“These circulating tumor cells are so few that if you just take a regular blood sample, those test tubes likely won’t even have a single circulating tumor cell in them,” said Gambhir, the Virginia and D.K. Ludwig Professor of Clinical Investigation in Cancer Research. It would be like searching for a grain of sand in […]Continue Reading ...
“It’s been difficult to get a handle on early regulators of reprogramming to pluripotency,” Blau said. “The process is highly heterogeneous and asynchronous, so the earliest events have been hard to study.” To overcome this limitation, Mai turned to a cell fusion model used successfully by Blau in the 1980s to show that specialized human […]Continue Reading ...
School of Medicine researcher Bertha Chen, MD, has been awarded $5.98 million by the California Institute for Regenerative Medicine to investigate ways of using a person’s own stem cells to treat urinary incontinence. The award was one of four given out May 24 by the state stem cell agency as part of its Translation Research […]Continue Reading ...
Human immune cells in blood can be converted directly into functional neurons in the laboratory in about three weeks with the addition of just four proteins, researchers at the Stanford University School of Medicine have found. The dramatic transformation does not require the cells to first enter a state called pluripotency but instead occurs through […]Continue Reading ...
July 13, 2018 Several different treatment methods are used against cancer and multiple promising approaches are currently under examination by various institutions around the world. In Japan, one method in particular, calcium electrotransfer, is being studied at Kumamoto University’s Institute of Pulsed Power Science. Pulsed electric fields (PEFs) have multiple applications in biology, ranging from […]Continue Reading ...
July 13, 2018 In an unexpected discovery, UCLA researchers have found that a gene previously known to control human metabolism also controls the equilibrium of bone and fat in bone marrow as well as how an adult stem cell expresses its final cell type. The findings could lead to a better understanding of the disruption […]Continue Reading ...
While scientists have made enormous headway in the fight against cancer, scientific understanding of tumors at the level of their most fundamental unit – the cell – has been relatively limited. With the advent of new technologies such as single-cell sequencing, big data analytics and advanced bioinformatics pipelines, it is now possible to examine individual […]Continue Reading ...
Brains are composed of different cell types and the image from microscopy shows what cells EcoHIV infects in a mixture of mouse brain cells in tissue culture. The colors label specific elements in the cell mixture: blue shows DNA found in all cells, red shows a specific protein CD11b that is found in microglia, the […]Continue Reading ...
July 12, 2018 When a cell divides, its constituents are usually evenly distributed among the daughter cells. UZH researchers have now identified an enzyme that guarantees that cell constituents that are concentrated in organelles without a membrane are properly distributed. Their discovery opens up new opportunities for the treatment of cancer, neurodegenerative diseases, aging processes […]Continue Reading ...
Schematic showing nonsurgical injection of mesh electronics into the vitreous body of the eye, allowing conformal coating of the mesh on the surface of retina for electrophysiological recording of individual retinal ganglion cells in live animals. Credit: Lieber Group, Harvard University. All rights reserved. Charles Lieber and his group are rewriting the rules of how […]Continue Reading ...
July 11, 2018 Researchers from the University of California San Diego have identified an unexpected mechanism that could help determine whether a cancer patient will respond to immunotherapy. Ideally, the immune system identifies tumors as threatening elements and deploys immune cells (T cells) to find and kill them. However, tumor cells have evolved to employ […]Continue Reading ...
July 13, 2018 Scientists have developed a technique that allows them to measure how well cancer drugs reach their targets inside the body. It shows individual cancer cells in a tumor in real time, revealing which cells interact with the drug and which cells the drug fails to reach. In the future, the findings, published […]Continue Reading ...
Injecting senescent cells into young mice results in a loss of health and function but treating the mice with a combination of two existing drugs cleared the senescent cells from tissues and restored physical function. The drugs also extended both life span and health span in naturally aging mice, according to a new study in […]Continue Reading ...
July 13, 2018 When it comes to diagnosing a condition in which the plasma cells that normally make antibodies to protect us instead become cancerous, it may be better to look at the urine as well as the serum of our blood for answers, pathologists say. The condition is monoclonal gammopathy, in which immune cells […]Continue Reading ...
July 12, 2018 In a “proof of concept” study, scientists at Johns Hopkins Medicine say they have successfully delivered nano-size packets of genetic code called microRNAs to treat human brain tumors implanted in mice. The contents of the super-small containers were designed to target cancer stem cells, a kind of cellular “seed” that produces countless […]Continue Reading ...
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