Dr Jana Gerstmeier und Markus Werner investigate the effect of active compounds on the formation of endogenous signalling substances in immune cells during an inflammatory reaction. This will help to develop new active drugs with fewer side effects. Credit: Jan-Peter Kasper/FSU An international research team led by Friedrich Schiller University in Jena has developed a […]Continue Reading ...
An initial gene analysis may yield better outcomes when patients are treated with the antipsychotic drugs risperidone and aripiprazole. A novel study shows how the activity of a specific enzyme, which metabolizes the two drugs, affects the individual dose that should be given for optimal treatment. The study is published in The Lancet Psychiatry and […]Continue Reading ...
UC San Francisco scientists have designed a large-scale screen that efficiently identifies drugs that are potent cancer-killers when combined, but only weakly effective when used alone. Using this technique, the researchers eradicated a devastating blood cancer and certain solid tumor cells by jointly administering drugs that are only partially effective when used as single-agent therapies. […]Continue Reading ...
Despite many successes, modern medicine is still struggling to find effective treatments for serious pathologies such as cancer and neurodegenerative and inflammatory diseases. For Alzheimer’s disease, for example, only 30% of patients respond to therapy whereas for cancers the figure is only 25%. ‘The real bottleneck is not the absence of an efficient drug but […]Continue Reading ...
A collaboration between researchers from the UAB Institute of Neurosciences (INc) and the pharmaceutical company GlaxoSmithKline, published in March in Trends in Pharmacological Sciences, describes a mathematical model to quantify the activity of biased G-protein-coupled receptors. The G-protein-coupled receptors are present in many neurological and psychological disorders thanks to the activation of G proteins. In […]Continue Reading ...
If we could tell authentic from counterfeit or adulterated drugs and foods just by looking at them, we could save money and lives every year, especially in the developing world, where the problem is worst. Unfortunately, the technologies that can detect what a sample is made of are expensive, energy-intensive, and largely unavailable in regions […]Continue Reading ...
Researchers at Eindhoven University of Technology and Utrecht University have discovered the parameters that govern the encapsulation of drugs. This gives more control over the slow and steady release of drugs in patients. Moreover, designing encapsulations for new drugs will now require far less experimentation which makes for faster and cheaper drug development. The researchers […]Continue Reading ...
People with Alzheimer’s disease using antiepileptic drugs have twice the risk of pneumonia compared to non-users, a new study from the University of Eastern Finland shows. The risk was highest in the beginning of use, but remained on an elevated level even in long-term use. The results were published in the Journal of Alzheimer’s Disease. […]Continue Reading ...
Apr 16 2019 The initial results from an artificial intelligence project show a number of existing drugs have the potential to reduce sight loss from age-related macular degeneration, the leading cause of sight loss. Action Against AMD, a research collaboration formed by four UK sight loss charities (Blind Veterans UK, Fight for Sight, the Macular […]Continue Reading ...
The abuse of alcohol and other drugs like narcotics, sedatives and stimulants continues to be a major global public health concern. This international crisis is further heightened by the tendency of many users to poly-drug abuse, which is a condition defined as the simultaneous or successive abuse of more than one drug or type of […]Continue Reading ...
Tuberculosis (TB), an ancient and notoriously difficult disease to treat, has killed millions through the course of human history; and the antibiotics that have been used to fight the disease in recent history are becoming less and less effective. In the face of this reality, Dennis Wright, professor of medicinal chemistry in the University of […]Continue Reading ...
Experimenting with mice, Johns Hopkins researchers report they have successfully used positron emission tomography (PET) scans to calculate in real time how much of an immunotherapy drug reaches a tumor and what parts of a cancer remain unaffected. The technique uses PET imaging of a synthesized radiolabeled protein that locks on to tumor cells, letting […]Continue Reading ...
A new study reveals that preventive medications–such as those to lower blood pressure or cholesterol, or to protect bone health, among others–are commonly prescribed during the last year of life of older adults with cancer, even though they are unlikely to provide meaningful benefits. Published early online in CANCER, a peer-reviewed journal of the American […]Continue Reading ...
Current treatments for tuberculosis (TB) are very effective in controlling TB infection caused by Mycobacterium tuberculosis (Mtb). They don’t, however, always prevent reinfection. Why this happens is one of the long-standing questions in TB research. So why are our bodies unable to generate permanent immunity to TB, – the leading infectious disease killer worldwide? A […]Continue Reading ...
Credit: CC0 Public Domain Canadian researchers, working in partnership with Brazilian colleagues, have developed 13 bioluminescence sensors for use in testing the effectiveness of new medical drugs in the laboratory. The study, published in the journal Science Signaling, paves the way for characterizing and testing new drugs. The biosensors are based on the action of […]Continue Reading ...
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