Breaking News
May 3, 2019 - Vaping and Smoking May Signal Greater Motivation to Quit
May 3, 2019 - Dementia looks different in brains of Hispanics
May 3, 2019 - Short-Staffed Nursing Homes See Drop In Medicare Ratings
May 3, 2019 - Study of teens with eating disorders explores how substance users differ from non-substance users
May 3, 2019 - Scientists develop new video game that may help in the study of Alzheimer’s
May 3, 2019 - Arc Bio introduces Galileo Pathogen Solution product line at ASM Clinical Virology Symposium
May 3, 2019 - Cornell University study uncovers relationship between starch digestion gene and gut bacteria
May 3, 2019 - How to Safely Use Glucose Meters and Test Strips for Diabetes
May 3, 2019 - Anti-inflammatory drugs ineffective for prevention of Alzheimer’s disease
May 3, 2019 - Study tracks Pennsylvania’s oil and gas waste-disposal practices
May 3, 2019 - Creating a better radiation diagnostic test for astronauts
May 3, 2019 - Vegans are often deficient in these four nutrients
May 3, 2019 - PPDC announces seed grants to develop medical devices for children
May 3, 2019 - Study maps out the frequency and impact of water polo head injuries
May 3, 2019 - Research on Reddit identifies risks associated with unproven treatments for opioid addiction
May 3, 2019 - Good smells may help ease tobacco cravings
May 3, 2019 - Medical financial hardship found to be very common among people in the United States
May 3, 2019 - Researchers develop multimodal system for personalized post-stroke rehabilitation
May 3, 2019 - Study shows significant mortality benefit with CABG over percutaneous coronary intervention
May 3, 2019 - Will gene-editing of human embryos ever be justifiable?
May 3, 2019 - FDA Approves Dengvaxia (dengue vaccine) for the Prevention of Dengue Disease in Endemic Regions
May 3, 2019 - Why Tonsillitis Keeps Coming Back
May 3, 2019 - Fighting the opioid epidemic with data
May 3, 2019 - Maggot sausages may soon be a reality
May 3, 2019 - Deletion of ATDC gene prevents development of pancreatic cancer in mice
May 2, 2019 - Targeted Therapy Promising for Rare Hematologic Cancer
May 2, 2019 - Alzheimer’s disease is a ‘double-prion disorder,’ study shows
May 2, 2019 - Reservoir bugs: How one bacterial menace makes its home in the human stomach
May 2, 2019 - Clinical, Admin Staff From Cardiology Get Sneak Peek at Epic
May 2, 2019 - Depression increases hospital use and mortality in children
May 2, 2019 - Vicon and NOC support CURE International to create first gait lab in Ethiopia
May 2, 2019 - Researchers use 3D printer to make paper organs
May 2, 2019 - Viral infection in utero associated with behavioral abnormalities in offspring
May 2, 2019 - U.S. Teen Opioid Deaths Soaring
May 2, 2019 - Opioid distribution data should be public
May 2, 2019 - In the Spotlight: “I’m learning every single day”
May 2, 2019 - 2019 Schaefer Scholars Announced
May 2, 2019 - Podcast: KHN’s ‘What The Health?’ Bye-Bye, ACA, And Hello ‘Medicare-For-All’?
May 2, 2019 - Study describes new viral molecular evasion mechanism used by cytomegalovirus
May 2, 2019 - SLU study suggests a more equitable way for Medicare reimbursement
May 2, 2019 - Scientists discover first gene involved in lower urinary tract obstruction
May 2, 2019 - Researchers identify 34 genes associated with increased risk of ovarian cancer
May 2, 2019 - Many low-income infants receive formula in the first few days of life, finds study
May 2, 2019 - Global study finds high success rate for hip and knee replacements
May 2, 2019 - Taking depression seriously: What is it?
May 2, 2019 - With Head Injuries Mounting, Will Cities Put Their Feet Down On E-Scooters?
May 2, 2019 - Scientists develop small fluorophores for tracking metabolites in living cells
May 2, 2019 - Study casts new light into how mothers’ and babies’ genes influence birth weight
May 2, 2019 - Researchers uncover new brain mechanisms regulating body weight
May 2, 2019 - Organ-on-chip systems offered to Asia-Pacific regions by Sydney’s AXT
May 2, 2019 - Adoption of new rules drops readmission penalties against safety net hospitals
May 2, 2019 - Kids and teens who consume zero-calorie sweetened beverages do not save calories
May 2, 2019 - Improved procedure for cancer-related erectile dysfunction
May 2, 2019 - Hormone may improve social behavior in autism
May 2, 2019 - Alzheimer’s disease may be caused by infectious proteins called prions
May 2, 2019 - Even Doctors Can’t Navigate Our ‘Broken Health Care System’
May 2, 2019 - Study looks at the impact on criminal persistence of head injuries
May 2, 2019 - Honey ‘as high in sugars as table sugar’
May 2, 2019 - Innovations to U.S. food system could help consumers in choosing healthy foods
May 2, 2019 - FDA Approves Mavyret (glecaprevir and pibrentasvir) as First Treatment for All Genotypes of Hepatitis C in Pediatric Patients
May 2, 2019 - Women underreport prevalence and intensity of their own snoring
May 2, 2019 - Concussion summit focuses on science behind brain injury
May 2, 2019 - Booker’s Argument For Environmental Justice Stays Within The Lines
May 2, 2019 - Cornell research explains increased metastatic cancer risk in diabetics
May 2, 2019 - Mount Sinai study provides fresh insights into cellular pathways that cause cancer
May 2, 2019 - Researchers to study link between prenatal pesticide exposures and childhood ADHD
May 2, 2019 - CoGEN Congress 2019: Speakers’ overviews
May 2, 2019 - A new strategy for managing diabetic macular edema in people with good vision
May 2, 2019 - Sagent Pharmaceuticals Issues Voluntary Nationwide Recall of Ketorolac Tromethamine Injection, USP, 60mg/2mL (30mg per mL) Due to Lack of Sterility Assurance
May 2, 2019 - Screen time associated with behavioral problems in preschoolers
May 2, 2019 - Hormone reduces social impairment in kids with autism | News Center
May 2, 2019 - Researchers synthesize peroxidase-mimicking nanozyme with low cost and superior catalytic activity
May 2, 2019 - Study results of a potential drug to treat Type 2 diabetes in children announced
May 2, 2019 - Multigene test helps doctors to make effective treatment decisions for breast cancer patients
May 2, 2019 - UNC School of Medicine initiative providing unique care to dementia patients
May 2, 2019 - Nestlé Health Science and VHP join forces to launch innovative COPES program for cancer patients
May 2, 2019 - Study examines how our brain generates consciousness and loses it during anesthesia
May 2, 2019 - Transition Support Program May Aid Young Adults With Type 1 Diabetes
May 2, 2019 - Study shows how neutrophils exacerbate atherosclerosis by inducing smooth muscle-cell death
May 2, 2019 - Research reveals complexity of how we make decisions
Researchers to study link between prenatal pesticide exposures and childhood ADHD

Researchers to study link between prenatal pesticide exposures and childhood ADHD

According to the U.S. Centers for Disease Control and Prevention, 6.1 million children have been diagnosed with attention deficit hyperactivity disorder (ADHD) as of 2016. Symptoms of ADHD include trouble concentrating, paying attention, staying organized and remembering details.

Melissa Furlong, PhD, a postdoctoral fellow and epidemiologist in the Department of Environmental Health Sciences at the University of Arizona Mel and Enid Zuckerman College of Public Health, will study the link between prenatal and childhood pesticides and childhood ADHD. Findings from this research will provide some of the first estimates of the association between prenatal pesticide exposures and ADHD in children.

The study is funded by a $910,000, five-year career development grant from the National Institute of Environmental Health Sciences (K99ES028742). Dr. Furlong will focus on two types of pesticides widely used in agriculture, the home and gardens: organophosphates (OPs) and pyrethroids.

Environmental epidemiology is a branch of epidemiology that examines associations between environmental exposures and human health. Dr. Furlong’s research examines the association between environmental contaminants and neurological disorders.

Prenatal levels of OP biomarkers have been associated with characteristic symptoms of ADHD, including deficits in working memory, social responsiveness and other indicators. Cross-sectional studies also have shown that children with ADHD, and higher levels of ADHD behaviors, have higher levels of pyrethroid metabolites.

However, several gaps exist in the existing research, for no studies have evaluated prenatal exposure to these pesticides and ADHD in a large prospective study that follows a group of similar individuals over time.

“I’m interested in this particular study because there is a relaxed attitude toward organophosphate and pyrethroid pesticide use among the general public. But if a link exists between exposure to these pesticides and childhood ADHD, consumers and regulators deserve to know. Use during sensitive periods of development, such as pregnancy and early childhood, might need to be limited or avoided,” Dr. Furlong said.

“One of the most challenging aspects of this type of research is identifying what it means to be exposed. Does it mean you ate a diet high in conventional (non-organic) fruits and vegetables, lived near an agricultural pesticide application during pregnancy and/or lived in the path of a pesticide plume drift during pregnancy?” Dr. Furlong added.

To identify women who were exposed to pesticides during pregnancy, Dr. Furlong will use data from the Arizona Pesticides Use Registry, a list of all commercial pesticide applications in the state.

Using birth certificates and data from Arizona Medicaid (AHCCCS) claim records, she aims to identify 4,000 children with ADHD and 16,000 “controls” without ADHD born between 1992 and 2012.

From this information, Dr. Furlong and colleagues will be able to calculate an individual’s exposure to pesticides across her entire pregnancy.

“We will know where people were living from the address on the birth certificate. So if they lived near some of these applications during pregnancy, we will know when they were exposed and how many pesticides they were exposed to,” Dr. Furlong explained.

Dr. Furlong will collaborate with Avellino Arrelano, PhD, associate professor of data assimilation and atmospheric chemistry in the UA Department of Hydrology and Atmospheric Sciences, to develop a geospatial model to track the spread of pesticides and estimate exposure to pesticide drift, the unintentional spreading of pesticides, including off-target contamination due to spray drift.

Dr. Furlong and her collaborators will have access to the facility cores at the UA Southwest Environmental Health Sciences Center (SWEHSC), a collaborative and interdisciplinary research center, which is investigating the health effects of environmental agents and serving as a community resource.

“Dr. Furlong’s study will expand on existing research on pesticide mixtures and neurodevelopment. This will be among the first to report associations between estimates of prenatal exposures from pesticide applications and ADHD in children,” said Paloma Beamer, PhD, associate professor of environmental health sciences at the UA Zuckerman College of Public Health, president of the International Society of Exposure Science and a member of SWEHSC.

As Dr. Furlong’s mentor, Dr. Beamer will provide expertise in exposure science. Dr. Furlong’s co-mentor, Beate Ritz, MD, PhD, professor of epidemiology at the UCLA Fielding School of Public Health and president of the International Society of Environmental Epidemiology, will contribute epidemiology support. Edward Bedrick, PhD, professor and director of the biostatistics program at the UA Zuckerman College of Public Health; and Avellino Arrelano, PhD, associate professor in the UA Department of Hydrology and Atmospheric Sciences, will act as collaborators.


Tagged with:

About author

Related Articles