HIV-1 Virus. Credit: J Roberto Trujillo/Wikipedia In a proof-of-principle study, researchers at Johns Hopkins report that a certain liver immune cell called a macrophage contains only defective or inert HIV-1 copies, and aren’t likely to restart infection on their own in HIV-1-infected people on long-term antiretroviral therapy (ART). The study, the investigators say, strongly suggest […]Continue Reading ...
Credit: Mary Ann Liebert, Inc., publishers Diagnosis of HIV-1 infection in the 4-year old child of an HIV-negative mother led to a forensic analysis to determine the source of the infection and try to date the transmission of the virus. The results of genetic, phylogenetic, and serologic data analysis on both the father and son […]Continue Reading ...
That men who have sex with men run a greater risk of HIV than others has been known since the virus was discovered. However a thesis from Karolinska Institutet now shows that it is a small sub-group of these men who account for the greater part of the risk increase. The results are important to […]Continue Reading ...
Marina Caskey, a researcher who is part of a new clinical trial that shows that broadly neutralizing antibodies can suppress HIV for up to four months, far longer than currently available drugs. Credit: Mario Morgado/The Rockefeller University Thanks to improvements in antiretroviral therapy, HIV is now a manageable condition. Yet even the best drugs do […]Continue Reading ...
Credit: CC0 Public Domain Injecting drug use, through the sharing of needles, syringes and other injecting equipment, is a primary route of transmission for both HIV and hepatitis C virus (HCV), blood-borne infections that cause considerable morbidity and mortality worldwide. New research led by the University of Bristol has found among people who inject drugs, […]Continue Reading ...
Microglia in the hippocampus. Credit: stock.adobe.com Rare cells resembling those previously thought to exist only in the brain have been discovered in the spinal fluid of HIV patients by using a sensitive new genetic test that could provide insights into a host of neurological diseases. In many infected adults, HIV affects the central nervous system […]Continue Reading ...
Young women participating in FRESH have their fingers pricked twice per week for HIV testing. Credit: Rachel Regina A program established by investigators from the Ragon Institute of Massachusetts General Hospital (MGH), MIT and Harvard is addressing the persistently elevated risk of HIV infection among young women in South Africa from two angles—first, investigating biological […]Continue Reading ...
The fight against epidemics such as AIDS and tuberculosis needs greater funding and cooperation in order to wipe out the diseases, a leading aid group said Wednesday. Launching its annual report in Paris, The Global Fund said countries where it invests had seen 17.5 million people receive antiretroviral treatment against HIV and five million people […]Continue Reading ...
Credit: CC0 Public Domain In the quest to develop a vaccine that triggers the immune system to prevent HIV infection, researchers have focused on identifying and eliciting a particular type of antibody that is capable of neutralizing the virus. These broadly neutralizing antibodies, or bnAbs, eventually arise naturally in about half of HIV-infected people, but […]Continue Reading ...
The researchers’ anti-integrin therapy using the approved medication vedolizumab (VDZ) reduced aggregates of immune cells (green) in intestinal biopsies from a patient with HIV and IBD. Credit: M. Uzzan et al., Science Translational Medicine (2018) In a study published today in Science Translational Medicine, Mount Sinai researchers describe for the first time a mechanism that […]Continue Reading ...
HIV (yellow) infecting a human immune cell. Credit: Seth Pincus, Elizabeth Fischer and Austin Athman, National Institute of Allergy and Infectious Diseases, National Institutes of Health Gay and bisexual men are getting tested and using medications to prevent HIV transmission more than ever, with UNSW researchers recording an encouraging major shift towards new forms of […]Continue Reading ...
HIV infecting a human cell. Credit: NIH Preliminary results from a phase I clinical trial have demonstrated the safety and tolerability of a cell therapy involving the ex vivo expansion of T cells and their subsequent infusion into HIV-infected individuals previously treated with antiretroviral therapy (ART). The study appears September 21st in the journal Molecular […]Continue Reading ...
HIV infecting a human cell. Credit: NIH An HIV outbreak among people who inject drugs in Indiana from 2011 to 2015 could have been avoided if the state’s top health and elected officials had acted sooner on warnings, a new study by the Yale School of Public Health finds. The study, published in The Lancet […]Continue Reading ...
Credit: CC0 Public Domain Most HIV patients need to take daily anti-retroviral therapy—if they suspend treatment, HIV will rebound within 3-4 weeks. But clinical trials have revealed that a small fraction of patients can stop taking medications yet keep the virus suppressed for 24 weeks or longer, maintaining viral control without the assistance of medication. […]Continue Reading ...
Credit: CC0 Public Domain Only 4 percent of sexually active gay and bisexual men in the United States use Truvada, a highly effective medication used to prevent the transmission of HIV, according to the results of a first-of-its-kind study. Led by Psychology Professor Phillip Hammack, the study, “HIV Testing and Pre-Exposure Prophylaxis (PrEP) Use, Familiarity, […]Continue Reading ...
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