Breaking News
February 18, 2019 - New dental adhesive prevents tooth decay around orthodontic brackets
February 18, 2019 - New eHealth tool shows potential to improve quality of asthma care
February 18, 2019 - New Australian initiative helps emergency clinicians to improve patient care
February 17, 2019 - Apellis Pharmaceuticals’ APL-2 Receives Fast Track Designation from the FDA for the Treatment of Patients with Paroxysmal Nocturnal Hemoglobinuria
February 17, 2019 - Researchers identify faulty ‘brake’ that interferes with heart muscle’s ability to contract and relax
February 17, 2019 - Support from trusted adults can reduce risk of dying in suicidal teens, finds study
February 17, 2019 - Heart attack awareness improved since 2008
February 17, 2019 - Exercise gives a better brain boost to older men than women
February 17, 2019 - New research disproves previous assumptions of how looks influence personality
February 17, 2019 - Cannabis use as a teenager linked to depression later in life
February 17, 2019 - Sinks by Toilets in ICU Patient Rooms Harbor Harmful Bacteria
February 17, 2019 - Cancer cells’ plasticity makes them harder to stop
February 17, 2019 - Young cannabis users have increased risk of depression and suicidal behavior
February 17, 2019 - Tasmanian Devils Likely to Survive Cancer Scourge
February 17, 2019 - Neoadjuvant PD-1 blockade seems effective in glioblastoma
February 17, 2019 - Personal, social factors play role in enabling sustainable return to work after ill health
February 17, 2019 - Mouse studies show ‘inhibition’ theory of autism wrong
February 17, 2019 - Study shows how neuroactive steroids inhibit activity of pro-inflammatory proteins
February 17, 2019 - Use of liver grafts from older donors decreased despite better outcomes in recipients
February 17, 2019 - MUSC researchers discover new mechanism for a class of anti-cancer drugs
February 17, 2019 - HPV misconceptions are causing women to miss smear tests
February 17, 2019 - Sanofi and Regeneron Offer Praluent (alirocumab) at a New Reduced U.S. List Price
February 17, 2019 - Researchers say auditory testing can identify children for autism screening
February 17, 2019 - New method analyzes how single biological cells react to stressful situations
February 17, 2019 - WVU gynecologic oncologist investigates novel treatment for cervical and vaginal cancers
February 17, 2019 - ADHD diagnoses poorly documented
February 17, 2019 - Majority of gender minority youth do not identify with traditional sexual identity labels
February 17, 2019 - AbbVie, Teneobio enter into strategic transaction to develop potential treatment for multiple myeloma
February 17, 2019 - Lower Birth Weight May Up Risk for Psychiatric Disorders
February 17, 2019 - Scientists identify reversible molecular defect underlying rheumatoid arthritis
February 17, 2019 - Moffitt researchers shed light on how CAR T cells function mechanistically
February 16, 2019 - Female Anatomy May Play Big Role in Sperm’s Success
February 16, 2019 - BMI may mediate inverse link between fiber intake, knee OA
February 16, 2019 - Movement impairments in autism can be reversed through behavioral training
February 16, 2019 - Studies address racial disparities in postpartum period and cardiovascular health
February 16, 2019 - Scientists implicate hidden genes in the severity of autism symptoms
February 16, 2019 - Decreased deep sleep linked to early signs of Alzheimer’s disease
February 16, 2019 - Neuroscientists show how the brain responds to texture
February 16, 2019 - Gilead Announces Topline Data From Phase 3 STELLAR-4 Study of Selonsertib in Compensated Cirrhosis (F4) Due to Nonalcoholic Steatohepatitis (NASH)
February 16, 2019 - What Can I Do About Sweating? (for Teens)
February 16, 2019 - Companies navigate dementia conversations with older workers
February 16, 2019 - Newly developed stem cell technologies show promise for treating PD patients
February 16, 2019 - Collaborative material research could advance self-assembling nanomaterials
February 16, 2019 - Researchers take major step in creating technology that mimics the human brain
February 16, 2019 - Erasing memories associated with cocaine use reduces drug seeking behavior
February 16, 2019 - Artificial intelligence can accurately predict prognosis of ovarian cancer patients
February 16, 2019 - Racial disparities in cancer deaths on the decline for America
February 16, 2019 - FDA authorizes new interoperable insulin pump for children, adults with diabetes
February 16, 2019 - Coexisting Medical Conditions, Smoking Explain PTSD-CVD Link
February 16, 2019 - Skin Cancer Screening: MedlinePlus Lab Test Information
February 16, 2019 - ‘Happiness’ exercises can boost mood in those recovering from substance use disorder
February 16, 2019 - Cell manipulation could soon halt or reverse aging
February 16, 2019 - Pumped Breast Milk Falls Short of Breastfed Version
February 16, 2019 - Men’s porn habits could fuel partners’ eating disorders, study suggests
February 16, 2019 - Rapid progression of age-related diseases may result from formation of vicious cycles
February 16, 2019 - Immune checkpoint molecule protects against future development of cancer
February 16, 2019 - New method produces hydrogels that have properties similar to cells’ environment
February 16, 2019 - $4.1 million funding for heart research on Valentine’s Day
February 16, 2019 - General anesthesia in early infancy unlikely to have lasting effects on developing brains
February 16, 2019 - New breakthroughs for muscular dystrophy research
February 16, 2019 - First Opinion: Embryo editing for higher IQ is a fantasy. Embryo profiling for it is almost here
February 16, 2019 - Vapers develop cancer-related gene deregulation as cigarette smokers
February 16, 2019 - Bringing Antimicrobial Susceptibility Testing (AST) to the Community
February 16, 2019 - Decolonization protocol after hospital discharge can prevent dangerous infections
February 16, 2019 - Children with ASD more likely to face maltreatment, study finds
February 16, 2019 - Study finds genetic vulnerability to use of menthol cigarettes
February 16, 2019 - Promising drug developed to rejuvenate muscle cells
February 16, 2019 - H-RT should be the standard of care for men with low risk prostate cancer, study shows
February 16, 2019 - New technique using patients’ own modified cells could help treat Crohn’s disease
February 16, 2019 - Therapeutic endoscopy has an expanding role in the treatment of IBD
February 16, 2019 - Blood clot discovery could lead to development of better treatments for blood diseases
February 16, 2019 - Intervention can increase exclusive breastfeeding rates
February 16, 2019 - New project explores how gaming technologies can help cancer patients communicate better
February 16, 2019 - Catalyst Biosciences Presents Updated Data from Its Phase 2/3 Trial of Subcutaneous Marzeptacog Alfa (Activated) in Individuals with Hemophilia A or B with Inhibitors at the 12th Annual EAHAD Congress
February 16, 2019 - Rerouting nerves during amputation reduces phantom limb pain before it starts
February 16, 2019 - A Hormone Produced When We Exercise Might Help Fight Alzheimer’s
February 16, 2019 - Millions of British people breathe toxic air travelling to GPs
February 16, 2019 - Conformance of genetic characteristics found to be crucial for longer preservation of kidney graft
February 16, 2019 - Researchers use optogenetic tool to control, visualize receptor signals in neural cells
February 16, 2019 - New reversible antiplatelet therapy could reduce risk of blood clots, prevent cancer metastasis
Depressed people have an increased risk of atrial fibrillation

Depressed people have an increased risk of atrial fibrillation

image_pdfDownload PDFimage_print

Depressed people have an increased risk of atrial fibrillation, according to a study published today in the European Journal of Preventive Cardiology, a European Society of Cardiology (ESC) journal. Medication was not responsible for the high frequency of atrial fibrillation in depressed people. The findings are reported during Global AF Aware Week.

Study author Morten Fenger-Grøn, senior statistician, Research Unit for General Practice, Aarhus University, Denmark, said: “It is common knowledge that there is a connection between the mind and the heart. Depression predicts the development of coronary artery disease and worsens its prognosis. Our study investigated whether depression is also linked with atrial fibrillation.”

Atrial fibrillation is the most common heart rhythm disorder (arrhythmia). It causes 20-30% of all strokes and increases the risk of dying prematurely. One in four middle-aged adults in Europe and the US will develop atrial fibrillation. It is estimated that by 2030 there will be 14-17 million patients with atrial fibrillation in the European Union, with 120,000-215,000 new diagnoses each year. Signs of atrial fibrillation include palpitations, shortness of breath, tiredness, chest pain and dizziness.

Previous studies have found associations between depression and both more severe symptoms and higher mortality in atrial fibrillation patients.5 Antidepressants have been linked with some serious, but rare, heart rhythm disturbances, prompting the question of whether they might also raise the risk of atrial fibrillation.

This study investigated the association of depression, and antidepressant treatment, with the risk of developing atrial fibrillation. Filling a prescription for antidepressants for the first time was used as an indicator of depression.

The study included all 785,254 Danish citizens initiating antidepressant treatment from 2000 to 2013 and a 1:5 random sample of the Danish population matched on sex and birth month. The risk of atrial fibrillation was assessed after starting treatment and in the month before, when it was assumed that patients were depressed but medically untreated.

Compared with the general population, patients taking antidepressants had a 3.18-fold higher risk of atrial fibrillation during the first month of treatment. The association gradually reduced thereafter, to 1.37-fold at 2-6 months, and 1.11-fold at 6-12 months.

Mr Fenger-Grøn said: “Filling a prescription for antidepressants, which we used as an indicator of depression, was associated with a three-fold greater risk of atrial fibrillation. The decrease with time could suggest that treatment may alleviate this risk.”

The risk of atrial fibrillation risk was even higher in the month before starting antidepressants (7.65-fold). “This suggests that antidepressant medication itself is not associated with the development of atrial fibrillation,” said Mr Fenger-Grøn. “If you are depressed, there is no reason to worry that taking drug treatment will cause atrial fibrillation.”

Mr Fenger-Grøn noted that in the month before starting medication, the risk of atrial fibrillation was 7.65-fold from 30 to 15 days before, and 4.29-fold in the last 15 days before. He said: “In Denmark it is not typical for doctors to prescribe antidepressants at the first appointment. Our findings indicate that the initial conversation with a doctor may start to ease depressive symptoms.”

He added: “The message for patients who already have atrial fibrillation is that you do not need to be concerned about taking antidepressant medication if you need it. Look after your mental health because our study supports existing evidence that problems with the mind can be detrimental for the heart.”


Explore further:
Migraines that affect vision may increase risk of irregular heartbeat

More information:
Morten Fenger-Grøn et al. Depression, antidepressants, and the risk of non-valvular atrial fibrillation: A nationwide Danish matched cohort study, European Journal of Preventive Cardiology (2018). DOI: 10.1177/2047487318811184

Journal reference:
European Journal of Preventive Cardiology

Provided by:
European Society of Cardiology

Tagged with:

About author

Related Articles