July 12, 2018 Supplementing a single protein found in the spinal cord could help prevent symptoms of Lou Gehrig’s disease, according to a new study out of Case Western Reserve University School of Medicine. Researchers found high levels of the protein–called mitofusion 2 or Mfn2–prevented nerve degeneration, muscle atrophy, and paralysis in a mouse model […]Continue Reading ...
ALS patient motor neurons obtained through optopatch recordings. Credit: Northwestern University Northwestern Medicine scientists have discovered that some neurons affected by amyotrophic lateral sclerosis (ALS) display hypo-excitability, using a new method to measure electrical activity in cells, according to a study published in Stem Cell Reports. “The excitability changes observed in these patient neurons most […]Continue Reading ...
June 21, 2018 Aquinnah Pharmaceuticals, leaders in stress granule biology, an exciting new target for the development of neurodegenerative therapeutics, announced today that it has been awarded $3.4 million from the National Institute of Neurological Disorders and Stroke (NINDS) in a competing grant to advance novel therapeutic drug candidates towards the clinic for treating patients […]Continue Reading ...
May 23, 2018 Scientists have just discovered that a small region of a cellular protein that helps long-term memories form also drives the neurodegeneration seen in Amyotrophic Lateral Sclerosis (ALS). This small part of the Ataxin-2 protein thus works for good and for bad. When a version of the protein lacking this region was substituted […]Continue Reading ...
May 23, 2018 A new Tel Aviv University study identifies a previously unknown mechanism involved in the development of Lou Gehrig’s disease, or amyotrophic lateral sclerosis (ALS). The research focuses on a specific microRNA whose levels were found to decrease as a result of ALS-causing muscular mutations. The study highlights, for the first time, the […]Continue Reading ...
Credit: CC0 Public Domain The largest analysis to date of genetic data in amyotrophic lateral sclerosis (ALS) – the muscle-crippling neurodegenerative disease that afflicted the late astrophysicist Stephen Hawking and cut short the career of iconic Yankee baseball slugger Lou Gehrig – has identified two previously unrecognized genetic risks that are significantly associated with the […]Continue Reading ...
April 17, 2018 Scientists at the UNC School of Medicine have made a significant advance in the understanding of the complex and fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease. Autopsy studies of ALS patients often reveal the accumulation of large, fibrous aggregates of a protein called SOD1 in disease-affected […]Continue Reading ...
An MRI with increased signal in the posterior part of the internal capsule which can be tracked to the motor cortex consistent with the diagnosis of ALS. Credit: Frank Gaillard/Wikipedia In a new application of gene-editing technology, researchers at the Stanford University School of Medicine have gleaned insights into the genetic underpinnings of amyotrophic lateral […]Continue Reading ...
An MRI with increased signal in the posterior part of the internal capsule which can be tracked to the motor cortex consistent with the diagnosis of ALS. Credit: Frank Gaillard/Wikipedia Recent research from Houston Methodist Hospital showed that a new immunotherapy was safe for patients with ALS and also revealed surprising results that could bring […]Continue Reading ...
MONDAY, June 4, 2018 — A new immunotherapy appears to be well tolerated and possibly of benefit in patients with amyotrophic lateral sclerosis (ALS), according to a phase 1, first-in-human study published online May 18 in Neurology: Neuroimmunology & Neuroinflammation. Jason R. Thonhoff, M.D., Ph.D., from the Houston Methodist Neurological Institute, and colleagues assessed the […]Continue Reading ...
May 25, 2018 As the old adage goes, ‘two heads are better than one’. With the development of new technologies and increasingly specialist expertise, ground-breaking science needs to be a team effort. But it isn’t always easy for researchers to work together. Finding the right people to collaborate with can be tricky, especially when some […]Continue Reading ...
May 21, 2018 Recent research from Houston Methodist Hospital showed that a new immunotherapy was safe for patients with ALS and also revealed surprising results that could bring hope to patients who have this relentlessly progressive and fatal disease. Amyotrophic lateral sclerosis, commonly known as ALS or Lou Gehrig’s disease, is a nervous system disorder […]Continue Reading ...
April 16, 2018 Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease damaging motor neurons in brain and spinal cords. ALS patients show progressive muscle weakness and atrophy, leading to a fatal respiratory muscle paralysis. There are no effective therapies for ALS. There are compelling evidence that glial and immune cells contribute to the progression of […]Continue Reading ...
April 9, 2018 Nearly half of all patients with amyotrophic lateral sclerosis (ALS), a fatal neuromuscular disorder, develop cognitive problems that affect memory and thinking. Why a disease that primarily affects movement also disrupts thinking has been unclear. But now, an international team of researchers has identified genetic links between ALS and frontotemporal dementia, a […]Continue Reading ...
March 22, 2018 New research into Amyotrophic Lateral Sclerosis (ALS) – also known as motor neuron disease – shows that specific immune cells may help slow progression of the disease, an important step towards developing new therapies to treat patients. The research team investigated the relationship between T-cells and the progression of ALS. The human […]Continue Reading ...
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