In the brain, as in business, connections are everything. To maintain cellular associates, the outer surface of a neuron, its membrane, must express particular proteins–proverbial hands that reach out and greet nearby cells. And, like a creepily long handshake, surface molecules can overstay their welcome: A protein that lingers too long on the membrane may […]Continue Reading ...
A study by researchers at Rockefeller University has shown that defects in a brain protein may underlie a number of neurodevelopmental disorders. Romanova Natali | Shutterstock In the brain, nerve cells maintain interaction with other neurons through the expression of certain proteins on their membranes. However, surface proteins that stay on the membrane for too […]Continue Reading ...
Recombinant proteins can be produced using many types of cells including, yeast, bacteria, insect and mammalian cells. What advantages are there to producing recombinant proteins using mammalian cells over others? In many cases mammalian cells are the only option to produce recombinant proteins with correct post-translational modifications, e.g. glycosylation, which are required for proper function […]Continue Reading ...
Treating bacterial infections with antibiotics often kills intestinal flora, leading to diarrhoea and inflammation of the gut. Often it is bacteria known as Clostridium difficile which are responsible; they proliferate when the normal microbiome is killed by antibiotics. A working group headed by Professor Dr. Dr. Klaus Aktories of the Institute of Experimental and Clinical […]Continue Reading ...
Human papillomavirus (HPV) is widely known to cause nearly all cases of cervical cancer. However, you might not know that HPV also causes 70 percent of oropharyngeal cancer, a subset of head and neck cancers that affect the mouth, tongue, and tonsils. Although vaccines that protect against HPV infection are now available, they are not […]Continue Reading ...
An interview with Dr. George Tetz, MD, Ph.D., discussing the discovery of prion-like domains in eukaryotic viruses, and the implications of this study on gene therapies and common neurological diseases such as Alzheimer’s Disease. What are prions? Prions are proteins that are known to have some unique features. They differ slightly in structure from regular […]Continue Reading ...
Most people infected with Zika never show symptoms. But the virus sometimes causes severe disability — from microcephaly in babies to weakness or partial paralysis in adults — and there is no treatment. In a recent study in the journal Molecular & Cellular Proteomics, researchers report a comprehensive study of how the virus interacts with […]Continue Reading ...
Researchers work on scientific foundation for new forms of therapy in neurodegenerative processes Protective proteins that mitigate the destruction of nerve cells after a stroke can be administered into the brain through the nose, as Heidelberg University researchers demonstrated using a mouse model. The team led by Prof. Dr Hilmar Bading at the Interdisciplinary Center […]Continue Reading ...
A novel study indicates promising avenues in an innovative approach for developing a vaccine against Plasmodium vivax, the most prevalent human malaria parasite outside sub-Saharan Africa. The study led by Hernando A. del Portillo, ICREA researcher, and Carmen Fernandez-Becerra, Assistant Research Professor, both at IGTP and ISGlobal – an institution supported by “la Caixa” Foundatoin, […]Continue Reading ...
Proteins are essential constituents of cells and their compartments. Prof. Johannes Herrmann, a researcher at the Technische Universität Kaiserslautern, Germany, and his team discovered a novel mechanism by which newly synthesized proteins reach their respective target compartment in the cell. Proteins destined to mitochondria, the cell’s powerhouse, are not directly transported to mitochondria but are […]Continue Reading ...
Scientists from the European Molecular Biology Laboratory (EMBL) have created the first interactive map of the proteins involved in cell division. Image Credit: Andrii Vodolazhskyi / Shutterstock The tool enables researchers to pinpoint which proteins work together to drive this essential process. The importance of this is paramount, as the failure of mitosis leads to […]Continue Reading ...
Novel role for widely studied heat-shock protein Researchers from the Verstreken lab (VIB-KU Leuven) have identified a completely novel function for Hsp90, one of the most common and most studied proteins in our body. In addition to its well-known role as a protein chaperone, Hsp90 stimulates exosome release. These findings shed new light on treatment […]Continue Reading ...
Researchers from the University of Zurich can, for the first time, precisely characterize the protein modification ADP-ribosylation for all proteins in a tissue sample. The changes, which are a typical reaction to stress, provide information about the condition of a cell. Together with the University Hospital Zurich, they are now testing the new method to […]Continue Reading ...
Researchers from the National Institutes of Health and other institutions have deciphered the role of a key protein that the malaria parasite Plasmodium falciparum uses to obtain nutrients while infecting red blood cells. Their study appears in Nature Microbiology. According to the World Health Organization, in 2016 there were an estimated 216 million malaria cases […]Continue Reading ...
August 20, 2018 Saliva is crucial for tasting and digesting food, but scientists have now found that it may have another, more subtle role. Salivary proteins could be part of a feedback loop that influences how food tastes to people -; and by extension, what foods they’re willing to eat. The researchers hope that, one […]Continue Reading ...
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