Breaking News
May 3, 2019 - Vaping and Smoking May Signal Greater Motivation to Quit
May 3, 2019 - Dementia looks different in brains of Hispanics
May 3, 2019 - Short-Staffed Nursing Homes See Drop In Medicare Ratings
May 3, 2019 - Study of teens with eating disorders explores how substance users differ from non-substance users
May 3, 2019 - Scientists develop new video game that may help in the study of Alzheimer’s
May 3, 2019 - Arc Bio introduces Galileo Pathogen Solution product line at ASM Clinical Virology Symposium
May 3, 2019 - Cornell University study uncovers relationship between starch digestion gene and gut bacteria
May 3, 2019 - How to Safely Use Glucose Meters and Test Strips for Diabetes
May 3, 2019 - Anti-inflammatory drugs ineffective for prevention of Alzheimer’s disease
May 3, 2019 - Study tracks Pennsylvania’s oil and gas waste-disposal practices
May 3, 2019 - Creating a better radiation diagnostic test for astronauts
May 3, 2019 - Vegans are often deficient in these four nutrients
May 3, 2019 - PPDC announces seed grants to develop medical devices for children
May 3, 2019 - Study maps out the frequency and impact of water polo head injuries
May 3, 2019 - Research on Reddit identifies risks associated with unproven treatments for opioid addiction
May 3, 2019 - Good smells may help ease tobacco cravings
May 3, 2019 - Medical financial hardship found to be very common among people in the United States
May 3, 2019 - Researchers develop multimodal system for personalized post-stroke rehabilitation
May 3, 2019 - Study shows significant mortality benefit with CABG over percutaneous coronary intervention
May 3, 2019 - Will gene-editing of human embryos ever be justifiable?
May 3, 2019 - FDA Approves Dengvaxia (dengue vaccine) for the Prevention of Dengue Disease in Endemic Regions
May 3, 2019 - Why Tonsillitis Keeps Coming Back
May 3, 2019 - Fighting the opioid epidemic with data
May 3, 2019 - Maggot sausages may soon be a reality
May 3, 2019 - Deletion of ATDC gene prevents development of pancreatic cancer in mice
May 2, 2019 - Targeted Therapy Promising for Rare Hematologic Cancer
May 2, 2019 - Alzheimer’s disease is a ‘double-prion disorder,’ study shows
May 2, 2019 - Reservoir bugs: How one bacterial menace makes its home in the human stomach
May 2, 2019 - Clinical, Admin Staff From Cardiology Get Sneak Peek at Epic
May 2, 2019 - Depression increases hospital use and mortality in children
May 2, 2019 - Vicon and NOC support CURE International to create first gait lab in Ethiopia
May 2, 2019 - Researchers use 3D printer to make paper organs
May 2, 2019 - Viral infection in utero associated with behavioral abnormalities in offspring
May 2, 2019 - U.S. Teen Opioid Deaths Soaring
May 2, 2019 - Opioid distribution data should be public
May 2, 2019 - In the Spotlight: “I’m learning every single day”
May 2, 2019 - 2019 Schaefer Scholars Announced
May 2, 2019 - Podcast: KHN’s ‘What The Health?’ Bye-Bye, ACA, And Hello ‘Medicare-For-All’?
May 2, 2019 - Study describes new viral molecular evasion mechanism used by cytomegalovirus
May 2, 2019 - SLU study suggests a more equitable way for Medicare reimbursement
May 2, 2019 - Scientists discover first gene involved in lower urinary tract obstruction
May 2, 2019 - Researchers identify 34 genes associated with increased risk of ovarian cancer
May 2, 2019 - Many low-income infants receive formula in the first few days of life, finds study
May 2, 2019 - Global study finds high success rate for hip and knee replacements
May 2, 2019 - Taking depression seriously: What is it?
May 2, 2019 - With Head Injuries Mounting, Will Cities Put Their Feet Down On E-Scooters?
May 2, 2019 - Scientists develop small fluorophores for tracking metabolites in living cells
May 2, 2019 - Study casts new light into how mothers’ and babies’ genes influence birth weight
May 2, 2019 - Researchers uncover new brain mechanisms regulating body weight
May 2, 2019 - Organ-on-chip systems offered to Asia-Pacific regions by Sydney’s AXT
May 2, 2019 - Adoption of new rules drops readmission penalties against safety net hospitals
May 2, 2019 - Kids and teens who consume zero-calorie sweetened beverages do not save calories
May 2, 2019 - Improved procedure for cancer-related erectile dysfunction
May 2, 2019 - Hormone may improve social behavior in autism
May 2, 2019 - Alzheimer’s disease may be caused by infectious proteins called prions
May 2, 2019 - Even Doctors Can’t Navigate Our ‘Broken Health Care System’
May 2, 2019 - Study looks at the impact on criminal persistence of head injuries
May 2, 2019 - Honey ‘as high in sugars as table sugar’
May 2, 2019 - Innovations to U.S. food system could help consumers in choosing healthy foods
May 2, 2019 - FDA Approves Mavyret (glecaprevir and pibrentasvir) as First Treatment for All Genotypes of Hepatitis C in Pediatric Patients
May 2, 2019 - Women underreport prevalence and intensity of their own snoring
May 2, 2019 - Concussion summit focuses on science behind brain injury
May 2, 2019 - Booker’s Argument For Environmental Justice Stays Within The Lines
May 2, 2019 - Cornell research explains increased metastatic cancer risk in diabetics
May 2, 2019 - Mount Sinai study provides fresh insights into cellular pathways that cause cancer
May 2, 2019 - Researchers to study link between prenatal pesticide exposures and childhood ADHD
May 2, 2019 - CoGEN Congress 2019: Speakers’ overviews
May 2, 2019 - A new strategy for managing diabetic macular edema in people with good vision
May 2, 2019 - Sagent Pharmaceuticals Issues Voluntary Nationwide Recall of Ketorolac Tromethamine Injection, USP, 60mg/2mL (30mg per mL) Due to Lack of Sterility Assurance
May 2, 2019 - Screen time associated with behavioral problems in preschoolers
May 2, 2019 - Hormone reduces social impairment in kids with autism | News Center
May 2, 2019 - Researchers synthesize peroxidase-mimicking nanozyme with low cost and superior catalytic activity
May 2, 2019 - Study results of a potential drug to treat Type 2 diabetes in children announced
May 2, 2019 - Multigene test helps doctors to make effective treatment decisions for breast cancer patients
May 2, 2019 - UNC School of Medicine initiative providing unique care to dementia patients
May 2, 2019 - Nestlé Health Science and VHP join forces to launch innovative COPES program for cancer patients
May 2, 2019 - Study examines how our brain generates consciousness and loses it during anesthesia
May 2, 2019 - Transition Support Program May Aid Young Adults With Type 1 Diabetes
May 2, 2019 - Study shows how neutrophils exacerbate atherosclerosis by inducing smooth muscle-cell death
May 2, 2019 - Research reveals complexity of how we make decisions
Heart failure patients with stronger hearts have more depressive symptoms, lower quality of life

Heart failure patients with stronger hearts have more depressive symptoms, lower quality of life

Heart failure patients fall into two general categories: those with weaker hearts, and those with stronger, but stiffer hearts that continue to eject the normal volume of blood with every beat. Although their hearts have different pump strength, new research shows that both groups suffer from similar levels of physical and cognitive impairments after a hospitalization for their heart failure, and that surprisingly, patients with stronger hearts have higher rates of depressive symptoms and lower quality of life.

“The results speak to how bad heart failure is across the board,” says senior author Gordon Reeves, MD, Associate Professor of Cardiology at the Sidney Kimmel Medical College at Thomas Jefferson University. “Heart failure is one of the most common reasons for older patients to be in the hospital and the issues experienced as a consequence of a heart failure hospitalization can have a huge effect on their daily function and independence. This appears to be true regardless of the pumping function of the heart and, in some regards, may actually be worse in those in whom the squeezing function is preserved.” The results were published online in the journal Circulation: Heart Failure.

Many treatments for heart failure – for example medications like angiotensin converting enzyme inhibitors or beta blockers, and certain types of pacemakers, — are only effective in patients with weaker hearts, those with a so-called reduced ejection fraction (rEF), meaning the main pumping chamber of their heart pumps out or ejects a smaller portion of blood than it should with each heartbeat. Heart failure in patients with stronger hearts, those with preserved ejection fraction (pEF), is actually the most common form of heart failure in older adults and is more likely to affect women, but there are far fewer effective therapies currently available.

“This research gives us a much clearer picture of the symptoms and potential barriers to successful care affecting older patients with both reduced and preserved ejection fractions following a heart failure hospitalization, and gives us new insight into the interventions that might improve their quality of life and clinical outcomes,” said Dr. Reeves.

Dr. Reeves and colleagues from the coordinating center, Wake Forest School of Medicine, and Duke University Medical Center analyzed data from the first 202 patients enrolled in the ongoing multi-center REHAB-HF (NIH study number: NCT02196038) clinical trial. The overarching goal of that study, which aims to enroll 360 patients, is to determine the benefit of rehabilitation interventions for older patients recovering from a heart failure hospitalization who may find it challenging to complete the types of physical activity that are included in traditional cardiac rehabilitation. In fact, such patients are currently excluded from participating in cardiac rehabilitation by CMS policy because there has been so little prior research in these patients. The early baseline analysis presented in this interim report, is the first to look at the differences in physical performance, frailty, depression and cognition between preserved and reduced ejection fraction patients.

In an accompanying editorial, Kelsey M Flint, MD from Rocky Mountain Regional VA Medical Center and Daniel E Forman, MD, from the University of Pittsburgh Department of Medicine; say that this characterization is significant, because heart failure is a condition that hasn’t been fully addressed by current standards of care. “Over 70% of Medicare beneficiaries who are hospitalized for heart failure (HF) die or are re-hospitalized by one year after discharge,” the editorial authors write.

Using a number of assessments more common in the field of geriatric medicine than cardiology, the researchers found that both types of patients scored equally poorly on measures of physical ability, such as walking speed, getting up from a chair unassisted and endurance. They had similar scores on measures of frailty and also cognitive impairment. However, depression and quality of life scores were consistently lower in patients with preserved ejection fractions, or stronger hearts.

“We think of these results as a call to action for the cardiology community,” said Dr. Reeves. “These findings indicate we need to do more than decongesting the hearts of these patients.”

Source:

http://www.jefferson.edu/

Tagged with:

About author

Related Articles