Knowledge from gypsy moth genome could aid fight against deforestation, give insights into immunity The European gypsy moth (EGM) is perhaps the country’s most famous invasive insect – a nonnative species accidentally introduced to North America in the 1860s when a few escaped from a breeding experiment in suburban Boston. The caterpillars have been slowly […]Continue Reading ...
Our DNA is under constant attack. The delicate molecule that contains our genetic information is extremely vulnerable to everything from environmental agents, such as radiation, to the chemicals in the air we breathe and the food we eat. Genome instability can lead to genetic disorders, chronic diseases and a predisposition to cancer. A new Tel […]Continue Reading ...
The New York Genome Center (NYGC) has received approval from the New York State Department of Health to offer whole genome and RNA transcriptome sequencing in its Clinical Laboratory Evaluation Program (CLEP)-certified laboratory. This is the first approval by New York State for a whole genome sequencing test for oncology, and currently NYGC’s Clinical Lab […]Continue Reading ...
For the past 17 years, most scientists around the globe have been using the nucleic acid sequence, or genome, an assembly of DNA information, from primarily a single individual as a kind of “baseline” reference and human species representation for comparing genetic variety among groups of people. Known as the GRCh38 reference genome, it is […]Continue Reading ...
With a genome that’s regularly broken into 225,000 pieces and reassembled, a pond protist may be the perfect creature to teach us how genomic stability—often lost in cancer—is maintained.Continue Reading ...
Studying the three-dimensional structure of DNA and its dynamics is revealing a lot of information about gene expression, expanding our knowledge of how cells, tissues and organs actually work in health and disease. Properly producing and managing this large amount of data is both challenging and necessary for the progress of this field. In a […]Continue Reading ...
Two Arizona State University professors are among the first recipients of Somatic Cell Genome Editing (SCGE) grants from the National Institutes of Health Common Fund. The $2,600,000, five-year grant will fund the first study of the genome editing technology CRISPR to be used on a “human liver on-a-chip” platform. The SCGE program, launched in January […]Continue Reading ...
Many wild and cultivated plants arise through the combination of two different species. The genome of these so-called polyploid species often consists of a quadruple set of chromosomes – a double set for each parental species – and thus has about twice as many genes as the original species. About 50 years ago, evolutionary biologists […]Continue Reading ...
Jan 11 2019 Using a technique called circular permutation, researchers at the University of California Berkeley have created a new suite of Cas9 variants called Cas9-CPs, which will simplify design of Cas9-fusion proteins for diverse applications beyond simple DNA cutting, such as base editing and epigenetic modifications. The work appears January 10 in the journal […]Continue Reading ...
Given this morning’s reports of infants possibly born in China whose genomes were edited by CRISPR-based technology, the American Society of Human Genetics (ASHG) reaffirms the cautious but proactive approach recommended in its 2017 position statement on human germline genome editing, published in The American Journal of Human Genetics. Along with 10 other global organizations […]Continue Reading ...
Credit: CC0 Public Domain Studying the three-dimensional structure of DNA and its dynamics is revealing a lot of information about gene expression, expanding our knowledge of how cells, tissues and organs actually work in health and disease. Properly producing and managing this large amount of data is both challenging and necessary for the progress of […]Continue Reading ...
The speed and error rate of DNA synthesis is influenced by the three-dimensional structure of the DNA. Using “third-generation” genome-wide DNA sequencing data, a team of researchers from Penn State and the Czech Academy of Sciences showed that sequences with the potential to form unusual DNA conformations, which are frequently associated with cancer and neurological […]Continue Reading ...
Researchers at Stanford University have reworked CRISPR-Cas9 gene-editing technology to manipulate the genome in three-dimensional space, allowing them to ferry genetic snippets to different locations in a cell’s nucleus. The new technique, dubbed CRISPR-genome organization or simply CRISPR-GO, uses a modified CRISPR protein to reorganize the genome in three dimensions. If CRISPR is like molecular […]Continue Reading ...
As genome editing technologies quickly advance toward clinical therapies, they are raising hopes of a completely new way to treat disease. They are also bringing to light a number of challenges that need to be addressed before potential treatments can be widely used in patients. To tackle these challenges and fuel efforts across the country, […]Continue Reading ...
More than half of adults in the Western hemisphere over the age of 40 have small bulging pouches inside their intestine known as diverticula. Caused by weakening of the outer lining of the intestine, these pouches are typically harmless. But for some, these pouches can become painfully inflamed or infected, requiring treatment with antibiotics — […]Continue Reading ...
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