Breaking News
October 19, 2018 - The Current issue of “The view from here” is concerned with Nanotherapeutic strategies
October 19, 2018 - Delay in replacing the Pap smear with HPV screening is costing lives
October 19, 2018 - Physicians battle pediatric diseases of ear, nose, throat in Zimbabwe | News Center
October 19, 2018 - Researchers investigate why some cancers affect only young women
October 19, 2018 - Drugmakers funnel millions to lawmakers; a few dozen get $100,000-plus
October 19, 2018 - Unselfish people tend to have more children and receive higher salaries
October 19, 2018 - New findings reveal potential cellular players in tumor microenvironment
October 19, 2018 - Human brain cell transplant offers insights into neurological conditions
October 19, 2018 - Parental education associated with increased family health care spending
October 19, 2018 - New statistical method estimates long- and short-term risk of recurrence of breast cancer in US women
October 19, 2018 - Father’s exposure to nicotine may cause cognitive deficits in descendants
October 19, 2018 - Could we prevent Alzheimer’s disease by treating herpes?
October 19, 2018 - Nurse-led care can be more successful in managing gout
October 19, 2018 - Trump administration, pharma exchange verbal volleys on drug-price transparency
October 19, 2018 - Duke researchers find way to detect blood doping in athletes
October 19, 2018 - Many primary care doctors are still prescribing sedative drugs for older adults
October 19, 2018 - Finger length can predict sexuality in women say researchers
October 19, 2018 - Study finds differences in side-effects experienced by male and female OG cancer patients
October 19, 2018 - Few Seniors Who Self-Harm Referred for Mental Health Care
October 19, 2018 - Don’t sweat the sweet stuff
October 19, 2018 - URMC researchers discover new approach to deliver therapeutics to the brain
October 19, 2018 - Middlemen suppliers can increase drug prices and hospital bills, say Johns Hopkins researchers
October 19, 2018 - Human neurons employ highly compartmentalized signaling, study shows
October 19, 2018 - Ultromics expands multiple clinical trials for coronary heart disease to the U.S.
October 19, 2018 - $11 million NIH grant for Clemson University helps launch new center for musculoskeletal research
October 19, 2018 - A new approach identified to control Zika virus, dengue fever
October 19, 2018 - Head Blows Without Concussion May Not Damage Brain, Study Claims
October 19, 2018 - US opioid use not declined, despite focus on abuse and awareness of risk
October 19, 2018 - Next-generation RNA sequencing technology sheds new light on human mitochondrial diseases
October 19, 2018 - UT Southwestern biochemist receives 2019 Breakthrough Prize in Life Sciences for innate immunity discovery
October 19, 2018 - The immune system also plays a key role in day-to-day function of healthy organs
October 19, 2018 - New tool may reveal how the brain structure impacts brain activity, human behavior
October 19, 2018 - Trump Administration announces ‘Winning on Reducing Food Waste’ initiative
October 19, 2018 - For-profit nursing home residents more likely to experience health issues caused by substandard care
October 19, 2018 - Incidence of stroke has risen steadily among marijuana users, show studies
October 19, 2018 - Conceptual framework proposed to examine role of exercise in multiple sclerosis
October 19, 2018 - Near infrared spectroscopy technique for accurate evaluation of chondral injuries
October 19, 2018 - Scientists receive $5.1 million grant to develop stem cell-based therapy for blinding retinal conditions
October 19, 2018 - Shorter physician encounters associated with antibiotic prescribing
October 19, 2018 - In the Spotlight: Enjoying research and exploring opportunities
October 19, 2018 - Physical activity lowers cardiovascular mortality risk in frail older adults
October 19, 2018 - New imaging tool helps visualize how sound-induced vibrations travel through the ear
October 19, 2018 - Key insights into the application, production of bioactive materials
October 19, 2018 - New urea sorbent could speed up the development of wearable artificial kidney
October 19, 2018 - Intensive care patients’ muscles less able to use fats for energy
October 19, 2018 - FDA Advisory Committee Recommends Approval of Dsuvia for the Treatment of Moderate-to-Severe Acute Pain
October 19, 2018 - 48,XXXY syndrome – Genetics Home Reference
October 19, 2018 - Physical exercise improves the elimination of toxic proteins from muscles
October 19, 2018 - How a new system improved wait times for Stanford kidney transplant patients
October 19, 2018 - Nutrition has bigger positive impact on bone mass and strength than exercise
October 19, 2018 - Study finds lack of progress in media representation of nurses over last 20 years
October 19, 2018 - Many people have trouble understanding differences between OCD and OCPD
October 19, 2018 - New family planning app found to be as effective as modern methods
October 19, 2018 - Gastric Banding, Metformin Similar for Improving Glycemia
October 19, 2018 - Physiologist publishes findings on the role of the protein titin in muscle contraction
October 19, 2018 - What digital health companies need to do to succeed
October 19, 2018 - N. Carolina Sees Alarming Spike in Heart Infections Among Opioid Users
October 19, 2018 - Video monitoring of TB therapy works well in urban and rural areas
October 19, 2018 - Determining acid-neutralizing capacity for OTC antacids
October 19, 2018 - Males who spend more time taking care of kids have greater reproductive success
October 18, 2018 - Study to explore bioethics of brain organoids
October 18, 2018 - Environmental conditions may drive development of multiple sclerosis
October 18, 2018 - Genetically modifying zebrafish provides more accurate disease models
October 18, 2018 - Purdue Pharma, Eisai announce positive topline results from Phase 3 study of lemborexant
October 18, 2018 - 5 Strength-Training Mistakes to Avoid
October 18, 2018 - Immune system’s balancing act keeps bowel disease in check
October 18, 2018 - Anti-inflammatory drug effective for treating lymphedema symptoms | News Center
October 18, 2018 - Keeping Your Voice Young
October 18, 2018 - One-time universal screening recommended to tackle increase in hepatitis C
October 18, 2018 - Researchers to develop new stem cell-based strategies for treating vision disorders
October 18, 2018 - Detecting epigenetic signature may help people stay ahead of inflammatory bowel disease
October 18, 2018 - Understanding AFib: Slowing down the dancing heart
October 18, 2018 - Using NMR to Reduce Fraud
October 18, 2018 - New automated model identifies dense breast tissue in mammograms
October 18, 2018 - Mysterious polio-like illness baffles medical experts while frightening parents
October 18, 2018 - Cases of Acute Flaccid Myelitis on the rise across U.S.
October 18, 2018 - Dietary fiber reduces brain inflammation during aging
October 18, 2018 - New tool could help prioritize recovery efforts for the poorest hit by natural disasters
October 18, 2018 - Hundreds of dietary supplements shown to contain unapproved drugs
October 18, 2018 - Active Pharmaceuticals ID’d in >700 Dietary Supplements
MRI Connects the Dots in Again Ache (CME/CE)

MRI Connects the Dots in Again Ache (CME/CE)

image_pdfDownload PDFimage_print

Motion Issues

  • Word that this observational learn about discovered that MRI findings historically related to “put on and tear” injury have been related to inflammatory again ache signs.
  • Bear in mind that inflammatory signs have been assessed by means of questionnaire.

Adjustments on spinal magnetic resonance imaging (MRI) associated with each axial spondylarthritis (axSpA) and degeneration are related to inflammatory again ache — a discovering that helps “a shift clear of the ancient dichotomy between inflammatory and noninflammatory/mechanical again ache,” consistent with Danish investigators.

Within the learn about, MRI adjustments have been related to inflammatory again ache in younger sufferers with continual low again ache. The associations have been susceptible, the authors famous, due to this fact compromising the usage of inflammatory again ache as a marker of axial irritation in medical follow.

The consequences upload to the elemental wisdom of axial inflammatory processes. “General, the associations between inflammatory MRI findings and ache traits discovered within the present learn about point out that during some circumstances axial irritation induces a particular ache development,” the staff wrote in Arthritis Care & Analysis.

“Jointly, the consequences from this learn about problem the ancient view of degeneration as a easy ‘put on and tear’ situation,” and due to this fact, “the dichotomy between inflammatory and non-inflammatory/mechanical again ache will not be as easy as up to now believed.”

The researchers, led by way of Bodil Ambak, MSc, PhD, from Clinic Lillebaelt in Middelfart, Denmark, used information from a cohort of sufferers 18 to 40 years previous who have been enrolled in a Danish learn about to analyze the usage of MRI findings within the diagnoses of low again ache and axSpA. MRI information from the entire backbone and sacroiliac joints (SIJs) and self-reported responses to questions associated with inflammatory again ache have been to be had for 1,020 sufferers. A complete of 53% of the cohort have been feminine, and the median age used to be 33.

Virtually all sufferers (97%) incorporated within the learn about had a minimum of one inflammatory again ache feature, and 61% had a minimum of one MRI discovering associated with energetic or late-stage axial irritation, corresponding to vertebral endplate bone marrow edema, vertebral endplate fatty marrow deposition, erosions, and sclerosis.

In multivariable analyses, associations have been discovered between MRI findings and ache traits, as follows:

  • The percentages ratio (OR) for inflammatory again ache with SIJ erosions on MRI ranged from 1.nine to two.7, relying at the definition used for inflammatory again ache
  • The OR for inflammatory again ache with vertebral endplate fatty marrow deposition ranged from 1.four to one.6
  • The OR for morning stiffness >60 mins with SIJ bone marrow edema used to be 1.four (95% CI 1.Zero-2.Zero)
  • The OR for ache at night time with SIJ sclerosis used to be 2.three
  • The OR for particular person ache traits with spinal MRI findings ranged from 1.four to two.Zero
  • SIJ erosions and vertebral endplate fatty marrow deposition associated with late-stage irritation have been extra persistently related to ache traits in comparison with the bone marrow edema findings associated with energetic irritation.

There used to be no affiliation between inflammatory again ache as outlined by way of the Evaluate of SpondyloArthritis global Society and MRI findings.

On put up hoc analyses that incorporated handiest sign adjustments >25% of the vertebral endplate, the magnitude of the ORs, used to be very similar to that within the preliminary analyses, even though the sum of statistically important associations used to be lowered — possibly on account of the decrease occurrence of the findings, the researchers wrote.

“The consequences counsel that MRI findings associated with axSpA handiest correlate weakly with inflammatory again ache.”

That MRI findings associated with late-stage irritation (i.e., SIJ erosions and vertebral endplate fatty marrow deposition) have been extra persistently related to ache traits than bone marrow edema findings associated with energetic irritation suggests positive stage of irritation is had to lead to structural adjustments corresponding to fatty marrow deposition and erosions, the staff defined. “Thus, an reason for the extra constant associations between the structural findings and inflammatory again ache is also that those findings constitute a extra critical inflammatory procedure.”

Learn about barriers famous by way of the authors come with the usage of a self-reported questionnaire that had no longer been validated for inflammatory again ache traits, the loss of sensitivity of MRI for detecting early- or low-grade inflammatory adjustments, and inclusion of all vertebral endplate sign adjustments — most likely expanding the danger of together with clinically beside the point findings (even though the ORs have been an identical when restricting the research to sign adjustments >25% of the vertebral endplate).

The learn about used to be financially supported by way of the Basis for Chiropractic Analysis and Submit-Graduate Training in Denmark.

The authors reported having no competing pursuits.

  • Reviewed by way of
    F. Perry Wilson, MD, MSCE Assistant Professor, Segment of Nephrology, Yale College of Drugs and Dorothy Caputo, MA, BSN, RN, Nurse Planner


Tagged with:

About author

Related Articles