Breaking News
December 14, 2018 - Researchers discover Ebola-fighting protein in human cells
December 14, 2018 - Fentanyl surpasses heroin in cause of U.S. drug overdose deaths
December 14, 2018 - When Heart Attack Strikes, Women Often Hesitate to Call for Help
December 14, 2018 - A warning about costume contacts
December 14, 2018 - Study examines link between peripheral artery disease and heart attack
December 14, 2018 - Researchers develop biotechnological tool to produce antifungal proteins in plants
December 14, 2018 - 3D-printed adaptive aids can benefit patients with arthritis
December 14, 2018 - Chronic bullying during adolescence impacts mental health
December 14, 2018 - Integral Molecular and Merus collaborate to develop bispecific antibody therapeutics
December 13, 2018 - Importance of cell cycle and cellular senescence in the placenta discovered
December 13, 2018 - Gold “nanoprisms” open new window into vessels and single cells
December 13, 2018 - Research findings could lead to new targets for cancer-fighting therapeutics
December 13, 2018 - Butantan Institute signs collaboration agreement with MSD to develop dengue vaccines
December 13, 2018 - Study explores how patients want to discuss symptoms with doctors
December 13, 2018 - RUDN medics first to gather scattered data on hepatitis morbidity in Somalia
December 13, 2018 - Age and gender disparities found in use of bed nets to prevent malaria in sub-Saharan Africa
December 13, 2018 - Caffeine therapy benefits developing brains of premature babies
December 13, 2018 - New review focuses on electrospinning techniques used in musculoskeletal tissue engineering
December 13, 2018 - A new division focused on human immune system
December 13, 2018 - Zogenix Announces Positive Phase 3 Trial Results on the Efficacy and Safety of Fintepla (ZX008) in Dravet Syndrome
December 13, 2018 - BCR ABL Genetic Test: MedlinePlus Lab Test Information
December 13, 2018 - Caffeinated beverages during pregnancy linked to lower birth weight babies
December 13, 2018 - Stanford Medicine Health Trends Report examines opportunity to democratize health care
December 13, 2018 - Obsessive-compulsive disorder may protect individuals from obesity
December 13, 2018 - Scientists investigate how a painful event is processed in the brain
December 13, 2018 - Genetic study reveals new insights into underlying causes of moderate-to-severe asthma
December 13, 2018 - Vitamin C supplementation for pregnant smokers may reduce harm to infants’ lungs
December 13, 2018 - New study reveals yin-yang personality of dopamine
December 13, 2018 - Research identifies nerve-signaling pathway behind sustained pain after injury
December 13, 2018 - Children with high levels of callous traits show widespread differences in brain structure
December 13, 2018 - Long-term Benefit of Steroid Injections for Knee Osteoarthritis Challenged
December 13, 2018 - Adding new channels to the brain remote control
December 13, 2018 - In the Spotlight: A different side of neuroscience
December 13, 2018 - Medical Marvels: Using immunotherapy for melanoma that spread to the brain
December 13, 2018 - Puzzles do not keep dementia away finds study
December 13, 2018 - New mouse model shows potential for rapid identification of promising muscular dystrophy therapies
December 13, 2018 - Study reveals urban and rural differences in prenatal exposure to essential and toxic elements
December 13, 2018 - New collaborative partnership in quest of novel antibiotics
December 13, 2018 - Single tau molecule holds clues to help diagnose neurodegeneration in its earliest stages
December 13, 2018 - AHA Scientific Statement: Low Risk of Side Effects for Statins
December 13, 2018 - What Is Acute Flaccid Myelitis?
December 13, 2018 - How bereaved people control their thoughts without knowing it
December 13, 2018 - Health care democratization underway, according to 2nd annual Stanford Medicine Health Trends Report | News Center
December 13, 2018 - Going Beyond a Single Color
December 13, 2018 - London-based startup launches ‘’ aiming to clean up CBD industry
December 13, 2018 - Loss of tight junction barrier protein results in gastric cancer development
December 13, 2018 - Novel way to efficiently deliver anti-parasitic medicines
December 13, 2018 - RKI publishes new data on disease prevention and utilization of medical services
December 13, 2018 - High-tech, flexible patches sewn into clothes could help to stay warm
December 13, 2018 - The CCA releases three reports on requests for medical assistance in dying
December 13, 2018 - Restoring Hair Growth on Scarred Skin? Mouse Study Could Show the Way
December 13, 2018 - Probiotic use may reduce antibiotic prescriptions, researchers say
December 13, 2018 - Drug repositioning strategy identifies potential new treatments for epilepsy
December 13, 2018 - Chronic rhinitis associated with hospital readmissions for asthma and COPD patients
December 13, 2018 - Food poisoning discovery could save lives
December 13, 2018 - Cloned antibodies show potential to treat, diagnose life-threatening fungal infections
December 13, 2018 - Exercise may reduce colorectal cancer risk after weight loss
December 13, 2018 - Russian scientists create hardware-information system for brain disorders treatment
December 13, 2018 - Moderate alcohol consumption linked with lower risk of hospitalization
December 13, 2018 - Nurturing Healthy Neighborhoods | NIH News in Health
December 13, 2018 - Rise in meth and opioid use during pregnancy
December 13, 2018 - Researchers gain new insights into pediatric tumors
December 13, 2018 - FSU study finds racial disparity among adolescents receiving flu vaccine
December 13, 2018 - Study investigates attitudes toward implementation of ‘sex as a biological variable’ policy
December 13, 2018 - Drug cocktail induces cancer cell death by switching off energy supply
December 13, 2018 - Baculovirus virion completely eliminates liver-stage parasites in mouse model
December 13, 2018 - Researchers create noninvasive technology that detects when nerve cells fire
December 13, 2018 - Allen Institute for Immunology to partner with CU Anschutz to understand dynamics of human immune system
December 13, 2018 - Inability to do daily living tasks delays discharge of mental health patients
December 13, 2018 - Treating patients with hypertension induced albuminuria
December 13, 2018 - New substance could improve efficacy of established breast cancer treatments
December 13, 2018 - Scientists develop new stem cell line to study conversion of stem cells into muscle
December 13, 2018 - Re-programming the body’s energy pathway boosts kidney self-repair
December 13, 2018 - Research findings could help improve treatment of anxiety and post-traumatic stress disorders
December 13, 2018 - The Microbiome Movement announce Microbiotica as official industry partner
December 13, 2018 - New study reveals potential benefits of cEEG monitoring for infant ICU patients
December 13, 2018 - Whole-body imaging PET/MRI offers information to guide treatment options for prostate cancer
December 13, 2018 - International investigators fight against the negative campaign on benzodiazepines
December 13, 2018 - Targeting biochemical pathway may lead to new therapies for alleviating symptoms of anxiety disorders
December 13, 2018 - FDA Approves Tolsura (SUBA®-itraconazole capsules) for the Treatment of Certain Fungal Infections
Newly found out molecule performs central position in urge for food keep watch over mechanisms

Newly found out molecule performs central position in urge for food keep watch over mechanisms

image_pdfDownload PDFimage_print

A newly found out molecule will increase urge for food right through fasting — and reduces it right through gorging. The neuron-exciting protein, named NPGL – it sounds as if goals to care for frame mass at a relentless, come banquet or famine. An evolutionary masterstroke, however now not nice information for the ones having a look to trim down — or toughen for the summer season.

Over fresh many years, our working out of starvation has a great deal larger, however this new discovery turns issues on their head. Up till now, scientists knew that leptin — a hormone launched through fatty tissue, reduces urge for food, whilst ghrelin — a hormone launched through abdomen tissue makes us wish to devour extra. Those hormones, in flip, turn on a number of neurons within the mind’s hypothalamus — the frame’s power keep watch over middle.

The invention of NPGL through Professor Kazuyoshi Ukena of Hiroshima College presentations that starvation and effort intake mechanisms are much more advanced than we discovered — and that NPGL performs a central position in what have been considered well-understood processes.

Professor Ukena first found out NPGL in chickens after noticing that rising birds grew greater regardless of weight loss plan — suggesting there was once extra to power metabolism than meets the attention. Intrigued, the researchers at HU carried out a DNA database seek to peer if mammals may also possess this elusive substance. They discovered that it exists in all vertebrates – together with people.

In an effort to examine its position, if any, in mammals, Professor Ukena’s crew fed 3 teams of mice, on 3 distinct diets, to peer how NPGL ranges are altered. The primary set of mice was once consumed a low-calorie weight loss plan for 24 hours. The second one team was once consumed a high-fat weight loss plan for five weeks — and the 3rd fortunate team was once consumed a high-fat weight loss plan, however for a longer duration of 13 weeks.

The mice consumed a low calorie weight loss plan have been discovered to enjoy an excessive build up in NPGL expression, whilst the Five-week high-fat-diet team noticed a big lower in NPGL expression.

Additional research discovered that mice possess NPGL, and its related neuron community, in the very same places of the mind as the ones areas already recognized to keep watch over urge for food suppression and effort use.

Professor Ukena proposes that NPGL performs an important position in those mechanisms — expanding urge for food when power ranges fall and lowering urge for food when an power overload is detected — in combination, serving to to stay us at a wholesome and functioning weight, and extra importantly alive!

As NPGL ranges a great deal larger in mice uncovered to a low calorie weight loss plan, Professor Ukena believes it’s an urge for food promoter, operating against urge for food suppressing hormones equivalent to leptin. Backing this speculation up, it was once discovered that mice without delay injected with NPGL exhibited a voracious urge for food.

Curiously NPGL ranges, which plummeted within the Five-week-long high-fat-diet mice – fell again to standard ranges in mice who gorged themselves for the longer duration of 13 weeks.

It’s proposed that publicity to high-fat diets for lengthy classes of time result in insensitivity to leptin’s appetite-suppressing results, and so NPGL — even at standard ranges – results in weight acquire and weight problems, appearing that the frame can most effective do such a lot to stay our weight in take a look at.

Professor Ukena says that additional find out about is needed to grasp the interplay of prior to now recognized urge for food mechanisms with this new child at the homeostasis block. It does appear on the other hand, that we nonetheless have so much to be informed about urge for food, starvation, and effort intake. It’s was hoping that this find out about into mammalian NPGL provides any other piece to the puzzle.

What is bound — however you knew this already – is that weight loss plan is tricky. The invention and find out about of mammalian NPGL is helping provide an explanation for why, and gives a believable excuse for the ones whose excellent intentions fall quick.

Tagged with:

About author

Related Articles