Breaking News
April 26, 2019 - The Inflamed Brain | NIH News in Health
April 26, 2019 - Stress-free training may enhance surgical skill
April 26, 2019 - Newsom: California Leads On Prescription Drugs
April 26, 2019 - Exploring novel strategies to heal damage after a heart attack
April 26, 2019 - Small army of tiny robots can remove dental plaque
April 26, 2019 - Cellular communication in emotion-processing brain region motivates us to keep eating tasty food
April 26, 2019 - Greater spousal life satisfaction associated with lower mortality risk
April 26, 2019 - Genetic mutations in brain development lead to discovery of rare genetic diseases
April 26, 2019 - Speech-Based Algorithm Helps ID Posttraumatic Stress Disorder
April 26, 2019 - First birth via robot-assisted uterus transplant
April 26, 2019 - CircRNAs bind to dsRNA-activated protein kinase which is linked to innate immunity
April 26, 2019 - MR Solutions wins third Queen’s Award
April 26, 2019 - Study details how optimism can bias prognosis in serious illness
April 26, 2019 - Vascular surgery after firearm injury linked with higher morbidity and mortality
April 26, 2019 - New findings about aggressive blood cancer may help develop drugs with less harmful side effects
April 26, 2019 - People with intense feelings of responsibility susceptible to developing OCD, anxiety
April 26, 2019 - Despite expansion of insurance coverage for depression, treatment rates are lower than expected
April 26, 2019 - Huge Malaria vaccine trial in Malawi
April 26, 2019 - Can Obesity Shrink Your Brain?
April 26, 2019 - This oral appliance could help you (and your partner) sleep better
April 26, 2019 - Myelination deficits cause abnormal hypersocial behavior associated with Williams syndrome
April 26, 2019 - New sepsis detector uses photonics to make accurate diagnosis in less than thirty minutes
April 26, 2019 - New study describes process to diagnose rare genetic diseases in record time
April 26, 2019 - Scientists and patients gather in Vancouver to discuss about Stevens-Johnson syndrome
April 26, 2019 - Advance in breakthrough cancer treatment eliminates serious side effects
April 26, 2019 - Discovery about cold sensing could pave way for new pain relief drugs
April 26, 2019 - Children often turn to sugary drinks instead of water
April 26, 2019 - Genome analysis shows the combined effect of many genes on cognitive traits
April 26, 2019 - Patients Caught In Middle Of Fight Between Health Care Behemoths
April 26, 2019 - Drug overdoses among adolescents and young adults on the rise
April 26, 2019 - Implementing a Paperless QC Micro Laboratory”
April 25, 2019 - Obesity linked to a reduction in gray matter
April 25, 2019 - Smart assistants could help combat opioid crisis
April 25, 2019 - Diagnostic stewardship strategy reduces inappropriate testing
April 25, 2019 - Three-antibiotic cocktail eradicates ‘persister’ Lyme bacteria in mouse model
April 25, 2019 - Study investigates how early blindness shapes sound processing
April 25, 2019 - Outcomes Worse for Cancer Patients Seen at Noncancer EDs
April 25, 2019 - Link found between temperament of high-risk infants and obesity
April 25, 2019 - Al Letson explores ties between journalists and doctors at Medicine and the Muse symposium
April 25, 2019 - New mobile phone game can detect people at risk of Alzheimer’s
April 25, 2019 - Scientists discover trigger region for absence epileptic seizures
April 25, 2019 - Stretchy wearable patch can do a health check while you work out
April 25, 2019 - Exercise activates brain circuits associated with memory in older adults
April 25, 2019 - Veggies, Fruits and Grains Keep Your Heart Pumping
April 25, 2019 - Healthy meal kits can boost children’s long-term health
April 25, 2019 - Designing an inexpensive surgical headlight: A Q&A with a Stanford surgeon
April 25, 2019 - States Weigh Banning A Widely Used Pesticide Even Though EPA Won’t
April 25, 2019 - Integrator complex proteins are crucial for healthy brain development in fruit flies, study finds
April 25, 2019 - Device converts brain signals into speech, offering hope for patients
April 25, 2019 - Measles vaccination rates are a ‘public health time bomb’
April 25, 2019 - Maths made easier for scientists students who shun the subject wins award
April 25, 2019 - Researchers decode how cancer drug works in brains of Parkinson’s disease patients
April 25, 2019 - Smarter Brain Cancer Trial Comes to Columbia
April 25, 2019 - Researchers Seek Sage Advice Of Elders On Aging Issues
April 25, 2019 - New chemical synthesis strategy leads to identification of novel, simpler derivatives
April 25, 2019 - Vanderbilt investigators discover link between vascular biology and eye disease
April 25, 2019 - Feces transplantation is effective and provides economic benefits
April 25, 2019 - Eisenhower Health first in Southern California to offer new lung valve treatment for COPD/emphysema
April 25, 2019 - Johns Hopkins researchers uncover role of neurotransmitter in the spread of aggressive cancers
April 25, 2019 - Porvair Sciences offers highly effective P3 microplate for biological sample clean-up
April 25, 2019 - Air pollution increases risk for respiratory hospitalization among childhood cancer survivors
April 25, 2019 - We are sitting more! How bad is that?
April 25, 2019 - Majority of stroke survivors not screened for osteoporosis, despite increased risk
April 25, 2019 - ADHD Screening: MedlinePlus Lab Test Information
April 25, 2019 - Cellular alterations increase vulnerability of obese and diabetic individuals to infection
April 25, 2019 - Association Insurance Pushes On Despite Court Ruling
April 25, 2019 - Traditional and e-cigarette users may be more receptive to smoking cessation interventions
April 25, 2019 - Delving into tumor’s cellular lineage may offer clues for customized therapies
April 25, 2019 - Two studies uncover brain mechanisms underlying decision making process
April 25, 2019 - Cardiometabolic Risk Better ID’d in Children Reclassified to Higher BP
April 25, 2019 - How the obesity epidemic is taking a toll on our bones and joints
April 25, 2019 - E-cigarettes contaminated with dangerous microbial toxins
April 25, 2019 - Researchers document specific characteristics of storefront tobacco advertisements
April 25, 2019 - Oncotype DX-guided treatment could reduce cost for breast cancer care, study suggests
April 25, 2019 - Predicting whether a patient will benefit from chemotherapy
April 25, 2019 - New review highlights how lifestyle affects our genes
April 25, 2019 - Study provides evidence that blood tests can detect Alzheimer’s risk
April 25, 2019 - Computer program mimics natural speech using brain signals from epilepsy patients
April 25, 2019 - Physicians turning to antibiotic alternatives for long-term acne treatment
April 25, 2019 - Preschool Is Prime Time to Teach Healthy Lifestyle Habits
Scientists develop nanoscale tweezers that can move freely within cells

Scientists develop nanoscale tweezers that can move freely within cells

image_pdfDownload PDFimage_print

Researchers at Imperial College London have developed nanoscale “tweezers” that can extract cellular components such as DNA, proteins, and organelles, without causing damage or bursting the cell.

Nanoscale tweezers removing the mitochondria of a cellImperial College London

The development, which was recently described in the journal Nature Nanotechnology, could help researchers build a human cell atlas that would shed light on cellular function and the disruptions that occur in disease.

Although scientists are continually learning more about cellular function, many questions still remain. One problem is that individual cells that are of the same type are composed differently at the single-molecule level.

By cataloging the differences between individual cells of the same type, researchers can improve their understanding of cellular processes, design better models of disease and even develop new, patient-specific treatments.

However, the methods used to study these differences generally entail bursting a cell open, which results in the cellular contents becoming mixed and the loss of spatial and dynamic information.

Now, the nanoscale “tweezers,” developed by Professor Joshua Edel and Dr Alex Ivanov, have enabled single molecules to be extracted from cells in real-time, without the cells having to be burst.

We have demonstrated that we can manipulate and extract several different parts from different regions of the cell – including mitochondria from the cell body, RNA from different locations in the cytoplasm and even DNA from the nucleus.”

Professor Joshua Edel, Lead Author

The tweezers are made up of a sharp glass rod with a 50-nanometer-wide tip that is split into two electrodes separated by a gap of 20 nanometers.

The technique is based on a phenomenon referred to as dielectrophoresis; the application of an alternating current causes the 20-nanometer gap to generate a highly localized electrical field that traps and extracts single molecules and particles within the cell.

The ability to extract single molecules in this way sets the technology apart from traditional methods and could enable studies that have not previously been possible.

Ivanov says the tweezers could be an important addition to the toolbox for manipulating single cells and their components:

By studying living cells at the molecular level, we can extract individual molecules from the same location with unprecedented spatial resolution and over multiple points in time. This may provide a deeper understanding of cellular processes, and in establishing why cells from the same type can be very different to each other.”

Professor Joshua Edel, Lead Author

Source:

Nanoscale tweezers can perform single-molecule ‘biopsies’ on individual cells.

Tagged with:

About author

Related Articles