Pancreatic cancer cells are known for their ability to thrive under extreme conditions of low nutrients and oxygen, a trait known in the cancer field as “austerity.” The cells’ remarkable resistance to starvation is one reason why pancreatic cancer is so deadly. Now researchers have identified a compound from a Congolese plant that has strong […]Continue Reading ...
Kidney infection with the fungal pathogen Candida albicans causes tissue damage. In wild-type mice, DNGR-1 expressed on dendritic cells detects this injury, and this triggers a reduction in the production of Mip-2, a chemokine that attracts neutrophils. Mice lacking DNGR-1 do not recognize the tissue injury and therefore do not reduce Mip-2 production. The resulting […]Continue Reading ...
Scanning electron micrograph of human T lymphocyte or T cell. Credit: NIAID/NIH A new discovery by an international research team—co-led by UBC Canada 150 Research Chair Josef Penninger and Harvard Medical School neurobiologist Clifford Woolf—could have implications for therapies for cancer and autoimmune diseases. In a study published today in Nature, researchers outline a new […]Continue Reading ...
Nov 16 2018 In optogenetics, researchers use light to control protein activity. This technique allows them to alter the shape of embryonic tissue and to inhibit the development of abnormalities. Now, scientists in EMBL’s De Renzis group have enhanced the technique to stop organ-shaping processes in fruit fly embryos. Their results, published in The EMBO […]Continue Reading ...
A majority of the HIV-infected cells that persist in HIV-infected individuals even during suppressive antiretroviral therapy (ART) originated from cellular proliferation, not viral replication, according to new research published in Nature Communications. Reducing the population size of this “reservoir” of infected cells represents the largest challenge for cure of HIV. Based on these results, study […]Continue Reading ...
The number of critically endangered animals has been increasing in recent years. According to data from the International Union for the Conservation of Nature (IUCN), 1375 avian species are categorized as being endangered animals, and around 12% of the endangered species are avian. The conservation of endangered species is an important task for our next […]Continue Reading ...
Breast cancer cells. Credit: NIH Scientists have long known that cancer can hijack a cell’s existing regulatory circuitry and transform healthy cells into deadly malignancies. But a new discovery from UC San Francisco demonstrates that cancer is more than just a mutineer that seizes control of the cell’s administrative operations—it’s also a clever engineer, capable […]Continue Reading ...
Nov 16 2018 Mechanisms that govern HIV transcription and latency differ in the gut and blood, according to a study published November 15 in the open-access journal PLOS Pathogens by Steven Yukl of San Francisco Veterans Affairs Medical Center and the University of California, San Francisco, and colleagues. According to the authors, the findings could […]Continue Reading ...
Credit: Australian National University Australian researchers have developed ground-breaking new technology which could prove crucial in treating brain injuries and have multiple other applications, including testing the success of cancer therapies. Associate Professor David Nisbet from The Australian National University (ANU) and Dr. Richard Williams from RMIT have developed a 3-D tool to model brain […]Continue Reading ...
Credit: CC0 Public Domain Scientists have made a major discovery that shines a new, explanatory light on the link between obesity and cancer. Their research confirms why the body’s immune surveillance systems—led by cancer-fighting Natural Killer cells—stutter and fail in the presence of excess fat. Additionally, it outlines possible paths to new treatment strategies that […]Continue Reading ...
Scientists have made a major discovery that shines a new, explanatory light on the link between obesity and cancer. Their research confirms why the body’s immune surveillance systems – led by cancer-fighting Natural Killer cells – stutter and fail in the presence of excess fat. Additionally, it outlines possible paths to new treatment strategies that […]Continue Reading ...
Credit: CC0 Public Domain When it comes to diet-induced obesity, your immune system is not always your friend. Adipose (fatty) tissue is infiltrated by white blood cells that have been linked to the development of inflammation, insulin resistance and type 2 diabetes. How this happens is complicated and under intense investigation by researchers around the […]Continue Reading ...
New research published in The Journal of Physiology presents a breakthrough in the treatment of Restless Legs Syndrome (RLS). RLS is a common condition of the nervous system that causes an overwhelming irresistible urge to move the legs. Patients complain of unpleasant symptoms such as tingling, burning and painful cramping sensations in the leg. More […]Continue Reading ...
Researchers at the University of California have developed a CRISPR-based tool called SLICE that can boost the effectiveness of immune cell therapies. Juan Gaertner | Shutterstock Scientists have become expert at manipulating the immune system to target and kill cancer, but although they understand how to reprogram immune cell pathways, they often cannot pinpoint which […]Continue Reading ...
Researchers at the Washington University School of Medicine in St. Louis have discovered the presence of rogue cells inside kidney organoids. The rogue cells, which were identified as brain and muscle cells, constituted 10-20% of the cells making up the organoid. Humphreys lab | Shutterstock Organoids are 3D cell cultures that self-organize to replicate an […]Continue Reading ...
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