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Study of nearly 41,000 women who almost died giving birth shows who’s most at risk

Study of nearly 41,000 women who almost died giving birth shows who’s most at risk

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Key findings from the new study of life-threatening maternal conditions arising during hospitalization for delivery. Credit: University of Michigan

Tens of thousands of American women each year need emergency treatment to save their lives while they deliver their babies, or immediately after. A new study shows how much their risk of a life-threatening birth depends on their racial and ethnic background, and their underlying health.

In all, 1.6 percent of women faced such a situation. Women of color, and those of Hispanic heritage, had higher rates of severe birth-related health issues than non-Hispanic white women—even if they were otherwise healthy.

The largest gap the researchers saw involved non-Hispanic black women, who had a 70 percent higher rate of major birth problems than non-Hispanic white women.

Women of any race or ethnicity who had a health condition like asthma, diabetes, depression or substance use issues before giving birth also had a higher risk of severe problems after giving birth. Women of color or Hispanic heritage who had two or more such conditions faced two to three times the risk of a severe birth problem.

The new study, published in the journal Obstetrics & Gynecology by a team from the University of Michigan, shines a detailed spotlight on the issue of what physicians call severe maternal morbidity.

Shining a spotlight

Deaths among new mothers have received public attention in recent years, notes lead author Lindsay Admon, M.D., M.Sc. But far less data has been available on the far more common issue of birth problems that could have killed the mother if emergency care wasn’t given.

The new study focuses on 10 types of maternal morbidity. Blood transfusions, used mainly in women suffering a serious hemorrhage, were the most common. They accounted for three-quarters of cases and most of the racial disparity.

“Situations like these are often considered near-misses, and looking at them allows us to get a better picture of who the high-risk women really are,” says Admon, an obstetrician at Michigan Medicine’s Von Voigtlander Women’s Hospital and member of the U-M Institute for Healthcare Policy and Innovation.

“Celebrities like Serena Williams who have shared their birth-related emergency stories publicly have drawn the national spotlight to the urgent need to reduce racial and ethnic disparities in care for women around the time of delivery. To drive and target those changes, we need specific data like these.”

The findings have importance for health policy as well, because many births are paid for by Medicaid, using state and federal funds.

In fact, the new study shows that Medicaid paid for nearly two-thirds of all births among women of non-Hispanic black, Hispanic and American Indian/Alaskan Native backgrounds, and more than a third of all births among non-Hispanic white women and those of Asian/Pacific Islander backgrounds.

More about the study

The researchers used anonymous national data about hospital stays from 2012 to 2015, during which 40,873 women who gave birth underwent an emergency procedure or received a diagnosis of a life-threatening condition.

When calculating their rates of severe maternal morbidity, the researchers adjusted for factors like age, income, insurance source and rural/urban status that have already been shown to play a role in birth outcomes. They were not able to adjust for maternal obesity, another known health risk for birthing mothers.

The data in the study came from the National Inpatient Sample compiled by the Healthcare Cost and Utilization Project, part of the federal Agency for Healthcare Research and Quality.

Admon and her colleagues, including senior author Vanessa Dalton, M.D., M.P.H., note that this data source allowed them to look at severe maternal morbidity across racial and ethnic groups—including American Indians and Alaskan Natives, for whom little national data has been available.

In all, the researchers looked at data from more than 2.5 million birth hospitalizations across a four-year period—a representative sample of nearly 13.5 million total births that happened in the country from 2012 to 2015.

This allowed them to calculate rates of severe maternal morbidity across women of different backgrounds and different health status. For instance, they found that 231 of every 10,000 births among non-Hispanic black women led to one of the severe problems, compared with 139 of every 10,000 births among non-Hispanic white women.

If the rates were extended to the entire population of women who had babies in the U.S. from 2012 to 2015, more than 218,000 of them would have suffered a life-threatening problem.

In addition to blood transfusions, they compiled rates of blood-clotting disorders, heart failure, hysterectomy during or following delivery, acute lung problems, kidney failure, eclampsia (seizures caused by high blood pressure), shock and sepsis. Disparities between whites and blacks of non-Hispanic backgrounds emerged in these non-transfusion conditions, too: 50.5 black mothers per 10,000 suffered one of them, compared with 40.9 white mothers per 10,000.

The researchers focused on chronic health conditions that previous research has shown can increase the risk of a tricky birth. These included diabetes, chronic high blood pressure, chronic lung disease such as asthma, chronic heart or kidney disease, lupus, pulmonary hypertension, HIV/AIDS, depression and substance use disorders.

Non-Hispanic white women had higher rates overall of depression and substance use disorders, compared with women from any other group. Even so, the risk that a white woman with depression or substance issues would have a severe problem during birth was significantly lower than the risk experienced by a woman of color who had depression or substance issues.

Next steps

“Taken together, our findings shed light on women of color as a high-risk population for each of the problems examined occurring during delivery and immediately afterward,” says Admon. “Women of color who have multiple health conditions before they have their baby appear to experience a ‘double whammy’ effect, which should force us to think about how to structure care to best serve these vulnerable women, not only during pregnancy but before and after giving birth too.”

Targeting that effort in healthcare facilities that care for higher percentages of women of color should be a priority, she says. She also hopes to do more research on the longer-term health of newly delivered mothers, beyond the initial birth hospitalization, to understand patterns of health emergencies or “near misses” in the first year after birth.

Admon adds, “Taking care of pregnant women, it’s really heartbreaking to see women entering pregnancy or delivery in a state of health that you know could have been optimized, such as high A1C levels in diabetes, uncontrolled asthma, or untreated substance use disorders. Part of that has to do with underlying disparities in access to care prior to pregnancy, which is also necessary to address in order to ultimately reduce severe maternal morbidity and mortality in the United States.”


Explore further:
2006 to 2015 saw increase in severe maternal morbidity

Journal reference:
Obstetrics & Gynecology

Provided by:
University of Michigan

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