Using a novel optogenetic tool, researchers have successfully controlled, reproduced and visualized serotonin receptor signals in neural cells. To this end, they modified a photosensitive membrane receptor in the eye, namely melanopsin. As a result, they were able to switch the receptor on and off using light; it also acted like a sensor indicating via […]Continue Reading ...
New research on how cancer mutations influence a certain type of receptor on the cell membrane opens the way for the development of tailored drugs for certain cancers, such as rectal cancer and lung cancer. This according to researchers at Sweden’s Karolinska Institutet and Uppsala University, who have been collaborating with researchers in the UK […]Continue Reading ...
Patients undergoing long-term treatment with steroids may suffer from metabolic side effects. Researchers at the Helmholtz Zentrum München and the Ludwig Maximilians University of Munich (LMU), partners in the German Center for Diabetes Research (DZD), have now pinpointed a mechanism that leads to so-called steroid diabetes. Their findings have been published in Nature Communications. “Glucocorticoids […]Continue Reading ...
Researchers at the University of Zurich have determined the three-dimensional structure of the receptor that causes nausea and vomiting as a result of cancer chemotherapy. The study explains for the first time why some drugs work particularly well in ameliorating these side effects. The results also provide important insights into how to develop compounds to […]Continue Reading ...
A giant toadstool that swallow up vitamins and nutrients. This is how the receptor, which e.g. absorbs B12 vitamin, looks. For the first time, researchers have an insight into a biology which has survived millions of years. “What we’re looking at is evolution at a structural level. A receptor with a toadstool structure that stems […]Continue Reading ...
Instead of tackling tumors head-on, an international team of researchers from the University of Geneva (UNIGE) and the Amsterdam UMC, location VUmc in Amsterdam has chosen to regulate their vascularization by intervening with cellular receptor that is overexpressed specifically in cancer blood vessels. By acting on the development of the blood vessels within the tumor, […]Continue Reading ...
The discovery of a new gene in zebrafish could lead to a better understanding of how exposure to chemicals leads to disease in humans, according to a new Oregon State University study. The National Institutes of Health-funded study, published in the journal Environmental Health Perspectives, describes the interaction between potentially toxic chemical compounds, a protein […]Continue Reading ...
Fig. 1: The mechanism by which group A Streptococcus (GAS) evades the immune system. The immune receptor Mincle recognizes MGDG, an immunoactivating lipid present on GAS, and then activates the immune system to eliminate the invading pathogen. However, DGDG, an antagonistic lipid present on GAS, inhibits Mincle activity, thereby evading the host immune system. Credit: […]Continue Reading ...
WEDNESDAY, Jan. 23, 2019 — Concurrent use of benzodiazepine receptor modulators and opioids and of nonselective and selective benzodiazepine receptor modulators increased from 1999-2000 to 2013-2014, according to a study published online Jan. 17 in SLEEP. Nicholas T. Vozoris, M.D., from St. Michael’s Hospital in Toronto, conducted a cross-sectional study using U.S. health survey data […]Continue Reading ...
The ideal drug is one that only affects the exact cells and neurons it is designed to treat, without unwanted side effects. This concept is especially important when treating the delicate and complex human brain. Now, scientists at Cold Spring Harbor Laboratory have revealed a mechanism that could lead to this kind of long-sought specificity […]Continue Reading ...
An important new article reviews recently discovered properties of adenosine A2A receptor-dopamine D2 receptor (A2AR-D2R) and adenosine A1 receptor-dopamine D1 receptor (A1R-D1R) heteromers–both of which are main targets for caffeine–and discusses the therapeutic implications of these findings. Preclinical evidence is reviewed which indicates that caffeine and selective A2AR antagonists could be used to treat the […]Continue Reading ...
Results build on developing model of new druggable PCSK9 interactor High levels of low-density lipoproteins, parcels of lipids and protein that carry cholesterol, are a leading risk factor for heart disease. Many cholesterol medications lower LDL, some of them by targeting the protein PCSK9. In the January issue of the Journal of Lipid Research, scientists […]Continue Reading ...
A new compound that targets a receptor within sarcoma cancer cells shrank tumors and hampered their ability to spread in mice and pigs, a study from researchers at the University of Illinois reports. The researchers conducted a multi-year, cross-disciplinary study that went from screening potential drug candidates to identifying and synthesizing one compound, to packaging […]Continue Reading ...
Researchers at the University of Zurich have determined the three-dimensional structure of a receptor that controls the release of calcium from bones. The receptor is now one of the main candidates for developing new drugs to treat osteoporosis. Knowing the receptor’s blueprint will be instrumental for designing drugs that could even help to rebuild bones. […]Continue Reading ...
Serotonin (3A) receptors are common drug targets in the treatment of pain, gastrointestinal dysfunctions, and mood disorders yet little is known about their three-dimensional structure. Details about serotonin receptor structures could provide important clues to designing better drugs with less side effects. Now, a team of researchers from Case Western Reserve University School of Medicine […]Continue Reading ...
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