In a breakthrough study published today in Nature Medicine, researchers at Joslin Diabetes Center have identified a group of 17 circulating inflammatory proteins that are consistently associated with the development and progression of diabetic kidney disease. These 17 proteins, called the Kidney Risk Inflammatory Signature (KRIS), could allow doctors to determine the risk of progression […]Continue Reading ...
New North Carolina State University research shows that key proteins known for their ability to prevent viral infections by inducing cell death can also block certain bacterial infections without triggering the death of the host cells. Rather than killing host cells infected by Listeria in the gastrointestinal tract, the RIPK3 and MLKL proteins recognize the […]Continue Reading ...
Amyotrophic lateral sclerosis (ALS) is an incurable disease of the central nervous system. In most cases, ALS is fatal within a short period following diagnosis. However, people sometimes live with the disease for decades, as did the astrophysicist Steven Hawking. What happens in the body of an ALS patient? Muscle movement is controlled by specialised […]Continue Reading ...
HIV infecting a human cell. Credit: NIH A new way to create proteins that can sneak through HIV’s protective coating may be a step toward understanding the key components needed for developing a vaccine for the virus, according to researchers. Using computational modeling, a team of researchers led by Penn State designed and created proteins […]Continue Reading ...
A research team led by biophysical chemist Professor Edward Lemke has engineered a designer organelle in a living mammalian cell in a new complex biological translation process. The created membraneless organelle can build proteins from natural and synthetic amino acids carrying new functionalities. For example, scientists might incorporate fluorescent building blocks into proteins via the […]Continue Reading ...
New research by academics at Royal Holloway, University of London, urges scientists that are looking to finding a cure for Alzheimer’s disease to focus on the role of proteins in the brain that cause Alzheimer’s disease. This change in focus could enable the development of new treatments. It has long been recognised that genetically inherited […]Continue Reading ...
Low levels of amyloid-β and tau proteins, biomarkers of Alzheimer’s disease (AD), in eye fluid were significantly associated with low cognitive scores, according to a new study published in the Journal of Alzheimer’s Disease. Led by researchers at Boston Medical Center, the study is the first to connect these known AD protein biomarkers in the […]Continue Reading ...
Researchers at the University of New Hampshire are one step closer to helping answer the question of why autism is four times more common in boys than in girls after identifying and characterizing the connection of certain proteins in the brain to autism spectrum disorders (ASD). “Our study is the first to look at the […]Continue Reading ...
In recent years, it’s become clear that RNA-binding proteins play a major role in cancer growth. These proteins, active in all cells but especially so in cancer cells, bind to RNA molecules and accelerate cancer cell growth. Unfortunately, no cancer treatment has targeted these proteins. Until now. In the upcoming issue of Nature Communications, Professor […]Continue Reading ...
Apr 12 2019 When mitochondria become damaged, they avoid causing further problems by signaling cellular proteins to degrade them. In a paper publishing April 11, 2019, in the journal Developmental Cell, scientists in Norway report that they have discovered how the cells trigger this process, which is called mitophagy. In cells with broken mitochondria, two […]Continue Reading ...
Many viruses, including that perennial winter affliction, the influenza virus, are protected by a lipid membrane on loan from the host cell. The fusion proteins on the surface of the membrane are tasked with merging the lipid membrane of the virus with that of the cell. After this, the virus is able to slip inside […]Continue Reading ...
Researchers have identified a protein complex that marks misfolded proteins, stops them from interacting with other proteins in the cell and directs them towards disposal. In collaboration with the neurology department at the Ruhr-Ubiversität’s St. Josef-Hospital as well as colleagues at the Max Planck Institute of Biochemistry in Martinsried, an interdisciplinary team under the auspices […]Continue Reading ...
An active substance that has been known for 30 years could unexpectedly turn into a ray of hope against eye tumors. This is shown by a study conducted by researchers from the Universities of Bonn and Magdeburg together with US colleagues. The results are published in the renowned journal “Science Signaling“. The plant leaves of […]Continue Reading ...
Fewer than half of ovarian cancer patients survive until five years after diagnosis. According to the American Cancer Society, this is because only about one-fifth of ovarian cancer cases are detected early, when the chances of successful treatment and recovery are highest. “If we could change this reality by detecting (ovarian cancer) at a curable […]Continue Reading ...
In the cells of every living organism — humans, birds, bees, roses and even bacteria — proteins vibrate with microscopic motions that help them perform vital tasks ranging from cell repair to photosynthesis. These life-giving tremors are the topic of a study published on March 4 in Nature Communications. A team led by University at […]Continue Reading ...
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