Breaking News
February 22, 2019 - Successful testing of multi-organ “human-on-a-chip” could replace animals as test subjects
February 22, 2019 - Analysis of cervical precancer shows decline in two strains of HPV
February 22, 2019 - Sugary stent eases suturing of blood vessels
February 22, 2019 - From surgery to psychiatry: A medical student reevaluates his motivations
February 22, 2019 - Is New App From Feds Your Answer To Navigating Medicare Coverage? Yes And No
February 22, 2019 - New pacemakers powered by heartbeats could reduce need for surgery
February 22, 2019 - The United States records highest drug overdose death rates
February 22, 2019 - Phase 1 data reinforce safety profile of new drug for treating Duchenne muscular dystrophy
February 22, 2019 - Vitamin D supplementation less effective in the presence of obesity, shows study
February 22, 2019 - Sarepta Announces FDA Acceptance of Golodirsen (SRP-4053) New Drug Application for Patients with Duchenne Muscular Dystrophy Amenable to Skipping Exon 53
February 22, 2019 - An institutional effort to reduce the amount of opioids prescribed following lumbar surgery
February 22, 2019 - Failure to take statins leads to higher mortality rates | News Center
February 22, 2019 - New study explains why some patients report phantom sensations after limb amputation
February 22, 2019 - First motor-controlled heart valves implanted by Mainz University Medical Center
February 22, 2019 - Novel preclinical model mimics persistent interneuron loss seen in preterm infants
February 22, 2019 - Global health burden of glaucoma has increased, study reveals
February 22, 2019 - A holistic approach key to minimize treatment complexity in patients with interstitial lung disease
February 22, 2019 - 1 in 10 middle-aged Chinese adults are at high risk for heart disease, finds study
February 22, 2019 - More than half a million breast cancer patient’s lives saved by improvements in treatment
February 22, 2019 - Study finds no evidence that tougher policies prevent teenage cannabis use
February 22, 2019 - New blood test detects genetic disorders in fetuses
February 22, 2019 - Lower Self-Perception Observed in Children With Amblyopia
February 22, 2019 - Up to 15 percent of children have sleep apnea, yet 90 percent go undiagnosed
February 22, 2019 - Rare pulmonary defect prompts parents’ nationwide search for answers | News Center
February 22, 2019 - Lesbian and bisexual women at greater risk of being overweight, study finds
February 22, 2019 - UQ research may explain why vitamin D is essential for brain health
February 22, 2019 - Heart Attacks Rising Among Younger Women
February 22, 2019 - How your smartphone is affecting your relationship
February 22, 2019 - Orthopaedic surgeon receives prestigious award, $10 million grant | News Center
February 22, 2019 - New sepsis test could save thousands of lives
February 22, 2019 - Cervical cancer could be eradicated by 2100
February 21, 2019 - Sustained smoking cessation can lower risk of seropositive RA
February 21, 2019 - Thousands with chronic UTIs are not receiving the treatment they need
February 21, 2019 - Are teens getting high on social media? The surprising study seeking the pot-Instagram link
February 21, 2019 - Stanford expands biobank services | News Center
February 21, 2019 - Scientists identify link between drinking contexts and early onset intoxication among adolescents
February 21, 2019 - Strong social support may reduce cardiovascular disease risk in postmenopausal women
February 21, 2019 - Rapid expansion of interventions could prevent up to 13 million cases of cervical cancer within 50 years
February 21, 2019 - Motif Bio Receives Complete Response Letter From The FDA
February 21, 2019 - Researchers map previously unknown disease in children
February 21, 2019 - A skeptical look at popular diets: Going gluten-free
February 21, 2019 - Podcast: KHN’s ‘What The Health?’ How Safe Are Your Supplements?
February 21, 2019 - Factors associated with increased risk of developing surgical site infections
February 21, 2019 - Anticipatory signals in eye movements can help measure attentive capacity, learning with greater precision
February 21, 2019 - Study explores daily exposure to indoor air pollutants
February 21, 2019 - Evening exercise does not negatively affect sleep, may also reduce hunger
February 21, 2019 - Artificial intelligence technique can be used to identify alcohol misuse in trauma setting
February 21, 2019 - Overweight, obesity in adolescence associated with increased risk of renal cancer later in life
February 21, 2019 - BGU develops new AI platform for monitoring and predicting ALS progression
February 21, 2019 - Researchers discover a new promising target to improve HIV vaccines
February 21, 2019 - Brief Anesthesia in Infancy Does Not Mar Neurodevelopment
February 21, 2019 - Gaming system helps with autism diagnosis
February 21, 2019 - Heart Disease: Six Things Women Should Know
February 21, 2019 - More States Say Doctors Must Offer Overdose Reversal Drug Along With Opioids
February 21, 2019 - Researchers explore case studies focused on industries that kill more people than employed
February 21, 2019 - Only half of GP practice buildings are fit for purpose
February 21, 2019 - Intense exercise, fasting and hormones can enhance waste-protein removal, study shows
February 21, 2019 - Scientists can monitor brain activity to predict epileptic seizures few minutes in advance
February 21, 2019 - Study quantifies hepatic and intestinal mRNA expression of Ugt isoforms in rats
February 21, 2019 - ‘Apple-Shaped’ Body? ‘Pear-Shaped’? Your Genes May Tell
February 21, 2019 - Can we repair the brain? The promise of stem cell technologies for treating Parkinson’s disease
February 21, 2019 - Trump Plan To Beat HIV Hits Rough Road In Rural America
February 21, 2019 - PENTAX Medical introduces new electrosurgical and argon plasma coagulation platforms
February 21, 2019 - Trump plan to beat HIV hits rough road in rural America
February 21, 2019 - Eating blueberries every day could help decrease blood pressure
February 21, 2019 - ‘No Second Chances’ report calls for new measures to combat cardiovascular disease in Australia
February 21, 2019 - Mayo clinic researchers discuss local case studies of leprosy
February 21, 2019 - Scientists demonstrate key role of salt in allergic immune reactions
February 21, 2019 - Experts propose revising the criteria for diagnosis of Parkinson’s disease
February 21, 2019 - The med student and the machine
February 21, 2019 - Hey, Hey! Ho, Ho! Is Striking For School Nurses The Way To Go?
February 21, 2019 - Latest research encourages children to move out and learn through physical activity
February 21, 2019 - Proper oral hygiene and regular visits to dentist can promote heart health
February 21, 2019 - New, versatile technique for remote control of transplanted cells in Parkinson’s
February 21, 2019 - Why melanoma tumors in the brain may be worse?
February 21, 2019 - New project aims to improve lung disease care in Appalachia
February 21, 2019 - Drug increases melanin production in some people with albinism
February 21, 2019 - Over 1 in 3 adults miss the mark on protein, finds study
February 21, 2019 - CymaBay Therapeutics Announces Seladelpar Granted Breakthrough Therapy Designation by the FDA for the Treatment of Primary Biliary Cholangitis
February 21, 2019 - A correlation between obesity and income has only developed in the past 30 years
“Placental organoids” could be the future of pregnancy and conception research say researchers

“Placental organoids” could be the future of pregnancy and conception research say researchers

image_pdfDownload PDFimage_print

Researchers have successfully managed to develop “mini placentas” or placenta organoids in the laboratories that could transform research of pregnancy, conception, stillbirth, miscarriages and pregnancy diseases and disorders.

The results of the study developing these organoids have been published in the latest issue of the journal Nature.

These organoids can successfully mimic the placenta in its early stages during the first trimester explain the researchers. This means that the drugs or diseases that affect the placenta during this phase and lead to miscarriages can be studied. In fact these tiny placentas are so like the real placenta that they can also test positive with a pregnancy test the team explains. Ashley Moffett, a senior researcher on the team and professor of reproductive immunology at Cambridge University confirmed this saying, “If we put a pregnancy stick into the medium from the organoids it reads ‘pregnant’.”

The team explains that studying a placenta within the womb has been notoriously difficult till date. The healthy placenta develops and attaches to the walls of the womb and supplies nutrients and oxygenated blood to the growing embryo and fetus. It not only secretes hormones and chemicals that allow the fetus to grow but also excretes the waste generated by the growing fetus. The placenta also secretes hormones into the maternal blood stream that helps carry the pregnancy successfully. These phenomenon could not be studied in humans till now. With the development of the organoids, now the researchers can understand the functions and workings of the placenta in details. Moffett said, “We can now begin to do experiments on how placental development occurs in the uterine environment.”

The team used cells from the villi of the placental tissue. These villi are hair like structures of the normal placenta. These placental cells when grown in the lab can organize into multi-cellular clumps or structures that can act like the real placenta by secreting proteins and hormones. These are of sizes ranging from a tenth of a millimetre to half a millimetre and can be stored in frozen form only to be thawed before use.

Experts in the filed have hailed this research and have said that it would provide invaluable insights into common pregnancy disorders including still births, growth restriction within the uterus (IUGR) and pre-eclampsia. Infections of the fetus such as Zika and how they affect the development and growth could also be studied they add.

Lead author of the research, Margherita Turco, in a statement said, “The placenta is absolutely essential for supporting the baby as it grows inside the mother. When it doesn’t function properly it can result in serious problems, from pre-eclampsia to miscarriage, with immediate and lifelong consequences for both mother and child.” The team adds that this would also be invaluable in testing teratogenic drugs or drugs that could harm the unborn baby if administered to the mother. Placental organoids would also be a source of stem cell therapies in failing or threatened pregnancies the team explains. In short, there are several uses of these organoids in pregnancy research.

According to Moffett, “It has taken 30 years to reach this point and to have mini-placentas which we know will grow in the laboratory for at least a year.”

Source:

https://www.nature.com/articles/s41586-018-0753-3

Posted in: Medical Research News | Women’s Health News

Tags: Baby, Blood, Cell, Conception, Drugs, Eclampsia, Embryo, Hair, Immunology, Laboratory, Miscarriage, Nutrients, Organoids, Placenta, Pre-eclampsia, Pregnancy, Research, Stem Cell, Stillbirth, Uterus, Villi, Womb

Tagged with:

About author

Related Articles