New research on how cancer mutations influence a certain type of receptor on the cell membrane opens the way for the development of tailored drugs for certain cancers, such as rectal cancer and lung cancer. This according to researchers at Sweden’s Karolinska Institutet and Uppsala University, who have been collaborating with researchers in the UK […]Continue Reading ...
Cells communicate through complex mechanisms that typically involve receptors and ligands that bind to them. Endogenous ligands, produced by the body, have been identified for the vast majority of cellular receptors, helping explain receptor existence and function. But in the case of sigma-1 receptors, which interact with a diverse array of psychoactive drugs, an endogenous […]Continue Reading ...
The University of Birmingham has been awarded £1.78 million by the Wellcome Trust for research aimed at finding new therapies to treat diseases such as heart failure, diabetes and neurodegenerative disorders. The Wellcome Trust Senior Research Fellowship funding has been awarded to Davide Calebiro, Professor of Molecular Endocrinology at the University of Birmingham’s Institute of […]Continue Reading ...
Credit: CC0 Public Domain A team of researchers at Johns Hopkins have found that activating nerve cell receptors along two chemical pathways—one that has previously been linked to how the brain senses “itch”—may improve pain relief when combined with conventional ways to blunt pain using opioid drugs, such as morphine. The study results, published in […]Continue Reading ...
By Dr Ananya Mandal, MDAugust 16, 2018 Researchers at Rockefeller have used an ultra sensitive device to detect the olfactory systems of insects that help them smell out food and danger. The study titled, “Cryo-EM structure of the insect olfactory receptor Orco,” on the ion channels that form the basis of the odour detecting systems […]Continue Reading ...
August 15, 2018 A study in Biological Psychiatry examines cannabinoid CB1 receptor binding in healthy male tobacco smokers Chronic, frequent tobacco smokers have a decreased number of cannabinoid CB1 receptors, the “pot receptor”, when compared with non-smokers, reports a study in Biological Psychiatry. The study, the result of a collaboration of researchers affiliated with the […]Continue Reading ...
Lawrence Steinman and his team have found that nicotine-mimicking molecules might work as anti-inflammatory drugs for conditions like gout and rheumatoid arthritis. Credit: Norbert von der Groeben Stanford researchers discovered that a receptor that binds to nicotine and to clusters of beta-amyloid molecules is found on certain types of immune cells that can act as […]Continue Reading ...
Until the day that science identifies the precise genetic factors that allow some of us to live to be 100 despite the immensely damaging effects of inhaling the particulate byproducts of combusted plant biomaterials — also known as smoking — nobody should smoke. From any rational health care standpoint, it’s a really bad idea. But here’s a dirty little […]Continue Reading ...
There is a large, untapped potential for developing drugs against cancer, fibrosis and cardiovascular diseases by targeting a family of receptors known as Frizzleds, researchers at Karolinska Institutet in Sweden believe. In a new study published in Science Signaling, they identify how these receptors are activated in the cell membrane and the processes that are […]Continue Reading ...
Researchers of the University of Würzburg have developed a method that makes it possible to measure the activation of receptors in a very short time. This might speed up the development of new drugs. Hormones and other neurotransmitters, but also drugs, act upon receptors. “Their active substances bind to the receptors and modify the three-dimensional […]Continue Reading ...
August 21, 2018 Serotonin, known as the “happiness” neurotransmitter, is a chemical found in the body responsible for feelings of well-being. But serotonin isn’t the only chemical that binds to the 13 serotonin receptors found on the surface of cells. Far from it. Many approved drugs also bind to serotonin receptors. And one of these […]Continue Reading ...
August 14, 2018 Two receptors in the spinal cord and the right experimental drug: Researchers at the University of Zurich have discovered a new approach that suppresses itch. In a series of experiments in mice and dogs they successfully alleviated different forms of acute as well as chronic itch. For the latter, current treatment options […]Continue Reading ...
July 16, 2018 Numerous studies to date have shown that olfactory receptors are relevant not only for smell perception, but that they also play a significant physiological and pathophysiological role in all organs. An overview of receptors detected so far and of the functions they fulfil within the human body is provided by Prof Dr […]Continue Reading ...
July 12, 2018 A review of more than 200 studies reveals that olfactory receptors–proteins that bind to odors that aid the sense of smell–perform a wide range of mostly unknown functions outside the nose. The function of extra-nasal olfactory receptors has the potential to be used in the diagnosis and treatment of health conditions such […]Continue Reading ...
July 9, 2018 Like a mentor helping medical students choose between specialties, a protein complex helps shape the destiny of developing T cells, St. Jude Children’s Research Hospital scientists have reported. The research appears today in the journal Science Immunology and adds to growing evidence of the critical role cell metabolism plays in the immune […]Continue Reading ...
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