Toxic amyloid plaques (red) and tau tangles (brown) form on the brain of a mouse modeled to have Alzheimer’s disease. A study shows a DNA vaccine reduces both amyloid and tau in the mouse AD model, with no adverse immune responses. Credit: UT Southwestern A DNA vaccine tested in mice reduces accumulation of both types […]Continue Reading ...
Credit: CC0 Public Domain Some neurons in the brain protect themselves from Alzheimer’s with a cellular cleaning system that sweeps away toxic proteins associated with the disease, according to a new study from Columbia University and the University of Cambridge. The study, led by neuroscientist Karen Duff, Ph.D., of Columbia University Vagelos College of Physicians […]Continue Reading ...
An interview with Dr. Lloyd Tran from NeuroActiva, discussing the major barriers to Alzheimer’s research and development over the past 40 years, and how the IUFAA are working to overcome these challenges. Why have so many Alzheimer’s drugs failed in the past 40 years? It has now been 112 years since Dr. Alois Alzheimer first […]Continue Reading ...
Researchers at the University of California, San Francisco, have used PET scans to train a machine-learning algorithm to detect early-stage Alzheimer’s disease. James Steidl | Shutterstock The algorithm was able to detect the condition about six years before it was clinically diagnosed. Given that drugs are available that can help stem Alzheimer’s progression if it […]Continue Reading ...
Incorporating genetic diversity into a mouse model of Alzheimer’s disease resulted in greater overlap with the genetic, molecular and clinical features of this pervasive human disease, according to a study funded by the National Institute on Aging (NIA), part of the National Institutes of Health. The study also suggests that adding genetic diversity may be […]Continue Reading ...
Findings could lead to early diagnosis, better treatment studies An ultrasensitive test has been developed that detects a corrupted protein associated with Alzheimer’s disease and chronic traumatic encephalopathy (CTE), a condition found in athletes, military veterans, and others with a history of repetitive brain trauma. This advance could lead to early diagnosis of these conditions […]Continue Reading ...
UT Southwestern researchers have succeeded in neutralizing what they believe is a primary factor in late-onset Alzheimer’s disease, opening the door to development of a drug that could be administered before age 40, and taken for life, to potentially prevent the disease in 50 to 80 percent of at-risk adults. Apolipoprotein E (ApoE) is a […]Continue Reading ...
A new study shows how cellular “housekeeping” protects some neurons against the toxic proteins of Alzheimer’s disease and suggests new treatment possibilities.Continue Reading ...
WEDNESDAY, Jan. 9, 2019 — Poor sleep is common among Alzheimer’s patients, and researchers say they’re beginning to understand why. Scientists studied 119 people aged 60 and older. Eighty percent had no thinking or memory problems, while the rest had only mild problems. The researchers found that participants with less slow-wave sleep — deep sleep […]Continue Reading ...
Genetic data supported the contention that a particular way of sorting people resulted in biologically coherent subgroups (pictured lower right). Credit: University of Washington School of Medicine Researchers studying Alzheimer’s disease have created an approach to classify patients with Alzheimer’s disease, a finding that may open the door for personalized treatments. “Alzheimer’s, like breast cancer, […]Continue Reading ...
Neurofibrillary tangle in brainstem. Credit: Grinberg Lab / UCSF. UC San Francisco researchers, in collaboration with the unique Brazilian Biobank for Aging Studies (BBAS) at the University of São Paulo, have shown that the earliest stages of the brain degeneration associated with Alzheimer’s disease (AD) are linked to neuropsychiatric symptoms including anxiety, depression, loss of appetite, and […]Continue Reading ...
In Florida, there are more than 540,000 people living with Alzheimer’s disease (AD), the most recognized form of dementia. The number of people in Florida who are age 65 and older with AD is expected to increase 41.2 percent by 2025 to a projected 720,000, highlighting the urgency of finding medical and treatment breakthroughs. Research […]Continue Reading ...
Research on toxic proteins could drive treatment strategies Better tactics for detecting, preventing and treating Alzheimer’s disease depend on a clearer understanding of cellular-level changes in the minds of patients, and a new study has uncovered novel details about the vulnerability of one type of brain cell. Researchers found that excitatory neurons – those that […]Continue Reading ...
Β-amyloid formation, an indicative element of Alzheimer’s disease (AD), is a consequence of alternative expression of enzymes involved in the cleavage of amyloid precursor protein (APP), leading to dementia in elderly populations. A comprehensive genomic study was conducted by Dr. Wongchitrat et al. to investigate the peripheral blood markers of Alzheimer’s disease. Blood samples were […]Continue Reading ...
Credit: CC0 Public Domain USC scientists say Alzheimer’s could be diagnosed earlier if scientists focus on an early warning within the brain’s circulation system. That’s important because researchers believe that the earlier Alzheimer’s is spotted, the better chance there is to stop or slow the disease. “Cognitive impairment, and accumulation in the brain of the […]Continue Reading ...
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