University of Tsukuba researchers develop high-throughput screening for factors promoting cardiac reprogramming, and identify a non-steroidal anti-inflammatory drug as one such factor in postnatal and adult fibroblasts Once damaged, the human heart does a poor job of repairing itself, so this is a key priority for treating heart failure. One way of restoring cardiac function […]Continue Reading ...
The incidence of some neurological diseases–especially those related to aging, such as Alzheimer’s and Parkinson’s diseases–is increasing. To better understand these conditions and evaluate potential new treatments, researchers need accurate models that they can study in the lab. Researchers from the Salk Institute, along with collaborators at Stanford University and Baylor College of Medicine, have […]Continue Reading ...
A new study has revealed that breast cancer cells recruit bone marrow-derived fibroblasts to enhance their growth. It is hoped that the discovery will lead to the development of new treatments that target the cells in and around the tumor. DrimaFilm | Shutterstock Many breast cancers show the presence of abundant fibroblasts from neighboring breast […]Continue Reading ...
With age, our tissues lose their function and capacity to regenerate after being damaged. A study published today in Cell by scientists at the Institute for Research in Biomedicine (IRB Barcelona) and the Centro Nacional de Análisis Genómico of the Center for Genomic Regulation (CNAG-CRG) explains how dermal fibroblasts age. The main conclusion drawn is […]Continue Reading ...
May 9, 2018 Idiopathic pulmonary fibrosis (IPF) is one of the most challenging and frustrating diseases that pulmonologists face. And despite affecting 1 out of 200 adults over the age of 65 in the United States, general awareness of IPF is low. “There’s a tremendous disconnect between the human impact of this disease and its […]Continue Reading ...
Dermal fibroblasts are specialized cells deep in the skin that generate connective tissue and help the skin recover from injury. Some fibroblasts have the ability to convert into fat cells that reside under the dermis, giving the skin a plump, youthful look and producing a peptide that plays a critical role in fighting infections. In […]Continue Reading ...
Skin of a young mouse. The image shows a cross section of the skin with the fibroblasts indicated in green. The thickness of the dermis and the density of fibroblasts is much greater in young skin than in aged skin– cell nuclei, in blue. Credit: M Salzer, IRB Barcelona With age, tissues lose their function […]Continue Reading ...
By Sally Robertson, BScJuly 26, 2018 Researchers from Mount Sinai School of Medicine have discovered a new gene that is associated with disease severity in rheumatoid arthritis. It is hoped that the finding will lead to new treatments and new ways of assessing the prognosis of patients with the condition. Image Credit: Damian Ryszawy / […]Continue Reading ...
April 9, 2018 An article published in Experimental Biology and Medicine (Volume 243, Issue 7, April, 2018) reports that supporting cells in the heart, known as fibroblasts, are selectively activated by factors present in heart disease. The study, led by Dr. Megan McCain, Assistant Professor in the Department of Biomedical Engineering and Department of Stem […]Continue Reading ...
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