Researchers at Wake Forest Baptist Health have identified a novel mechanism and potential new therapeutic target for Alzheimer’s disease (AD). The findings are published in the current issue of the Journal of Clinical Investigation. “Alzheimer’s is such a devastating disease and currently there is no cure or effective therapy,” said Tao Ma, Ph.D., assistant professor […]Continue Reading ...
An increasing number of new anti-cancer drugs are made available each year. During the authorization process, such new drugs usually undergo comparisons to one, but only rarely to multiple established drugs. This practice leads to a lack of comparisons between therapies, and makes it increasingly difficult for physicians to choose the best treatment for their […]Continue Reading ...
The microbiome in our intestine plays a vital role in people’s health and the immune system. Any lack of balance there has not only been linked to chronic inflammatory intestinal inflammation, but also type 2 diabetes and other diseases. A group of researchers at the University Hospital Tübingen has now reported for the first time […]Continue Reading ...
THURSDAY, Feb. 7, 2019 — For people with type 2 diabetes, could the days of having to jab themselves with a needle whenever they need insulin be over? It’s now a distinct possibility, say researchers who have developed a capsule that can deliver insulin once it reaches the stomach. The new device has only been […]Continue Reading ...
A new study in the Journal of Antimicrobial Chemotherapy suggests that providing more information about how doctors prescribe drugs could reduce problems associated with overprescription. In 2016 the National Health Service described the resistance to antibiotics as “one of the most significant threats to patients’ safety worldwide.” Antibiotics are often the go-to prescription for many […]Continue Reading ...
Researchers sketched a vivid line Friday linking the dollars spent by drugmakers to woo doctors around the country to a vast opioid epidemic that has led to tens of thousands of deaths. The study, published in JAMA Network Open, looked at county-specific federal data and found that the more opioid-related marketing dollars were spent in […]Continue Reading ...
An interview with Dr. Dave Fancy from Jackson ImmunoResearch at SfN 2018, discussing the use of secondary antibodies in neurobiology and the future of nanobodies. How are secondary antibodies used in neurobiology? Neuroscientists have been using secondary antibodies for years. They are generally used to provide or amplify the signal from a primary antibody bound […]Continue Reading ...
The researchers first tested the sensor in an artificial setting where they pumped air through an artery-sized tube to mimic pulsing blood flow. Surgeon Yukitoshi Kaizawa, MD, PhD, a former postdoctoral scholar at Stanford and co-author of the paper, also implanted the sensor around an artery in a rat. Even at such a small scale, the […]Continue Reading ...
Women in science could be losing ground because of methods to review requests for research funding that favor men, say two Stanford researchers in a commentary in The Lancet. In their piece, researchers Jennifer Raymond, PhD, and Miriam Goodman, PhD, explore gender bias in scientific research funding, highlighting a related article by Canadian researchers about an analysis […]Continue Reading ...
Researchers at The University of Texas MD Anderson Cancer Center have discovered that malignant rhabdoid tumors (MRT), a rare pediatric cancer without effective treatments, may be sensitive to drugs that block the cancer cell’s ability to dispose of misfolded proteins. The findings provide a much-needed therapeutic target for these and other cancers caused by mutations […]Continue Reading ...
Credit: CC0 Public Domain A team of researchers from the Netherlands, the U.S. and the U.K. has found evidence that suggests tumor necrosis factor (TNF) cannot be used as a biomarker for rheumatoid arthritis (RA) treatment discontinuation. In their paper published in the journal Science Translational Medicine, the group describes developing an assay that could […]Continue Reading ...
Jan 21 2019 Researchers have identified a cellular response to repeated concussions that may contribute to seizures in mice like those observed following traumatic brain injury in humans. The study, published in JNeurosci, establishes a new animal model that could help improve our understanding of post-traumatic epilepsy. Stefanie Robel, Oleksii Shandra and colleagues induced mild […]Continue Reading ...
Using X-ray fluorescence at synchrotrons DESY and ESRF, researchers in the Centre d’Etudes Nucléaires de Bordeaux Gradignan (CNRS/Université de Bordeaux) have demonstrated the consequences of a mutation responsible for a hereditary parkinsonian syndrome: accumulated manganese in the cells appears to disturb protein transport.This work, carried out with colleagues at the University of Texas at Austin […]Continue Reading ...
An interview with Dr. Kathyrn Cunningham from Active Motif at SfN 2018, discussing the importance of epigenetics and overcoming the problems that arise when carrying out Chromatin Immunoprecipitation Sequencing (ChIP-seq) with low cell numbers. Why is epigenetics important in neuroscience? Epigenetics describes factors that control gene expression and can, therefore, influence diseased and healthy phenotypes. […]Continue Reading ...
Under threat of being scrubbed away with disinfectant, individual bacteria can improve their odds of survival by joining together to form colonies, called biofilms. What Arnold Mathijssen, PhD, wanted to understand was how stationary biofilms find food once they’ve devoured nearby nutrients. Leading an international team of researchers in creating simulations of how fluids move, Mathijssen, […]Continue Reading ...
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- Racial disparities in cancer deaths on the decline for America
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