Breaking News
May 3, 2019 - Vaping and Smoking May Signal Greater Motivation to Quit
May 3, 2019 - Dementia looks different in brains of Hispanics
May 3, 2019 - Short-Staffed Nursing Homes See Drop In Medicare Ratings
May 3, 2019 - Study of teens with eating disorders explores how substance users differ from non-substance users
May 3, 2019 - Scientists develop new video game that may help in the study of Alzheimer’s
May 3, 2019 - Arc Bio introduces Galileo Pathogen Solution product line at ASM Clinical Virology Symposium
May 3, 2019 - Cornell University study uncovers relationship between starch digestion gene and gut bacteria
May 3, 2019 - How to Safely Use Glucose Meters and Test Strips for Diabetes
May 3, 2019 - Anti-inflammatory drugs ineffective for prevention of Alzheimer’s disease
May 3, 2019 - Study tracks Pennsylvania’s oil and gas waste-disposal practices
May 3, 2019 - Creating a better radiation diagnostic test for astronauts
May 3, 2019 - Vegans are often deficient in these four nutrients
May 3, 2019 - PPDC announces seed grants to develop medical devices for children
May 3, 2019 - Study maps out the frequency and impact of water polo head injuries
May 3, 2019 - Research on Reddit identifies risks associated with unproven treatments for opioid addiction
May 3, 2019 - Good smells may help ease tobacco cravings
May 3, 2019 - Medical financial hardship found to be very common among people in the United States
May 3, 2019 - Researchers develop multimodal system for personalized post-stroke rehabilitation
May 3, 2019 - Study shows significant mortality benefit with CABG over percutaneous coronary intervention
May 3, 2019 - Will gene-editing of human embryos ever be justifiable?
May 3, 2019 - FDA Approves Dengvaxia (dengue vaccine) for the Prevention of Dengue Disease in Endemic Regions
May 3, 2019 - Why Tonsillitis Keeps Coming Back
May 3, 2019 - Fighting the opioid epidemic with data
May 3, 2019 - Maggot sausages may soon be a reality
May 3, 2019 - Deletion of ATDC gene prevents development of pancreatic cancer in mice
May 2, 2019 - Targeted Therapy Promising for Rare Hematologic Cancer
May 2, 2019 - Alzheimer’s disease is a ‘double-prion disorder,’ study shows
May 2, 2019 - Reservoir bugs: How one bacterial menace makes its home in the human stomach
May 2, 2019 - Clinical, Admin Staff From Cardiology Get Sneak Peek at Epic
May 2, 2019 - Depression increases hospital use and mortality in children
May 2, 2019 - Vicon and NOC support CURE International to create first gait lab in Ethiopia
May 2, 2019 - Researchers use 3D printer to make paper organs
May 2, 2019 - Viral infection in utero associated with behavioral abnormalities in offspring
May 2, 2019 - U.S. Teen Opioid Deaths Soaring
May 2, 2019 - Opioid distribution data should be public
May 2, 2019 - In the Spotlight: “I’m learning every single day”
May 2, 2019 - 2019 Schaefer Scholars Announced
May 2, 2019 - Podcast: KHN’s ‘What The Health?’ Bye-Bye, ACA, And Hello ‘Medicare-For-All’?
May 2, 2019 - Study describes new viral molecular evasion mechanism used by cytomegalovirus
May 2, 2019 - SLU study suggests a more equitable way for Medicare reimbursement
May 2, 2019 - Scientists discover first gene involved in lower urinary tract obstruction
May 2, 2019 - Researchers identify 34 genes associated with increased risk of ovarian cancer
May 2, 2019 - Many low-income infants receive formula in the first few days of life, finds study
May 2, 2019 - Global study finds high success rate for hip and knee replacements
May 2, 2019 - Taking depression seriously: What is it?
May 2, 2019 - With Head Injuries Mounting, Will Cities Put Their Feet Down On E-Scooters?
May 2, 2019 - Scientists develop small fluorophores for tracking metabolites in living cells
May 2, 2019 - Study casts new light into how mothers’ and babies’ genes influence birth weight
May 2, 2019 - Researchers uncover new brain mechanisms regulating body weight
May 2, 2019 - Organ-on-chip systems offered to Asia-Pacific regions by Sydney’s AXT
May 2, 2019 - Adoption of new rules drops readmission penalties against safety net hospitals
May 2, 2019 - Kids and teens who consume zero-calorie sweetened beverages do not save calories
May 2, 2019 - Improved procedure for cancer-related erectile dysfunction
May 2, 2019 - Hormone may improve social behavior in autism
May 2, 2019 - Alzheimer’s disease may be caused by infectious proteins called prions
May 2, 2019 - Even Doctors Can’t Navigate Our ‘Broken Health Care System’
May 2, 2019 - Study looks at the impact on criminal persistence of head injuries
May 2, 2019 - Honey ‘as high in sugars as table sugar’
May 2, 2019 - Innovations to U.S. food system could help consumers in choosing healthy foods
May 2, 2019 - FDA Approves Mavyret (glecaprevir and pibrentasvir) as First Treatment for All Genotypes of Hepatitis C in Pediatric Patients
May 2, 2019 - Women underreport prevalence and intensity of their own snoring
May 2, 2019 - Concussion summit focuses on science behind brain injury
May 2, 2019 - Booker’s Argument For Environmental Justice Stays Within The Lines
May 2, 2019 - Cornell research explains increased metastatic cancer risk in diabetics
May 2, 2019 - Mount Sinai study provides fresh insights into cellular pathways that cause cancer
May 2, 2019 - Researchers to study link between prenatal pesticide exposures and childhood ADHD
May 2, 2019 - CoGEN Congress 2019: Speakers’ overviews
May 2, 2019 - A new strategy for managing diabetic macular edema in people with good vision
May 2, 2019 - Sagent Pharmaceuticals Issues Voluntary Nationwide Recall of Ketorolac Tromethamine Injection, USP, 60mg/2mL (30mg per mL) Due to Lack of Sterility Assurance
May 2, 2019 - Screen time associated with behavioral problems in preschoolers
May 2, 2019 - Hormone reduces social impairment in kids with autism | News Center
May 2, 2019 - Researchers synthesize peroxidase-mimicking nanozyme with low cost and superior catalytic activity
May 2, 2019 - Study results of a potential drug to treat Type 2 diabetes in children announced
May 2, 2019 - Multigene test helps doctors to make effective treatment decisions for breast cancer patients
May 2, 2019 - UNC School of Medicine initiative providing unique care to dementia patients
May 2, 2019 - Nestlé Health Science and VHP join forces to launch innovative COPES program for cancer patients
May 2, 2019 - Study examines how our brain generates consciousness and loses it during anesthesia
May 2, 2019 - Transition Support Program May Aid Young Adults With Type 1 Diabetes
May 2, 2019 - Study shows how neutrophils exacerbate atherosclerosis by inducing smooth muscle-cell death
May 2, 2019 - Research reveals complexity of how we make decisions
Feces transplantation is effective and provides economic benefits

Feces transplantation is effective and provides economic benefits

Healthy donor feces is a life-saving therapy. In addition, the treatment provides huge cost savings. When used in the right intestines, feces transplantations saves at least USD 1.2 million (EUR 1.1 million) each time fifty patients are treated for the deadly diarrhea infection Clostridium difficile at a public hospital.

These are the perspectives of the first observational study in the world to detail how things went for the fifty patients who received a feces transplantation for Clostridium difficile colitis in 2014 and 2015 as an alternative to the antibiotics that are otherwise regarded state-of-the-art.

“Our study shows that on average the patients each avoided seventeen days in hospital the first year after their feces transplantation. They went from being hospitalized 37 days a year to 20 days a year in average, following the feces transplantation,” says Christian Lodberg Hvas. He is a consultant at the Department of Hepatology and Gastroenterology at Aarhus University Hospital and a Clinical Associate Professor at the Department of Clinical Medicine at Aarhus University, as well as last author on the study which has just been published in the scientific journal Therapeutic Advances in Gastroenterology.

The study concludes that the total hospital costs per patient were 42% lower and that the average cost decreased from USD 63,300 to 36,800 (EUR 56,400 to 32,800) per year. The average amount covers large individual differences that influence the bottom line because some of the patients were so ill that they ended up being moved in and out of intensive care, where a bed costs up to USD 5,300 USD (EUR 4,700) a day. The cost of an ordinary hospital bed is approx. USD 1,200 (EUR 1,100) per day depending on how it is calculated.

“The USD 26,500 (EUR 23,600) that we save with each patient each year is calculated based on the costs of hospitalization, antibiotics and the feces transplantation. Although a huge annual saving, it is a very conservative estimate. We only included hospital costs, and because half of the patients were below 60 years of age, factors such as loss of earnings should also be counted in,” says Christian Lodberg Hvas.

It is the first time a scientific study has been published based on real world data that describe the costs of feces transplantation compared to the alternative – which is treatment with antibiotics using products such as vancomycin and fidaxomicin.

“There are other studies that make theoretical calculations about what the different types of treatment cost society, but this is the first time anyone has made calculations based on the patients’ actual medical history – with costs and derived hospital savings calculated one year before and one year after the feces transplantation,” he says.

In the actual study, the Department of Hepatology and Gastroenterology has provided data in the form of patient medical records for all of the fifty patients who received a feces transplantation at Aarhus University Hospital during 2014 and 2015.

All of the medical records and documents have then been reviewed in minute detail with a calculator at hand at the Department of Business and Management at Aalborg University with health economist and Professor Lars Holger Ehlers overseeing things. Following this, the results have been put through what is known as a sensitivity analysis to prevent any over-interpretation of the results.

“As an example, we take into account that these patients have already contracted Clostridium difficile in connection with another illness – and this is what characterizes the bacteria – and that they spend many days in hospital for this reason alone. So we can be certain that the large difference in hospital costs is due to the Clostridium difficile disease itself and the subsequent feces transplantation and not other diseases. This is where we use the sensitivity analysis and test different scenarios,” professor Lars Holger Ehlers explains.

Lars Holger Ehlers collaborates with Christian Lodberg Hvas in CEFTA, the Centre for Faecal Microbiota Transplantation at Aarhus University Hospital, which also includes Professor Tine Rask Licht from the Technical University of Denmark and Consultant and Professor and Chair Christian Erikstrup from the Blood Bank and Immunology at Aarhus University Hospital.

CEFTA works with the support of the Innovation Fund Denmark to turn feces from healthy, registered and thoroughly tested donors into a standard treatment for the persistent bacteria which is today regarded as one of the most dangerous bacteria to humans. To do this, a feces bank is being created in Aarhus organized according to the principles of the blood bank.

“The faeces transplantation is a new and extremely effective treatment. The introduction of new treatments is usually very expensive, but here we have a form of treatment that on top of everything also saves society millions of Euro every month. If we can establish a system that safeguards both patients and donors, then it’ll be of huge benefit for everyone. And we’re well on the way to doing that,” says Christian Lodberg Hvas.

The research results – more information

The study was an observational study that included all patients who were given a feces transplantation for recurrent Clostridium difficile infections during 2014 and 2015 at the Department of Hepatology and Gastroenterology, Aarhus University Hospital.

The study was carried out in collaboration with the Department of Business and Management at Aalborg University led by Professor Lars Ehlers.

In the study, all hospital costs in both the year before and the year after the feces transplantation were calculated according to health economic research methods, in particular the time-driven activity-based costing approach.

Tagged with:

About author

Related Articles