Some severe forms of leukemia develop because proteins on the epigenetic level lose their regulative function. Now, in a broad international collaboration, UK researchers have identified molecules that can effectively inhibit the dysregulated proteins. In the journal Angewandte Chemie, researchers report the discovery, design, and testing of potential drugs on the cellular level. The findings […]Continue Reading ...
While it has long been recognized that mutated gene NPM1 plays an important role in acute myeloid leukemia, no one has determined how the normal and the mutated forms of the protein NPM1 function. “It is one of the biggest enigmas in acute myeloid leukemia,” said Dr. Margaret Goodell, professor in the Center for Stem […]Continue Reading ...
Credit: CC0 Public Domain Something as simple as a change in diet can potentially help to increase the cancer survival rate of obese children with acute lymphoblastic leukemia, the most common childhood cancer, according to a new study by UCLA scientists. The research team, led by Dr. Steven Mittelman, chief of pediatric endocrinology at UCLA […]Continue Reading ...
UT Southwestern scientists, working with colleagues at a sister institution in Houston, have identified a new target for battling a deadly form of leukemia. The findings raise the possibility of a novel treatment for this subtype of blood and bone marrow cancer – known as acute myeloid leukemia or AML – by attacking a harmful […]Continue Reading ...
Acute myeloid leukemia is one of the most aggressive cancers. While other cancers have benefited from new treatments, there has been no encouraging news for most leukemia patients for the past 40 years. Until now. As published today in the scientific journal Cell, Professor Yinon Ben-Neriah and his research team at the Hebrew University of […]Continue Reading ...
July 10, 2018 An international team of leukemia scientists has discovered how to predict healthy individuals at risk of developing acute myeloid leukemia (AML), an aggressive and often deadly blood cancer. The findings, published today in Nature, illuminate the ‘black box of leukemia’ and answer the question of where, when and how the disease begins, […]Continue Reading ...
By Sally Robertson, BScMay 23, 2018 Researchers from the University of Barcelona, August Pi i Sunyer Biomedical Research Institute and Hospital Clínic Barcelona have created a high-resolution map of the entire epigenome of chronic lymphocytic leukemia, the most common form of leukemia. Image Credit: Kateryna Kon/Shutterstock.com Comparing the map with one of healthy cells flagged […]Continue Reading ...
April 20, 2018 International research consortium led by researchers from the University of Helsinki, Finland, discovered new information related to a rare form of leukemia called aggressive NK-cell leukemia. Potential new treatment options were found which are highly warranted as currently this disease usually leads to rapid death of patients. The study was published in […]Continue Reading ...
St. Jude Children’s Research Hospital today announced the availability of one of the world’s largest collections of leukemia samples from children and adults. The effort, called PROPEL (Public Resource of Patient-derived and Expanded Leukemias), aims to advance fundamental research on the biology of leukemia and to help develop cures by sharing unique patient-derived xenograft samples […]Continue Reading ...
A cancer therapy based on fusing two types of cells into a single unit shows promise in strengthening existing treatments for acute myeloid leukemia. The approach joins blood platelets that carry cancer drugs with stem cells that guide the platelets into bone marrow where leukemia begins. Researchers found that when injected into mice that had […]Continue Reading ...
Bristol-Myers Squibb Company (NYSE: BMY) today announced that the U.S. Food and Drug Administration (FDA) accepted its supplemental Biologics License Application (sBLA) for Sprycel (dasatinib) in combination with chemotherapy for the treatment of pediatric patients with newly diagnosed Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). The FDA action date is December 29, 2018. “Sprycel was […]Continue Reading ...
August 13, 2018 Childhood leukemia is a diagnosis that no family ever wants to endure. While the treatment of most types of leukemia has improved steadily over the years, a few specific types remain very difficult to treat. One of these is called “mixed lineage leukemia,” and for children affected by this cancer, their chance […]Continue Reading ...
June 2, 2018 — AstraZeneca and MedImmune, its global biologics research and development arm, today presented results from the Phase III (‘1053’) clinical trial (Abstract #7004) that evaluated moxetumomab pasudotox in 80 patients with relapsed or refractory hairy cell leukemia (HCL) who had received at least two prior lines of therapy.1 Moxetumomab pasudotox, an investigational […]Continue Reading ...
April 27, 2018 Researchers have identified a protein critical for the aggressiveness of T-cell leukemia, a subtype of leukemia that afflicts children and adults. The identification of ubiquitin-fusion degradation 1 (UFD1) allows for better understanding what causes leukemia to progress and become highly aggressive and treatment-resistant, and may lead to a new treatment for this […]Continue Reading ...
April 6, 2018 The key genetic events responsible for initiating the early stages of a type of childhood leukemia have been identified by scientists at The Institute of Cancer Research, London. Insights into the ‘founder’ genetic mutation for this type of leukemia, present in all the cancer cells, could be used in the development of […]Continue Reading ...
- Study provides new information regarding microRNA function in cellular homeostasis of zebrafish
- Study provides new understanding of mysterious ‘hereditary swelling’
- Researchers shed new light on how to combat Shiga and ricin toxins
- Pregnant Women Commonly Refuse Vaccines
- Drug treatment could offer new hope for some patients with brain bleeding
- Health care financial burden of animal-related injuries is growing, study says
- Macrophage cells could help repair the heart following a heart attack, study finds
- Researchers develop new system for efficiently producing human norovirus
- New artificial intelligence-based system to differentiate between different types of cancer cells
- Healthy Lifestyle Lowers Odds of Breast Cancer’s Return
- New research identifies two genes linked to serious congenital heart condition
- NIH Director talks science, STEM careers with preteens
- Disabling a Cellular Antivirus System Could Improve Gene Therapy
- New tool swiftly provides accurate measure of patients’ cognitive difficulties
- NICE releases new guidelines for diagnosis and management of COPD
- Without Obamacare penalty, think it’ll be nice to drop your plan? Better think twice
- Researchers capture high-resolution X-ray and NMR image of key immune regulator
- Natural flavonoid is effective at treating leishmanisis infections, study shows
- Avoidant grievers unconsciously monitor and block mind-wandering contents, study shows
- Study identifies how hantaviruses infect lung cells