Acute T-cell lymphoblastic leukemia is a rare type of blood cancer that affects mostly children. This blood cancer appears from the precursor cells that produce T lymphocytes (a type of white blood cells). A new study from Instituto Gulbenkian de Ciencia (IGC), conducted in mice, shows that leukemia can emerge as a consequence of prolonging […]Continue Reading ...
An international research team led by researchers from Vetmeduni Vienna have made an important discovery that could lead to a better understanding of lymphocytic leukemia. They identified the STAT5B protein as crucial for the development of the disease. The findings represent a possible therapeutic approach involving new, precision medicine strategies. The BCR/ABL gene, which does […]Continue Reading ...
Illustration of gene expression. Credit: Northwestern University Northwestern Medicine scientists have discovered two successful therapies that slowed the progression of pediatric leukemia in mice, according to three studies published over the last two years in the journal Cell, and the final paper published Dec. 20 in Genes & Development. When a key protein responsible for […]Continue Reading ...
Actually, cancer can hide. A researcher at Children’s Hospital Los Angeles tells us exactly how leukemia burrows within bone marrow, where it is shielded from chemotherapy treatments. Yong-Mi Kim, MD, PhD, MPH just received a $1.2M grant from the NIH to further her research on acute lymphoblastic leukemia. Thanks to Kim’s research, leukemia won’t be […]Continue Reading ...
Rapid drug response screening for leukemia stem cells offers clues to relapse and to improving patient-specific therapies Advances in rapid screening of leukemia cells for drug susceptibility and resistance are bringing scientists closer to patient-tailored treatment for acute myeloid leukemia (AML). Research on the drug responses of leukemia stem cells may reveal why some attempts […]Continue Reading ...
While it has long been recognized that mutated gene NPM1 plays an important role in acute myeloid leukemia, no one has determined how the normal and the mutated forms of the protein NPM1 function. “It is one of the biggest enigmas in acute myeloid leukemia,” said Dr. Margaret Goodell, professor in the Center for Stem […]Continue Reading ...
Credit: CC0 Public Domain Something as simple as a change in diet can potentially help to increase the cancer survival rate of obese children with acute lymphoblastic leukemia, the most common childhood cancer, according to a new study by UCLA scientists. The research team, led by Dr. Steven Mittelman, chief of pediatric endocrinology at UCLA […]Continue Reading ...
UT Southwestern scientists, working with colleagues at a sister institution in Houston, have identified a new target for battling a deadly form of leukemia. The findings raise the possibility of a novel treatment for this subtype of blood and bone marrow cancer – known as acute myeloid leukemia or AML – by attacking a harmful […]Continue Reading ...
A mechanism which drives leukemia cell growth has been discovered by researchers at the University of Sussex, who believe their findings could help to inform new strategies when it comes to treating the cancer. Acute myeloid leukemia (AML) is a devastating blood cancer with around 3,000 new cases annually in the UK. Despite considerable improvement […]Continue Reading ...
Northwestern Medicine scientists have discovered two successful therapies that slowed the progression of pediatric leukemia in mice, according to three studies published over the last two years in the journal Cell, and the final paper published Dec. 20 in Genes & Development. When a key protein responsible for leukemia, MLL, is stabilized, it slows the […]Continue Reading ...
What is a BCR-ABL genetic test? A BCR-ABL genetic test looks for a genetic mutation (change) on a specific chromosome. Chromosomes are the parts of your cells that contain your genes. Genes are parts of DNA passed down from your mother and father. They carry information that determines your unique traits, such as height and […]Continue Reading ...
Some severe forms of leukemia develop because proteins on the epigenetic level lose their regulative function. Now, in a broad international collaboration, UK researchers have identified molecules that can effectively inhibit the dysregulated proteins. In the journal Angewandte Chemie, researchers report the discovery, design, and testing of potential drugs on the cellular level. The findings […]Continue Reading ...
St. Jude Children’s Research Hospital today announced the availability of one of the world’s largest collections of leukemia samples from children and adults. The effort, called PROPEL (Public Resource of Patient-derived and Expanded Leukemias), aims to advance fundamental research on the biology of leukemia and to help develop cures by sharing unique patient-derived xenograft samples […]Continue Reading ...
A cancer therapy based on fusing two types of cells into a single unit shows promise in strengthening existing treatments for acute myeloid leukemia. The approach joins blood platelets that carry cancer drugs with stem cells that guide the platelets into bone marrow where leukemia begins. Researchers found that when injected into mice that had […]Continue Reading ...
Bristol-Myers Squibb Company (NYSE: BMY) today announced that the U.S. Food and Drug Administration (FDA) accepted its supplemental Biologics License Application (sBLA) for Sprycel (dasatinib) in combination with chemotherapy for the treatment of pediatric patients with newly diagnosed Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). The FDA action date is December 29, 2018. “Sprycel was […]Continue Reading ...
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