CytoReason, developer of the world’s first machine learning platform for human immune system cell-level simulation, today announces publication of a groundbreaking new model for translating data from mouse models to human disease. Described in Nature Methods, the mouse to human model (Found In Translation or FIT), proved its ability to more accurately and effectively extrapolate […]Continue Reading ...
Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia Parkinson’s disease (PD) is a neurodegenerative disorder that presents clinically with abnormal movement and tremors at rest. In the brain, PD is marked by the accumulation of the protein, α-synuclein (αS), into clumps known as […]Continue Reading ...
Oct 17 2018 Mice can be used to study the neural circuits underlying complex decision-making, suggests an analysis of more than 500,000 mouse decisions reported in JNeurosci. Some of the most advanced tools in neuroscience are developed for use with mice, yet studies of behaviors most relevant to humans typically involve other model organisms. Anne […]Continue Reading ...
Scientists studying how genetics impact brain disease have long sought a better experimental model. Cultures of genetically-modified cell lines can reveal some clues to how certain genes influence the development of psychiatric disorders and brain cancers. But such models cannot offer the true-to-form look at brain function that can be provided by genetically-modified mice. Even […]Continue Reading ...
August 16, 2018 The biggest hurdle to finding effective therapies for idiopathic pulmonary fibrosis (IPF) – a life-threatening condition in which the lungs become scarred and breathing is increasingly difficult – has been the inability to fully model the disease in animals, limiting the ability to observe and understand the disease. Now, a team of […]Continue Reading ...
July 23, 2018 The MODEL-AD Center, an ambitious project to develop and distribute precise mouse models of late-onset Alzheimer’s disease (AD), has released eight new models carrying genetic mutations found in patients. In past decades, most AD researchers had to rely on mouse models that carried a genetic mutation associated with the relatively rare, early-onset, […]Continue Reading ...
March 27, 2018 Peripheral obstructive arterial disease develops when blood vessels narrow due to arteriosclerosis and blood flow in the legs (or rarely the arms) becomes clogged. Intermittent claudication is when blood flow disturbances in a limb causes pain, numbness, or coldness during physical activity. In severe cases, where the tissue has gone without blood […]Continue Reading ...
Pictures of mice bones from the find out about that display the other results of genetic enhancing. Most sensible left is a mouse with out an edited genome. It has wholesome femur shaft with a robust expansion plate (black). Backside left is from a mouse with the gene Cyp27b1 knocked out, devoid of any calcitriol […]Continue Reading ...
WEDNESDAY, Oct. 17, 2018 — A precision map of a part of the brain of the lowly mouse could be a potent new research tool against Alzheimer’s, researchers say. The highly detailed look at the mouse hippocampus should provide new insight into a range of brain diseases in humans, according to the research team from […]Continue Reading ...
Parkinson’s disease (PD) is a neurodegenerative disorder that presents clinically with abnormal movement and tremors at rest. In the brain, PD is marked by the accumulation of the protein, α-synuclein (αS), into clumps known as Lewy bodies, which diminish neural health. Previous research suggests abnormal αS can alter cell membrane function and lead to cell […]Continue Reading ...
Screen shot of Jackson Laboratory-Alzheimer’s Association slide: Together we can end Alzheimer’s disease. Credit: The Jackson Laboratory The MODEL-AD Center, an ambitious project to develop and distribute precise mouse models of late-onset Alzheimer’s disease (AD), has released eight new models carrying genetic mutations found in patients. In past decades, most AD researchers had to rely […]Continue Reading ...
July 30, 2018 Researchers at Tokyo Institute of Technology propose an improved mouse model that could revolutionize bone metastasis research. Their method, which involves injecting cancer cells via the so-called caudal artery in the mouse tail, overcomes many limitations of traditional mouse models. The new model could thus open a new chapter in the development […]Continue Reading ...
June 8, 2018 Dr. Thomas Hainmüller and Prof. Dr. Marlene Bartos of the Institute of Psychology of the University of Freiburg have established a new model to explain how the brain stores memories of tangible events. The model is based on an experiment that involved mice seeking a place where they received rewards in a […]Continue Reading ...
Researchers have found out a strategy to hose down odd immune responses in mouse fashions of MS, restoring the rodents’ skill to stroll.Continue Reading ...
Credit score: CC0 Public Area New analysis from McLean Health center neuroscientists presentations in an animal type that being bullied may have long-term, dramatic results on sleep and different circadian rhythm-related purposes, signs which might be function of scientific melancholy and different stress-induced psychological diseases. The researchers, alternatively, additionally discovered that it can be conceivable […]Continue Reading ...
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