The image represents the first proof of principle for the successful regeneration of a functional organ (the skin) inside a mammal, by a technique known as AAV-based in vivo reprogramming. Epithelial (skin) tissues were generated by converting one cell type (red: mesenchymal cells) to another (green: basal keratinocytes) within a large ulcer in a laboratory […]Continue Reading ...
Bo Håkansson, Professor of Electrical Engineering, undergoes testing using the new compact vibrating device he and the team helped design. . Credit: Chalmers University of Technology Half of over-65s suffer from dizziness and problems with balance. But some tests to identify the causes of such problems are painful and can risk hearing damage. Now, researchers from […]Continue Reading ...
Lack of dysferlin is associated with increased lipid mobility in the limb girdle muscular dystrophy type 2B (LGMD2B) cell membrane, which is further increased by injury and prednisolone treatment, causing failure of these cells to undergo repair. By contrast, vamorolone treatment stabilizes the LGMD2B muscle cell membrane to near healthy cell level, enabling repair of […]Continue Reading ...
Credit: CC0 Public Domain Even with an acute sense of hearing adults don’t always pick up exactly what someone has said. That’s because from childhood to adulthood we rely on vision to understand speech and this can influence our perception of sound. A study, carried out by Rebecca Hirst, a Ph.D. student in the School […]Continue Reading ...
The preprogrammed mechanism of bone formation a) primary ossification (embryonic) b) secondary ossification (postnatal). Credit: Bone Research, doi: 10.1038/s41413-018-0021-z Cell differentiation is a widely studied phenomenon forming the basis of all developmental processes including fetal growth and bone fracture healing. A series of recent studies indicates the emerging role of chondrocyte-to-osteoblast transdifferentiation during bone tissue […]Continue Reading ...
Researchers studying infertility in obese female mice found dramatically lower levels of a protein called TIGAR, which controls redox metabolism. When they reduced TIGAR levels from healthy oocytes by RNA interference (shown above), many cells showed disruptions in meiosis, either dividing symmetrically instead of asymmetrically (pink stars) or failing to divide (blue arrows). Credit: Wang […]Continue Reading ...
Salk scientists find that common dietary elements cure lethal infections, eliminating the need for antibiotics. From left: (front) Yujung Lee and Karina Sanchez; (back) Janelle Ayres, Samuel Redford, Grischa Chen and Alexandria Palaferri Schieber Credit: Salk Institute Antibiotic use is driving an epidemic of antibiotic resistance, as more susceptible bacteria are killed but more resilient […]Continue Reading ...
The in-lab 3D printing system: a) the mechanical-extrusion system developed in-house mounted to the multi-arm bioprinter, b) thermal images obtained during the extrusion deposition with FLIR (forward looking infrared) camera to detect the temperature range during polymer fabrication. Credit: Journal of Materials Research (2018). DOI: 10.1557/jmr.2018.111 When skeletal defects are unable to heal on their […]Continue Reading ...
Human chromosomes (grey) capped by telomeres (white). Credit: PD-NASA; PD-USGOV-NASA People with a form of heart disease called cardiomyopathy have abnormally short telomeres in heart muscle cells responsible for contraction, according to a new study by researchers at the Stanford University School of Medicine. A telomere is a DNA sequence that serves as a protective […]Continue Reading ...
An extract of camu camu—a fruit native to the Amazon—prevents obesity in mice fed a diet rich in sugar and fat, say researchers at Université Laval and the Quebec Heart and Lung Institute Research Centre. The discovery, which was recently published in the scientific journal Gut, suggests that camu camu phytochemicals could play a leading […]Continue Reading ...
Three of the head and neck alignments modeled by the researchers (with hits simulated at the red dot) shows how small differences affect angular acceeration, also called rotational acceleration. Greater angular acceleration increases the likelihood of concussion. Credit: Michael Fanton If you’re about to run headfirst into something, your reflex might be to tense your […]Continue Reading ...
Credit: CC0 Public Domain What’s the secret to aging well? University of Minnesota Medical School researchers have answered it- on a cellular level. Aging starts in our cells, and those aging cells can hasten cellular senescence, leading to tissue dysfunction and related health impacts. New research involving University of Minnesota Medical School faculty Paul D. […]Continue Reading ...
3D bioplotted scaffolds for applications in bone tissue engineering (BTE). Credit: Open Biomedical Initiative, European bioprinting program. Doi: 10.1088/1758-5090/aad36d Bone tissue engineering (BTE) is a developing field in materials science and bioengineering, in which researchers aim to engineer an ideal, bioinspired material to promote assisted bone repair. Since experimental strategies are yet to translate from […]Continue Reading ...
David Porciani and his team demonstrated that specialized nucleic acid-based nanostructures could be used to target cancer cells while bypassing normal cells. Credit: Erica Overfelt, Bond Life Sciences Center More than 100 years ago, German Nobel laureate Paul Ehrlich popularized the “magic bullet” concept—a method that clinicians might one day use to target invading microbes […]Continue Reading ...
Brown adipose tissue in a woman shown in a PET/CT exam. Credit: Public Domain Abundant in human babies and small mammals, brown adipose tissue (BAT), or brown fat, was only recently discovered in human adults, and its role remains unclear. Known to play an integral part in generating body heat and burning stored energy, its […]Continue Reading ...
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