Mature iPSC-derived RPE cells are visible by super resolution confocal microscopy. One primary cilium resides in the center of each cell. RPE cell borders are stained showing tight junction markers. Credit: Ruchi Sharma, Ph.D., NEI Scientists at the National Eye Institute (NEI), part of the National Institutes of Health, report that tiny tube-like protrusions called […]Continue Reading ...
The complex and mysterious mechanisms that drive communication and reactions within human cells could be on the verge of being unravelled, due to a pioneering new technique. Researchers from the Universities of Exeter, Leeds and Cambridge have harnessed an innovative new method to gain a greater understanding of signalling stations within the cells, called nanodomains. […]Continue Reading ...
Credit: University of Pennsylvania When a cancer patient receives a bone marrow transplant, time is of the essence. Healthy stem cells, which can restart the production of blood cells and immune system components after a patient’s own are compromised, need to make their way from the circulatory system into the bones as quickly as possible. […]Continue Reading ...
Credit: Mary Ann Liebert, Inc., publishers Researchers have reported the ability to modify the structure of small interfering RNAs (siRNAs) to improve their stability and therapeutic potential without negatively affecting their potency and ability to silence targeted genes. The oligonucleotide modifications used and the experimental measures of thermal stability, helical structure, and gene expression are […]Continue Reading ...
Cisplatin (appearing in green) in the stria vascularis of a mouse inner ear. Credit: National Institutes of Health Scientists have found a new way to explain the hearing loss caused by cisplatin, a powerful drug used to treat many forms of cancer. Using a highly sensitive technique to measure and map cisplatin in mouse and […]Continue Reading ...
The skin transplant required one square metre of tissue. Credit: CMR Unimore Decades of scientific research into areas including plant genetics and data science helped doctors successfully carry out an experimental therapy to create a new skin for a seven-year-old boy suffering from a rare genetic disorder. Hassan’s doctors had never seen anything like it: […]Continue Reading ...
Estradiol, the major estrogen sex hormone in humans and a widely used medication. Credit: Public Domain Estrogen produced in the brain is necessary for ovulation in monkeys, according to researchers at the University of Wisconsin-Madison who have upended the traditional understanding of the hormonal cascade that leads to release of an egg from the ovaries. […]Continue Reading ...
C. elegans (roundworms). Credit: UT Southwestern Medical Center UT Southwestern Medical Center researchers find that an FDA-approved drug to treat high blood pressure seems to extend life span in worms via a cell signaling pathway that may mimic caloric restriction. The drug, hydralazine, extended life span about 25 percent in two strains of C. elegans […]Continue Reading ...
Credit: Salk Institute The experimental drug J147 is something of a modern elixir of life; it’s been shown to treat Alzheimer’s disease and reverse aging in mice and is almost ready for clinical trials in humans. Now, Salk scientists have solved the puzzle of what, exactly, J147 does. In a paper published January 7, 2018, […]Continue Reading ...
Conceptual image of Thor’s hammer. Credit: Ella Maru Studio, Inc. and Yashar Niknafs It turns out Thor, the Norse god of thunder and the Marvel superhero, has special powers when it comes to cancer too. Researchers at the University of Michigan Comprehensive Cancer Center uncovered a novel gene they named THOR while investigating previously unexplored […]Continue Reading ...
A depiction of the double helical structure of DNA. Its four coding units (A, T, C, G) are color-coded in pink, orange, purple and yellow. Credit: NHGRI A team of Massachusetts General Hospital (MGH) researchers has identified a specific genetic change that may be the cause of a rare but severe neurological disorder called X-linked […]Continue Reading ...
Ewelina Mamcarz, M.D., presents research at the 2017 ASH conference that indicates that the St. Jude XSCID gene therapy has been well tolerated and effective for infants as young as 2 months old. Credit: Peter Barta / St. Jude Children’s Research Hospital. Early evidence suggests that gene therapy developed at St. Jude Children’s Research Hospital […]Continue Reading ...
Credit: National Cancer Institute (Medical Xpress)—A large team of researchers from the U.S. and Canada has conducted a randomized double-blind study of the effectiveness of an HIV vaccine and has found it to be ineffective in suppressing the virus. In their paper published in Science Translational Medicine, the group describes the study, what they found […]Continue Reading ...
A normal mouse muscle fiber (top left) is contrasted with a muscle fiber from a mouse model of Duchenne muscular dystrophy (bottom right). In normal mice, stem cells (pink) express dystrophin (green) and are able to easily generate new muscle fibers, but in the disease model, there is no dystrophin and the stem cells lose […]Continue Reading ...
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