Image shows the DNMT3A-DNA complex. A research team led by Jikui Song cracked the crystal structure for DNMT3A-DNA complex. The structure reveals that DNMT3A molecules attack two substrate sites adjacent to each other on the same DNA molecule. DNMT3L (green) is a regulatory protein of DNMT3A. Bp (base pairs) is a unit of length, with […]Continue Reading ...
Special Issue: Seniors Print this issue Take Care of Yourself While Caring for Others It can be a labor of love, and sometimes a job of necessity. Millions of Americans provide unpaid care for someone with a serious health condition each year. These often-unsung heroes provide hours of assistance to others. Yet the stress and […]Continue Reading ...
A new study published today found that a newly discovered gene helps grow blood vessels when it senses inadequate blood flow to tissues. The research was led by Dr. Philip Marsden (photo), a clinician scientist in the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, and Dr. Jeffrey Man, a researcher in his […]Continue Reading ...
In these two microscopy images, human islets (the source of insulin cells) were poisoned with a drug to remove the insulin cells, and then treated with either an empty virus (left panel) or the therapeutic virus (right panel), and then grown in a diabetic mouse. The green staining on the right reflects abundant insulin cell […]Continue Reading ...
A bomb scare delays her flight, she’s struggling with Swahili, and the rainy season has swept away the bridges that Médecins Sans Frontières (MSF) uses to reach the remote hospital in the Democratic Republic of Congo. These are just the first challenges Swedish physician Ida Moberg, MD, faces on her first assignment with MSF. I […]Continue Reading ...
Presentation Case Findings: A 20-year-old man went to the doctor complaining of a fever. He had been hiking recently with friends and had gotten a significant number of insect bites, which he had been scratching non-stop – particularly one on his hand, which had become quite red. An erythematous rash in a linear configuration had […]Continue Reading ...
Prof. Dr. Eicke Latz and Dr. Anette Christ from the Institute for Innate Immunity of the University of Bonn investigated this question in a study. Credit: Volker Lannert/Uni Bonn The immune system reacts similarly to a high fat and high calorie diet as to a bacterial infection. This is shown by a recent study led […]Continue Reading ...
HIV-infected H9 T cell. Credit: NIAID A first-of-its-kind study has found that the genetic diversity of human immunodeficiency virus type 1 (HIV-1) is higher in the vaginal tract than in the blood stream during early infection. This finding, published in PLOS Pathogens, supports the existence of a genetic bottleneck between the vaginal tract and the […]Continue Reading ...
Credit: CC0 Public Domain Say you’re the coach of a basketball team that’s trailing by two points in the dying seconds of a game. Your team has the ball and you call a timeout to set up a play. Or imagine your football team has just scored a touchdown with three seconds to play to […]Continue Reading ...
If you get regular exercise—and especially if you’re an athlete and compete in sporting events—you know that a nutritionally adequate diet and plenty of fluids are important for maximizing your physical performance. But you may wonder if dietary supplements could help you train harder, improve performance, or gain a competitive edge. This fact sheet describes […]Continue Reading ...
The image here represents a mosaically labeled embryonic heart. Each colored patch is derived from the early labeling of a cardiac progenitor cell expressing the key gene Mesp1. Credit: Fabienne Lescroart Researchers at the Université libre de Bruxelles and University of Cambridge identified the role of key gene Mesp1 in the earliest step of cardiovascular […]Continue Reading ...
Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia Parkinson’s disease is a progressive disorder of the nervous system that affects movement. It develops gradually, sometimes starting with a barely noticeable tremor in just one hand. But while a tremor may be the most […]Continue Reading ...
Saint Augustine called patience the companion of wisdom, but did he ever treat an argumentative rosacea patient who wants to bring her drooling Chihuahua into the exam room for comfort? Or did he ever juggle a full-time career with the physical and emotional needs of a spouse and children? Or balance both a medical practice […]Continue Reading ...
Just sign here. How many times a day are we asked to do this? “Just sign here.” “Just put down your license number.” “We need a stamp with your doctor’s info on it.” “Give us your NPI.” “Initial here, here, and here.” If we took the time to read all the things we’re signing, we […]Continue Reading ...
Doctoral students Alan Chiu, left, and Duo An hold a sample of TRAFFIC (Thread-Reinforced Alginate Fiber for Islets enCapsulation). In the background, left to right, are Minglin Ma, Dan Luo, Meredith Silberstein and Dr. James Flanders. Credit: Cornell University For the more than 1 million Americans who live with type 1 diabetes, daily insulin injections […]Continue Reading ...
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- NeuroTrauma Sciences and Henry Ford join hands to advance exosome technology
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