Hongbo Chi, PhD, led the group that showed disrupting either mTORC1 or metabolic activity blocked Th1-like features in Th17 cells in the laboratory as well as neuroinflammation in models. Credit: St. Jude Children’s Research Hospital St. Jude Children’s Research Hospital scientists have discovered a subset of helper T cells that may help to redefine understanding […]Continue Reading ...
Brain cells involved in memory play an important role after a meal in reducing future eating behavior, a finding that could be key in understanding and fighting obesity, according to a study led by Georgia State University. The study suggests neurons in the hippocampus, a brain region that is vital for personal memories, inhibit future […]Continue Reading ...
A team of scientists from the National University of Science and Technology “MISIS”, the Moscow Technological University (MIREA) and the Pirogov Russian National Research Medical University has experimentally proved the effectiveness of the formerly suggested “light” method in oncotherapy. In a series of laboratory preclinical tests, the tumor growth stopped in 70% of mice, treated […]Continue Reading ...
Osaka University-led study shows that TAK1 preserves endothelial cell survival in an inflammatory environment, and can be targeted for tumor suppression Cell death is an important aspect of tissue homeostasis, as well as inflammation and disease pathogenesis related to infection, injury, and tumor growth. Tumor necrosis factor-α (TNFα) coordinates cell death in a variety of […]Continue Reading ...
Researchers at the Washington University School of Medicine have managed to refine a stem-cell based approach to treating diabetes that improves how recipients respond to fluctuating glucose levels in the blood. Nixx Photography | Shutterstock Scientists have previously worked with stem cells to transform them into insulin-producing beta cells, but until now, they have had […]Continue Reading ...
Fever is known to help power up our immune cells, and scientists in Shanghai have new evidence explaining how. They found in mice that fever alters surface proteins on immune cells like lymphocytes to make them better able to travel via blood vessels to reach the site of infection. Their work appears on January 15 […]Continue Reading ...
Jan 16 2019 As cancer cells respond to cues in their microenvironment, they can enter a highly plastic state in which they are susceptible to transdifferentiation into a different type of cell. Researchers at the University of Basel in Switzerland exploited this critical phase, known as an epithelial-mesenchymal transition (EMT), to coax breast cancer cells […]Continue Reading ...
The incidence of some neurological diseases–especially those related to aging, such as Alzheimer’s and Parkinson’s diseases–is increasing. To better understand these conditions and evaluate potential new treatments, researchers need accurate models that they can study in the lab. Researchers from the Salk Institute, along with collaborators at Stanford University and Baylor College of Medicine, have […]Continue Reading ...
HIV infecting a human cell. Credit: NIH A new study suggests that a genetic switch that causes latent HIV inside cells to begin to replicate can be manipulated to completely eradicate the virus from the human body. Cells harboring latent HIV are “invisible” to the natural defenses of the immune system. The findings, which suggest […]Continue Reading ...
When the FDA announced in 2017 that it was approving an immunotherapy treatment for children with certain relapsed blood cancers, doctors and patients were pretty excited. That treatment, tisagenlecleucel (brand name Kymriah), involves engineering the patient’s own immune cells to make biological chimeras, called CAR-T cells, that recognize and attack cancer. But on the heels […]Continue Reading ...
Immune cells engineered to attack childhood cancers were able to eradicate different types of pediatric tumors in mice, according to a new study from the Stanford University School of Medicine. The study, which was published online Jan. 17 in Clinical Cancer Research, provides evidence that these engineered cells can target many types of pediatric solid tumors, […]Continue Reading ...
Researchers at the University of Basel have discovered a way to prevent rejection of transplanted organs, without affecting the immune system’s ability to fight microbial infection. Juan Gaertner | Shutterstock The findings, which were recently published in the journal Immunity, could pave the way for new approaches to reducing transplant rejection in the future. Organ […]Continue Reading ...
A team of scientists led by Prof. Antonella Consiglio from the IDIBELL and the University of Barcelona (UB), and Prof. Angel Raya from the Center of Regenerative Medicine of Barcelona (CMR[B]/IDIBELL) have discovered that defective versions of human brain cells called astrocytes are linked to the buildup of a toxic protein that is one the […]Continue Reading ...
The University of Texas MD Anderson Cancer Center and Dragonfly Therapeutics, Inc., today announced a strategic collaboration to bring Dragonfly’s TriNKET™ (tri-specific natural killer cell engager therapy) immunotherapy drug candidates to patients in clinical trials beginning in 2019. Dragonfly committed more than $10 million to launch the studies, which will be available for patients with […]Continue Reading ...
For cancer to spread, it needs a hospitable environment in distant organs. This fertile “soil” can provide a home to circulating malignant cells. Recent research has shown that cancer cells from the primary tumor can help ready this soil by sending out small vesicles. These vesicles contain a cocktail of molecules that “educate” healthy cells […]Continue Reading ...
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