In what the authors believe is the first documented comparison of several real-time infectious disease forecasting models by different teams across many seasons, five research groups report this week that a majority of models consistently showed higher accuracy than historical baseline models. Led by biostatistician Nicholas Reich at the University of Massachusetts Amherst, the research […]Continue Reading ...
A study led by researchers at Brigham and Women’s Hospital and Harvard Medical School has shed light on the role fatty acids play in Parkinson’s disease and pointed towards an enzyme as a potential therapeutic target for the disease. Naeblys | Shutterstock Researchers studying Parkinson’s have become increasingly interested in brain lipids, since previous studies […]Continue Reading ...
CytoReason, developer of the world’s first machine learning platform for human immune system cell-level simulation, today announces publication of a groundbreaking new model for translating data from mouse models to human disease. Described in Nature Methods, the mouse to human model (Found In Translation or FIT), proved its ability to more accurately and effectively extrapolate […]Continue Reading ...
Oct 30 2018 A new gold standard for electrical measurement in the emerging in vitro world of three dimensional models. That’s what Swiss medtech 3Brain has established by partnering with CSEM. Its Khíron chip enables fast, accurate intra-tissue measurement and continuous nutrient and oxygen supply through all tissue layers for the first time. And it […]Continue Reading ...
A team of Tufts University-led researchers has developed three dimensional (3D) human tissue culture modelsfor the central nervous system that mimic structural and functional features of the brain and demonstrate neural activity sustained over a period of many months. With the ability to populate a 3D matrix of silk protein and collagen with cells from […]Continue Reading ...
An interview with Dr. Eshan Mitra, Ph.D., from Los Alamos National Laboratory, discussing the importance of computer models in biology and the development of a more accurate model of the RAF phosphorylation pathway. Why are computer models used in systems biology? We use computer models to study processes in biology that are challenging to directly […]Continue Reading ...
Compared with 2D monolayers the use of 3D cell cultures, like those described in the current review, more faithfully recapitulate some of the subtle interactions between pathogens and hosts within the living body. Credit: Jennifer Barrila, Cheryl Nickerson and Michael Northrop and licensed by ASU through Shutterfly. The inset looking into the intestine is from […]Continue Reading ...
There is an urgent need to develop a vaccine to prevent gonorrhea infection due to rapidly increasing incidence and growing antibiotic resistance. BUSM researchers (in collaboration with University of Toronto researchers) have been investigating the use of animal models of gonorrhea, to study how the infection evolves and for potential use to determine the efficacy […]Continue Reading ...
An interview with Dr. Philip Dubé, discussing the importance of genetically modified models for understanding neurodegenerative diseases, conducted at SfN by Alina Shrourou, BSc. What challenges do researchers face when developing drugs for the brain? The first challenge is access to animal models. There are a lot of licensing issues when it comes to using […]Continue Reading ...
Ground-breaking computer models that simulate the workings of individual patients’ hearts could boost treatment of a common cardiac condition that affects a million people in the UK and countless more worldwide. With funding from the Engineering and Physical Sciences Research Council (EPSRC) and in collaboration with St Thomas’ Hospital, a team at King’s College London […]Continue Reading ...
Thrombosis-on-a-chip, vasculature-on-a-chip and engineered models of human cardiac fibrosis are just a few of the new technologies revolutionizing research into human cardiovascular disease–a condition responsible for 17 million deaths per annum globally. A new study entitled Cardiovascular Disease Models: A Game Changing Paradigm in Drug Discovery and Screening, published this week in the journal Biomaterials […]Continue Reading ...
The architecture of each person’s brain is unique, and differences may influence how quickly people can complete various cognitive tasks. But how neuroanatomy impacts performance is largely an open question. To learn more, scientists are developing a new tool — computational models of the brain — to simulate how the structure of the brain may […]Continue Reading ...
The streamlines captured in the mid-sagital plane of (a) the mean-structure and (b) the individual structure half-side models. The last column is the numerical predictions. Credit: ©Science China Press Researchers in the Capital Medical University, Beijing, China, have successfully developed a unique method to visualize streamlines of air directly in in-vitro models, and reveal the […]Continue Reading ...
Sep 27 2018 Unique well-characterized prostate models derived from castration resistant and hormone sensitive primary tissue now available for studies Crown Bioscience, a global drug discovery and development services company providing translational platforms to advance oncology, inflammation, cardiovascular and metabolic disease research, has announced the addition of unique, well characterized, fully annotated patient-derived xenograft (PDX) […]Continue Reading ...
Screen shot of Jackson Laboratory-Alzheimer’s Association slide: Together we can end Alzheimer’s disease. Credit: The Jackson Laboratory The MODEL-AD Center, an ambitious project to develop and distribute precise mouse models of late-onset Alzheimer’s disease (AD), has released eight new models carrying genetic mutations found in patients. In past decades, most AD researchers had to rely […]Continue Reading ...
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