Led by ICREA research professors at the Centre for Genomic Regulation, Luciano Di Croce and Marc A. Marti-Renom, the study focused on a set of genes with what’s known as bivalent promoters – two-way genetic ‘control switches’ that are poised either to turn on in early development and rapidly drive high levels of gene activity, […]Continue Reading ...
A new cell culture platform allows researchers to observe never-before-seen behaviors of live cancer cells under the microscope, leading to explanations of long-known cancer characteristics. The easy-to-produce platform developed by Hokkaido University researchers offers cancer cells micro-scale attachment sites that elicit never-before-seen behaviors highly relevant to cancer’s clinical properties. The observation of these behaviors shed […]Continue Reading ...
Drinking green tea has been linked to health benefits ranging from cardiovascular disease prevention to weight loss. Although many of these claims still need to be verified in the clinic, an antioxidant in green tea called epigallocatechin gallate (EGCG) appears to have beneficial effects in cells and animals. Now, researchers have found a surprising use […]Continue Reading ...
An international team of researchers has successfully deployed a Zika virus vaccine to target and kill human glioblastoma brain cancer stem cells, which had been transplanted into mice. In a study published this week in mBio®, an open-access journal of the American Society for Microbiology, the team shows that a live, attenuated version of the […]Continue Reading ...
With age, expression of a small molecule that can silence others goes way up while a key signaling molecule that helps stem cells make healthy bone goes down, scientists report. They have the first evidence in both mouse and human mesenchymal stem cells that this unhealthy shift happens, and that correcting it can result in […]Continue Reading ...
The image represents the first proof of principle for the successful regeneration of a functional organ (the skin) inside a mammal, by a technique known as AAV-based in vivo reprogramming. Epithelial (skin) tissues were generated by converting one cell type (red: mesenchymal cells) to another (green: basal keratinocytes) within a large ulcer in a laboratory […]Continue Reading ...
Macrophages are not just the vacuum cleaners of the immune system. They also support other cells. These long-lived macrophages in the intestines of mice (in green) make contact with the nerve cells of the gastrointestinal tract (in red). The macrophages provide growth factors for the nerve cells. The nerve cells die off without the macrophages. […]Continue Reading ...
Researchers from the University of Luxembourg have discovered a molecular mechanism that is responsible for the spread of cancer cells in the body and the development of metastases in patients with colon cancer. Their findings could help to develop treatments that inhibit tumor growth. Colorectal cancer (CRC) is among the most prevalent cancer types worldwide, […]Continue Reading ...
Studying the fundamental aspects of biology can sometimes lead to unexpected findings that directly relate to human disease. In one of the latest examples of scientific serendipity, researchers from the Salk Institute found that an important quality control mechanism in baker’s yeast is closely connected to hypomyelinating leukodystrophy, a debilitating disease found in children. The […]Continue Reading ...
The body’s immune system is a valiant weapon against disease, and harnessing its power through a technique called immunotherapy is at the forefront of current research to treat cancer and other diseases. That’s why an unexpected finding by University of Notre Dame researchers and their collaborators, related to the way two distinctively different peptide antigens […]Continue Reading ...
Recombinant proteins can be produced using many types of cells including, yeast, bacteria, insect and mammalian cells. What advantages are there to producing recombinant proteins using mammalian cells over others? In many cases mammalian cells are the only option to produce recombinant proteins with correct post-translational modifications, e.g. glycosylation, which are required for proper function […]Continue Reading ...
At right, a close-up of mouse brain tissue shows an engineered protein (stained green) being expressed by astrocytes, but no other cells. UCLA scientists used this technique to selectively silence astrocytes to explore their roles in mouse behavior. Credit: UCLA Health Repetitive behavior disorders are relatively common. One of the best known in this family […]Continue Reading ...
Killer T cells surround a cancer cell. Credit: NIH Scientists at the VIB-UGent Center for Medical Biotechnology have taken important steps toward the development of cancer-targeting immunotherapy. The research team developed a treatment in mice that destroys part of the tumor and stimulates the immune system to attack persistent surviving cancer cells. In addition, the […]Continue Reading ...
Research has shed new light on genetic processes that may one day lead to the development of therapies that can slow, or even reverse, how our cells age. A study led by the University of Exeter Medical School has found that certain genes and pathways that regulate splicing factors – a group of proteins in […]Continue Reading ...
New research suggests that obesity changes how airway muscles function, increasing the risk of developing asthma. The study is published ahead of print in the American Journal of Physiology–Lung Cellular and Molecular Physiology. The prevalence of asthma and obesity–as both separate and coexisting conditions–has grown considerably in the U.S. in recent years. Obesity is a […]Continue Reading ...
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