Breaking News
February 19, 2018 - Researchers uncover how excess calcium may influence development of Parkinson’s disease
February 19, 2018 - Psoriasis drug also effective at reducing aortic inflammation
February 19, 2018 - Excess emissions can make serious contributions to air pollution, study shows
February 19, 2018 - Diabetes Drugs Differ on HF; School-Based Obesity Program Flop; Plaque Type in ACS
February 19, 2018 - Surgical infections linked to drug-resistant bugs, study suggests
February 19, 2018 - Poor awareness may hinder a child’s early dental care
February 19, 2018 - FDA Approves Apalutamide (Erleada) to Help Curb a Tough-to-Treat Prostate Cancer
February 19, 2018 - Educational Tool Boosts Cervical Length Screening
February 19, 2018 - Spider’s web inspires removable implant that may control type 1 diabetes
February 19, 2018 - Scientists develop fluorescent probe to identify cancer stem cells
February 19, 2018 - University Hospital of Santiago de Compostela participates in large pancreatic cancer study
February 19, 2018 - New blood test shows promise to revolutionize diagnosis of tick-borne diseases
February 19, 2018 - Report: Use, Not Price, Drives State Health Costs
February 19, 2018 - Emergency services crews often unprepared for diabetic crises
February 19, 2018 - Scientists in Sweden create DNA nanowires that offer hope for treatment of diseases
February 19, 2018 - ID Break: Clean Hands, Fewer Abx; $11 Million HIV Cure?; MenB Vax for Kids
February 19, 2018 - Patient exposure to X-rays depends on how dentists are paid
February 19, 2018 - Study reveals parents’ views toward children’s tanning bed use
February 19, 2018 - Shot may help reduce risk of shingles
February 19, 2018 - FDA approves first treatment to reduce risk of NSCLC progression
February 19, 2018 - FDA Expands Approval of Imfinzi (durvalumab) to Reduce the Risk of Non-Small Cell Lung Cancer Progressing
February 19, 2018 - D.C. Week: Congress Passes Spending Bill
February 19, 2018 - Heart-muscle patches made with human cells improve heart attack recovery
February 19, 2018 - FDA Approves First Blood Test to Detect Concussions
February 19, 2018 - Survival Bump in Bladder Cancer with Keytruda
February 18, 2018 - Scientists describe the mechanism of heart regeneration in the zebrafish
February 18, 2018 - Scientists uncover the structure of microtubule motor proteins
February 18, 2018 - Light-activated cancer drugs without toxic side effects are closer to becoming reality
February 18, 2018 - Pioneering research could provide novel insight into how genomic information is read
February 18, 2018 - Pearls From: David Putrino, PhD
February 18, 2018 - Researchers uncover how cancer stem cells drive triple-negative breast cancer
February 18, 2018 - Morning Break: Anti-Anti-Vaxxers; Private Piercings Prohibited; A Case for Pelvic Massage
February 18, 2018 - Lower-dose radiation effective, safe for HPV+ head and neck cancer after induction chemo
February 18, 2018 - Specialist residential service for adults with autism opens in Swansea
February 18, 2018 - FDA Moves to Limit Loperamide Doses per Package
February 18, 2018 - Alcohol use disorder – Genetics Home Reference
February 18, 2018 - Autism might be better detected using new two-minute questionnaire
February 18, 2018 - Hand hygiene-intervention practices may reduce risk of infection among nursing home patients
February 18, 2018 - Researchers develop most sophisticated mini-livers to date
February 18, 2018 - Obamacare Helped More Young Women Get Prenatal Care: Study
February 18, 2018 - School-Based Program Fails to Dent Kids’ Obesity
February 18, 2018 - Research compares neural activity in children with and without autism spectrum disorder
February 18, 2018 - Poor fitness levels increase the risk dementia, concludes study
February 18, 2018 - Risk Score May Reveal if Kids are Victims of Ill-Treatment
February 18, 2018 - Adding Folic Acid to Corn Masa Flour May Prevent Birth Defects
February 18, 2018 - Acute treatment suppresses posttraumatic arthritis in ankle injury
February 18, 2018 - A Role for Budesonide in Autoimmune Hepatitis?
February 18, 2018 - Lupus patients exhibit altered cell proteins, a discovery with potential implications for diagnostics
February 18, 2018 - Muscle plays vital role in regulating heat loss from the hands
February 18, 2018 - High-tech brain scans can provide new way to define intelligence
February 18, 2018 - Study reveals the association between ultra-processed foods and cancer
February 18, 2018 - Prescription Opioid Use Tied to Higher Pneumonia Risk
February 18, 2018 - A non-invasive method to detect Alzheimer’s disease
February 18, 2018 - Deletion of specific enzyme leads to improvement in memory and cognitive functions
February 18, 2018 - Amyloid protein may be transmitted through neurosurgical instruments, study suggests
February 18, 2018 - Electric brain signals of males and females show differences
February 18, 2018 - American Heart Association commends McDonald’s for offering healthier menu in kids’ meals
February 18, 2018 - Parents Find Kids’ Weight Report Cards Hard to Swallow
February 18, 2018 - Does a Financial Conflict of Interest Ever Expire?
February 18, 2018 - Exercise can improve Alzheimer’s symptoms
February 18, 2018 - Scientists develop green chemistry method to improve pharmaceutical manufacturing efficiency
February 17, 2018 - ‘A Time Clock to a Tissue Clock’ for Acute Stroke Care
February 17, 2018 - Cancer Care Gets Personal | NIH News in Health
February 17, 2018 - Do more youth use or do youth use more?
February 17, 2018 - Eating faster linked to obesity
February 17, 2018 - Who’s Still Smoking? ACS Report Highlights Most Vulnerable Adults
February 17, 2018 - Study of smoking and genetics illuminates complexities of blood pressure
February 17, 2018 - Study reveals new link between bone cells and blood glucose level
February 17, 2018 - Children with reading challenges may have lower than expected binocular vision test results
February 17, 2018 - Mass Shootings Trigger Change for Emergency Medicine
February 17, 2018 - ECMO helps revive woman thought to be drowned
February 17, 2018 - Learning stress-reducing techniques may benefit people with epilepsy
February 17, 2018 - Shedding Pounds Before Weight-Loss Surgery a Smart Move
February 17, 2018 - FDA Approves New Cystic Fibrosis Drug Combo
February 17, 2018 - Augmented Reality helps surgeons to ‘see through’ tissue and reconnect blood vessels
February 17, 2018 - Emotional state affects operation of the entire brain instead of being restricted to specific regions
February 17, 2018 - Apalutamide Slows Metastasis in Prostate Cancer
February 17, 2018 - Kids’ well visits linked to lower appendicitis complications
February 17, 2018 - New NK cell-based immunotherapy effective against several types of leukemia
February 17, 2018 - Producing Super-Swelled Lyotropic Crystals for Drug Development
Genetics are key to hormone remedy decreasing chance of damaged bones in older ladies

Genetics are key to hormone remedy decreasing chance of damaged bones in older ladies

image_pdfDownload PDFimage_print
Heather Ochs-Balcom is an affiliate professor of epidemiology and environmental well being, College at Buffalo. Credit score: College at Buffalo

Girls on the easiest genetic chance for fracture receive advantages probably the most from hormone remedy, in keeping with a first-of-its-kind learn about led via researchers on the College at Buffalo.

The learn about integrated just about 10,000 members from the Girls’s Well being Initiative (WHI), a countrywide, long-term learn about of greater than 150,000 ladies.

“We discovered that ladies who’re genetically on the easiest fracture chance can benefit from the biggest coverage from fracture once they use hormone remedy,” stated Heather Ochs-Balcom, affiliate professor of epidemiology and environmental well being in UB’s Faculty of Public Well being and Well being Professions, who led the analysis group.

The findings have been revealed on-line forward of print within the Magazine of Medical Endocrinology and Metabolism. The paper’s first creator, Youjin Wang, carried out the analysis as a doctoral candidate in epidemiology and environmental well being at UB.

“This learn about supplies a greater figuring out of who can receive advantages probably the most relating to bone well being from hormone remedy use,” Ochs-Balcom stated, including that the effects have implications for personalised medication. “It is vital knowledge as ladies and their docs make choices about hormone remedy use.”

The learn about, believed to be the primary to research gene-hormone remedy interplay on fracture in postmenopausal white ladies, makes use of the biggest set of recognized genes connected to fracture chance from a meta-analysis of genome-wide affiliation research.

Researchers checked out a subset of nine,922 ladies from a few of the greater than 27,000 who had participated in WHI hormone remedy scientific trials. They puzzled whether or not ladies who’re extra genetically vulnerable to fractures may get pleasure from hormone remedy.

“That is necessary as a result of, as earlier WHI research have recognized, there are dangers and advantages with hormone remedy,” Ochs-Balcom stated. “That is the place precision or personalised medication is available in—the try to get the precise medicine to the precise particular person to verify probably the most receive advantages and least hurt.”

As ladies age, their bone mineral density (BMD) decreases, leaving them at better chance of breaking bones from falling, which additionally will increase as they age. However some ladies are also extra genetically vulnerable to fractures. “Our learn about represents a primary have a look at how inherited predisposition to fracture is said to hormone remedy use,” stated Ochs-Balcom, who additionally holds a college appointment within the Division of Genetics, Genomics and Bioinformatics in UB’s Jacobs Faculty of Drugs and Biomedical Sciences.

Wang notes that “additional research on gene-therapy interplay are warranted to judge the benefits of centered interventions in keeping with genetic profile.” The analysis group is lately examining different gene-environment interactions and not too long ago revealed any other paper at the affiliation of calcium plus diet D supplementation and genetic chance of fracture.

Along with Wang and Ochs-Balcom, different UB co-authors come with Jean Wactawski-Wende, dean of the Faculty of Public Well being and Well being Professions and SUNY Prominent Professor and professor of epidemiology and environmental well being; and Leah Preus, Kathleen Hovey and Jing Nie from the Faculty of Public Well being and Well being Professions.

Further co-authors come with Lara Sucheston-Campbell, Rebecca Jackson and Samuel Handelman, The Ohio State College; Rami Nassir, College of California, Davis; and Carolyn Crandall, College of California, Los Angeles.

The Girls’s Well being Initiative started in 1991 and consisted of a suite of scientific trials and an observational learn about. Mixed, they integrated greater than 161,000 normally wholesome postmenopausal ladies elderly 50 to 79.

Considered one of 40 WHI facilities national, the College at Buffalo serves because the Northeast Regional Heart, managing knowledge assortment and medical coordination amongst 9 WHI-affiliated establishments within the mid-Atlantic and Northeast areas. UB has won WHI extension investment to behavior follow-up research at the authentic members, lots of whom at the moment are between ages 67 and 100.

Discover additional:
New learn about confirms hyperlink between early menopause and better chance of fracture

Additional info:
Gene-hormone remedy interplay and fracture chance in postmenopausal ladies, The Magazine of Medical Endocrinology & Metabolism (2017). DOI: 10.1210/jc.2016-2936

Tagged with:

About author

Related Articles