Credit: CC0 Public Domain A 49-year-old man notices a painless rash on his shoulder but doesn’t seek care. Months later, during a routine physical, his doctor notices the rash and diagnoses it as a benign skin condition. More time passes, and during a routine screening test, a nurse points out the rash to another physician […]Continue Reading ...
MSCs from elderly patients were reprogrammed into iPSCs and further differentiated into iMSCs. These iMSCs are endowed with typical MSC features such as making bone, cartilage and fat. The iMSCs acquired a gene signature associated with rejuvenation and secreted factors present in native MSCs, thereby emphasizing their clinical potential. Credit: Spitzhorn LS, et. al. The […]Continue Reading ...
Clusters of pancreatic beta cells derived from human pluripotent stem cells in a lab dish. Insulin producing cells are labeled in green. Red indicates the presence of PDX1, a key protein involved in insulin production. Credit: Hebrok Lab / UCSF UC San Francisco researchers have for the first time transformed human stem cells into mature […]Continue Reading ...
A leukocyte embedded in a 3D collagen network. Imaged by light sheet microscopy; imaged by Meghan K. Driscoll, University of Texas Southwestern Medical Center, Dallas, USA Credit: Meghan K. Driscoll How do mobile cell types like leukocytes or metastatic cancer cells reach their place of action during immune surveillance or cancer dissemination, respectively? The research […]Continue Reading ...
Credit: Bellvitge Biomedical Research Institute (IDIBELL) Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) led by Dr. Montse Olivé have described in Nature Communications a new muscular disease caused by a mutation in the myoglobin gene. The study was led by Prof. Nigel Laing and researchers from the Karolinska Institute (Stockholm, Sweden). Myoglobin, the protein […]Continue Reading ...
Credit: CC0 Public Domain A team of researchers affiliated with multiple institutions in and around the Boston area in the U.S. and one in Finland has identified hundreds of possible causal variants associated with blood cell traits, and tied them to important blood-related mechanisms. The team sought to learn more about genetic variants in blood […]Continue Reading ...
This innovation has been developed by researchers based in Brazil and the US. According to researcher Julio Cesar Batista Ferreira (ICB-USP), it not only halts the progression of heart failure but also improves the heart’s capacity to pump blood. Credit: Cecilia Bastos / Jornal da USP A group of researchers based in Brazil and the […]Continue Reading ...
CBX4 maintains nucleolar homeostasis, alleviates senescence and osteoarthritis. Credit: IOZ Aging is a risk factor for the development of osteoarthritis (OA), a chronic disease characterized by degeneration of articular cartilage leading to pain and physical disability. Senescent mesenchymal stem cells (hMSCs) are found in cartilage tissues isolated from patients suffering from osteoarthritis. Notably, senescent MSCs […]Continue Reading ...
Micrograph showing inflammation of the large bowel in a case of inflammatory bowel disease. Colonic biopsy. Credit: Wikipedia/CC BY-SA 3.0 What if a special diet could reduce inflammation and repair your gut? USC researchers provided evidence that a low-calorie “fasting-mimicking” diet has the potential to do just that. Published in the March 5 edition of […]Continue Reading ...
Zhao and her team have shown the potential of biomimicry to grow microvessels in tissues suitable for a cardiac patch. The next steps will be animal trials and refining medical technology for implants and devices. With the help of tiny, dense, neatly aligned blood vessels, engineered tissues could help hearts, skin, bones and muscles regenerate […]Continue Reading ...
Hematologist Daniel Bauer, MD, PhD in the lab Credit: KC Cohen/Boston Children’s Hospital Researchers at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center and the University of Massachusetts Medical School have developed a strategy to treat two of the most common inherited blood diseases—sickle cell disease and beta thalassemia—applying CRISPR-Cas9 gene editing to patients’ own blood […]Continue Reading ...
High-resolution model of six insulin molecules assembled in a hexamer. Credit: Isaac Yonemoto/Wikipedia The crucial hormone insulin needs help acquiring the right structure. A protein that assists in the process of insulin folding has just been discovered in a new study conducted by researchers at the Department of Biomedical Sciences, University of Copenhagen. They hope […]Continue Reading ...
Credit: CC0 Public Domain Researchers at Rensselaer Polytechnic Institute who developed a blood test to help diagnose autism spectrum disorder have now successfully applied their distinctive big data-based approach to evaluating possible treatments. The findings, recently published in Frontiers in Cellular Neuroscience, have the potential to accelerate the development of successful medical interventions. One of […]Continue Reading ...
Credit: Wikimedia Commons Celastrol’s potent anti-obesity effects were widely reported in 2015. Derived from the roots of the thunder god vine, the drug curbed food intake in obese mice by nearly 80 percent, producing up to a 45 percent weight loss. Celastrol increases the brain’s sensitivity to leptin, the hormone that signals we’ve had enough […]Continue Reading ...
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