Breaking News
April 25, 2019 - Prolonged exposure therapy is more effective in treating veterans with PTSD, alcohol use disorder
April 24, 2019 - Our artificial cornea breakthrough could lead to self-assembling organs
April 24, 2019 - A Stanford black, female, gay surgery resident speaks out
April 24, 2019 - Donna Lynne on Extreme Sports, Lessons From the '60s, and Taking CUIMC to the Next Level
April 24, 2019 - Pain Clinics’ Doctors Needlessly Tested Hundreds Of Urine Samples, Court Records Show
April 24, 2019 - Researchers uncover potential clue to halt destruction of nerve cells in people with ALS
April 24, 2019 - Study uncovers reasons for poor mental health in bisexual people
April 24, 2019 - Screenings, interventions, and referrals can help adolescents overcome substance abuse
April 24, 2019 - Febrile seizures following vaccination are self-resolving and not dangerous
April 24, 2019 - Flow-UV inline UV-Visible spectrometer monitors dispersion in real time
April 24, 2019 - Rates of Marijuana Use in Cancer Patients on the Rise in U.S.
April 24, 2019 - Versatile drug may protect baby from hazards of intraamniotic infections
April 24, 2019 - Financial transparency may diminish trust in doctors, new study finds
April 24, 2019 - Calling all Riders: Velocity Extends Free Registration 
April 24, 2019 - The Homeless Are Dying In Record Numbers On The Streets Of L.A.
April 24, 2019 - Simple mobility test helps predict hospital readmission in elderly heart attack patients
April 24, 2019 - Novel fluorescence imaging system helps surgeons remove small ovarian tumors
April 24, 2019 - Uncovering the Structure of HIV Integrase to Inform Drug Discovery
April 24, 2019 - Medical Marijuana Use Rising Among Cancer Patients
April 24, 2019 - Artificial intelligence approach optimizes embryo selection for IVF
April 24, 2019 - Doctor or detective? Sleuthing mysteries in medical school
April 24, 2019 - CUIMC Community Gives Blood During Spring 2019 Columbia University Blood Drive
April 24, 2019 - Americans Overwhelmingly Want Federal Protections Against Surprise Medical Bills
April 24, 2019 - Making Laboratories More Efficient with the Most Modern LIMS on the Market
April 24, 2019 - Treating cancer patients with personalized, combination therapies improves outcomes
April 24, 2019 - Researchers engineer new molecules to help stop lung cancer
April 24, 2019 - Acupuncture can be a wonderful tool for preventing number of diseases
April 24, 2019 - Daily life disability before hip replacement may predict poor post-operative outcomes
April 24, 2019 - Study finds involuntary staying in housing estates to be a potential health risk
April 24, 2019 - Older kidney disease patients starting dialysis die at higher rates than previously thought
April 24, 2019 - Time-restricted eating shows promise for controlling blood glucose levels
April 24, 2019 - Ambiguous genitalia in newborns may be more common than previously thought
April 24, 2019 - Research provides important insight on the brain-body connection
April 24, 2019 - In 10 Years, Half Of Middle-Income Elders Won’t Be Able To Afford Housing, Medical Care
April 24, 2019 - Researchers study how E. coli clones have become major cause of drug-resistant infections
April 24, 2019 - Bacterial and fungal toxins found in popular electronic cigarettes
April 24, 2019 - Factors affecting absorption of ‘sunshine vitamin’ during spring/summer months
April 24, 2019 - Texting helps improve medication adherence, health outcomes for patients with schizophrenia
April 24, 2019 - Cochrane Review looks at different ways to use nicotine replacement therapies
April 24, 2019 - New review on relationship between COPD and Type 2 diabetes
April 24, 2019 - Brain areas linked to memory and emotion aid odor navigation in humans
April 24, 2019 - Brain stimulation reverses age-related memory loss
April 24, 2019 - Amid Opioid Prescriber Crackdown, Health Officials Reach Out To Pain Patients
April 24, 2019 - $4 million NIH award will help establish UCI Skin Biology Resource-based Center
April 24, 2019 - Cancer drugs reprogram genes in breast tumors to prevent endocrine resistance, finds study
April 24, 2019 - Combination-imaging technique provides new window into macaque brain connections
April 24, 2019 - Researchers identify new allergen responsible for allergy to durum wheat
April 24, 2019 - Researchers define role of rare, influential cells in the bone marrow
April 24, 2019 - DNA rearrangement may predict poor outcomes in multiple myeloma
April 24, 2019 - FDA Approves Skyrizi (risankizumab-rzaa) for Moderate to Severe Plaque Psoriasis
April 24, 2019 - Combination therapy might be beneficial in schizophrenia
April 24, 2019 - Blood test can help match cancer patients to early phase clinical trials
April 24, 2019 - Women tend to underreport snoring and underestimate its loudness
April 24, 2019 - Comprehensive molecular test introduced for diagnosis of malaria caused by P. vivax parasites
April 24, 2019 - New range prediction approach increases accuracy, safety and tolerability of proton therapy
April 24, 2019 - Need for Sedation Up for Regular Cannabis Users
April 24, 2019 - Lack of access to antibiotics is a major global health challenge
April 24, 2019 - New study provides better understanding on safety of deworming programs
April 24, 2019 - EEG used to detect impact of maternal stress on neurodevelopment in 2-month-old infants
April 24, 2019 - FDA Approves First Generic Naloxone Nasal Spray Against Opioid Overdose
April 24, 2019 - A new way of finding compounds that prevent aging
April 24, 2019 - Mechanical training makes synthetic hydrogels perform more like muscle
April 24, 2019 - Study provides new insights into regulatory T cells’ role in protecting against autoimmune disease
April 24, 2019 - Pregnant women with type 1 diabetes are at greater risk of preterm birth
April 24, 2019 - ‘Tummy tuck’ can be safely performed in obese patients with no increase in complications
April 23, 2019 - ‘First’ 3-D print of heart with human tissue, vessels unveiled
April 23, 2019 - Which blood-based method works best to detect TB?
April 23, 2019 - Gene therapy cures infants suffering from ‘bubble boy’ immune disease
April 23, 2019 - Chemical-sampling wristbands detect similar exposures across three continents
April 23, 2019 - Management of Residual Limb Pain
April 23, 2019 - Molecular clock influences immune cell responses
April 23, 2019 - On the importance of culture, partnerships and diversity at the Dean’s Lecture Series
April 23, 2019 - Siddhartha Mukherjee Receives Lewis Thomas Prize for Writing About Science
April 23, 2019 - Dengue mosquito poses greatest danger of spreading Zika virus in Australia
April 23, 2019 - Scientists identify 104 high-risk genes for schizophrenia
April 23, 2019 - Abdominal etching can help patients to get classic ‘six-pack abs’ physique
April 23, 2019 - Alvogen Inc. Issues Voluntary Nationwide Recall of Fentanyl Transdermal System Due to Product Mislabeling
April 23, 2019 - Skype hypnotherapy is effective treatment for IBS
April 23, 2019 - The future hope of “flash” radiation cancer therapy
April 23, 2019 - Bicycling, Recycling, and Beyond: Public Safety to Host Shred Fest and Bike-to-Campus Day 
Study looks at effects of microdosing of psychedelics on mental health

Study looks at effects of microdosing of psychedelics on mental health

image_pdfDownload PDFimage_print

Microdosing of psychedelic substances involves taking very small doses of a psychedelic drug such as LSD or psilocybin (magic mushrooms) over weeks or even months. There have been anecdotal claims that such microdosing can improve health and also performance and relationships. These earlier studies dealt with the one time effect of microdosing.

Hallucinogenic mushrooms. Image Credit: ANDREA DELBO / Shutterstock

Hallucinogenic mushrooms. Image Credit: ANDREA DELBO / Shutterstock

In this new study, researchers Vince Polito and Richard J. Stevenson of Macquarie University, Australia, looked over the effects of microdosing over a period of six weeks. The latest study titled, “A systematic study of microdosing psychedelics,” was published in the latest issue of the journal PLOS One.

Microdoses are typically a twentieth of the recreational dose and taken at around three or four days intervals over weeks or months. Due to the small doses, the drug is claimed to not affect the daily functioning and people can perform their daily activities. Studies have shown that microdosing can cause elevation of mood and energy and also raises creativity and wisdom. It can change the perception of time in some individuals.

The study looked at 98 individuals who were microdosing themselves. The participants experienced both positive and negative effects of their microdosing. The researchers included only those individuals who were themselves microdosing and did not provide the psychedelics to them. The participants were asked to rate their experience with microdosing each day to understand the daily effects of microdosing. They were also asked to record the dose of the drug they had used on that day. At baseline – start of the study, and at the end of the study, a detailed psychological assessment and tests were conducted. This helped understand the long term effects of microdosing. The researchers also looked at another set of individuals who were interested in microdosing.

The results of the study showed that on a daily basis, there was an elevation of mood, concentration, creativity, happiness, sense of well being and connectedness as well as deep thought or contemplation on microdosing. However this high faded with regular use. In fact some of the participants reported that there was a loss of productivity and focus after two days of microdosing.

Over six weeks of microdosing however, there was a significant reduction in levels of stress and depression. The authors of the study add that their study involved participants who were not depressed at the start of the study, so this finding may not be very valid. Many of the participants however said that their distractions due to unwanted thoughts and anxieties were removed after microdosing. With increase in focus, the participants could become more creative. Some participants on the other hand, had unpleasant sensations and experiences. These individuals tried microdosing once or twice and then did not continue due to the unpleasant side effects.

Lead author Vince Polito explained, “There seems to be two different sets of effects from microdosing… There is a direct, dose related effect that seems to last only 24 hours or so. But then it seems there may also be an additional cumulative effect of regular ingestion of doses over a long time period.”

The authors of the study wrote that participants had expected more creativity and better life satisfaction from microdosing and the results of the experiment did not match their expectations. For this 263 participants who were interested in microdosing were included. Some of these had never tried microdosing and some were experienced microdosers, the authors wrote.

Polito said, “If the effects of microdosing were entirely driven by expectations we should have seen increases in all the variables that people most expected would change. That is not the pattern of results we found. That makes me think that microdosing is having an effect regardless of people’s beliefs.”

Authors concluded from this study that more studies are needed “on the impacts of microdosing on mental health and attentional capabilities.” They added that “the effects of microdosing may not match the experience of long term microdosers.”

Source:

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211023

Tagged with:

About author

Related Articles