Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia A new way to examine stress and inflammation in the heart will help Parkinson’s researchers test new therapies and explore an unappreciated way the disease puts people at risk of falls and hospitalization. By the […]Continue Reading ...
Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia A new study, published today in Nature Structural and Molecular Biology, moves researchers closer to understanding one of the crucial proteins involved in Parkinson’s disease. Parkinson’s disease is the second most common neurodegenerative disease and […]Continue Reading ...
Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia Deep brain stimulation (DBS) may slow the progression of tremor for early-stage Parkinson’s disease patients, according to a Vanderbilt University Medical Center study released in the June 29 online issue of Neurology, the medical journal […]Continue Reading ...
A crew are rowing across the Indian Ocean to shake up our understanding of Parkinson’s disease—and break a world record while they’re at it. For people with Parkinson’s disease, exercise is prescribed to treat the symptoms most commonly associated with the condition. The muscle tremors, cramps and gait issues that characterise the disease appear to […]Continue Reading ...
A multidisciplinary team of researchers at Purdue University and the University of Bordeaux in France has received a grant from The Michael J. Fox Foundation for Parkinson’s Disease to study a new gene associated with Parkinson’s disease, which was linked to the disease using novel big data methodologies. The findings from this research could potentially […]Continue Reading ...
In the first study of its kind, researchers from the New York-based Human Microbiology Institute have discovered the role certain bacteriophages may play in the onset of Parkinson’s disease (PD). The research is presented at ASM Microbe, the annual meeting of the American Society for Microbiology, held from June 7th to June 11th in Atlanta, […]Continue Reading ...
A study involving scientists from the University of Alicante and the United States notes that the accumulation of a protein known as alpha-synuclein in the retina is a key Parkinson’s biomarker that could help detect the degree of severity of the disease. The work has been published this month in Movement Disorders, a journal in […]Continue Reading ...
Nerve cells (purple) grown from stem cells derived from Parkinson’s patients. The nuclei are colored blue and the mitochondria green. Credit: Deleidi Unsteady hands, stiff muscles and slow movements – all these are typical symptoms of Parkinson’s disease. Some 220,000 people in Germany are affected by the disease, which becomes more likely to occur as […]Continue Reading ...
Cross section of an alpha-synuclein fibril. Left: 3D reconstruction of the fibril, showing two interacting protein molecules. Right: atomic model of the fibril structure. Credit: Universität Basel Parkinson’s disease was first described by a British doctor more than 200 years ago. The exact causes of this neurodegenerative disease are still unknown. In a study recently […]Continue Reading ...
Credit: CC0 Public Domain Systemic treatment of animal models with israpidine, a calcium channel inhibitor, reduced mitochondrial stress that might cause Parkinson’s disease, according to a Northwestern Medicine study published in the Journal of Clinical Investigation. These findings bode well for the STEADY-PD III study, a nationwide clinical trial testing isradipine in patients at Northwestern […]Continue Reading ...
Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia Over time, half of the people taking certain drugs for Parkinson’s disease may develop impulse control disorders such as compulsive gambling, shopping or eating, according to a study published in the June 20, 2018, online […]Continue Reading ...
Dr. Hugo Bellen. Credit: Baylor College of Medicine Researchers at Baylor College of Medicine and Texas Children’s Hospital have identified unexpected new key players in the development of an early onset form of Parkinson’s disease called Parkinsonism. These key players are ceramides, a family of lipid molecules that are found within cell membranes. The researchers […]Continue Reading ...
Credit: The Francis Crick Institute Detailed brain cell analysis has helped researchers uncover new mechanisms thought to underlie Parkinson’s disease. The study, published in Nature Communications, adds to our growing understanding of the causes of Parkinson’s and other neurodegenerative diseases, and could influence drug design in the future. For years, scientists have known that Parkinson’s […]Continue Reading ...
Credit: Universidad de Barcelona An international team has designed the first potentially therapeutic photoactive drug, MRS7145, to fight Parkinson’s disease, according to the new article in Journal of Controlled Release. This compound, which proved effective in laboratory animals in vivo, has been carried out by a team led by Francisco Ciruela, from the Faculty of […]Continue Reading ...
Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia A team of researchers at VIB and KU Leuven has uncovered why people with a hereditary form of Parkinson’s disease suffer from sleep disturbances. The molecular mechanisms uncovered in fruit flies and human stem cells […]Continue Reading ...
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