The gene editing technique known as CRISPR is a revolutionary approach to treating inherited diseases. However, the tool has yet to be used to effectively treat long-term, chronic conditions. A research team led by Dongsheng Duan, PhD, at the University of Missouri School of Medicine has identified and overcome a barrier in CRISPR gene editing […]Continue Reading ...
Jan 11 2019 Using a technique called circular permutation, researchers at the University of California Berkeley have created a new suite of Cas9 variants called Cas9-CPs, which will simplify design of Cas9-fusion proteins for diverse applications beyond simple DNA cutting, such as base editing and epigenetic modifications. The work appears January 10 in the journal […]Continue Reading ...
Scientists at the Francis Crick Institute have discovered a set of simple rules that determine the precision of CRISPR/Cas9 genome editing in human cells. These rules, published in Molecular Cell, could help to improve the efficiency and safety of genome editing in both the lab and the clinic. Despite the wide use of the CRISPR […]Continue Reading ...
Given this morning’s reports of infants possibly born in China whose genomes were edited by CRISPR-based technology, the American Society of Human Genetics (ASHG) reaffirms the cautious but proactive approach recommended in its 2017 position statement on human germline genome editing, published in The American Journal of Human Genetics. Along with 10 other global organizations […]Continue Reading ...
As an advocate for the genomics age, Integrated DNA Technologies (IDT), will showcase its renowned CRISPR expertise at a series of European-focused events. The genomics solution provider is well-known across the United States for its innovative nucleic acid-based products including oligonucleotides and PCR solutions, genes and gene fragments, NGS, functional genomics and CRISPR genome editing. […]Continue Reading ...
Credit: CC0 Public Domain New research led by the South Australian Health and Medical Research Institute (SAHMRI) and the University of Adelaide has uncovered a significant hurdle for realising the potential benefits of gene editing in embryos. The team, led by Professor Paul Thomas, investigated North American research published last year that seemed to demonstrate […]Continue Reading ...
August 17, 2018 An in-depth study on the regulation of adenosine-to-inosine (A-to-I) RNA editing by researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore found that a protein, known as DHX9, acts as a bidirectional regulator of the molecular process which is linked to various types of cancer […]Continue Reading ...
By Dr Ananya Mandal, MDJuly 26, 2018 A new survey from Pew Research Center has found that nearly half of the surveyed Americans believe that in the coming 50 years, nearly all genetic birth defects could be eliminated due to advances in gene editing. CRISPR-Cas9. Image Credit: Meletios Verras Most of the participants in the […]Continue Reading ...
Scientists at The Francis Crick Institute have discovered a simple set of rules that can be used to precisely predict how DNA will be modified by the CRISPR gene editing technique. Alpha Tauri 3D Graphics | Shutterstock CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a recently discovered gene-editing technology that utilizes the bacterial innate […]Continue Reading ...
The introduction of the tool for gene editing, the so-called gene scissors CRISPR, in 2007 was a revolution within medical science and cell biology. But even though the perspectives are great, the launch of CRISPR has been followed by debate, especially focussing on ethical issues and the technology’s degree of accuracy and side effects. However, […]Continue Reading ...
For the first time scientists have identified how to halt kidney disease in a life-limiting genetic condition, which may pave the way for personalized treatment in the future. Experts at Newcastle University, UK, have shown in a cell model and in a mouse model that gene editing could be used for Joubert syndrome to stop […]Continue Reading ...
As genome editing technologies quickly advance toward clinical therapies, they are raising hopes of a completely new way to treat disease. They are also bringing to light a number of challenges that need to be addressed before potential treatments can be widely used in patients. To tackle these challenges and fuel efforts across the country, […]Continue Reading ...
Researchers from the Cancer Science Institute of Singapore have discovered a bidirectional regulator of adenosine-to-inosine (A-to-I) RNA editing that could serve as a new cancer drug target. Image Credit: Nikolay Chaban / Shutterstock The study, which was recently published in the journal Nucleic Acids Research, found that a protein called DHX9 serves as a bidirectional […]Continue Reading ...
July 31, 2018 Despite high hopes and high investment in CRISPR-Cas9 gene editing, scientists still have a lot to learn about how it works in humans. In the latest example, University of California, Berkeley, scientists found that people’s assumptions about how cells repair the genome after the Cas9 enzyme snips DNA are wrong. The discovery […]Continue Reading ...
July 16, 2018 Scientists at the Wellcome Sanger Institute have discovered that CRISPR/Cas9 gene editing can cause greater genetic damage in cells than was previously thought. These results create safety implications for gene therapies using CRISPR/Cas9 in the future as the unexpected damage could lead to dangerous changes in some cells. Reported today (16 July […]Continue Reading ...
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