Breaking News
May 3, 2019 - Vaping and Smoking May Signal Greater Motivation to Quit
May 3, 2019 - Dementia looks different in brains of Hispanics
May 3, 2019 - Short-Staffed Nursing Homes See Drop In Medicare Ratings
May 3, 2019 - Study of teens with eating disorders explores how substance users differ from non-substance users
May 3, 2019 - Scientists develop new video game that may help in the study of Alzheimer’s
May 3, 2019 - Arc Bio introduces Galileo Pathogen Solution product line at ASM Clinical Virology Symposium
May 3, 2019 - Cornell University study uncovers relationship between starch digestion gene and gut bacteria
May 3, 2019 - How to Safely Use Glucose Meters and Test Strips for Diabetes
May 3, 2019 - Anti-inflammatory drugs ineffective for prevention of Alzheimer’s disease
May 3, 2019 - Study tracks Pennsylvania’s oil and gas waste-disposal practices
May 3, 2019 - Creating a better radiation diagnostic test for astronauts
May 3, 2019 - Vegans are often deficient in these four nutrients
May 3, 2019 - PPDC announces seed grants to develop medical devices for children
May 3, 2019 - Study maps out the frequency and impact of water polo head injuries
May 3, 2019 - Research on Reddit identifies risks associated with unproven treatments for opioid addiction
May 3, 2019 - Good smells may help ease tobacco cravings
May 3, 2019 - Medical financial hardship found to be very common among people in the United States
May 3, 2019 - Researchers develop multimodal system for personalized post-stroke rehabilitation
May 3, 2019 - Study shows significant mortality benefit with CABG over percutaneous coronary intervention
May 3, 2019 - Will gene-editing of human embryos ever be justifiable?
May 3, 2019 - FDA Approves Dengvaxia (dengue vaccine) for the Prevention of Dengue Disease in Endemic Regions
May 3, 2019 - Why Tonsillitis Keeps Coming Back
May 3, 2019 - Fighting the opioid epidemic with data
May 3, 2019 - Maggot sausages may soon be a reality
May 3, 2019 - Deletion of ATDC gene prevents development of pancreatic cancer in mice
May 2, 2019 - Targeted Therapy Promising for Rare Hematologic Cancer
May 2, 2019 - Alzheimer’s disease is a ‘double-prion disorder,’ study shows
May 2, 2019 - Reservoir bugs: How one bacterial menace makes its home in the human stomach
May 2, 2019 - Clinical, Admin Staff From Cardiology Get Sneak Peek at Epic
May 2, 2019 - Depression increases hospital use and mortality in children
May 2, 2019 - Vicon and NOC support CURE International to create first gait lab in Ethiopia
May 2, 2019 - Researchers use 3D printer to make paper organs
May 2, 2019 - Viral infection in utero associated with behavioral abnormalities in offspring
May 2, 2019 - U.S. Teen Opioid Deaths Soaring
May 2, 2019 - Opioid distribution data should be public
May 2, 2019 - In the Spotlight: “I’m learning every single day”
May 2, 2019 - 2019 Schaefer Scholars Announced
May 2, 2019 - Podcast: KHN’s ‘What The Health?’ Bye-Bye, ACA, And Hello ‘Medicare-For-All’?
May 2, 2019 - Study describes new viral molecular evasion mechanism used by cytomegalovirus
May 2, 2019 - SLU study suggests a more equitable way for Medicare reimbursement
May 2, 2019 - Scientists discover first gene involved in lower urinary tract obstruction
May 2, 2019 - Researchers identify 34 genes associated with increased risk of ovarian cancer
May 2, 2019 - Many low-income infants receive formula in the first few days of life, finds study
May 2, 2019 - Global study finds high success rate for hip and knee replacements
May 2, 2019 - Taking depression seriously: What is it?
May 2, 2019 - With Head Injuries Mounting, Will Cities Put Their Feet Down On E-Scooters?
May 2, 2019 - Scientists develop small fluorophores for tracking metabolites in living cells
May 2, 2019 - Study casts new light into how mothers’ and babies’ genes influence birth weight
May 2, 2019 - Researchers uncover new brain mechanisms regulating body weight
May 2, 2019 - Organ-on-chip systems offered to Asia-Pacific regions by Sydney’s AXT
May 2, 2019 - Adoption of new rules drops readmission penalties against safety net hospitals
May 2, 2019 - Kids and teens who consume zero-calorie sweetened beverages do not save calories
May 2, 2019 - Improved procedure for cancer-related erectile dysfunction
May 2, 2019 - Hormone may improve social behavior in autism
May 2, 2019 - Alzheimer’s disease may be caused by infectious proteins called prions
May 2, 2019 - Even Doctors Can’t Navigate Our ‘Broken Health Care System’
May 2, 2019 - Study looks at the impact on criminal persistence of head injuries
May 2, 2019 - Honey ‘as high in sugars as table sugar’
May 2, 2019 - Innovations to U.S. food system could help consumers in choosing healthy foods
May 2, 2019 - FDA Approves Mavyret (glecaprevir and pibrentasvir) as First Treatment for All Genotypes of Hepatitis C in Pediatric Patients
May 2, 2019 - Women underreport prevalence and intensity of their own snoring
May 2, 2019 - Concussion summit focuses on science behind brain injury
May 2, 2019 - Booker’s Argument For Environmental Justice Stays Within The Lines
May 2, 2019 - Cornell research explains increased metastatic cancer risk in diabetics
May 2, 2019 - Mount Sinai study provides fresh insights into cellular pathways that cause cancer
May 2, 2019 - Researchers to study link between prenatal pesticide exposures and childhood ADHD
May 2, 2019 - CoGEN Congress 2019: Speakers’ overviews
May 2, 2019 - A new strategy for managing diabetic macular edema in people with good vision
May 2, 2019 - Sagent Pharmaceuticals Issues Voluntary Nationwide Recall of Ketorolac Tromethamine Injection, USP, 60mg/2mL (30mg per mL) Due to Lack of Sterility Assurance
May 2, 2019 - Screen time associated with behavioral problems in preschoolers
May 2, 2019 - Hormone reduces social impairment in kids with autism | News Center
May 2, 2019 - Researchers synthesize peroxidase-mimicking nanozyme with low cost and superior catalytic activity
May 2, 2019 - Study results of a potential drug to treat Type 2 diabetes in children announced
May 2, 2019 - Multigene test helps doctors to make effective treatment decisions for breast cancer patients
May 2, 2019 - UNC School of Medicine initiative providing unique care to dementia patients
May 2, 2019 - Nestlé Health Science and VHP join forces to launch innovative COPES program for cancer patients
May 2, 2019 - Study examines how our brain generates consciousness and loses it during anesthesia
May 2, 2019 - Transition Support Program May Aid Young Adults With Type 1 Diabetes
May 2, 2019 - Study shows how neutrophils exacerbate atherosclerosis by inducing smooth muscle-cell death
May 2, 2019 - Research reveals complexity of how we make decisions
UTA nursing professor receives $6.575 million to attack musculoskeletal diseases

UTA nursing professor receives $6.575 million to attack musculoskeletal diseases

A University of Texas at Arlington College of Nursing and Health Innovation professor will use a series of grants totaling approximately $6.575 million during the next five years to attack a variety of debilitating musculoskeletal diseases.

Marco Brotto–the George W. and Hazel M. Jay Professor in the college, and an internationally renowned scientist and an expert in bone, muscle physiology and sarcopenia–recently obtained renewal for two grants, and funding for three new grants from the National Institutes of Health. These awards will further his work in tackling sarcopenia and osteoporosis, and support his new work on diabetic skeletal muscle disease and amyotrophic lateral sclerosis, also known as ALS or Lou Gehrig’s disease.

Sarcopenia, the progressive loss of skeletal muscle mass and muscle strength, is prevalent in the aging population and affects 30 to 45 percent of people over the age of 60. It contributes to debilitating injuries, loss of independence, reduced quality of life in the elderly and more than $40 billion in health care costs in the United States alone, according to Brotto. Musculoskeletal diseases affect more than one in two adults and run up health care expenses of about $1 trillion around the world annually, Brotto said.

“Our view of aging is changing as we live longer,” said Brotto, who heads the college’s Bone-Muscle Research Center.

“Who would want to live longer and be sick, full of chronic disorders? Aging affects the human musculoskeletal, or MSK, system, causing an array of problems from premature deaths to serious disabilities,” Brotto said. “Our studies over the next five years aim to advance discovery of how aging leads to osteoporosis, sarcopenia, diabetes, etc. This knowledge will translate into new diagnostics and treatments for MSK disorders and aging decline in MSK function.”

Paul Fadel, the college’s associate dean for research, said the outcome of Brotto’s work could lead to significant living improvements for the elderly and ultimately for all people.

“With 10,000 people turning 65 each day, it is incumbent to seek solutions that further advance health and the quality of life for this population,” Fadel said. “These studies will help us take gigantic steps in achieving that. As you age, your risk for falls increases because you’re losing strength and balance. And this increases your risk for fractures, which can be very debilitating. Dr. Brotto and his team are tackling these problems from a variety of important angles.”

Elizabeth Merwin, dean of the College of Nursing and Health Innovation, said, “These grants are a boon for the college, for UTA and for health care. These studies are potentially transformative. The outcome of the work of Dr. Brotto and his team of fellow researchers could significantly enhance the quality of life of the elderly.”

Following are snapshots of the five NIH grants:

Bone-Muscle Crosstalk: bone cells regulation of skeletal muscle function–This grant is part of a special NIH mechanism called Program Project Grant, or PPG, involving four principal Investigators, or PIs, at Indiana University, the University of Missouri-Kansas City and UTA. Brotto is the PI of Project 2 of this PPG. He will use this $1.89 million grant to determine how bone cells can influence and change the function of muscles by releasing hormone-like molecules. Brotto has discovered that this process is altered with aging.

Regulation of store-operated calcium entry during muscle aging:–Brotto will use this $1.97 million grant to examine the mechanisms that contribute to the loss of strength in muscle during aging and determine if regulating certain proteins can improve the function of aged skeletal muscles. He is collaborating with Professor Noah Weisleder at Ohio State University.

Loss of a protein in muscle dysfunction in aging–With this $1 million grant, Brotto and his team will work with Christopher Cardozo, a professor at the Icahn School of School of Medicine at Mount Sinai, to investigate the role of a protein called “numb” in muscle function and weakness with aging. He believes the knowledge is likely to increase understanding of the causes of muscle weakness. “It could lead to treatments to prevent and mitigate weakness and frailty in the elderly,” Brotto said.

Protecting the diabetic skeletal muscle by Nampt activation–The major objective of this $965,000 grant is to develop Nampt, or protein gene activators, to protect skeletal muscles from diabetes. “Diabetes is a metabolic disease associated with skeletal muscle injury,” Brotto said. “This research project will generate high-impact pharmacological data through the discovery of new agents and develop molecular insights into preventing muscle injury in diabetes.” Brotto is collaborating with Srinivas Tipparaju, an associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida.

Alleviating the progression of Amyotrophic Lateral Sclerosis, or ALS–Research shows that muscles appear to be primary targets as the ALS gene mutates. This is the primary research topic of Jingsong Zhou, UTA professor of kinesiology and associate director of the Bone-Muscle Research Center. In collaboration with the Zhou team, Brotto and his team plan to use this $750,000 grant to develop alternative therapeutic strategies for combatting ALS.


Tagged with:

About author

Related Articles