Breaking News
December 17, 2018 - How the Mediterranean Diet Can Help Women’s Hearts
December 17, 2018 - Sustained connections associated with symptoms of autism
December 17, 2018 - Concussion rates among young football players were higher than previously reported
December 17, 2018 - Cresco Labs granted approval to operate marijuana dispensary in Ohio
December 17, 2018 - Study provides insight into health risks facing new mothers
December 17, 2018 - AMSBIO expands Wnt signaling pathway product range to aid research
December 16, 2018 - Surgical treatment unnecessary for many prostate cancer patients
December 16, 2018 - Excess weight responsible for cancers globally finds report
December 16, 2018 - Regular sex associated with greater enjoyment of life in seniors
December 16, 2018 - Social stigma contributes to poor mental health in the autistic community
December 16, 2018 - Multidisciplinary team successfully performs complex surgery on patient suffering from enlarged skull
December 16, 2018 - Experts analyze data that can guide antidepressant discontinuation
December 16, 2018 - Menlo Therapeutics’ Successful Phase 2 Clinical Trial of Serlopitant Demonstrates Reduction of Pruritus Associated with Psoriasis
December 16, 2018 - Siblings of children with autism or ADHD are at elevated risk for both disorders
December 16, 2018 - New project aims to understand why and how metabolic disorders develop in patients
December 16, 2018 - Diets containing GM maize have no harmful effects on health or metabolism of rats
December 16, 2018 - Are doctors and teachers confusing immaturity and attention deficit?
December 16, 2018 - Hearing loss linked with increased risk for premature death
December 16, 2018 - Chromatrap buffer reagents for lysing cells offer many benefits
December 16, 2018 - Young Breast Cancer Patients Face Higher Risk for Osteoporosis
December 16, 2018 - 3-D printing offers helping hand to people with arthritis
December 16, 2018 - Community Health Choice helps manage complex and chronic care conditions
December 16, 2018 - Regular trips out could dramatically reduce depression in older age
December 16, 2018 - CWRU to use VivaLNK’s Vital Scout device for stress study in student athletes
December 16, 2018 - ‘Easy Way Out’? Stigma May Keep Many From Weight Loss Surgery
December 16, 2018 - Gout drug may protect against chronic kidney disease
December 16, 2018 - Talking about memories enhances the wellbeing of older and younger people
December 16, 2018 - Occupational exposure to pesticides increases risk for cardiovascular disease among Latinos
December 16, 2018 - A biomarker in the brain’s circulation system may be Alzheimer’s earliest warning
December 16, 2018 - Magnesium may play important role in optimizing vitamin D levels, study shows
December 16, 2018 - The effect of probiotics on intestinal flora of premature babies
December 16, 2018 - Parents spend more time talking with kids about mechanics of using mobile devices
December 16, 2018 - Biohaven Announces Positive Results from Ongoing Rimegepant Long-Term Safety Study
December 16, 2018 - Arterial stiffness may predict dementia risk
December 16, 2018 - Study explores link between work stress and increased cancer risk
December 16, 2018 - Sex work criminalization linked to incidences of violence finds study
December 16, 2018 - Johns Hopkins researchers discover swarming behavior in fish-dwelling parasite
December 16, 2018 - Schistosomiasis prevention and treatment could help control HIV
December 16, 2018 - Early postpartum opioids linked with persistent usage
December 16, 2018 - Johns Hopkins researchers identify molecular causes of necrotizing enterocolitis in preemies
December 16, 2018 - Advanced illumination expands capabilities of light-sheet microscopy
December 16, 2018 - Alzheimer’s could possibly be spread via contaminated neurosurgery
December 16, 2018 - Unraveling the complexity of cancer biology can prompt new avenues for drug development
December 16, 2018 - Inflammatory Bowel Disease, Prostate Cancer Linked
December 16, 2018 - Cannabis youth prevention strategy should target mental wellbeing
December 15, 2018 - Recent developments and challenges in hMAT inhibitors
December 15, 2018 - Sewage bacteria found lurking in Hudson River sediments
December 15, 2018 - CDC selects UMass Amherst biostatistician model that helps predict influenza outbreaks
December 15, 2018 - Researchers reveal brain mechanism that drives itch-evoked scratching behavior
December 15, 2018 - New computer model helps predict course of the disease in prostate cancer patients
December 15, 2018 - Obesity to Blame for Almost 1 in 25 Cancers Worldwide
December 15, 2018 - How the brain tells you to scratch that itch
December 15, 2018 - New findings could help develop new immunotherapies against cancer
December 15, 2018 - World’s largest AI-powered medical research network launched by OWKIN
December 15, 2018 - Young people suffering chronic pain battle isolation and stigma as they struggle to forge their identities
December 15, 2018 - Lifespan extension at low temperatures depends on individual’s genes, study shows
December 15, 2018 - New ingestible capsule can be controlled using Bluetooth wireless technology
December 15, 2018 - Researchers uncover microRNAs involved in the control of social behavior
December 15, 2018 - Research offers hope for patients with serious bone marrow cancer
December 15, 2018 - Link between poverty and obesity is only about 30 years old, study shows
December 15, 2018 - Mass spectrometry throws light on old case of intentional heavy metal poisoning
December 15, 2018 - BeyondSpring Announces Phase 3 Study 105 of its Lead Asset Plinabulin for Chemotherapy-Induced Neutropenia Meets Primary Endpoint at Interim Analysis
December 15, 2018 - Study finds that in treating obesity, one size does not fit all
December 15, 2018 - Tenacity and flexibility help maintain psychological well-being, mobility in older people
December 15, 2018 - Study reveals role of brain mechanism in memory recall
December 15, 2018 - High levels of oxygen encourage the brain to remain in deep, restorative sleep
December 15, 2018 - Experimental HIV vaccine strategy works in non-human primates, research shows
December 15, 2018 - Genetically modified pigs could limit replication of classical swine fever virus, study shows
December 15, 2018 - FDA Approves Herzuma (trastuzumab-pkrb), a Biosimilar to Herceptin
December 15, 2018 - Cost and weight-loss potential matter most to bariatric surgery patients
December 15, 2018 - Cancer Research UK and AstraZeneca open new Functional Genomics Centre
December 15, 2018 - New research lays out potential path for treatment of Huntington’s disease
December 15, 2018 - Prestigious R&D 100 Award presented to Leica Microsystems
December 15, 2018 - Study shows septin proteins detect and kill gut pathogen, Shigella
December 15, 2018 - Study sheds new light on disease-spreading mosquitoes
December 15, 2018 - 2017 Saw Slowing in National Health Care Spending
December 15, 2018 - Monitoring movement reflects efficacy of mandibular splint
December 15, 2018 - Study supports BMI as useful tool for assessing obesity and health
December 15, 2018 - Self-guided, internet-based therapy platforms effectively reduce depression
December 15, 2018 - Organically farmed food has bigger climate impact than conventional food production
Exercise program during adjuvant breast cancer treatment may provide cardiovascular benefits

Exercise program during adjuvant breast cancer treatment may provide cardiovascular benefits

image_pdfDownload PDFimage_print

Women who underwent a supervised program of cardiovascular exercise during adjuvant breast cancer treatment experienced better cardiovascular function than those who were not part of the exercise program, according to results of the EBBA-II trial presented at the 2018 San Antonio Breast Cancer Symposium, held Dec. 4-8.

“Breast cancer survival rates have improved, but many survivors experience a decline in cardiovascular function,” said the study’s lead author, Inger Thune, MD, PhD, professor and senior consultant in oncology, Oslo University Hospital, Norway. “Treatment-induced cardiotoxicity is a major concern, and cardiovascular disease is a competing cause of death among breast cancer survivors.”

Thune said that while previous studies have indicated that exercise can benefit breast cancer survivors, little research has examined type, dose, intensity, and duration of exercise during adjuvant breast cancer therapy and whether patients benefit from exercising after the initial therapy.

In this study, researchers enrolled 375 women who were part of the Energy Balance and Breast Cancer Aspect (EBBA)-II trial. All the women had undergone surgery for stage 1 or stage 2 breast cancer. Approximately 57 percent of the women were receiving adjuvant chemotherapy, 78 percent were receiving radiation, and 67 percent were receiving endocrine therapy. (Some women were receiving more than one type of treatment.)

Measurements of cardiovascular function were initially performed before any treatment, including surgery. The women were randomly assigned to either an exercise intervention group or a control group. The exercise intervention program began two to three weeks after surgery. Patients received a detailed training program based on their VO2 max (maximal oxygen uptake, a common measure of cardiovascular fitness) at baseline. The group worked out twice a week for 60 minutes each time, in small-group settings led by trained personnel, in a combination of aerobic exercise, stretching, and weight training, Thune explained. They were also asked to do an additional 120 minutes of physical activity each week on their own, which they would report to the researchers.

At the six-month follow-up, patients in both groups experienced an average decline in VO2 max from their pre-surgery levels, which Thune said was typical in the months following surgery or any other treatment. The decline was more significant in the control group–10 percent, compared with 2.7 percent in the group receiving the exercise intervention.

At the 12-month follow-up, patients in the intervention group had improved their VO2 max by 2.3 percent compared to their VO2 max prior to surgery. Patients in the control group had a 3.8 percent decrease in VO2 max compared with their levels prior to surgery.

The researchers found that among the patients who were receiving chemotherapy, the group who was enrolled in the exercise program had returned to their pre-surgery cardiovascular strength by the 12-month follow-up, whereas the control group continued to experience reduced cardiovascular function. Final data from the study will be presented at the symposium.

Thune said the results indicate that many patients could benefit from physical activity during breast cancer treatment. Aside from the cardiovascular benefits measured in this study, exercise may also help reduce fatigue and improve quality of life, Thune said. She said future research will measure the effect of exercise on breast cancer patients’ risk of recurrence, metastasis, metabolic profile, and ability to work.

“Patients should discuss their plans with their doctor, but in general, our study supports incorporation of supervised clinical exercise programs into breast cancer treatment guidelines,” she said.

Thune said this study is believed to be the largest trial that has measured cardiovascular function before any breast cancer treatment. She said one limitation is that attenuation of the main effect may exist as some patients in the control arm may have increased their activity level on their own. She said a strength of the study was measurements before, during, and after treatment and a high degree of adherence; very few patients dropped out or failed to follow the exercise guidelines.

Source:

https://www.aacr.org/Newsroom/Pages/News-Release-Detail.aspx?ItemID=1259

Tagged with:

About author

Related Articles