A C. elegans worm expresses a calcium indicator molecule in its muscles. When muscles contract and calcium is released, this molecule (called GCaMP) binds to it and emits light. This allows scientists to measure how hard the muscles of the animals are working, and how fast calcium is released and cleared from the cell. Credit: […]Continue Reading ...
The picture shows a mouse nerve bridge tissue section. The pink colour shows cells that express Robo1, the green colour shows Schwann cells. Credit: University of Plymouth New research led by the University of Plymouth has shed light on the science behind peripheral nerve repair, by highlighting the novel function of a cell called a […]Continue Reading ...
High-resolution model of six insulin molecules assembled in a hexamer. Credit: Isaac Yonemoto/Wikipedia Researchers at the Icahn School of Medicine at Mount Sinai have discovered a novel combination of two classes of drugs that induces the highest rate of proliferation ever observed in adult human beta cells—the cells in the pancreas that produce insulin. The […]Continue Reading ...
Credit: CC0 Public Domain Stem cells are the true jacks-of-all-trades of our bodies, as they can turn into the many different cell types required by different organs. This allows the tissues such as muscle or even brain to renew and to heal after injury, and this amazing multipotency makes stem cells in the adult body […]Continue Reading ...
Credit: CC0 Public Domain Researchers from Skoltech (Maxim Fedorov’s group, CDISE) and the German Research Center for Environmental Health, Helmholtz Zentrum München (HMGU; Igor Tetko’s group) have developed an enhanced drug candidate toxicity prediction technology based on multi-task machine learning algorithms and analysis of various types of toxicity data. The new approach accurately predicts adverse […]Continue Reading ...
Beta cells made from stem cells, as seen under the microscope. Credit: Melton laboratory The immune system normally defends the body against everything from microscopic viruses to meters-long parasitic worms. But sometimes, it sets its sights on the wrong target: the body’s own cells. Autoimmunity problems cause many different diseases, depending on which cells are […]Continue Reading ...
Figure 1: a concept model of the findings. Credit: Kobe University Permanently arrested cell growth is known as “cellular senescence”, and the accumulation of senescent cells may be one cause of aging in our bodies. Japanese researchers have discovered that a certain enzyme in our bodies promotes cellular senescence by producing reactive oxygen species. Drugs […]Continue Reading ...
Imaging mass cytometry can make a valuable contribution to a better understanding of how type 1 diabetes progresses. Credit: UZH Using the new Imaging Mass Cytometry method, researchers of UZH have investigated the pancreas of healthy organ donors and those with type 1 diabetes. The study shows that many beta cells, which normally produce insulin, […]Continue Reading ...
Dean hopes his finding will lead to better measures of blood pressure. Credit: Peter Mathew New blood pressure categories are helping to inform the development of more accurate measurement devices, following a discovery by Tasmanian researchers. Blood pressure subtleties are being missed by the current cuff measure, according to a recent study led by Dean Picone […]Continue Reading ...
Figure: Two different pathways in a humanized cereblon mouse model.Kishimoto and colleagues found that the degradative effect of IMiDs on IKZF1 and CK-1α, as well as upregulation of IL-2, is dependent on the CRBN-IMiD binding region. Therefore, the anti-inflammatory bowel disease benefit of IMiD is mediated through a CRBN–IMiD binding region-independent pathway. Credit: Osaka University […]Continue Reading ...
The epidermal-equivalent models generated from epidermal cells with (right) or without (left) a basal layer made of polyester mesh. Living layers are indicated by blue arrows and stratum corneum by red arrows. Asterisks indicate cross sections of polyester fibers. Scale bars = 50 μm. Credit: Kumamoto J. et al., Scientific Reports, December 20, 2018 The […]Continue Reading ...
Alessandra Sacco, Ph.D., senior author of the paper and associate professor in the Development, Aging and Regeneration Program at Sanford Burnham Prebys Medical Discovery Institute (SBP) Credit: Sanford Burnham Prebys Medical Discovery Institute (SBP) People with Duchenne muscular dystrophy (DMD) can develop an otherwise-rare muscle cancer, called rhabdomyosarcoma, due to the muscle cells’ continuous work […]Continue Reading ...
A section of an artificial thymic organoid showing T cells (outlined in red) created from human embryonic stem cells Credit: UCLA Broad Stem Cell Research Center/Cell Stem Cell A study by UCLA researchers is the first to demonstrate a technique for coaxing pluripotent stem cells—which can give rise to every cell type in the body […]Continue Reading ...
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