Breaking News
February 23, 2019 - Intensive therapy during early stages of MS leads to better long-term outcomes
February 23, 2019 - Prenatal Fluconazole Exposure Increases Neonatal Risks
February 23, 2019 - Mental Health Screening: MedlinePlus Lab Test Information
February 23, 2019 - Study suggests birth mechanics are part of the process that leads to autism
February 23, 2019 - Unhealthy diet linked to poor mental health
February 23, 2019 - Study gives a snapshot of crocodile evolution
February 23, 2019 - Research finds steep rise in self-poisonings among young people
February 23, 2019 - American Gastroenterological Association announces “AGA Future Leaders Program”
February 23, 2019 - Scientists uncover new mechanisms regulating neural stem cells
February 23, 2019 - Combinations of certain insecticides turn out to be lethal for honeybees
February 23, 2019 - AHA News: Why Are Black Women at Higher Risk of Dying From Pregnancy Complications?
February 23, 2019 - NIMH » Anxiety Disorders
February 23, 2019 - Autistic people urgently need access to tailored mental health support
February 23, 2019 - Newly designed molecule could benefit people with Friedrich’s Ataxia
February 23, 2019 - Chinese CRISPR twins may have better cognition and memory
February 23, 2019 - Study finds new genetic clues associated with asthma in African ancestry populations
February 23, 2019 - Fetal signaling pathways may offer future opportunities to treat lung damage
February 23, 2019 - Early-stage osteoarthritis drug wins prestigious innovation award
February 23, 2019 - Researchers report positive findings with dasotraline for ADHD in children ages 6-12
February 23, 2019 - News study reanalyzes the effects of noncaloric sweeteners on gut microbiota
February 23, 2019 - New device allows scientists to reproduce blow effects on the heart in lab
February 23, 2019 - Holy herb identified as a potential treatment for Alzheimer’s disease
February 23, 2019 - New technology platform digitally counts growth factors in single cells
February 23, 2019 - Surgery and other treatments offer viable options for adult scoliosis
February 23, 2019 - Reduced antibody adaptability may make the elderly more vulnerable to influenza
February 23, 2019 - Neighborhood income, education associated with risk of disability progression in MS patients
February 23, 2019 - Endocrine Society opposes new rule that restricts access to Title X Family Planning Program
February 23, 2019 - 2019 guidelines for management of patients with atrial fibrillation
February 23, 2019 - Surprise rheumatoid arthritis discovery points to new treatment for joint inflammation
February 23, 2019 - A just-right fix for a tiny heart
February 23, 2019 - UMass Amherst scientist explores role of citrus peel in decreasing gut inflammation
February 23, 2019 - Owlstone Medical and Shanghai Renji Hospital collaborate to initiate breath biopsy lung cancer trial
February 23, 2019 - AMSBIO’s comprehensive portfolio of knock-out cell lines and lysates
February 23, 2019 - New app reliably determines physicians’ skills in forming accurate, efficient diagnoses
February 23, 2019 - Peripheral nerve injury can trigger the onset and spread of ALS, shows study
February 23, 2019 - Researchers uncover mechanisms that prevent tooth replacement in mice
February 23, 2019 - Once-a-day capsule offers new way to reduce symptoms of chronic breathlessness
February 23, 2019 - FDA Adds Boxed Warning for Increased Risk of Death with Gout Medicine Uloric (febuxostat)
February 23, 2019 - Phone-based intervention aids rheumatoid arthritis care
February 23, 2019 - Opioid epidemic makes eastern inroads and targets African-Americans
February 23, 2019 - New identified biomarker predicts patients who might benefit from HER2-targeted agents
February 23, 2019 - Study offers new insights into mechanisms of changes in erythrocytes under stress
February 23, 2019 - Antipsychotic polypharmacy may be beneficial for schizophrenia patients
February 23, 2019 - Researchers investigate how marijuana and tobacco co-use affects quit attempts by smokers
February 23, 2019 - Patients with diabetes mellitus have high risk of stable ischemic heart disease
February 23, 2019 - Transparency on healthcare prices played key role in Arizona health system’s turnaround
February 23, 2019 - A comprehensive, multinational review of peppers around the world
February 23, 2019 - Study finds modest decrease in burnout among physicians
February 23, 2019 - A simple change can drastically reduce unnecessary tests for urinary tract infections
February 23, 2019 - Deep Learning-Enhanced Device Detects Diabetic Retinopathy
February 23, 2019 - Researchers discover new binding partner for amyloid precursor protein
February 23, 2019 - Modest decrease seen in burnout among physicians, researchers say | News Center
February 23, 2019 - Transplanting bone marrow of young mice into old mice prevents cognitive decline
February 23, 2019 - Mogrify to accelerate novel IP and cell therapies using $3.7m USD funding
February 23, 2019 - Johns Hopkins study describes cells that may help speed bone repair
February 23, 2019 - Scientists demonstrate influence of food odors on proteostasis
February 23, 2019 - Researchers unlock the secret behind reproduction of fish called ‘Mary’
February 23, 2019 - Acupuncture Could Help Ease Menopausal Symptoms
February 23, 2019 - Researchers use AI to detect early signs of Alzheimer’s
February 23, 2019 - On recovery, vulnerability and ritual: An exhibit in white | News Center
February 23, 2019 - Memory Stored in Unexpected Region of the Brain
February 23, 2019 - Several health experts worldwide gather at EUDONORGAN event
February 23, 2019 - Discovery of potent compound in native California shrub may lead to treatment for Alzheimer’s
February 22, 2019 - Researchers create new map of the brain’s own immune system
February 22, 2019 - ICHE’s reviews on surgical infections, unnecessary urine tests, and nurses’ role in antibiotic stewardship
February 22, 2019 - UK Research and Innovation invests £200 million to create new generation of AI leaders
February 22, 2019 - Takeda collaboration to boost fight against Alzheimer’s and other neurodegenerative diseases
February 22, 2019 - Heavy drinking may change DNA, leading to increased craving for alcohol
February 22, 2019 - U.S. opioid deaths jump fourfold in 20 years; epidemic shifts to Eastern states | News Center
February 22, 2019 - 5 Questions with William Turner on Diversity in Medicine
February 22, 2019 - HHS Finalizes Rule Seeking To Expel Planned Parenthood From Family Planning Program
February 22, 2019 - Researchers uncover biochemical pathway that may help identify drugs to treat Alzheimer’s
February 22, 2019 - Biologist uses new grant to find ways to eliminate schistosomiasis
February 22, 2019 - Bag-mask ventilation to help patients breathe during intubation prevents complications
February 22, 2019 - AbbVie Announces New Drug Application Accepted for Priority Review by FDA for Upadacitinib for Treatment of Moderate to Severe Rheumatoid Arthritis
February 22, 2019 - Nature versus nurture and addiction
February 22, 2019 - New website connects researchers with data experts, resources | News Center
February 22, 2019 - Today’s Concerns About Drug Prices Echo The Past
February 22, 2019 - CT and Doppler equipment have low accuracy in detecting cerebral vasospasm and ischemia
February 22, 2019 - Study finds out similarity in function between healthy retina cell and tumor cell
Study looks at effects of microdosing of psychedelics on mental health

Study looks at effects of microdosing of psychedelics on mental health

image_pdfDownload PDFimage_print

Microdosing of psychedelic substances involves taking very small doses of a psychedelic drug such as LSD or psilocybin (magic mushrooms) over weeks or even months. There have been anecdotal claims that such microdosing can improve health and also performance and relationships. These earlier studies dealt with the one time effect of microdosing.

Hallucinogenic mushrooms. Image Credit: ANDREA DELBO / Shutterstock

Hallucinogenic mushrooms. Image Credit: ANDREA DELBO / Shutterstock

In this new study, researchers Vince Polito and Richard J. Stevenson of Macquarie University, Australia, looked over the effects of microdosing over a period of six weeks. The latest study titled, “A systematic study of microdosing psychedelics,” was published in the latest issue of the journal PLOS One.

Microdoses are typically a twentieth of the recreational dose and taken at around three or four days intervals over weeks or months. Due to the small doses, the drug is claimed to not affect the daily functioning and people can perform their daily activities. Studies have shown that microdosing can cause elevation of mood and energy and also raises creativity and wisdom. It can change the perception of time in some individuals.

The study looked at 98 individuals who were microdosing themselves. The participants experienced both positive and negative effects of their microdosing. The researchers included only those individuals who were themselves microdosing and did not provide the psychedelics to them. The participants were asked to rate their experience with microdosing each day to understand the daily effects of microdosing. They were also asked to record the dose of the drug they had used on that day. At baseline – start of the study, and at the end of the study, a detailed psychological assessment and tests were conducted. This helped understand the long term effects of microdosing. The researchers also looked at another set of individuals who were interested in microdosing.

The results of the study showed that on a daily basis, there was an elevation of mood, concentration, creativity, happiness, sense of well being and connectedness as well as deep thought or contemplation on microdosing. However this high faded with regular use. In fact some of the participants reported that there was a loss of productivity and focus after two days of microdosing.

Over six weeks of microdosing however, there was a significant reduction in levels of stress and depression. The authors of the study add that their study involved participants who were not depressed at the start of the study, so this finding may not be very valid. Many of the participants however said that their distractions due to unwanted thoughts and anxieties were removed after microdosing. With increase in focus, the participants could become more creative. Some participants on the other hand, had unpleasant sensations and experiences. These individuals tried microdosing once or twice and then did not continue due to the unpleasant side effects.

Lead author Vince Polito explained, “There seems to be two different sets of effects from microdosing… There is a direct, dose related effect that seems to last only 24 hours or so. But then it seems there may also be an additional cumulative effect of regular ingestion of doses over a long time period.”

The authors of the study wrote that participants had expected more creativity and better life satisfaction from microdosing and the results of the experiment did not match their expectations. For this 263 participants who were interested in microdosing were included. Some of these had never tried microdosing and some were experienced microdosers, the authors wrote.

Polito said, “If the effects of microdosing were entirely driven by expectations we should have seen increases in all the variables that people most expected would change. That is not the pattern of results we found. That makes me think that microdosing is having an effect regardless of people’s beliefs.”

Authors concluded from this study that more studies are needed “on the impacts of microdosing on mental health and attentional capabilities.” They added that “the effects of microdosing may not match the experience of long term microdosers.”

Source:

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211023

Tagged with:

About author

Related Articles