Scientists at Winship Cancer Institute of Emory University, Children’s Healthcare of Atlanta and Georgia Tech have found that modulating blood-forming stem cells’ stiffness could possibly facilitate mobilization procedures used for stem cell-based transplants. Temporary squishiness could help drive blood-forming stem cells out of the bone marrow and into the blood, but the cells need to […]Continue Reading ...
Researchers from Mount Sinai and IBM have discovered a novel clue in explaining how cancer cells with identical genomes can respond differently to the same therapy. In a Nature Communications paper published today, researchers reveal for the first time that the number of mitochondria in a cell is, in great part, associated with how the […]Continue Reading ...
Xiaojun “Lance” Lian, assistant professor of biomedical engineering, was one of three recipients of the College of Engineering’s ENGineering for Innovation & Entrepreneurship (ENGINE) grant for “Small Molecule-Based Definitive Endoderm Kit and Pancreatic Progenitor Kit for Stem Cell Research and Therapy.” The project focuses on differentiating stem cells into pancreatic beta cells to be used […]Continue Reading ...
A new study identifies a single molecule as a key entry point used by two types of dangerous bacteria to break through cellular barriers and cause disease. The findings, published March 19 in the journal mBio, suggest that blocking the interaction between the molecule, known as CD40, and bacteria may represent a universal strategy for […]Continue Reading ...
Most patients with chronic myelogenous leukemia can be treated with tyrosine kinase inhibitors. These drugs are highly effective and lead to deep remission and prolonged survival. Yet quiescent leukemic stem cells persist in these patients, and they therefore must continue inhibitor treatment to maintain remission. These ‘sleeper cell,’ quiescent leukemic stem cells are maintained in […]Continue Reading ...
Credit: CC0 Public Domain A drug used to treat tapeworm infections could also be used to fight a wide range of cancers, an A*STAR study suggests. More than half of human cancers carry a mutation in the tumor suppressor gene p53, making it an attractive target for cancer therapy. Many research efforts have focused on […]Continue Reading ...
A new study by researchers at The University of Texas at Dallas, UT MD Anderson Cancer Center, UT Health Science Center at Houston and Baylor College of Medicine has produced evidence of the source of chronic pain in humans, revealing several new targets for pain treatment. The paper — published March 19 in Brain, one […]Continue Reading ...
In a study of narcolepsy patients, researchers at the University of Copenhagen have made an important discovery that could help pave the way for improved treatment of the chronic condition. Shutterstock | fizkes The team found that the patients had autoreactive cytotoxic CD8 T cells in their blood, providing important new evidence that the condition […]Continue Reading ...
Left: Mouse nerves show tight bundling and orderly patterning facilitated by normal Schwann cells. Middle: Nerves without Schwann cells but with acetylcholine experience degeneration from the blood-clotting protein thrombin. Right: Nerves lacking both Schwann cells and acetylcholine are unable to individually bundle axons but do not undergo axon degeneration. Credit: Salk Institute Salk researchers have […]Continue Reading ...
UT Southwestern researchers have identified two proteins that act as gatekeepers to dampen a potentially life-threatening immune response to chronic infection. The proteins – the transcription factors SIX1 and SIX2 – activate cellular pathways required for fetal development and later switch to a new role in which they repress these pathways in adult immune system […]Continue Reading ...
University of Otago scientists have discovered a way to view the immune cell “landscape” of bowel cancer tumours, paving the way towards more individualised medicine and treatment for many other diseases in future. In a paper recently published and featuring on the cover of the Journal of Immunology, the scientists have shown the incredible diversity […]Continue Reading ...
A healthy adult makes about 2 million blood cells every second, and 99 percent of them are oxygen-carrying red blood cells. The other one percent are platelets and the various white blood cells of the immune system. How all the different kinds of mature blood cells are derived from the same “hematopoietic” stem cells in […]Continue Reading ...
Researchers from the University of Oulu and Harvard University have found a previously unknown mechanism by which cells in the body sense oxygen. Lack of oxygen had a direct influence on the functioning of genes, and prevented cell differentiation. This observation will open up new opportunities for the development of cancer drugs. The study was […]Continue Reading ...
Researchers have successfully created miniature organoid brains in the labs that when attached to a spinal cord and muscles could help move the muscles. This could be beneficial in the research for debilitating conditions such as motor neurone disease, say the researchers. The results of the experiment were published in the latest issue of the […]Continue Reading ...
A new bioengineering trick turns immune cells, typically protectors of the body, into disease detectives as well. Sanjiv “Sam” Gambhir, MD, PhD, the researcher behind the engineering feat, is using the technique as a new approach to diagnose cancer, which he’s so far demonstrated in mice. “We said, if nature doesn’t give you sufficient signal […]Continue Reading ...
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