pennsylvania’s oil and gas waste-disposal practices
May 3, 2019 - Creating a better radiation diagnostic test for astronauts
May 3, 2019 - Vegans are often deficient in these four nutrients
May 3, 2019 - PPDC announces seed grants to develop medical devices for children
May 3, 2019 - Study maps out the frequency and impact of water polo head injuries
May 3, 2019 - Research on Reddit identifies risks associated with unproven treatments for opioid addiction
May 3, 2019 - Good smells may help ease tobacco cravings
May 3, 2019 - Medical financial hardship found to be very common among people in the United States
May 3, 2019 - Researchers develop multimodal system for personalized post-stroke rehabilitation
May 3, 2019 - Study shows significant mortality benefit with CABG over percutaneous coronary intervention
May 3, 2019 - Will gene-editing of human embryos ever be justifiable?
May 3, 2019 - FDA Approves Dengvaxia (dengue vaccine) for the Prevention of Dengue Disease in Endemic Regions
May 3, 2019 - Why Tonsillitis Keeps Coming Back
May 3, 2019 - Fighting the opioid epidemic with data
May 3, 2019 - Maggot sausages may soon be a reality
May 3, 2019 - Deletion of ATDC gene prevents development of pancreatic cancer in mice
May 2, 2019 - Targeted Therapy Promising for Rare Hematologic Cancer
May 2, 2019 - Alzheimer’s disease is a ‘double-prion disorder,’ study shows
May 2, 2019 - Reservoir bugs: How one bacterial menace makes its home in the human stomach
May 2, 2019 - Clinical, Admin Staff From Cardiology Get Sneak Peek at Epic
May 2, 2019 - Depression increases hospital use and mortality in children
May 2, 2019 - Vicon and NOC support CURE International to create first gait lab in Ethiopia
May 2, 2019 - Researchers use 3D printer to make paper organs
May 2, 2019 - Viral infection in utero associated with behavioral abnormalities in offspring
May 2, 2019 - U.S. Teen Opioid Deaths Soaring
May 2, 2019 - Opioid distribution data should be public
May 2, 2019 - In the Spotlight: “I’m learning every single day”
May 2, 2019 - 2019 Schaefer Scholars Announced
May 2, 2019 - Podcast: KHN’s ‘What The Health?’ Bye-Bye, ACA, And Hello ‘Medicare-For-All’?
May 2, 2019 - Study describes new viral molecular evasion mechanism used by cytomegalovirus
May 2, 2019 - SLU study suggests a more equitable way for Medicare reimbursement
May 2, 2019 - Scientists discover first gene involved in lower urinary tract obstruction
May 2, 2019 - Researchers identify 34 genes associated with increased risk of ovarian cancer
May 2, 2019 - Many low-income infants receive formula in the first few days of life, finds study
May 2, 2019 - Global study finds high success rate for hip and knee replacements
May 2, 2019 - Taking depression seriously: What is it?
May 2, 2019 - With Head Injuries Mounting, Will Cities Put Their Feet Down On E-Scooters?
May 2, 2019 - Scientists develop small fluorophores for tracking metabolites in living cells
May 2, 2019 - Study casts new light into how mothers’ and babies’ genes influence birth weight
May 2, 2019 - Researchers uncover new brain mechanisms regulating body weight
May 2, 2019 - Organ-on-chip systems offered to Asia-Pacific regions by Sydney’s AXT
May 2, 2019 - Adoption of new rules drops readmission penalties against safety net hospitals
May 2, 2019 - Kids and teens who consume zero-calorie sweetened beverages do not save calories
May 2, 2019 - Improved procedure for cancer-related erectile dysfunction
May 2, 2019 - Hormone may improve social behavior in autism
May 2, 2019 - Alzheimer’s disease may be caused by infectious proteins called prions
May 2, 2019 - Even Doctors Can’t Navigate Our ‘Broken Health Care System’
May 2, 2019 - Study looks at the impact on criminal persistence of head injuries
May 2, 2019 - Honey ‘as high in sugars as table sugar’
May 2, 2019 - Innovations to U.S. food system could help consumers in choosing healthy foods
May 2, 2019 - FDA Approves Mavyret (glecaprevir and pibrentasvir) as First Treatment for All Genotypes of Hepatitis C in Pediatric Patients
May 2, 2019 - Women underreport prevalence and intensity of their own snoring
May 2, 2019 - Concussion summit focuses on science behind brain injury
May 2, 2019 - Booker’s Argument For Environmental Justice Stays Within The Lines
May 2, 2019 - Cornell research explains increased metastatic cancer risk in diabetics
May 2, 2019 - Mount Sinai study provides fresh insights into cellular pathways that cause cancer
May 2, 2019 - Researchers to study link between prenatal pesticide exposures and childhood ADHD
May 2, 2019 - CoGEN Congress 2019: Speakers’ overviews
May 2, 2019 - A new strategy for managing diabetic macular edema in people with good vision
May 2, 2019 - Sagent Pharmaceuticals Issues Voluntary Nationwide Recall of Ketorolac Tromethamine Injection, USP, 60mg/2mL (30mg per mL) Due to Lack of Sterility Assurance
May 2, 2019 - Screen time associated with behavioral problems in preschoolers
May 2, 2019 - Hormone reduces social impairment in kids with autism | News Center
May 2, 2019 - Researchers synthesize peroxidase-mimicking nanozyme with low cost and superior catalytic activity
May 2, 2019 - Study results of a potential drug to treat Type 2 diabetes in children announced
May 2, 2019 - Multigene test helps doctors to make effective treatment decisions for breast cancer patients
May 2, 2019 - UNC School of Medicine initiative providing unique care to dementia patients
May 2, 2019 - Nestlé Health Science and VHP join forces to launch innovative COPES program for cancer patients
May 2, 2019 - Study examines how our brain generates consciousness and loses it during anesthesia
May 2, 2019 - Transition Support Program May Aid Young Adults With Type 1 Diabetes
May 2, 2019 - Study shows how neutrophils exacerbate atherosclerosis by inducing smooth muscle-cell death
May 2, 2019 - Research reveals complexity of how we make decisions
A new mechanism in the control of inflammation

A new mechanism in the control of inflammation

Kidney infection with the fungal pathogen Candida albicans causes tissue damage. In wild-type mice, DNGR-1 expressed on dendritic cells detects this injury, and this triggers a reduction in the production of Mip-2, a chemokine that attracts neutrophils. Mice lacking DNGR-1 do not recognize the tissue injury and therefore do not reduce Mip-2 production. The resulting excess neutrophil infiltration in the kidney results in more extensive, immunopathological tissue damage. Credit: CNIC

After infection or tissue injury, the inflammatory immune response attacks the infection and repairs the damaged tissue. However, sometimes excess inflammation can have the opposite effect, increasing injury in a process known as immunopathology. Now, researchers at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have discovered a new inflammation control mechanism that shows how the damage caused by the immune response can be controlled. The study is published today in Science.

Inflammation is a defense mechanism that facilitates the recruitment of immune cells to the injury site: for example, the pancreas during pancreatitis, the kidney after a Candida albicans fungal infection, or the heart during a myocardial infarction. The function of these immune cells is to eliminate the source of injury that provoked the inflammation and to contribute to tissue repair.

Lead author David Sancho says, “The first immune cells to arrive at the infection or inflammation site are the neutrophils, and these cells are tasked with eliminating the source of the problem. However, neutrophils are very destructive and not only act on the infecting pathogen, but also damage the infected tissue. This tissue damage caused by our own defense system is known as immunopathology. It is therefore important to understand how our immune system can control the neutrophil inflammatory response to prevent it damaging our own tissues. The current study shows that tissue infiltration by neutrophils is controlled by dendritic cells. These cells are more well known for the essential role they play in directing the specific responses of T lymphocytes. The new study shows that dendritic-cell regulation of neutrophil infiltration helps to avoid excessive tissue injury.”

A new mechanism in the control of inflammation Credit: CNIC

Neutrophils

Co-first author Carlos del Fresno says, “Dendritic cells attract neutrophils to the inflammatory focus by releasing factors such as the chemokine Mip-2. At the same time, these cells also express the surface receptor DNGR-1. This cell-surface molecule detects tissue injury by identifying cell components that become accessible only when the cell is damaged or ‘broken’. When DNGR-1 detects damaged tissue, it reduces the capacity of the dendritic cell to produce Mip-2, thus limiting neutrophil infiltration to the damaged organ. This mechanism prevents what could otherwise be a life-threatening expansion of tissue injury.”

Paula Saz, the other co-first author on the study, emphasized the importance of understanding immune system regulation, both as a positive response, favoring the fight against infection or cancer and promoting tissue repair, and in its negative manifestations that can cause excessive inflammatory injury during infection, as well as allergic reactions or major autoimmune diseases. “This balance always exists in the immune system, and learning how to control it is the key to the fight against many diseases with an immune component.”

The research was conducted in mouse models, the only experimental system that reproduces the complexity of the infections and inflammatory processes studied. These models can provide important insight into how to regulate the injurious immunopathological responses generated by our own defense systems. According to the CNIC researchers, knowledge in this area would be especially applicable to diseases featuring massive neutrophil infiltration, whether as a response to infection or to tissue injury, for example as occurs in a heart attack.


Explore further:
In cardiac injury, the NSAID carprofen causes dysfunction of the immune system

More information:
“DNGR-1 in dendritic cells limits tissue damage by dampening neutrophil recruitment,” Science (2018). science.sciencemag.org/cgi/doi … 1126/science.aan8423

Journal reference:
Science

Provided by:
Centro Nacional de Investigaciones Cardiovasculares

Tagged with:

About author

Related Articles