Oct 30 2018 A new gold standard for electrical measurement in the emerging in vitro world of three dimensional models. That’s what Swiss medtech 3Brain has established by partnering with CSEM. Its Khíron chip enables fast, accurate intra-tissue measurement and continuous nutrient and oxygen supply through all tissue layers for the first time. And it […]Continue Reading ...
Thrombosis-on-a-chip, vasculature-on-a-chip and engineered models of human cardiac fibrosis are just a few of the new technologies revolutionizing research into human cardiovascular disease–a condition responsible for 17 million deaths per annum globally. A new study entitled Cardiovascular Disease Models: A Game Changing Paradigm in Drug Discovery and Screening, published this week in the journal Biomaterials […]Continue Reading ...
The architecture of each person’s brain is unique, and differences may influence how quickly people can complete various cognitive tasks. But how neuroanatomy impacts performance is largely an open question. To learn more, scientists are developing a new tool — computational models of the brain — to simulate how the structure of the brain may […]Continue Reading ...
The streamlines captured in the mid-sagital plane of (a) the mean-structure and (b) the individual structure half-side models. The last column is the numerical predictions. Credit: ©Science China Press Researchers in the Capital Medical University, Beijing, China, have successfully developed a unique method to visualize streamlines of air directly in in-vitro models, and reveal the […]Continue Reading ...
Sep 27 2018 Unique well-characterized prostate models derived from castration resistant and hormone sensitive primary tissue now available for studies Crown Bioscience, a global drug discovery and development services company providing translational platforms to advance oncology, inflammation, cardiovascular and metabolic disease research, has announced the addition of unique, well characterized, fully annotated patient-derived xenograft (PDX) […]Continue Reading ...
Screen shot of Jackson Laboratory-Alzheimer’s Association slide: Together we can end Alzheimer’s disease. Credit: The Jackson Laboratory The MODEL-AD Center, an ambitious project to develop and distribute precise mouse models of late-onset Alzheimer’s disease (AD), has released eight new models carrying genetic mutations found in patients. In past decades, most AD researchers had to rely […]Continue Reading ...
The excitement of the Football World Cup is now over and we are well into the holiday season. This might be the silly season for the newspaper industry, but we get no such break in the white heat of Drug Discovery as covered by Drug Discovery Today. This month’s offering covers a very diverse field […]Continue Reading ...
June 25, 2018 Pancreatic cancer is lethal in about 95% of cases mostly due to failure of first-line therapy gemcitabine. AntiCancer Inc.’s oral methioninase (AC 00619), which is in late pre-clinical development as an anti-cancer as well as an anti-aging drug, has now been shown to overcome gemcitabine resistance in mouse models of human pancreatic […]Continue Reading ...
A team of Tufts University-led researchers has developed three dimensional (3D) human tissue culture modelsfor the central nervous system that mimic structural and functional features of the brain and demonstrate neural activity sustained over a period of many months. With the ability to populate a 3D matrix of silk protein and collagen with cells from […]Continue Reading ...
An interview with Dr. Eshan Mitra, Ph.D., from Los Alamos National Laboratory, discussing the importance of computer models in biology and the development of a more accurate model of the RAF phosphorylation pathway. Why are computer models used in systems biology? We use computer models to study processes in biology that are challenging to directly […]Continue Reading ...
Compared with 2D monolayers the use of 3D cell cultures, like those described in the current review, more faithfully recapitulate some of the subtle interactions between pathogens and hosts within the living body. Credit: Jennifer Barrila, Cheryl Nickerson and Michael Northrop and licensed by ASU through Shutterfly. The inset looking into the intestine is from […]Continue Reading ...
There is an urgent need to develop a vaccine to prevent gonorrhea infection due to rapidly increasing incidence and growing antibiotic resistance. BUSM researchers (in collaboration with University of Toronto researchers) have been investigating the use of animal models of gonorrhea, to study how the infection evolves and for potential use to determine the efficacy […]Continue Reading ...
August 13, 2018 The National Institutes of Health (NIH) have awarded $6.5 million to a consortium that includes the Icahn Institute for Genomics and Multiscale Biology at the Icahn School of Medicine at Mount Sinai, the University of Washington, the University of Connecticut, and the University of Auckland, New Zealand, to establish the Center for […]Continue Reading ...
Repositive initially created its unique PDX model sharing platform in 2017 and successfully extended the scope of the platform to become the broader Cancer Models Platform in 2018. Repositive will be demonstrating the platform’s new functionalities at the Tumor Models Conference in Boston, MA, 16 – 18 July 2018. Chris Taylor, Product Manager at Repositive, […]Continue Reading ...
June 11, 2018 New predictive computer models designed to optimize HIV therapy in countries with limited healthcare resources are published online this week in the Journal of Antimicrobial Chemotherapy (JAC). The models, which were developed with data from tens of thousands of patients around the world, accurately predict how an individual on failing therapy will […]Continue Reading ...
- Risk factors for cardiovascular disease closely track with changes in diet patterns
- Biogen Scoops Sixth Prix Galien Award with UK Win for Life-Changing Rare Disease Medicine
- Detectable HIV-1 in treated human liver cells found to be inert
- Using light to control crucial step in embryonic development
- Unusual case of father-to-son HIV transmission reported
- FDA Approves Aemcolo (rifamycin) to Treat Travelers’ Diarrhea
- Poverty blamed on widening north-south gap in young adult deaths in England
- Progress in meningitis lags far behind other vaccine-preventable diseases, analysis shows
- Consensus Statement Issued on Management of Foot, Ankle Gout
- Fine particle air pollution is a public health emergency hiding in plain sight
- In-hospital mortality higher among patients with drug-resistant infections
- Research shines new, explanatory light on link between obesity and cancer
- FIND explores new diagnostic assays for confirmatory HCV diagnosis in community settings
- Tracking Preemies’ Head Size May Yield IQ Clues
- Scientists call for unified standards in 3-D genome and epigenetic data
- Lab Innovations 2018 has beaten all records by attracting 3,113 attendees
- Sexuality education before age 18 may reduce risk of sexual assault in college
- New model of FSHD could be useful to study effectiveness of experimental therapeutics
- FDA approves antibacterial drug to treat travelers’ diarrhea
- Lab Innovations 2018 confirmed as a major hit with visitors, exhibitors and speakers