Breaking News
April 18, 2019 - Hickenlooper Expanded Medicaid, Created State-Run Marketplace To Insure Nearly All Coloradans
April 18, 2019 - Cancer cells grown in tumor-mimicking environment can help predict the effect of experimental drugs
April 18, 2019 - Albireo Announces FDA Clearance of IND to Commence Phase 2 Trial of Elobixibat for the Treatment of NAFLD/NASH
April 18, 2019 - Adhesive gel bonds to eye surface, could repair injuries without surgery
April 18, 2019 - The future of genomics: A podcast featuring Stanford geneticists
April 18, 2019 - As Syphilis Invades Rural America, A Fraying Health Safety Net Is Failing To Stop It
April 18, 2019 - APOE gene impacts sleep depending on gender and severity of Alzheimer’s
April 18, 2019 - PCORI’s newly approved awards focus on cancer pain and opioid use disorders
April 18, 2019 - New tool provides a standard way to measure effects of caring for survivors of TBI
April 18, 2019 - Smartphone use risks eye examination misdiagnosis
April 18, 2019 - How drug-resistant bugs grow in CF patients’ lungs
April 18, 2019 - Gordana Vunjak-Novakovic Elected to American Academy of Arts & Sciences
April 18, 2019 - Podcast: KHN’s ‘What The Health?’ You Have Questions, We Have Answers
April 18, 2019 - Diabetic drug shows potential to be repurposed as heart disease treatment for non-diabetic patients
April 18, 2019 - New estimation method assesses natural variations in sex ratio at birth
April 18, 2019 - UTA scientist receives $1.17 million grant for cancer research
April 18, 2019 - Coagulation factor VIIa prevents bleeds in hemophilia animal models
April 18, 2019 - Researchers identify risk factors for severe infection after knee replacement
April 18, 2019 - Mass drug administration can offer community-level protection against malaria
April 18, 2019 - FDA’s added sugar label could have substantial health and cost-saving benefits
April 18, 2019 - Researchers identify cause of inherited metabolic disorder
April 18, 2019 - Single strip of white paint not sufficient to protect people who ride bikes
April 18, 2019 - Partner status influences link between sexual problems and self-efficacy in breast cancer survivors
April 18, 2019 - Colorectal Neoplasia Risk Up for Hodgkin Lymphoma Survivors
April 18, 2019 - Rigid spine muscular dystrophy – Genetics Home Reference
April 18, 2019 - Simple bile acid blood test could tell risk of stillbirth
April 18, 2019 - Center for Experimental Therapeutics aims to enable all steps of drug development | News Center
April 18, 2019 - Falling for telephone scams could be an early sign of dementia
April 18, 2019 - Researchers annotate key neuronal proteins in lamprey genome
April 18, 2019 - Study uncovers new biomarker for personalized cancer treatments
April 18, 2019 - Scientists enter research collaboration to find a cure for cancer
April 18, 2019 - Study to compare benefits of tai chi and mindfulness meditation on MS symptoms
April 18, 2019 - Gestational diabetes during pregnancy may increase risk of type 1 diabetes in children
April 18, 2019 - Is a New Remedy for Body Odor on the Horizon?
April 18, 2019 - Orthostatic hypotension – Genetics Home Reference
April 18, 2019 - Healing the heartbreak of stillbirth and newborn death
April 18, 2019 - Conference to highlight advances in human immune monitoring, bioinformatics | News Center
April 18, 2019 - Bacteria use viruses for self-recognition, study reveals
April 18, 2019 - New adhesive patch could help reduce post-heart attack muscle damage
April 18, 2019 - Researchers analyze the effects of dark play in a serious video game
April 18, 2019 - Scientists revive pig brain cells four hours after death
April 18, 2019 - Filial cannibalism and offspring abandonment may be forms of parental care
April 18, 2019 - Two proteins act in concert to maintain a healthy heart in mice, shows study
April 18, 2019 - Scientists create a functioning 3D printed heart
April 18, 2019 - Non-invasive vagus nerve stimulation improves disease symptoms in patients with rheumatoid arthritis
April 18, 2019 - Majority of men struggle to understand diagnosis and treatment of prostate cancer
April 18, 2019 - Researchers create new small molecules that may combat equine encephalitis viruses
April 18, 2019 - Animal-assisted therapy improves social behavior in patients with brain injuries
April 18, 2019 - Some viruses help protect harmful bacteria in CF patients | News Center
April 18, 2019 - Outpatient healthcare providers inappropriately prescribe antibiotics to 40% of patients
April 18, 2019 - Men who have a resting heart rate of 75 bpm are twice as likely to die early
April 18, 2019 - Novel serum biomarkers to detect NAFLD-related fibrosis
April 18, 2019 - New study delves deeper into individual genomic differences than ever before
April 18, 2019 - Gilead and Galapagos Announce Filgotinib Meets Primary Endpoint in the Phase 3 FINCH 3 Study in Methotrexate-Naïve Rheumatoid Arthritis Patients
April 18, 2019 - Emotional mirror neurons found in rats
April 18, 2019 - Sylvia Plevritis appointed chair of biomedical data science | News Center
April 18, 2019 - Cervical cancer subtype increasing in several subpopulations of women
April 18, 2019 - Yeast strain provides manufacturing boost to low-calorie sweetener derived from lactose
April 18, 2019 - One in five children and youth suffer from a mental disorder
April 18, 2019 - Improper inhaler use common in children with asthma
April 18, 2019 - C-Path and CDISC release global Therapeutic Area Standard for HIV research
April 18, 2019 - Integrating AI to analyze imaging data allows early recognition of heart disease
April 18, 2019 - Low-cost, high-speed algorithm may allow animal-free chemical toxicity testing
April 18, 2019 - HPV-negative cervical cancers are more aggressive with worse prognosis
April 18, 2019 - AI detects prostate cancer with same level of accuracy as experienced radiologists
April 18, 2019 - Study resolves sex differences in psychiatric illness risk
April 18, 2019 - Novartis Announces FDA Filing Acceptance and Priority Review of Brolucizumab (RTH258) for Patients with Wet AMD
April 18, 2019 - Cocktail of common antibiotics can fight resistant E. coli
April 18, 2019 - Persis Drell to give keynote address at medical school diploma ceremony | News Center
April 18, 2019 - EpicTogether: Remembering Our Why
April 18, 2019 - Study identifies novel loci contributing to asthma susceptibility in adults
April 18, 2019 - Gut bacteria and pregnancy
April 18, 2019 - New study finds that screening could help prevent rare types of cervical cancer
April 17, 2019 - Spatial orgnization of the genome can be altered using small molecules
April 17, 2019 - AEDs Tied to Higher Pneumonia Risk in Alzheimer Patients
April 17, 2019 - Telemedicine tied to more antibiotics for kids, study finds
April 17, 2019 - Two medical students awarded 2019 Soros Fellowships for New Americans | News Center
April 17, 2019 - Sociologist Constance A. Nathanson Awarded Guggenheim Fellowship
April 17, 2019 - Empathy and hormones could account for aggressive behavior in children, shows study
April 17, 2019 - Researchers develop oral appliance to help sufferers of sleep apnea
GenoScreen’s Deeplex-MycTB test could help define appropriate treatment for tuberculosis patients

GenoScreen’s Deeplex-MycTB test could help define appropriate treatment for tuberculosis patients

image_pdfDownload PDFimage_print

The new Deeplex®-MycTB mycobacterial antibiotic resistance test, developed by GenoScreen, has been used by an international research team in a molecular epidemiology study published in The Lancet Infectious Diseases. This study highlights the spread of tuberculosis strains resistant to first-line antibiotics, not detected by actual international tests.

1: Visualisation and interpretation of Deeplex®-MycTB results.

The circle, or “Deeplex map”, represents the genes studied with their names on the inside and the antibiotic(s) concerned on the outside.

Color refers to the results of antibiotic susceptibility prediction (red for resistant, green for sensitive and blue for “not characterised until now in the scientific literature”).

Mutations are indicated on the outside of the circle, using the same colour code (grey for mutations without effect on resistance).

The resistance results are synthesised by a “resistotype” shown below, using the same color codes associated with the resistance prediction for each antibiotic (RIF, INH, PZA…).

With 10 million new cases per year and 1.6 million deceases in 2017, tuberculosis is the most deadly infectious disease in the world. The number of new cases of multidrug-resistant tuberculosis emerging each year (estimated at 450,000 new cases in 2017) is a global public health problem.

On October 18th 2018, a study conducted in southern Africa, co-directed by Dr P. SUPPLY (CNRS/CHU/INSERM/ The University of Lille /Institut Pasteur de Lille), Dr B. de JONG (Institute of Tropical Medecine of Antwerp) and Dr E. ANDRÉ (Université Catholique de Louvain), has been published in The Lancet Infectious Diseases. It reveals that multidrug-resistant strains of tuberculosis are not detected by current diagnostic tests which cause ineffective treatment for patients, increased mortality and contagion, as well as an accumulation of additional resistance in the bacterial strains involved.

These results were achieved, mainly, credits to the innovative molecular test for predicting antibiotic resistance to this disease: the Deeplex®-MycTB test, developed by GenoScreen.

This test is based on the latest DNA sequencing technologies (NGS) and the bioinformatic detection of mutations responsible for antibiotic resistance. A secure web application allows users to access analyze and interpret results using an interactive graphical interface wherever they are. Unlike the culture-specific testing which takes several weeks, the complete sample analyzis can be finalised in just one to three days. After certification (CE-IVD marking) for medical use, Deeplex®-MycTB will be able to help clinicians to define more precisely and more quickly the appropriate treatment for patients.

On the basis of a single molecular test, this test allows to:

  • identify more than 140 species of mycobacteria, including Mycobacterium tuberculosis, the agent responsible for tuberculosis,
  • predict resistance to more than a dozen antibiotic molecules used in the antituberculosis treatment of this infectious-agent,
  • identify the genetic type of the strain involved for epidemiological tracing purposes,
  • visualise the results on an interactive graphical interface giving access to the detail of the results.

Contrairement à d’autres tests de détection des résistances, Deeplex®-MycTB présente le triple-avantage d’être rapide, de détecter une large variété de mutations avec une grande sensibilité et de réaliser un typage facile des mycobactéries, pour suivre l’émergence de nouvelles souches résistantes.

[trad : Unlike other resistance detection tests, Deeplex®-MycTB offers the triple advantage of being fast, detecting a wide variety of mutations with high sensitivity and easily typing mycobacteria, to monitor the emergence of new resistant strains.]

Dr. Gaëlle BISCH – « isolated microorganism » R&D Team Manager, GenoScreen.”


About author

Related Articles