Breaking News
February 20, 2019 - Widespread confusion among consumers on food date labels lead to unnecessary discards
February 20, 2019 - Researchers unlock plant’s secret of producing specialized metabolites
February 20, 2019 - Newly released national framework identifies obstacles to improving EMS systems
February 20, 2019 - Exercise can shift human body clock depending on time when people work out
February 20, 2019 - Female adolescent blood donors more likely to have iron deficiency and related anemia
February 20, 2019 - Rubicon level linked to inhibition of autophagic process
February 20, 2019 - Researchers find potential therapeutic strategy to treat Alzheimer’s
February 20, 2019 - New forms of older anti-cancer agent appear to enhance immune response to fight melanoma
February 20, 2019 - Health Tip: Eat Less Saturated Fat
February 20, 2019 - Sleeping in contact lenses puts you at risk of dangerous infection
February 20, 2019 - “We should study that!”: How a nurse-scientist found her passion
February 20, 2019 - Cervical microbiome may influence HPV infection more than previously thought
February 20, 2019 - Sausage mislabeling in Canada is down, new study finds
February 20, 2019 - Study shows blood pressure benefits of morning exercise for older overweight/obese adults
February 20, 2019 - New screening method could catch organ rejection much earlier without a biopsy needle
February 20, 2019 - Study may have important implications for refining parenting during child’s adolescence
February 20, 2019 - Study sheds new light on how antibiotic resistance genes are transferred between bacteria
February 20, 2019 - Chronic Wasting Disease may soon spread to humans, warns CDC
February 20, 2019 - Scientists identify new genetic causes linked to abnormal pregnancies and miscarriages
February 20, 2019 - Using LyoSpeed technology to avoid residual solvent when drying HPLC fractions
February 20, 2019 - New screening tool more likely to identify sexual and labor exploitation of youth
February 20, 2019 - Newly licensed nurses work for long hours, also have a second paid job
February 20, 2019 - Physicists identify simple mechanism used by deadly bacteria to fend off antibiotics
February 20, 2019 - FDA Grants Priority Review to Genentech’s Personalized Medicine Entrectinib
February 20, 2019 - Exposure to chemicals before and after birth is associated with a decrease in lung function
February 20, 2019 - Neuroscientists reveal that simple brain region can guide complex feats of mental activity
February 20, 2019 - Study finds new link between food allergies and multiple sclerosis
February 20, 2019 - First gene therapy operation for macular degeneration is a success
February 20, 2019 - Physicians graduated outside the U.S. offer better care for Medicare patients with complex needs
February 20, 2019 - Study shows therapeutic potential of VEGF-A mRNA for regenerative angiogenesis in humans
February 20, 2019 - FDA Approves Keytruda (pembrolizumab) for the Adjuvant Treatment of Patients with Melanoma with Involvement of Lymph Node(s) Following Complete Resection
February 20, 2019 - Study identifies brain cells that modulate behavioral response to threats
February 20, 2019 - Researchers take closer look at how viruses bind cells and cause infection
February 20, 2019 - Newly developed gene therapy helps decelerate aging process
February 20, 2019 - Study suggests new treatment strategy for deadly brain cancer
February 20, 2019 - Scientists develop unique hybrid implant that imitates bone structure
February 20, 2019 - Push-ups can be tailored to meet specific needs of individuals
February 20, 2019 - Early-career job loss has long term health implications
February 20, 2019 - CVD Does Not Modify Depression-Mortality Link in Elderly
February 20, 2019 - Electrical activity early in fruit flies’ brain development could shed light on how neurons wire the brain
February 20, 2019 - Machine learning technique helps predict which asthma patients respond to corticosteroid therapy
February 20, 2019 - Self-reported sleep duration is a useful tool to measure sleep in children, study suggests
February 20, 2019 - T-cells play key role in how the body fights follicular lymphoma
February 20, 2019 - Study shows how 3D organization of genetic material helps perpetuate the species
February 20, 2019 - Researchers engineer stem cell with ‘suicide genes’ to induce cell death in all but beta cells
February 20, 2019 - Study reveals major sex differences in management of cardiovascular risk factors among U.S. adults
February 20, 2019 - Health Tip: Get Your Child to School on Time
February 20, 2019 - Shortcut strategy for screening compounds with clinical potentials for drug development
February 20, 2019 - Common acid reflux drugs tied to elevated risk for kidney disease
February 20, 2019 - Microbiome could be culprit when good drugs do harm
February 20, 2019 - Prenatal exposure to forest fires causes stunted growth in children
February 20, 2019 - Gene therapy restores hearing in mice with congenital genetic deafness
February 20, 2019 - First molecular test predicts treatment response for kidney cancer
February 20, 2019 - New method for improved visualization of single-cell RNA- sequencing data
February 20, 2019 - Researchers capture altered brain activity patterns of Parkinson’s in mice
February 20, 2019 - A possible blood test for detecting Alzheimer’s disease before symptoms show
February 20, 2019 - Primary care physicians associated with longevity, new research finds
February 19, 2019 - New study identifies many key lessons to establish sanctioned safe consumption sites
February 19, 2019 - Single CRISPR treatment can safely and stably correct genetic disease
February 19, 2019 - Multinational initiative to study familial primary distal renal tubular acidosis
February 19, 2019 - Breakthrough study highlights the promise of cell therapies for muscular dystrophy
February 19, 2019 - Subsymptom Threshold Exercise Speeds Concussion Recovery
February 19, 2019 - Midline venous catheters – infants: MedlinePlus Medical Encyclopedia
February 19, 2019 - Searching for side effects
February 19, 2019 - Humanity is all right, probably, although human extinction remains quite possible, researcher says
February 19, 2019 - Having Anesthesia Once as a Baby Does Not Cause Learning Disabilities, New Research Shows
February 19, 2019 - Anti-cancer immunotherapy could be used to fight HIV
February 19, 2019 - Customized Micropatterning for Improved Physiological Relevance
February 19, 2019 - Unique gene therapy approach paves new way to tackle rare, inherited diseases
February 19, 2019 - Activating gene that helps excite neurons reverses depression in male mice
February 19, 2019 - Science Puzzling Out Differences in Gut Bacteria Around the World
February 19, 2019 - Cells that destroy the intestine
February 19, 2019 - On recovery, vulnerability and ritual: An exhibit in white
February 19, 2019 - Scientific Duo Gets Back To Basics To Make Childbirth Safer
February 19, 2019 - COPD patients need more support when understanding new chest symptoms
February 19, 2019 - Using light-based method for production of pharmaceutical molecules
February 19, 2019 - Scientists find link between inflammation and cancer
February 19, 2019 - The High Cost Of Sex: Insurers Often Don’t Pay For Drugs To Treat Problems
February 19, 2019 - Hearing impairment associated with accelerated cognitive decline with age
February 19, 2019 - Researchers identify multiple genetic variants associated with body fat distribution
Study highlights prevalence of regional disparities in the treatment of type 1 diabetes

Study highlights prevalence of regional disparities in the treatment of type 1 diabetes

image_pdfDownload PDFimage_print

How the autoimmune disease type 1 diabetes is treated also depends on where the patients live in Germany. In socio-economically weaker regions, insulin pumps and long-acting insulin analogs are used less frequently. Here the patients have higher blood glucose levels (HbA1c) and a higher prevalence of overweight. However, the rate of severe hypoglycemia events is lower. This is the result of a study carried out by a team of researchers at the German Center for Diabetes Research (DZD) in Düsseldorf, Neuherberg and Ulm. The results have now been published in the journal ‘Diabetes Care‘.

Despite significant progress in the management of type 1 diabetes in children and adolescents over the past two decades, there are regional differences in treatment. Depending on the federal state, there were differences in the use of insulin pumps and rapid-acting or long-acting insulin analogs as well as blood glucose levels (HbA1c), the prevalence of overweight and the rate of severe hypoglycemia events. But what are the reasons for these differences? Is there a correlation between the socio-economic conditions of a region and the treatment modalities of children and adolescents with type 1 diabetes? And can this be used to derive differences in treatment outcomes? Researchers at the DZD investigated these questions in the current study.

For this they evaluated the data from the Diabetes Patient Follow-up Registry (DPV) of 29,284 patients under the age of 20 years. Among other things, they investigated how frequently pump therapy and rapid-acting or long-acting insulin analogs are used and the percentage of use of continuous tissue glucose measurement systems (CGMS). In addition to the type of treatment, treatment outcomes were also assessed. Among other things, the quality of metabolic control (assessed by the HbA1c value) and the prevalence of overweight in young type 1 diabetes patients were analyzed. “The study shows that the regional differences in treatment and treatment outcomes in young type 1 diabetes patients even exist at the district level and that these geographical differences can partly be explained by area deprivation, i.e. by a lack of material and social resources in the area measured by aggregated socio-economic indicators,” said Marie Auzanneau, first author and DZD scientist at the Institute for Epidemiology and Medical Biometry, ZIBMT, at Ulm University.

For the study, the research team used the “German Index of Multiple Deprivation 2010” (GIMD 2010) and its subdivision into quintiles. This deprivation index was conceived by the last author and DZD scientist Werner Maier of the Institute for Health Economics and Health Care Management, Helmholtz Zentrum München, Neuherberg. The results showed that patients in the most socio-economically disadvantaged regions were less likely to receive long-acting insulin analogs (64.3%) than patients in the socio-economically strongest regions (80.8%). Continuous glucose monitoring systems (CGMS) are also less frequently used in the socio-economically weakest regions (3.4% of patients) than in the socio-economically strongest regions (6.3% of patients). Differences can also be seen in the treatment outcomes. The average HbA1c value is 8.07% (65 mmol/mol) in the socio-economically weakest regions and 7.84% (62 mmol/mol) in the socio-economically strongest regions. In addition, patients in the most disadvantaged regions are more frequently overweight. The prevalence is 15.5% here and 11.8% in the socio-economically privileged regions. However, patients in the socio-economically weakest regions are less likely to suffer from severe hypoglycemia. The rate of severe hypoglycemia here is only 6.9 events per 100 patient years compared with 12.1 events in the socio-economically strongest areas.

“Our results suggest that the treatment outcomes of patients in socio-economically disadvantaged regions could be improved by more frequent use of pump therapy and continuous tissue glucose measurement,” said DZD scientist Stefanie Lanzinger of the ZIBMT. “In order to elucidate how the individual dimensions of area deprivation are associated with treatment and treatment outcomes in diabetes care, further studies will follow,” added Joachim Rosenbauer of the German Diabetes Center in Düsseldorf.

Source:

https://www.dzd-ev.de/en/latest/news/news/article/association-of-area-deprivation-and-regional-disparities-in-the-treatment-of-type-1-diabetes/index.html

Posted in: Medical Condition News | Healthcare News

Tags: Adolescents, Autoimmune Disease, Blood, Children, Diabetes, Epidemiology, Glucose, HbA1c, Health Care, Hypoglycemia, Insulin, Research, Type 1 Diabetes

Tagged with:

About author

Related Articles