HIV infecting a human cell. Credit: NIH HIV, the virus that causes AIDS, has a secret life. Though anti-retroviral therapy can reduce its numbers, the virus can hide and avoid both treatments and the body’s immune response. Researchers at UC Davis Health, together with colleagues at UC San Francisco and the University of North Carolina […]Continue Reading ...
Credit: CC0 Public Domain After receiving a course of antiretroviral therapy for their HIV-like infection, approximately half of a group of monkeys infused with a broadly neutralizing antibody to HIV combined with an immune stimulatory compound suppressed the virus for six months without additional treatment, according to scientists supported in part by the National Institute […]Continue Reading ...
Credit: CC0 Public Domain UC San Francisco scientists have uncovered new mechanisms by which HIV hides in infected cells, resting in a latent state that evades the body’s immune system and prevents antiviral drugs from flushing it out. The findings, published online February 28, 2018, in Science Translational Medicine, could help scientists design and test […]Continue Reading ...
High magnification fluorescence microscopy of HIV Nef in green and CD81-mCherry in red. CD81 is a marker for maturing vesicles that may be exported. In blue are the nuclei. Arrows point to areas where HIV-Nef and CD81 co-localize. Credit: Ryan McNamara HIV may be able to affect cells it can’t directly infect by packaging a […]Continue Reading ...
In this Jan. 26, 2018 photo, Matt Chappell, right, is checked by Dr. Christopher Schiessl during an appointment at a medical center in San Francisco. For more than a decade, the strongest AIDS drugs could not fully control Chappell’s HIV infection. Now his body does it by itself, thanks to the first gene editing experiments […]Continue Reading ...
Computational method to estimate the fitness landscape of HIV-envelope. Credit: Department of Electronic & Computer Engineering, HKUST Despite significant advances in medicine, there is still no effective vaccine for the human immunodeficiency virus (HIV), although recent hope has emerged through the discovery of antibodies capable of neutralizing diverse HIV strains. However, HIV can sometimes evade […]Continue Reading ...
Using robotics, Phil Berman’s lab at UC Santa Cruz was able to automate the process of screening tens of thousands of cells to find cell lines that produce large amounts of the desired protein for an HIV vaccine. Credit: Phil Berman, UCSC Research on HIV over the past decade has led to many promising ideas […]Continue Reading ...
LEFT: A depiction of the contact patterns by age group in the Thai Nguyen cohort of people who inject drugs. RIGHT: The corresponding estimates of the numbers of new HIV infections expected to be acquired (solid line) or transmitted by (dotted line) each age group, based on observed mixing and HIV prevalence patterns. Credit: Kumi […]Continue Reading ...
(HealthDay)—Almost 40 percent of women and more than 50 percent of men aged 15 to 44 years had never been tested for HIV between 2011 and 2015, according to a report published Jan. 25 by the U.S. Centers for Disease Control and Prevention’s National Center for Health Statistics. Isaedmarie Febo-Vazquez, from the National Center for […]Continue Reading ...
Credit: Mary Ann Liebert, Inc., publishers Researchers have shown that despite effective combined antiretroviral therapy (cART), HIV can hide in the spleen of patients with no detectable HIV in their blood. The study confirming the spleen as an HIV sanctuary is part of a comprehensive collection of articles describing the broad scope and current status […]Continue Reading ...
A variety of antiretroviral drugs used to treat HIV infection. Credit: NIAID The National Institutes of Health has launched a large international study to compare the safety and efficacy of three antiretroviral treatment regimens for pregnant women living with HIV and the safety of these regimens for their infants. The study will evaluate the current […]Continue Reading ...
David Margolis, M.D., leads the UNC HIV Cure Center. Credit: David Kinton, UNC School of Medicine The ability of HIV to mutate has been a major challenge to vaccine development. As the body produces antibodies to target the outer HIV envelope protein, this protein changes, thwarting the circulating antibodies’ ability to neutralize it. Yet recent […]Continue Reading ...
Credit: Mary Ann Liebert, Inc., publishers In the 10th anniversary year since a bone marrow stem cell transplant cured Timothy Ray Brown of his HIV infection, despite disappointment over decreasing public desire to find a cure for HIV, Timothy Ray Brown remains optimistic that the scientific and medical communities can and will achieve this if […]Continue Reading ...
Exploring ways to improve the turnaround times for HIV tests on babies. Credit: Shutterstock They say timing is everything. And in sub-Saharan Africa, where roughly a third of untreated HIV infected babies die before they reach the age of one, a timely diagnosis is everything. According to the latest UNAIDS data, 150 000 children are […]Continue Reading ...
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