Breaking News
April 20, 2018 - Metabolic Syndrome Common With Chronic Hep B Infection
April 20, 2018 - Tracking quality of life during prostate cancer treatment
April 20, 2018 - Study shows presence of beta-amyloid dimers in the brains of Alzheimer’s patients
April 20, 2018 - Researchers identify link between physical inactivity and increased risk of dying from cancer
April 20, 2018 - Breathtaking evolution amongst Indonesian tribe
April 20, 2018 - Study shows testosterone deficiency in men is associated with chronic diseases
April 20, 2018 - Simple one-page form helps improve satisfaction of patients with care
April 20, 2018 - Researchers evaluate accuracy of simple blood test to predict lung cancer
April 20, 2018 - Study looks at sperm producing ability in testicular cancer patients
April 20, 2018 - Exercise In, Vitamin D Out for Preventing Falls: U.S. Panel
April 20, 2018 - Skin cancers associated with decreased risk of developing AD
April 20, 2018 - Preserving fertility during chemotherapy
April 20, 2018 - Teva and Procter & Gamble Company terminate PGT Healthcare partnership
April 20, 2018 - People diagnosed with traumatic brain injury may have increased risk of Parkinson’s disease, shows study
April 20, 2018 - Researchers use smartphone to diagnose people infected with Loa loa worm
April 20, 2018 - College students with autism have high rate of suicidal thoughts
April 20, 2018 - Study sheds light on how the HSC niche is maintained
April 20, 2018 - Drug test spurs frank talk between hypertension patients and doctors
April 19, 2018 - Low-cost deworming drug improves female farmers’ physical fitness
April 19, 2018 - Genome editing identifies neural circuit behind leptin’s anti-obesity and anti-diabetes effects
April 19, 2018 - Many European countries lack comprehensive policy to eliminate viral hepatitis
April 19, 2018 - Young people with ADHD ‘more likely’ to come from deprived neighbourhoods
April 19, 2018 - SLU professor discovers new biomarkers for chlorine gas exposure
April 19, 2018 - Study proposes new mechanism that may contribute to gender differences in weight control
April 19, 2018 - Sleep restriction therapy does not interfere with insomnia patient’s driving ability, research shows
April 19, 2018 - Deep brain stimulation offers relief to UTHealth patient with treatment-resistant depression
April 19, 2018 - Study shows fatty fish and camelina oil boost HDL and IDL cholesterol
April 19, 2018 - FDA Alert: Euphoric Capsules by Epic Products: Recall
April 19, 2018 - Researchers identify peptide produced during cartilage deterioration as a potential source of osteoarthritis pain
April 19, 2018 - New breakthrough may allow scientists to orchestrate tissue regeneration in humans
April 19, 2018 - SYGNIS AG introduces new TruePrime apoptotic cell free DNA amplification kit
April 19, 2018 - Innovative device shows promise in capturing and releasing circulating tumor cells
April 19, 2018 - Researchers shed light on role of striosomal neurons in reinforcement learning
April 19, 2018 - Genetic make-up impacts long-term effectiveness of phobia treatment
April 19, 2018 - Novel biomarker can distinguish malignant lung nodules
April 19, 2018 - Study reports promising novel approach to treat therapy resistant pediatric brain tumors
April 19, 2018 - One-Hour Plasma Glucose Useful Predictor of Diabetic Retinopathy
April 19, 2018 - Hydroxychloroquine no more effective than placebo for relieving osteoarthritis hand pain
April 19, 2018 - Transplanted livers have a protective effect and reduce potential for organ rejection
April 19, 2018 - Researchers develop new method to study activity of inflammatory cells
April 19, 2018 - Researchers discover highly antibiotic resistant superbugs in Gulf States
April 19, 2018 - Smart-tooth technology shows promise in detecting certain diseases in high-risk patients
April 19, 2018 - Interaction between dioxin and HLA gene variant activates events associated with rheumatoid arthritis
April 19, 2018 - Eyes of adolescents could be associated with increased risk of cardiovascular disease in later life
April 19, 2018 - U.S. Women Less Likely Than Men to Get Statins After Heart Attack
April 19, 2018 - Health Canada grants cannabis cultivation license to High Park Farms
April 19, 2018 - Atypical brain development observed in preschoolers with ADHD symptoms
April 19, 2018 - SC Johnson releases annual Sustainability Report
April 19, 2018 - Positive attitudes about aging reduce risk of dementia in older adults
April 19, 2018 - Environmental pollutants found to worsen rheumatoid arthritis
April 19, 2018 - UT Southwestern scientists discover protein linked to metastatic breast cancer
April 19, 2018 - Study highlights need for further evidence to improve symptom management in end of life care
April 19, 2018 - Detecting diminished dopamine-firing cells inside brain could reveal earliest signs of Alzheimer’s
April 19, 2018 - Uniqsis offers high-power LED light unit for scalable flow photochemistry reactions
April 19, 2018 - Case study shows how intravascular ultrasound imaging helps detect acute aortic syndrome
April 19, 2018 - Research reveals new mechanism by which HIV evades the immune system
April 19, 2018 - Nanodisc-delivered cancer treatment helps eliminate tumors
April 19, 2018 - Functional connectivity MRI could help detect brain disorders and diseases
April 19, 2018 - Finding better way to quantify neuropathy symptoms and treatment efficacy
April 19, 2018 - Study examines effectiveness of caregiver education about sickle cell trait
April 19, 2018 - High-resolution images of tumor vasculature using new technology
April 19, 2018 - Lack of sleep may be linked to risk factor for Alzheimer’s disease
April 19, 2018 - Study finds neurotransmitter may play a role in alcohol relapse, addiction
April 19, 2018 - Researchers build molecular networks of calcific aortic valve disease
April 19, 2018 - Researchers develop highly specific apoptosis assay for pharmacodynamic analyses of tumor specimens
April 19, 2018 - Scientists decipher mechanism of chemotherapy induced female infertility
April 19, 2018 - New insight may allow researchers to design drugs that improve immune responses to vaccines
April 19, 2018 - FDA Approves Crysvita (burosumab-twza) for X-Linked Hypophosphatemia
April 19, 2018 - Researchers uncover origin of virus-fighting plasma B cells
April 19, 2018 - Study finds no evidence of lower intelligence in young children who had anesthesia
April 19, 2018 - Baboons break out of research facility briefly
April 19, 2018 - Study shows how deployment time increases risk of suicide attempt in soldiers
April 19, 2018 - Specific odors from malaria infected individuals attract more mosquitoes
April 19, 2018 - FDA Alert: Rhino 69 Extreme 50000 by AMA Wholesale: Recall
April 19, 2018 - Top HIV cure research team refutes major recent results on how to identify HIV persistence
April 19, 2018 - Experts propose new solutions to increase benefit, affordability of targeted cancer medicines
April 19, 2018 - Deficiency of innate immune adaptor TRIF shortens survival time of ALS mice
April 19, 2018 - New machine learning method offers better way to detect heart disease
April 19, 2018 - CNIO researchers determine structure of protein complex related to cell survival
April 19, 2018 - Faith-based diabetes support program launched by UTSA research team
New learn about goals to check protection and efficacy of antiplatelet drug in fighting blood clots

New learn about goals to check protection and efficacy of antiplatelet drug in fighting blood clots

image_pdfDownload PDFimage_print

A brand new medical learn about is beginning on the German Centre for Cardiovascular Analysis (DZHK) with an leading edge and extremely explicit blood thinner. Headed through the DZHK Munich website, the scientists need to verify how safely and successfully this compound, which handiest acts in the community, can save you blood clots in sufferers with a coronary center illness being handled with a cardiac catheter.

The coronary vessels are blocked in coronary center illness. If physicians dilate the vessels with a catheter, the deposits (plaques) can tear and injury the partitions of the blood vessels. Such small damages are a chance issue for circulatory issues and center assaults, as platelets can adhere to those websites and clots can shape. Sufferers due to this fact obtain blood thinning medication that save you platelet accumulation all over the process. The downside of the medication used up to now is that in addition they build up the chance of probably existence‑threatening bleedings, as a result of they inhibit a central step of haemostasis, or platelet accumulation, in all the frame. The aim of the DZHK learn about, which is headed through the German Center Centre Munich, is to analyze whether or not the brand new antiplatelet drug Revacept reduces the formation of blood clots all over cardiac catheterization with out expanding the bleeding chance. Compared to standard blood thinners, Revacept handiest binds to the broken websites within the vessel and shields them in order that no platelets can gather there. “Revacept is sort of a plaster that seals the lesion in a centered method”, exemplifies PD Dr. Stefanie Schüpke of the German Center Centre Munich.

From the laboratory to the affected person

Years of extensive fundamental analysis, by which scientists at LMU Munich and the Technical College Munich researched how platelets adhere to broken vessel websites, preceded the advance of Revacept. “It was once an important to focus on constructions that distinguish between wholesome and atherosclerotic vessels”, explains Prof. Adnan Kastrati of the German Center Centre Munich, probably the most leader investigators. Because of this, the scientists targeted at the adhesion of platelets to the collagen that handiest protrudes into the blood circulation the place vessel partitions are broken. The agent Revacept was once created in keeping with their findings. It binds to the collagen of the broken websites in a centered method and thus prevents the adhesion of platelets. “Revacept is an instance of a hit translational analysis, by which the findings from fundamental analysis result in the advance of leading edge remedies”, clarifies Prof. Thomas Eschenhagen, the consultant of the DZHK Board of Administrators.

For the primary time in sufferers with coronary center illness

Revacept was once additional evolved right into a drug to be used in people through the biotech corporate advanceCOR, a spin-off of the Technical College Munich. A prior learn about with wholesome volunteers has already confirmed that Revacept is secure and smartly tolerated. Additionally, a medical trial is already being performed investigating Revacept in stroke sufferers. Within the upcoming learn about, 332 sufferers with a coronary center illness for whom a catheterization is deliberate can be tested. Some sufferers can be handled with Revacept along with the standard drugs. Right through the learn about, bleeding chance can be monitored and a marker within the blood can be used to analyze whether or not Revacept sufficiently prevents injury of the guts muscle. In general, six DZHK websites are taking part within the learn about, which is co-financed through the producer, advanceCOR GmbH in Martinsried.

aca032be-c293-48f1-bef8-c1a06645af93|zero|.zero

Posted in: Drug Trial Information | Clinical Process Information | Clinical Situation Information

Tags: Blood, Blood Vessels, Catheter, Scientific Trial, Collagen, Compound, Coronary Center Illness, Medication, Center, Center Illness, Laboratory, Muscle, Platelets, Stroke

Tagged with:

About author

Related Articles