Breaking News
February 21, 2019 - Gaming system helps with autism diagnosis
February 21, 2019 - Heart Disease: Six Things Women Should Know
February 21, 2019 - More States Say Doctors Must Offer Overdose Reversal Drug Along With Opioids
February 21, 2019 - Researchers explore case studies focused on industries that kill more people than employed
February 21, 2019 - Intense exercise, fasting and hormones can enhance waste-protein removal, study shows
February 21, 2019 - Scientists can monitor brain activity to predict epileptic seizures few minutes in advance
February 21, 2019 - Study quantifies hepatic and intestinal mRNA expression of Ugt isoforms in rats
February 21, 2019 - ‘Apple-Shaped’ Body? ‘Pear-Shaped’? Your Genes May Tell
February 21, 2019 - Can we repair the brain? The promise of stem cell technologies for treating Parkinson’s disease
February 21, 2019 - Trump Plan To Beat HIV Hits Rough Road In Rural America
February 21, 2019 - PENTAX Medical introduces new electrosurgical and argon plasma coagulation platforms
February 21, 2019 - Trump plan to beat HIV hits rough road in rural America
February 21, 2019 - Eating blueberries every day could help decrease blood pressure
February 21, 2019 - ‘No Second Chances’ report calls for new measures to combat cardiovascular disease in Australia
February 21, 2019 - Mayo clinic researchers discuss local case studies of leprosy
February 21, 2019 - Scientists demonstrate key role of salt in allergic immune reactions
February 21, 2019 - Experts propose revising the criteria for diagnosis of Parkinson’s disease
February 21, 2019 - The med student and the machine
February 21, 2019 - Hey, Hey! Ho, Ho! Is Striking For School Nurses The Way To Go?
February 21, 2019 - Latest research encourages children to move out and learn through physical activity
February 21, 2019 - Proper oral hygiene and regular visits to dentist can promote heart health
February 21, 2019 - New, versatile technique for remote control of transplanted cells in Parkinson’s
February 21, 2019 - Why melanoma tumors in the brain may be worse?
February 21, 2019 - New project aims to improve lung disease care in Appalachia
February 21, 2019 - Drug increases melanin production in some people with albinism
February 21, 2019 - Over 1 in 3 adults miss the mark on protein, finds study
February 21, 2019 - CymaBay Therapeutics Announces Seladelpar Granted Breakthrough Therapy Designation by the FDA for the Treatment of Primary Biliary Cholangitis
February 21, 2019 - A correlation between obesity and income has only developed in the past 30 years
February 21, 2019 - Baby, then work: An effort to help resident-parents in emergency medicine
February 21, 2019 - Heavy cigarette smoking could damage vision, say researchers
February 21, 2019 - Some drug combinations may be more effective than others for schizophrenic patients
February 21, 2019 - Combination of common antibiotics can eliminate multi-drug resistant E. coli
February 21, 2019 - Number of calls to U.S. Poison Control regarding kratom exposure increased
February 21, 2019 - New computational tool searches for factors that cause specific diseases
February 21, 2019 - New method to assess effectiveness of psychotherapies for social anxiety disorder
February 21, 2019 - New technology measures hormones that influence reproductive health efficiently
February 21, 2019 - Bat influenza viruses could potentially attack the cells of humans and livestock
February 21, 2019 - Immunotherapeutic antibody therapy to kill cancer has now progressed to patient testing
February 21, 2019 - Johns Hopkins scientists find new compound that may prevent reperfusion injury
February 21, 2019 - Researchers develop new way to deliver treatment for cartilage regeneration
February 21, 2019 - Study sheds new light on left ventricular dysfunction in ischemic heart disease
February 21, 2019 - New technique could expedite cancer diagnosis, lead to better patient outcomes
February 21, 2019 - New map of infant brain may aid early diagnosis of autism
February 21, 2019 - Human consciousness depends on the brain’s ability to maintain dynamics of neural activity
February 21, 2019 - Harmony Biosciences Announces File Acceptance Of Its New Drug Application For Pitolisant
February 21, 2019 - Medications could fill treatment gap for adolescents with obesity
February 21, 2019 - New antibiotics are desperately needed: Machine learning could help | News Center
February 21, 2019 - Researchers develop new computer game for dementia carers
February 21, 2019 - University of Dundee partners with Takeda to develop new treatments for tau pathology
February 21, 2019 - Influenza vaccine may be less effective in elderly patients, finds study
February 21, 2019 - Researchers explain why T cells lose their protective ability in inflamed tissues
February 21, 2019 - New optimization method rapidly analyzes nanomedicines for cancer treatment
February 21, 2019 - Viruses in the intestinal tracts can lead to islet autoimmunity and Type 1 diabetes
February 21, 2019 - Link between dietary fatty acid intake and hypertension found to be influenced by diabetes status
February 21, 2019 - FDA Approves Esperoct (turoctocog alfa pegol, N8-GP) for Hemophilia A
February 21, 2019 - ‘Boy erased’—why conversion therapies and ex-gay ministries should be outlawed
February 21, 2019 - Titia de Lange to give annual McCormick Lecture on March 8 | News Center
February 21, 2019 - Study reveals how helper T cells support memory cells to function optimally
February 21, 2019 - Autistic children with co-occurring ADHD have greater adaptive behavior impairments
February 21, 2019 - Elevated levels of key cellular process implicated in intestinal inflammation and IBD
February 20, 2019 - Over Half of Hip Replacements Expected to Last 25 Years
February 20, 2019 - Microscopic eye movements affect how we see contrast
February 20, 2019 - Computer vs. patient: Fighting for residents’ attention | News Center
February 20, 2019 - New “Smart Drug” Shows Promise for Metastatic Triple-Negative Breast Cancer
February 20, 2019 - Researchers develop large-scale window material for high-efficiency PM2.5 capture
February 20, 2019 - Widespread confusion among consumers on food date labels lead to unnecessary discards
February 20, 2019 - Researchers unlock plant’s secret of producing specialized metabolites
February 20, 2019 - Newly released national framework identifies obstacles to improving EMS systems
February 20, 2019 - Exercise can shift human body clock depending on time when people work out
February 20, 2019 - Female adolescent blood donors more likely to have iron deficiency and related anemia
February 20, 2019 - Rubicon level linked to inhibition of autophagic process
February 20, 2019 - Researchers find potential therapeutic strategy to treat Alzheimer’s
February 20, 2019 - New forms of older anti-cancer agent appear to enhance immune response to fight melanoma
February 20, 2019 - Health Tip: Eat Less Saturated Fat
February 20, 2019 - Sleeping in contact lenses puts you at risk of dangerous infection
February 20, 2019 - “We should study that!”: How a nurse-scientist found her passion
February 20, 2019 - Cervical microbiome may influence HPV infection more than previously thought
February 20, 2019 - Sausage mislabeling in Canada is down, new study finds
February 20, 2019 - Study shows blood pressure benefits of morning exercise for older overweight/obese adults
February 20, 2019 - New screening method could catch organ rejection much earlier without a biopsy needle
Discovery would help specify role of genetics in the development of neuropsychiatric disorders

Discovery would help specify role of genetics in the development of neuropsychiatric disorders

image_pdfDownload PDFimage_print

Neurobiologists from I.M. Sechenov First Moscow State Medical University confirmed that stress in early age affects the mice with activated and deactivated CDH13 gene in different ways. Different variants of this gene are associated with the development of ASDs, ADHD, and depression. The discovery would help specify the role of genetics in the development of neuropsychiatric disorders. The results of the study were published in the Progress in Neuro-Psychopharmacology & Biological Psychiatry journal.

CDH13 codes the protein called cadherin 13 that participates in many processes in the brain, from cell migration in embryos to the axon guidance and target finding as well as synaptogenesis in adults. Different variations of this gene are associated with ASDs, ADHD, depression, memory loss, and other disorders. However, it’s been unclear whether these consequences are caused by enhancement or suppression of cadherin 13 functions.

To evaluate the influence of the absence of cadherin 13 on the development in cases of early exposure to stress, neurobiologists experimented on mice in which the CDH13 was deactivated. The stress factor was separation from the mother. During the first two weeks of life the mice with activated and deactivated CDH13 gene were left in their cells alone every day. They were separated from the mothers for three hours, but the conditions in the cells, namely comfortable temperature and humidity, were kept the same. Young mice from the control group (with various versions of the CDH13 gene) were not exposed to any stress. When the mice grew up, both the experimental and the control group underwent a number of behavioral tests to assess their anxiety levels, exploratory activity, and fear susceptibility. A thorough study of the structure of the brain called the hippocampus was also carried out.

According to the tests, the animals without cadherin 13 were different from conrols with the normal CDH13 function. Early exposure to stress, such as short-term separation from the mother, usually makes the mice more stress-resistant in adult age, and this was confirmed by the behavior of the mice with the working gene. The animals that were separated from their mothers during the first weeks of life quickly adapted to the new conditions in the majority of tests and were more active than the mice with the same genotype but without any stressful experience. However, short-term stress had no positive effect on the mice whose bodies did not produce cadherin 13. They were more anxious and less eager to show risky behavior during tests. For example, they didn’t want to leave the lighted area in a light and dark transition chamber and were slow to explore unknown spaces.

“Our earlier study of mice with CDH13 deficiency showed that it contributes to the development of the brain serotonin system. Mice like that exhibit higher density of serotonin neurons and increased innervation of the cerebral cortex. These symptoms have long been suspected to represent one of the pathogenetic mechanisms causing autism,” says Klaus-Peter Lesch, head of the Laboratory of Psychiatric Neurobiology at the Institute of Molecular Medicine, Sechenov University. “In our recent work we’ve demonstrated that CDH13 dysfunction impairs adaptation to early-life stress. Additionally, the assessment of gene expression in the brain suggests CDH13 as a neuroprotective factor impacting synaptic plasticity. Together, these findings show that the interaction of risk multiple genes and environmental factors is important for the pathophysiology of neuropsychiatric disorders. CDH13 gene variation in humans can be identified by genotyping for common and rare variants. However, the low penetrance and the small effect size these variants does not justify screening individuals for diagnostic purposes, preventive measures or therapeutic intervention”.


Tagged with:

About author

Related Articles