A new program at Columbia is looking for earlier signs of ALS so that future treatments can be delivered before extensive neurological damage occurs.Continue Reading ...
Virginia Tech Carilion Research Institute scientists have shown that mutations in specific genes that destroy motor neurons and thereby cause the devastating effects of amyotrophic lateral sclerosis– also known as ALS or Lou Gehrig’s disease — also attack sensory neurons. The discovery in today’s (Thursday, Nov. 8) Scientific Reports indicates that studying sensory neurons could […]Continue Reading ...
Brown University researchers have uncovered new clues about the progression of Amyotrophic Lateral Sclerosis (ALS), a surprisingly common disease that causes the death of motor neurons that control voluntary muscles such as those involved in walking, talking, chewing or breathing. A team led by Anne Hart, a professor of neuroscience at Brown, discovered that two […]Continue Reading ...
A mechanism for how the disease ALS evolves has been discovered at Umeå University, Sweden. The discovery concerns how proteins with a defect structure spread the deformation to other proteins. This according to results in a new thesis. The discovery can open up for novel pharmaceutical developments in the future. “We’ve been able to identify […]Continue Reading ...
August 20, 2018 ALS — amyotrophic lateral sclerosis — is a neurodegenerative disease that attacks motor neurons in the brain and spinal cord, slowly robbing its victims of their ability to walk, talk, breathe and swallow. In a cruel twist, some ALS patients also develop frontotemporal dementia, a disease that destroys an entirely different set […]Continue Reading ...
Robert Bucelli, MD, PhD, measures Gregory Easter’s neuromuscular function. Easter, who has an inherited form of amytrophic lateral sclerosis, a fatal neuromuscular disease, is taking part in a clinical trial to evaluate an experimental drug. New research at Washington University School of Medicine in St. Louis shows the drug extends survival and reverses some neuromuscular […]Continue Reading ...
July 12, 2018 Supplementing a single protein found in the spinal cord could help prevent symptoms of Lou Gehrig’s disease, according to a new study out of Case Western Reserve University School of Medicine. Researchers found high levels of the protein–called mitofusion 2 or Mfn2–prevented nerve degeneration, muscle atrophy, and paralysis in a mouse model […]Continue Reading ...
An MRI with increased signal in the posterior part of the internal capsule which can be tracked to the motor cortex consistent with the diagnosis of ALS. Credit: Frank Gaillard/Wikipedia Recent research from Houston Methodist Hospital showed that a new immunotherapy was safe for patients with ALS and also revealed surprising results that could bring […]Continue Reading ...
The normal function of a gene associated with the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) has been determined for the first time by University of Bath scientists. Both ALS, the most common form of motor neurone disease, and FTD progressively develop in adults and have been shown to be closely linked, […]Continue Reading ...
ITF Pharma Announces FDA Approval of Tiglutik (riluzole) Oral Suspension for the Treatment of Amyotrophic Lateral Sclerosis (ALS) BERWYN, Pa., Sept. 6, 2018 /PRNewswire/ — ITF Pharma, a U.S.-based specialty pharmaceutical company and a subsidiary of Italfarmaco, a privately-held European specialty pharmaceutical company, committed to investing in and commercializing impactful medicines in therapeutic areas with […]Continue Reading ...
Copenhagen, August 10, 2018 – Orphazyme A/S, a biopharmaceutical company dedicated to developing treatments for patients living with rare diseases, today announced that the first patient has received the first dose in its Phase III clinical trial of arimoclomol for Amyotrophic Lateral Sclerosis (ALS). Thomas Blaettler, Chief Medical Officer, said: “The enrollment of the first […]Continue Reading ...
July 27, 2018 NIH-funded researchers delayed signs of amyotrophic lateral sclerosis (ALS) in rodents by injecting them with a second-generation drug designed to silence the gene, superoxide dismutase 1 (SOD1). The results, published in the Journal of Clinical Investigation, suggest the newer version of the drug may be effective at treating an inherited form of […]Continue Reading ...
July 19, 2018 The mutated and aggregated protein FUS is implicated in two neurodegenerative diseases: amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Using a newly developed fruit fly model, researchers led by prof. Ludo Van Den Bosch (VIB-KU Leuven) have zoomed in on the protein structure of FUS to gain more insight into […]Continue Reading ...
ALS patient motor neurons obtained through optopatch recordings. Credit: Northwestern University Northwestern Medicine scientists have discovered that some neurons affected by amyotrophic lateral sclerosis (ALS) display hypo-excitability, using a new method to measure electrical activity in cells, according to a study published in Stem Cell Reports. “The excitability changes observed in these patient neurons most […]Continue Reading ...
June 21, 2018 Aquinnah Pharmaceuticals, leaders in stress granule biology, an exciting new target for the development of neurodegenerative therapeutics, announced today that it has been awarded $3.4 million from the National Institute of Neurological Disorders and Stroke (NINDS) in a competing grant to advance novel therapeutic drug candidates towards the clinic for treating patients […]Continue Reading ...
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