Lack of Foxp1 leads to inflammation of the large intestine (colitis). (Left) In healthy conditions, iTreg cells (blue) with sufficient Foxp1 keep a check over other immune cells (T-cells, orange, green and purple) in the large intestine. (Right) If Foxp1 is absent, iTreg cells are dramatically reduced and therefore can’t control the activity of other […]Continue Reading ...
Oregon State University researchers have discovered two key factors behind the intestinal inflammation that plagues people suffering from a disorder that affects their immune system. The findings, published in Clinical Immunology, are important because common variable immunodeficiency, known as CVID, afflicts hundreds of thousands of people worldwide. A significant proportion of them will have potentially […]Continue Reading ...
Credit: CC0 Public Domain Inflammation, which is the root cause of autoimmune disorders including arthritis, Type 1 diabetes, irritable bowel syndrome and Crohn’s disease, has unexpected effects on body clock function and can lead to sleep and shiftwork-type disorders, a new Northwestern Medicine study in mice found. The study was published in the journal Genes […]Continue Reading ...
Listeria monocytogenes. Credit: CDC PHIL The immune system keeps T cells under control by regulating precisely when they can respond to a pathogen. For instance, helper T cells only turn “on” if other immune cells, such as antigen-presenting cells (APCs) present bacterial peptides (protein fragments) on their surface in a protein complex called MHC class […]Continue Reading ...
Significantly higher levels of periostin were found in severe asthmatics compared with mild to moderate ones and controls. There were significantly higher T2 levels than in non-T2 endotype. Credit: CHEST In a novel study, researchers succeeded in identifying patients with a form of severe asthma (type 2 endotype) by measuring periostin concentrations in their airways. […]Continue Reading ...
Expanded population of gastrointestinal Wallemia enhances the severity of house dust mite (HDM) induced allergic airways disease. Fig 4E. Goblet cell numbers were quantified. Figure illustrates combined result of three experiments. Credit: Joseph Skalski A non-pathogenic fungus can expand in the intestines of antibiotic-treated mice and enhance the severity of allergic airways disease, according to […]Continue Reading ...
Dr Alan Yu and Associate Professor Seth Masters. Credit: Walter and Eliza Hall Institute of Medical Research Australian researchers have uncovered clues in the immune system that reveal how the balance of ‘good’ gut bacteria is maintained. The information could help in the prevention and treatment of inflammatory bowel disease (IBD). The study, published in […]Continue Reading ...
(HealthDay)—The U.S. Food and Drug Administration on Monday approved Gamifant (emapalumab-lzsg) for the treatment of primary hemophagocytic lymphohistiocytosis (HLH) in pediatric (as young as newborn) and adult patients who have refractory, recurrent, or progressive disease or intolerance with conventional HLH treatment. Gamifant is the first drug to be approved specifically for HLH. The drug’s efficacy […]Continue Reading ...
Credit: CC0 Public Domain Move over Bifidobacterium and Lactobacillus. There’s a new health-promoting gut bacterium in town, and it’s called Akkermansia muciniphila. You will not find its benefits at the bottom of a yogurt cup. But a new study has identified more than one way to nurture its growth in the gut, and offered evidence […]Continue Reading ...
Normal primary human airway culture. Cilia in blue. The CFTR protein in red. Credit: The Gentzsch Lab, UNC School of Medicine A new UNC School of Medicine study shows that two cystic fibrosis (CF) drugs aimed at correcting the defected CFTR protein seem to be more effective when a patient’s airway is inflamed. This is […]Continue Reading ...
Organs affected by autoimmune disease could be fighting back by “exhausting” immune cells that cause damage using methods similar to those used by cancer cells to escape detection, according to a study by researchers at the University of Pittsburgh School of Medicine published today in the Journal of Clinical Investigation. The conclusions, based on studies […]Continue Reading ...
High magnification micrograph of Crohn’s disease. Biopsy of esophagus. H&E stain. Credit: Nephron/Wikipedia Researchers at MRC HIU examined the large intestine using sophisticated single cell technology, in work that paves the way for better treatments for IBD. Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease with limited treatment options. The two main forms of […]Continue Reading ...
Credit: CC0 Public Domain A particular type of white blood cell becomes more pro-inflammatory as it deteriorates with age or ‘senesce’, according to research led by A*STAR scientists. The discovery could help explain why older people are often found to have persistent low levels of inflammation in the blood even when they’re not ill. Furthermore, […]Continue Reading ...
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