With a genome that’s regularly broken into 225,000 pieces and reassembled, a pond protist may be the perfect creature to teach us how genomic stability—often lost in cancer—is maintained.Continue Reading ...
The speed and error rate of DNA synthesis is influenced by the three-dimensional structure of the DNA. Using “third-generation” genome-wide DNA sequencing data, a team of researchers from Penn State and the Czech Academy of Sciences showed that sequences with the potential to form unusual DNA conformations, which are frequently associated with cancer and neurological […]Continue Reading ...
Researchers at Stanford University have reworked CRISPR-Cas9 gene-editing technology to manipulate the genome in three-dimensional space, allowing them to ferry genetic snippets to different locations in a cell’s nucleus. The new technique, dubbed CRISPR-genome organization or simply CRISPR-GO, uses a modified CRISPR protein to reorganize the genome in three dimensions. If CRISPR is like molecular […]Continue Reading ...
As genome editing technologies quickly advance toward clinical therapies, they are raising hopes of a completely new way to treat disease. They are also bringing to light a number of challenges that need to be addressed before potential treatments can be widely used in patients. To tackle these challenges and fuel efforts across the country, […]Continue Reading ...
More than half of adults in the Western hemisphere over the age of 40 have small bulging pouches inside their intestine known as diverticula. Caused by weakening of the outer lining of the intestine, these pouches are typically harmless. But for some, these pouches can become painfully inflamed or infected, requiring treatment with antibiotics — […]Continue Reading ...
July 31, 2018 A team led by scientists from the Johns Hopkins Bloomberg School of Public Health has sequenced and annotated the first complete mitochondrial genome of Anopheles funestus, one of the main vectors of malaria in sub-Saharan Africa. This milestone, published in June in Scientific Reports, offers a glimpse inside this insect’s genetic diversity, […]Continue Reading ...
July 10, 2018 Using genome editing to inactivate a protein called PCSK9 effectively reduces cholesterol levels in rhesus macaques, a species of monkey, according to researchers from the Perelman School of Medicine at the University of Pennsylvania. This is the first demonstration of a clinically relevant reduction of gene expression in a large animal model […]Continue Reading ...
June 27, 2018 UPMC and the University of Pittsburgh today announced the launch of an advanced genome sequencing center to support clinical diagnostics and research initiatives in precision medicine and immunotherapy. The UPMC Genome Center, established with funding from the recently announced UPMC Immune Transplant and Therapy Center (ITTC) and the Institute for Precision Medicine […]Continue Reading ...
Studying the three-dimensional structure of DNA and its dynamics is revealing a lot of information about gene expression, expanding our knowledge of how cells, tissues and organs actually work in health and disease. Properly producing and managing this large amount of data is both challenging and necessary for the progress of this field. In a […]Continue Reading ...
Two Arizona State University professors are among the first recipients of Somatic Cell Genome Editing (SCGE) grants from the National Institutes of Health Common Fund. The $2,600,000, five-year grant will fund the first study of the genome editing technology CRISPR to be used on a “human liver on-a-chip” platform. The SCGE program, launched in January […]Continue Reading ...
Many wild and cultivated plants arise through the combination of two different species. The genome of these so-called polyploid species often consists of a quadruple set of chromosomes – a double set for each parental species – and thus has about twice as many genes as the original species. About 50 years ago, evolutionary biologists […]Continue Reading ...
August 13, 2018 A research team at the Broad Institute of MIT and Harvard, Massachusetts General Hospital (MGH), and Harvard Medical School reports a new kind of genome analysis that could identify large fractions of the population who have a much higher risk of developing serious common diseases, including coronary artery disease, breast cancer, or […]Continue Reading ...
July 13, 2018 In cancer cells, genetic errors wreak havoc. Misspelled genes, as well as structural variations — larger-scale rearrangements of DNA that can encompass large chunks of chromosomes — disturb carefully balanced mechanisms that have evolved to regulate cell growth. Genes that are normally silent are massively activated and mutant proteins are formed. These […]Continue Reading ...
Researchers from Columbia University have developed a new technique for the powerful gene editing tool CRISPR to restore retinal function in mice afflicted by a degenerative retinal disease, retinitis pigmentosa. This is the first time researchers have successfully applied CRISPR technology to a type of inherited disease known as a dominant disorder. This same tool […]Continue Reading ...
June 21, 2018 The cell has its own paramedic team and emergency room to aid and repair damaged DNA, a new USC Dornsife study reveals. The findings are timely, as scientists are delving into the potential of genome editing with the DNA-cutting enzyme, CRISPR-Cas9, to treat diseases or to advance scientific knowledge about humans, plants, […]Continue Reading ...
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