Type 1 diabetes starts out as a sneak attack. For unknown reasons, the immune system makes antibodies against insulin and other proteins in the insulin-producing islet cells in the pancreas, targeting these healthy cells for destruction. Clinical trials have suggested that, if the attack is stopped early with immune-modulating therapies, full-blown type 1 diabetes might […]Continue Reading ...
Researchers from the National Institutes of Health have discovered that antibodies that may form the basis of a universal flu vaccine inhibit a second viral protein in addition to the one that they bind. The study, to be published January 25 in the Journal of Experimental Medicine, reveals that antibodies that recognize the viral surface […]Continue Reading ...
Credit: CC0 Public Domain HIV evades the body’s immune defenses through a multitude of mutations, and antibodies produced by the host’s immune system to fight HIV also follow convoluted evolutionary pathways that have been challenging to track. This complexity has made it difficult for researchers to develop a preventive HIV vaccine that elicits effective antibodies […]Continue Reading ...
Using DNA origami – DNA-based design of precise nanostructures – scientists at Karolinska Institutet in collaboration with researchers at University of Oslo, have been able to demonstrate the most accurate distance between densely packed antigens in order to get the strongest bond to antibodies in the immune system. The study, which is published in the […]Continue Reading ...
Researchers have generated six Zika virus antibodies that could be used to test for and possibly treat a mosquito-borne disease that has infected more than 1.5 million people worldwide. The antibodies “may have the dual utility as diagnostics capable of recognizing Zika virus subtypes and may be further developed to treat Zika virus infection,” corresponding […]Continue Reading ...
Marina Caskey, a researcher who is part of a new clinical trial that shows that broadly neutralizing antibodies can suppress HIV for up to four months, far longer than currently available drugs. Credit: Mario Morgado/The Rockefeller University Thanks to improvements in antiretroviral therapy, HIV is now a manageable condition. Yet even the best drugs do […]Continue Reading ...
Levels of antiphospholipid antibodies, which are associated with rheumatic diseases, are also elevated in myocardial infarction without any autoimmune co-morbidity, a study from Karolinska Institutet in Sweden published in The Annals of Internal Medicine reports. Antiphospholipid antibodies (aPL) are a group of antibodies that target endogenous tissue, including the fat molecule cardiolipin and the plasma […]Continue Reading ...
An antibody (dark grey) is binding to an HIV envelope protein (coloured) on the surface of the virus (light grey). Credit: University of Zurich Around one percent of people infected with HIV produce antibodies that block most strains of the virus. These broadly acting antibodies provide the key to developing an effective vaccine against HIV. […]Continue Reading ...
An interview with Tina Stoschek and Marcus Gerlach, discussing maximizing monoclonal antibody generation using lab-scale clarification of mammalian cell cultures expressing recombinant antibodies. Monoclonal antibodies are increasingly important as targeted therapeutics. Please give an overview of this industry and the challenges faced when producing these antibodies at scale. The production of monoclonal antibodies in varying […]Continue Reading ...
An interview with Dr. Dave Fancy from Jackson ImmunoResearch at SfN 2018, discussing the use of secondary antibodies in neurobiology and the future of nanobodies. How are secondary antibodies used in neurobiology? Neuroscientists have been using secondary antibodies for years. They are generally used to provide or amplify the signal from a primary antibody bound […]Continue Reading ...
Jan 11 2019 Published in the Peer-Reviewed Journal mAbs, the Paper Introduces Complex-Specific Antibodies for Pharmacokinetic Analysis of Biotherapeutics Bio-Rad Laboratories, Inc., a global leader of life science research and clinical diagnostic products, has published new findings on the generation and characterization of drug-target complex-specific antibodies for pharmacokinetic (PK) analysis of biotherapeutics. The paper published […]Continue Reading ...
An interview with Eugenia Kuteeva conducted at SfN 2018, by Alina Shrourou, BSc. How can Neuroscience markers be used to advance our understanding of the brain? Neuroscience markers are monoclonal antibodies, developed for identification of the main anatomical and histochemical cell types in the central nervous system. They can therefore be used as markers of […]Continue Reading ...
Scientists investigating how the human immune system defends against malaria have uncovered a rare phenomenon: antibodies working together to bind to a vulnerable spot on the parasite. The new research, published recently in Science Advances, shows that antibodies working together can result in a protein on the parasite’s cell surface locking it into a spiral […]Continue Reading ...
The National Institute of General Medical Sciences of NIH has awarded a Small Business Innovative Research grant to Allele Biotechnology and Pharmaceuticals to develop new single-domain nanoantibody (nAb) therapies for the treatment of sepsis. Sepsis and septic shock are among the leading causes of death in intensive care units (ICUs). The global incidence of sepsis […]Continue Reading ...
IONTAS Limited (IONTAS), a leader in the discovery and optimisation of fully human antibodies, today announced a collaborative paper published in Nature Communications with the Technical University of Denmark, and the Instituto Clodomiro Picado of the University of Costa Rica describing the development of a panel of human antibodies that neutralise elements of black mamba […]Continue Reading ...
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