The Zika virus is widely known for causing microcephaly and other brain defects in the fetuses of pregnant, infected women. Currently, there are no approved antiviral therapies specifically designed to treat Zika, but researchers at the Advanced Science Research Center (ASRC) at The Graduate Center of The City University of New York, Hunter College, and […]Continue Reading ...
Scientists from the Moscow Institute of Physics and Technology (MIPT), the Skolkovo Institute of Science and Technology (Skoltech), and the University of Southern California (USC) have developed a new computational method for the design of thermally stable G protein-coupled receptors (GPCR) that are of great help in creating new drugs. The method has already proved […]Continue Reading ...
Steroids act on adipocyte glucocorticoid receptors (GRs) :Activation of adipocyte GRs restricted healthy adipose expansion, causing insulin resistance, liver steatosis, and eventually diabetes. Credit: Osaka University Steroids are used for treating various diseases such as allergic disorders, but they occasionally cause adverse effects, such as steroid diabetes and other metabolic disturbances. Since steroids act throughout […]Continue Reading ...
A Chinese research team joined forces with Russian and U.S. biologists to obtain the crystal structure of the human type 2 cannabinoid receptor. Their findings will help develop drugs against inflammatory, neurodegenerative, and other diseases. The authors of the paper in Cell compare the newly discovered structure to that of the type 1 cannabinoid receptor, […]Continue Reading ...
Cells communicate through complex mechanisms that typically involve receptors and ligands that bind to them. Endogenous ligands, produced by the body, have been identified for the vast majority of cellular receptors, helping explain receptor existence and function. But in the case of sigma-1 receptors, which interact with a diverse array of psychoactive drugs, an endogenous […]Continue Reading ...
The University of Birmingham has been awarded £1.78 million by the Wellcome Trust for research aimed at finding new therapies to treat diseases such as heart failure, diabetes and neurodegenerative disorders. The Wellcome Trust Senior Research Fellowship funding has been awarded to Davide Calebiro, Professor of Molecular Endocrinology at the University of Birmingham’s Institute of […]Continue Reading ...
Credit: CC0 Public Domain A team of researchers at Johns Hopkins have found that activating nerve cell receptors along two chemical pathways—one that has previously been linked to how the brain senses “itch”—may improve pain relief when combined with conventional ways to blunt pain using opioid drugs, such as morphine. The study results, published in […]Continue Reading ...
By Dr Ananya Mandal, MDAugust 16, 2018 Researchers at Rockefeller have used an ultra sensitive device to detect the olfactory systems of insects that help them smell out food and danger. The study titled, “Cryo-EM structure of the insect olfactory receptor Orco,” on the ion channels that form the basis of the odour detecting systems […]Continue Reading ...
A collaboration between researchers from the UAB Institute of Neurosciences (INc) and the pharmaceutical company GlaxoSmithKline, published in March in Trends in Pharmacological Sciences, describes a mathematical model to quantify the activity of biased G-protein-coupled receptors. The G-protein-coupled receptors are present in many neurological and psychological disorders thanks to the activation of G proteins. In […]Continue Reading ...
Cannabinoid receptors in humans respond to compounds found in cannabis. Credit: @tsarcyanide/MIPT A Chinese research team joined forces with Russian and U.S. biologists to obtain the crystal structure of the human type 2 cannabinoid receptor. Their findings could lead to drugs against inflammatory, neurodegenerative, and other diseases. The authors of the paper, published in Cell, […]Continue Reading ...
New research on how cancer mutations influence a certain type of receptor on the cell membrane opens the way for the development of tailored drugs for certain cancers, such as rectal cancer and lung cancer. This according to researchers at Sweden’s Karolinska Institutet and Uppsala University, who have been collaborating with researchers in the UK […]Continue Reading ...
There is a large, untapped potential for developing drugs against cancer, fibrosis and cardiovascular diseases by targeting a family of receptors known as Frizzleds, researchers at Karolinska Institutet in Sweden believe. In a new study published in Science Signaling, they identify how these receptors are activated in the cell membrane and the processes that are […]Continue Reading ...
Researchers of the University of Würzburg have developed a method that makes it possible to measure the activation of receptors in a very short time. This might speed up the development of new drugs. Hormones and other neurotransmitters, but also drugs, act upon receptors. “Their active substances bind to the receptors and modify the three-dimensional […]Continue Reading ...
August 21, 2018 Serotonin, known as the “happiness” neurotransmitter, is a chemical found in the body responsible for feelings of well-being. But serotonin isn’t the only chemical that binds to the 13 serotonin receptors found on the surface of cells. Far from it. Many approved drugs also bind to serotonin receptors. And one of these […]Continue Reading ...
August 14, 2018 Two receptors in the spinal cord and the right experimental drug: Researchers at the University of Zurich have discovered a new approach that suppresses itch. In a series of experiments in mice and dogs they successfully alleviated different forms of acute as well as chronic itch. For the latter, current treatment options […]Continue Reading ...
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