Scanning electron micrograph of a human T lymphocyte (also called a T cell) from the immune system of a healthy donor. Credit: NIAID Spondyloarthritis is one of the most common types of chronic joint inflammation, affecting nearly 1 to 2 percent of the Western population. Cytokine blockade of tumor necrosis factor (TNF), and more recently, […]Continue Reading ...
Lingering inflammation in the colon is a known risk factor for colorectal cancer and now scientists report one way it resets the stage to enable this common and often deadly cancer. Inflammation is supposed to be a short-term response to an infection or other irritant in the body that is essential to eliminating it. But […]Continue Reading ...
Naglaa Shoukry, Ph. D., and her team have made a significant breakthrough in their research aiming to limit the progression of liver disease. They have characterized the mechanisms of action of type 3 inflammatory cytokines that are produced by the cells of the immune system, which result in a progression of hepatic scarring known as […]Continue Reading ...
BAFF increased the IL-6-producing effector B cells but suppressed the IL-10-producing regulatory B cells. Furthermore, effector B cells play a pathogenic role in scleroderma while regulatory B cells play a protective role. Credit: Kanazawa University Systemic sclerosis (SSc, also known as scleroderma), a connective tissue disorder of autoimmune etiology, is characterized by excessive fibrosis in […]Continue Reading ...
Background: Systemic sclerosis (SSc, also known as scleroderma), a connective tissue disorder of autoimmune etiology, is characterized by excessive fibrosis in the skin and various internal organs. More than 90% of SSc patients carry autoantibodies such as anti-DNA topoisomerase I, anti-centromere, and anti-RNA polymerase antibodies. In addition, B cell activating factor (BAFF) is present at […]Continue Reading ...
Inflammation is part of the body’s natural healing process. But when it becomes chronic, inflammation can lead to cancer, Alzheimer’s disease and other conditions. Inflammasomes—protein-based molecular machines—trigger inflammation in response to different signals generated by cell stress, tissue injury or infectious organisms. In a study published online July 25 in the journal Nature, University of […]Continue Reading ...
May 23, 2018 A new discovery about how the immune system responds to common sinus infections and asthma could explain why patients develop these issues in the first place and ultimately may lead to improved targeted therapies. Researchers from the Perelman School of Medicine at the University of Pennsylvania have identified the source of the […]Continue Reading ...
Other populations of white blood cells secrete other ranges of IL-1β, a pro-inflammatory protein that typically is helping the frame combat off an infection and damage, however may additionally cause autoimmune illness and inflammatory illnesses. An investigation by way of A*STAR researchers and collaborators displays regulatory protein referred to as Hsp27 is chargeable for a […]Continue Reading ...
Spondyloarthritis is one of the most common types of chronic joint inflammation affecting nearly 1-2% of the Western population. Cytokine blockade of Tumor necrosis factor (TNF) and more recently Interleukin-17 (IL-17) has revolutionized the perspectives of patients suffering from this disease by achieving high levels of therapeutic efficacy. The disease differs substantially from rheumatoid arthritis, […]Continue Reading ...
A new study describes the mechanistic relationship between the cytokine interleukin-1β, (IL-1β) and obesity, showing that when IL-1β levels are increased in obesity, IL-1 receptor signaling activates multiple pathways leading to colon cancer. The study shows that obesity is linked with systemic increases in IL-1β, activation of Wnt, and proliferation of mouse colon cells, as […]Continue Reading ...
Bottom Line: Neonatal concentrations of eight detectable inflammatory markers were significantly different in children later diagnosed with B-cell precursor acute lymphoblastic leukemia (ALL) compared with controls. Journal in Which the Study was Published: Cancer Research, a journal of the American Association for Cancer Research. Author: Signe Holst Søegaard, MSc, PhD fellow in the Department of […]Continue Reading ...
XBiotech Inc. announced today the publication of findings that point toward a white blood cell-derived interleukin-1 alpha (IL-1⍺) as a cause of blood clots that could lead to heart attacks or strokes. The research was headed by a world-leading cardiovascular researcher, Dr. Peter Libby, Mallinckrodt Professor of Medicine at Harvard Medical School and clinical cardiologist […]Continue Reading ...
July 26, 2018 Inflammation is part of the body’s natural healing process. But when it becomes chronic, inflammation can lead to cancer, Alzheimer’s disease and other conditions. Inflammasomes -; protein-based molecular machines -; trigger inflammation in response to different signals generated by cell stress, tissue injury or infectious organisms. In a study published online July […]Continue Reading ...
April 20, 2018 AYOXXA Biosystems GmbH, an international biotechnology company, focused on the development of innovative multiplex protein analysis technologies enabling translational research in basic and clinical research, today announced the expansion of its catalogue of immunoassays for multiplex protein analysis with the introduction of LUNARIS™ Mouse 12-Plex Th17 Kit for the quantitative analysis of […]Continue Reading ...
April three, 2017 Cytokines are proteins secreted through various kinds of immune cells in accordance with an infection, irritation, or harm. Interleukin-17 (IL-17) is one such cytokine that reasons irritation, through controlling the manufacturing of different cytokines and mobilizing one of those white blood cellular (neutrophil) that fights infections. All the way through some parasitic […]Continue Reading ...
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