Three children Alejandro Gutierrez, MD, treated for leukemia during his fellowship at Boston Children’s Hospital still haunt him more than a decade later. One 15-year-old boy died from the toxicity of the drugs he was given; the other two patients went through the whole treatment only to die when their leukemia came back. “That really […]
Continue Reading ...
Acute erythroid leukemia (AEL) is a high-risk cancer with a dismal prognosis, uncertain genetic basis and controversy surrounding the diagnosis. That is changing, thanks to research led by St. Jude Children’s Research Hospital that appears today in the journal Nature Genetics. The researchers completed the largest, most comprehensive genomic analysis yet of AEL and identified […]
Continue Reading ...
Chemistry researchers at Oregon State University have patented a method for making anti-leukemia compounds that until now have only been available via an Asian tree that produces them. The synthesis of cephalotaxine and homoharringtonine (HHT) paves the way toward less-expensive, more readily available leukemia drugs whose production is not subject to the risks and inefficiencies […]
Continue Reading ...
Acute T-cell lymphoblastic leukemia is a rare type of blood cancer that affects mostly children. This blood cancer appears from the precursor cells that produce T lymphocytes (a type of white blood cells). A new study from Instituto Gulbenkian de Ciencia (IGC), conducted in mice, shows that leukemia can emerge as a consequence of prolonging […]
Continue Reading ...
A mechanism which drives leukemia cell growth has been discovered by researchers at the University of Sussex, who believe their findings could help to inform new strategies when it comes to treating the cancer. Acute myeloid leukemia (AML) is a devastating blood cancer with around 3,000 new cases annually in the UK. Despite considerable improvement […]
Continue Reading ...
Northwestern Medicine scientists have discovered two successful therapies that slowed the progression of pediatric leukemia in mice, according to three studies published over the last two years in the journal Cell, and the final paper published Dec. 20 in Genes & Development. When a key protein responsible for leukemia, MLL, is stabilized, it slows the […]
Continue Reading ...
What is a BCR-ABL genetic test? A BCR-ABL genetic test looks for a genetic mutation (change) on a specific chromosome. Chromosomes are the parts of your cells that contain your genes. Genes are parts of DNA passed down from your mother and father. They carry information that determines your unique traits, such as height and […]
Continue Reading ...
Some severe forms of leukemia develop because proteins on the epigenetic level lose their regulative function. Now, in a broad international collaboration, UK researchers have identified molecules that can effectively inhibit the dysregulated proteins. In the journal Angewandte Chemie, researchers report the discovery, design, and testing of potential drugs on the cellular level. The findings […]
Continue Reading ...
Mar 25 2019 Genetic mutations that drive the development of a common type of childhood leukemia can be traced back to errors by the immune system during the production of antibodies. Dr. Christopher Kirkham, joint first author on the paper The discovery by scientists at the University of Leeds could lead to new ways to […]
Continue Reading ...
Cancer cells consume sugar at a higher rate than healthy cells, but they’re also hungry for amino acids, the building blocks of proteins and other biomolecules. Researchers at Winship Cancer Institute of Emory University have discovered a way to exploit that hunger to selectively block the growth of leukemias. The results were published online Monday, […]
Continue Reading ...
An international research team led by researchers from Vetmeduni Vienna have made an important discovery that could lead to a better understanding of lymphocytic leukemia. They identified the STAT5B protein as crucial for the development of the disease. The findings represent a possible therapeutic approach involving new, precision medicine strategies. The BCR/ABL gene, which does […]
Continue Reading ...
Illustration of gene expression. Credit: Northwestern University Northwestern Medicine scientists have discovered two successful therapies that slowed the progression of pediatric leukemia in mice, according to three studies published over the last two years in the journal Cell, and the final paper published Dec. 20 in Genes & Development. When a key protein responsible for […]
Continue Reading ...
Actually, cancer can hide. A researcher at Children’s Hospital Los Angeles tells us exactly how leukemia burrows within bone marrow, where it is shielded from chemotherapy treatments. Yong-Mi Kim, MD, PhD, MPH just received a $1.2M grant from the NIH to further her research on acute lymphoblastic leukemia. Thanks to Kim’s research, leukemia won’t be […]
Continue Reading ...,_analyze_by_microscope-Jarun_Ontakrai_8864dd9cfb3b4dff9a913aede7a7c915-620x480-300x300.jpg)
Rapid drug response screening for leukemia stem cells offers clues to relapse and to improving patient-specific therapies Advances in rapid screening of leukemia cells for drug susceptibility and resistance are bringing scientists closer to patient-tailored treatment for acute myeloid leukemia (AML). Research on the drug responses of leukemia stem cells may reveal why some attempts […]
Continue Reading ...
While it has long been recognized that mutated gene NPM1 plays an important role in acute myeloid leukemia, no one has determined how the normal and the mutated forms of the protein NPM1 function. “It is one of the biggest enigmas in acute myeloid leukemia,” said Dr. Margaret Goodell, professor in the Center for Stem […]
Continue Reading ...